Requirement for nuclear factor kappa B signalling in the interleukin-1-induced expression of the CCAAT/enhancer binding protein-δ gene in hepatocytes

International Journal of Biochemistry and Cell Biology

Volumn 42, Issue 1, 2010, Pages 113-119

  Ali, Saira ^a   Singh, Nishi N ^a   Yildirim, Hatice ^a   Ramji, Dipak P ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Acute phase proteins; CCAAT enhancer binding proteins; Cell signalling; Hepatocytes; Interleukin 1

Indexed keywords

ACUTE PHASE PROTEIN; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; APIGENIN; CCAAT ENHANCER BINDING PROTEIN DELTA; CURCUMIN; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1;

ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; LIVER CELL; NUCLEOTIDE SEQUENCE; PROTEIN DNA BINDING; PROTEIN EXPRESSION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

APIGENIN; BINDING SITES; CASEIN KINASE II; CCAAT-ENHANCER-BINDING PROTEIN-DELTA; CELL LINE, TUMOR; CURCUMIN; DNA; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HEPATOCYTES; HUMANS; INTERLEUKIN-1BETA; JNK MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; PROTEIN BINDING; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSCRIPTIONAL ACTIVATION;

EID: 70549097118     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2009.09.018     Document Type: Article

References (44)

1. Alam T., An M.R., and Papaconstantinou J. Differential expression of three C/EBP isoforms in multiple tissues during the acute phase response. J Biol Chem 267 (1992) 5021-5024
2. Bannach F.G., Gutierrez-Fernandez A., Parmer R.J., and Miles L.A. Interleukin-6-induced plasminogen gene expression in murine hepatocytes is mediated by transcription factor CCAAT/enhancer binding protein β (C/EBPβ). J Throb Haemost 2 (2004) 2205-2212
3. Baumann H., and Gauldie J. The acute phase response. Immunol Today 15 (1994) 74-80
4. Bird T.A., Schooley K., Dower S.K., Hagen H., and Virca G.D. Activation of nuclear transcription factor NF-κB by interleukin-1 is accompanied by casein kinase II-mediated phosphorylation of the p65 subunit. J Biol Chem 272 (1997) 32606-32612
5. Cantwell C.A., Sterneck E., and Johnson P.F. Interleukin-6-specific activation of the C/EBPδ gene in hepatocytes is mediated by Stat3 and Sp1. Mol Cell Biol 18 (1998) 2108-2117
6. Chen H.M., and Liao W.S. Differential acute-phase response of rat kininogen genes involves type I and type II interleukin-6 response elements. J Biol Chem 268 (1993) 25311-25319
7. Coulouarn C., Lefebvre G., Derambure C., Lequerre T., Scotte M., Francois A., et al. Altered gene expression in acute systemic inflammation detected by complete coverage of the human transcriptome. Hepatology 39 (2004) 353-364
8. Coulouarn C., Lefebvre G., Daveau R., Letellier F., Hiron M., Drouot L., et al. Genome-wide response of the human Hep3B hepatoma cell to proinflammatory cytokines, from transcription to translation. Hepatology 42 (2005) 946-955
9. Dong J., Fujii S., Li H., Nakabayshi H., Sakai M., Nishi S., et al. Interleukin-6 and mevastatin regulate plasminogen activator inhibitor-1 through CCAAT/enhancer-binding protein-δ. Arterioscler Thromb Vasc Biol 25 (2005) 1078-1084
10. Dong J., Fujii S., Li H., Nakabayashi H., Sakai M., Nishi S., et al. IL-1 and IL-6 induce hepatocyte plasminogen activator inhibitor-1 expression through independent signaling pathways converging on C/EBPδ. Am J Physiol Cell Physiol 292 (2007) C209-C215
11. Dunne A., and O'Neill L.A. The interleukin-1 receptor/toll-like receptor superfamily: signal transduction during inflammation and host defense. Sci STKE 171 (2003) re3
12. Foka P., Singh N.N., Salter R.C., and Ramji D.P. The tumour necrosis factor-α-mediated suppression of the CCAAT/enhancer binding protein-α gene transcription in hepatocytes involves inhibition of autoregulation. Int J Biochem Cell Biol 41 (2009) 1189-1197
13. Granger R.L., Hughes T.R., and Ramji D.P. Stimulus- and cell-type-specific regulation of CCAAT-enhancer binding protein isoforms in glomerular mesangial cells by lipopolysaccharide and cytokines. Biochim Biophys Acta 1501 (2000) 171-179
14. Han Z., Boyle D.L., Chang L., Bennett B., Karin M., Yang L., et al. c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis. J Clin Invest 108 (2001) 73-81
15. Harris S.M., Harvey E.J., Hughes T.R., and Ramji D.P. The interferon-γ-mediated inhibition of lipoprotein lipase gene transcription in macrophages involves casein kinase 2- and phosphoinositide-3-kinase-mediated regulation of transcription factors Sp1 and Sp3. Cell Signal 20 (2008) 2296-2301
16. Harvey E.J., Li N., and Ramji D.P. Critical role for casein kinase 2 and phosphoinositide-3-kinase in the interferon-γ-induced expression of monocyte chemoattractant protein-1 and other key genes implicated in atherosclerosis. Arterioscler Thromb Vasc Biol 27 (2007) 806-812
17. Heissmeyer V., Krappmann D., Wulczyn F.G., and Scheidereit C. NF-κB p105 is a target of IκB kinases and controls signal induction of Bcl-3-p50 complexes. EMBO J 18 (1999) 4766-4778
