The expression of a disintegrin and metalloproteinase with thrombospondin motifs 4 in human macrophages is inhibited by the anti-atherogenic cytokine transforming growth factor-β and requires Smads, p38 mitogen-activated protein kinase and c-Jun

International Journal of Biochemistry and Cell Biology

Volumn 43, Issue 5, 2011, Pages 805-811

  Salter, Rebecca C ^a   Arnaoutakis, Konstantinos ^a   Michael, Daryn R ^a   Singh, Nishi N ^a   Ashlin, Tim G ^a   Buckley, Melanie L ^a   Kwan, Alvin P L ^a   Ramji, Dipak P ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

A disintegrin and metalloproteinase with thrombospondin motifs 4 family; Atherosclerosis; Inflammation; Macrophages; Transforming growth factor

Indexed keywords

AGGRECANASE 1; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; SMAD PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; CONTROLLED STUDY; DOWN REGULATION; GENE ACTIVITY; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MACROPHAGE; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ADAM PROTEINS; ATHEROSCLEROSIS; CELL LINE, TUMOR; DOWN-REGULATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MACROPHAGES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROCOLLAGEN N-ENDOPEPTIDASE; PROMOTER REGIONS, GENETIC; RNA, MESSENGER; SMAD PROTEINS; TRANSFORMING GROWTH FACTOR BETA1;

EID: 79953200771     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2011.02.005     Document Type: Article

References (42)

1. S. Ali, N.N. Singh, H. Yildirim, and D.P. Ramji Requirement for nuclear factor kappa B signalling in the interleukin-1-induced expression of the CCAAT/enhancer binding protein-δ gene in hepatocytes Int J Biochem Cell Biol 42 2010 113 119
2. J. Auwerx The human leukemia cell line, THP-1: a multifaceted model for the study of monocyte-macrophage differentiation Experientia 47 1991 22 31
3. Q.T. Bui, M. Prempeh, and R.L. Wilensky Atherosclerotic plaque development Int J Biochem Cell Biol 41 2009 2109 2113
4. M.W. Feinberg, K. Shimizu, M. Lebedeva, R. Haspel, K. Takayama, and Z. Chen Essential role for Smad3 in regulating MCP-1 expression and vascular inflammation Circ Res 94 2004 601 608 (Pubitemid 38387742)
5. P. Foka, S.A. Irvine, F. Kockar, and D.P. Ramji Interleukin-6 represses the transcription of the CCAAT/enhancer binding protein-α gene in hepatoma cells by inhibiting its ability to autoactivate the proximal promoter region Nucleic Acids Res 31 2003 6722 6732 (Pubitemid 37508779)
6. P. Foka, N.N. Singh, R.C. Salter, and D.P. Ramji The tumour necrosis factor-α-mediated suppression of the CCAAT/enhancer binding protein-α gene transcription in hepatocytes involves inhibition of autoregulation Int J Biochem Cell Biol 41 2009 1189 1197
7. M. Fu, J. Zhang, Y. Lin, X. Zhu, L. Zhao, and M. Ahmad Early stimulation and late inhibition of peroxisome proliferator-activated receptor γ (PPARγ) gene expression by transforming growth factor-β in human aortic smooth muscle cells: role of early growth-response factor-1 (Egr-1), activator protein 1 (AP1) and Smads Biochem J 370 2003 1019 1025 (Pubitemid 36399096)
8. Z.S. Galis, and J.J. Khatri Matrix metalloproteinases in vascular remodelling and atherogenesis: the good, the bad and the ugly Circ Res 90 2002 251 262 (Pubitemid 34633925)
9. M.C. Hall, D.A. Young, J.G. Waters, A.D. Rowan, A. Chantry, and D.R. Edwards The comparative role of activator protein 1 and Smad factors in the regulation of Timp-1 and MMP-1 gene expression by transforming growth factor-β1 J Biol Chem 278 2003 10304 10313 (Pubitemid 36800292)
10. T.R. Hughes, T.S. Tengku-Muhammad, S.A. Irvine, and D.P. Ramji A novel role of Sp1 and Sp3 in the interferon-γ-mediated suppression of macrophage lipoprotein lipase gene transcription J Biol Chem 277 2002 11097 11106 (Pubitemid 34952870)
11. S.A. Irvine, P. Foka, S.A. Rogers, J.R. Mead, and D.P. Ramji A critical role for the Sp1-binding sites in the transforming growth factor-β-mediated inhibition of lipoprotein lipase gene expression in macrophages Nucleic Acids Res 33 2005 1423 1434 (Pubitemid 41418372)
12. G.C. Jones, and G.P. Riley ADAMTS proteinases: a multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritis Arthritis Res Ther 7 2005 160 169 (Pubitemid 40936607)
13. A.C. Jonsson-Rylander, T. Nilsson, R. Fritsche-Danielson, A. Hammarstrom, M. Behrendt, and J.O. Andersson Role of ADAMTS-1 in atherosclerosis: remodelling of carotid artery, immunohistochemistry, and proteolysis of versican Arterioscler Thromb Vasc Biol 25 2005 180 185 (Pubitemid 40054273)
14. N. Kalinina, A. Agrotis, Y. Antropova, O. Ilyinskaya, V. Smirnov, and E. Tararak Smad expression in human atherosclerotic lesions. Evidence for impaired TGF-β/Smad signalling in smooth muscle cells of fibrofatty lesions Arterioscler Thromb Vasc Biol 24 2004 1391 1396 (Pubitemid 39050430)
15. L.D. Kerr, D.B. Miller, and L.M. Matrisian TGF-β1 inhibition of transin/stromelysin gene expression is mediated through a Fos binding sequence Cell 61 1990 267 278
16. K. Kuno, N. Kanada, E. Nakashima, F. Fujiki, F. Ichimura, and K. Matsushima Molecular cloning of a gene encoding a new type of metalloproteinase-disintegrin family protein with thrombospondin motifs as an inflammation-associated gene J Biol Chem 272 1997 556 562 (Pubitemid 27021194)
17. A.C. Li, and C.K. Glass The macrophage foam cell as a target for therapeutic intervention Nat Med 8 2002 1235 1242 (Pubitemid 35373554)
18. N. Li, J.E. McLaren, D.R. Michael, M. Clement, C.A. Fielding, and D.P. Ramji ERK is integral to the IFN-γ-mediated activation of STAT1, the expression of key genes implicated in atherosclerosis, and the uptake of modified lipoproteins by human macrophages J Immunol 185 2010 3041 3048
19. A.J. Lusis, R. Mar, and P. Pajukanta Genetics of atherosclerosis Annu Rev Genomics Hum Genet 5 2004 189 218 (Pubitemid 39362746)
20. J.E. McLaren, C.J. Calder, B.P. McSharry, K. Sexton, R.C. Salter, and N.N. Singh The TNF-like protein 1A-death receptor 3 pathway promotes macrophage foam cell formation in vitro J Immunol 184 2010 5827 5834
21. J.E. McLaren, D.R. Michael, R.C. Salter, T.G. Ashlin, C.J. Calder, and A.M. Miller IL-33 reduces macrophage foam cell formation J Immunol 185 2010 1222 1229
22. Y. Mizui, K. Yamazaki, Y. Kuboi, K. Sagane, and I. Tanaka Characterization of the 5′-flanking region of human aggrecanase-1 (ADAMTS4) gene Mol Biol Rep 27 2000 167 173 (Pubitemid 32183859)
23. S. Naito, T. Shiomi, A. Okada, T. Kimura, M. Chijiiwa, and Y. Fujita Expression of ADAMTS-4 (aggrecanase-1) in human osteoarthritic cartilage Pathol Int 57 2007 703 711 (Pubitemid 47537631)
24. A.C. Newby Metalloproteinases and vulnerable atherosclerotic plaques Trends Cardiovasc Med 17 2007 253 258 (Pubitemid 350087694)
25. K. Ogawa, F. Chen, C. Kuang, and Y. Chen Suppression of matrix metalloproteinase-9 transcription by transforming growth factor-β is mediated by a nuclear factor-kappaB site Biochem J 381 2004 413 422 (Pubitemid 38969685)
26. S. Porter, I.M. Clark, L. Keveorkian, and D.R. Edwards The ADAMTS metalloproteinases Biochem J 386 2005 15 27
27. S. Ross, and C.S. Hill How the Smads regulate transcription Int J Biochem Cell Biol 40 2008 383 408 (Pubitemid 351241229)
28. R.C. Salter, T.G. Ashlin, A.P. Kwan, and D.P. Ramji ADAMTS proteases: key roles in atherosclerosis J Mol Med 88 2010 1203 1211
29. J.D. Sandy, J. Westling, R.D. Kenagy, M.L. Iruela-Arispe, C. Verscharen, and J.C. Rodriguez-Mazaneque Versican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site that is cleaved by recombinant ADAMTS-1 and ADAMTS-4 J Biol Chem 276 2001 13372 13378
30. N.N. Singh, and D.P. Ramji The role of transforming growth factor-β in atherosclerosis Cytokine Growth Factor Rev 17 2006 487 499 (Pubitemid 44793117)
31. N.N. Singh, and D.P. Ramji Transforming growth factor-β-induced expression of the apolipoprotein E requires c-Jun N-terminal kinase, p38 kinase, and casein kinase 2 Arterioscler Thromb Vasc Biol 26 2006 1323 1329 (Pubitemid 44305377)
32. B.L. Tang ADAMTS: a novel family of extracellular matrix proteases Int J Biochem Cell Biol 33 2001 33 44 (Pubitemid 32146465)
33. P. Ten Dijke, and C.S. Hill New insights into TGF-β-Smad signalling Trends Biochem Sci 29 2004 265 273
34. T.S. Tengku-Muhammad, A. Cryer, and D.P. Ramji Synergism between interferon γ and tumour necrosis factor α in the regulation of lipoprotein lipase in the macrophage J774.2 cell line Cytokine 10 1998 38 48 (Pubitemid 28068591)
35. K. Thirunavukkarasu, Y. Pei, T.L. Moore, H. Wang, X.P. Yu, and A.G. Geiser Regulation of human ADAMTS-4 promoter by transcription factors and cytokines Biochem Biophys Res Commun 345 2006 197 204
36. K. Thirunavukkarasu, Y. Pei, and T. Wei Characterization of the human ADAMTS-5 (aggrecanase-2) gene promoter Mol Biol Rep 34 2007 225 231 (Pubitemid 47624284)
37. L. Ulloa, J. Doody, and J. Massagué Inhibition of transforming growth factor-β/SMAD signalling by the interferon γ/STAT pathway Nature 397 1999 710 713
38. F. Verrecchia, and A. Mauviel Transforming growth factor-β signalling through the Smad pathway: role of extracellular matrix gene expression and regulation J Invest Dermatol 118 2002 211 215 (Pubitemid 34158472)
39. D. Wgsäter, H. Bjork, C. Zhu, J. Bjorkegren, G. Valen, and A. Hamsten ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques Atherosclerosis 196 2008 514 522
40. L.A. White, T.I. Mitchell, and C.E. Brinckerhoff Transforming growth factor β inhibitory element in the rabbit matrix metalloproteinase-1 (collagenase-1) gene functions as a repressor of constitutive transcription Biochim Biophys Acta 1490 2000 259 268 (Pubitemid 30103799)
41. T.N. Wight The ADAMTS proteases, extracellular matrix and vascular disease. Walking the sleeping giant(s)! Arterioscler Thromb Vasc Biol 25 2005 12 14 (Pubitemid 40054247)
42. J.R. Worley, M.D. Baugh, D.A. Hughes, D.R. Edwards, A. Hogan, and M.J. Sampson Metalloproteinase expression in PMA-stimulated THP-1 cells. Effects of peroxisome proliferator-activated receptor-gamma (PPARγ) agonists and 9-cis-retinoic acid J Biol Chem 278 2003 51340 51346 (Pubitemid 38020373)