18. Hiron M., Daveau M., Arnaud P., Bauer J., and Lebreton J.P. The human hepatoma Hep3B cell line as an experimental model in the study of the long-term regulation of acute-phase proteins by cytokines. Biochem J 287 (1992) 255-259
19. Hutt J.A., O'Rourke J.P., and DeWille J. Signal transducer and activator of transcription 3 activates CCAAT enhancer binding protein δ gene transcription in G0 growth-arrested mouse mammary epithelial cells and in involuting mouse mammary gland. J Biol Chem 275 (2000) 29123-29131
20. Li X., Shi X., Liang D.Y., and Clark J.D. Spinal CK2 regulates nociceptive signaling in models of inflammatory pain. Pain 115 (2005) 182-190
21. Lowell C.A., Soriano P., and Varmus H.E. Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity. Genes Dev 8 (1994) 387-398
22. Magalini A., Savoldi G., Ferrari F., Garnier M., Ghezzi P., Albertini A., et al. Role of IL-1β and corticosteroids in the regulation of the C/EBP-α, β and δ genes in vivo. Cytokine 7 (1995) 753-758
23. May M.J., and Ghosh S. Rel/NF-κB and IκB proteins: an overview. Semin Cancer Biol 8 (1997) 63-73
24. Mead J.R., Hughes T.R., Irvine S.A., Singh N.N., and Ramji D.P. Interferon-γ stimulates the expression of the inducible cAMP early repressor in macrophages through the activation of casein kinase 2. A potentially novel pathway for interferon-γ-mediated inhibition of gene transcription. J Biol Chem 278 (2003) 17741-17751
25. Mestre J.R., Mackrell P.J., Rivadeneira D.E., Stapleton P.P., Tanabe T., and Daly J.M. Redundancy in the signaling pathways and promoter elements regulating cyclooxygenase-2 gene expression in endotoxin-treated macrophage/monocytic cells. J Biol Chem 276 (2001) 3977-3982
26. Moshage H. Cytokines and the hepatic acute phase response. J Pathol 181 (1997) 257-266
27. O'Neill L.A., and Greene C. Signal transduction pathways activated by the IL-1 receptor family: ancient signalling machinery in mammals, insects, and plants. J Leukoc Biol 63 (1998) 650-657
28. Packard R.R.S., and Libby P. Inflammation in atherosclerosis: from vascular biology to biomarker discovery and risk production. Clin Chem 54 (2008) 24-38
29. Parhar K., Morse J., and Salh B. The role of protein kinase CK2 in intestinal epithelial cell inflammatory signaling. Int J Colorectal Dis 22 (2007) 601-609
30. Pereira S.G., and Oakley F. Nuclear factor-kappaB1: regulation and function. Int J Biochem Cell Biol 40 (2008) 1425-1430
31. Poli V. The role of C/EBP isoforms in the control of inflammatory and native immune functions. J Biol Chem 273 (1998) 29279-29282
32. Ramji D.P., Cortese R., and Ciliberto G. Regulation of C-reactive protein, haptoglobin and hemopexin gene expression. In: Mackiewicz A., Kushner I., and Baumann H. (Eds). Acute phase proteins: molecular biology, biochemistry and clinical applications (1993), CRC-Taylor and Francis 365-394
33. Ramji D.P., Vitelli A., Tronche F., Cortese R., and Ciliberto G. The two C/EBP isoforms, IL-6DBP/NF-IL6 and C/EBPδ/NF-IL6β, are induced by IL-6 to promote acute phase gene transcription via different mechanisms. Nucleic Acids Res 21 (1993) 289-294
34. Ramji D.P., and Foka P. CCAAT/enhancer binding proteins: structure, function and regulation. Biochem J 365 (2002) 561-575
35. Ray A., and Ray B.K. Serum amyloid A gene expression under acute-phase conditions involves participation of inducible C/EBP-β and C/EBP-δ and their activation by phosphorylation. Mol Cell Biol 14 (1994) 4324-4332
36. Sanford D.C., and DeWille J.W. C/EBPδ is a downstream mediator of IL-6 induced growth inhibition of prostate cancer cells. The Prostate 63 (2005) 143-154
37. Singh N.N., and Ramji D.P. Protein kinase CK2, an important regulator of the inflammatory response?. J Mol Med 86 (2008) 887-897
38. Singh N.N., and Ramji D.P. Transforming growth factor-β-induced expression of the apolipoprotein E gene requires c-Jun N-terminal kinase, p38 kinase, and casein kinase 2. Arterioscler Thromb Vasc Biol 26 (2006) 1323-1329
39. Tengku-Muhammad T.S., Hughes T.R., Ranki H., Cryer A., and Ramji D.P. Differential regulation of macrophage CCAAT-enhancer binding protein isoforms by lipopolysaccharide and cytokines. Cytokine 12 (2000) 1430-1436
40. Tobe M., Isobe Y., Tomizawa H., Nagasaki T., Takahashi H., Fukazawa T., et al. Discovery of quinazolines as a novel structural class of potent inhibitors of NF-κB activation. Bioorg Med Chem 11 (2003) 383-391
41. Wullaert A., Heyninck K., and Beyaert R. Mechanisms of crosstalk between TNF-induced NF-κB and JNK activation in hepatocytes. Biochem Pharmacol 72 (2006) 1090-1101
42. Yamada M., Katsuma S., Adachi T., Hirosawa A., Shiojima S., Kadowaki T., et al. Inhibition of protein kinase CK2 prevents the progression of glomerulonephritis. Proc Natl Acad Sci USA 102 (2005) 7736-7741
43. Yamada T., Tobita K., Osada S., Nishihara T., and Imagawa M. CCAAT/enhancer-binding protein-δ gene expression is mediated by APRF/STAT3. J Biochem 121 (1997) 731-738
44. Yao J., Kim T.W., Qin J., Jiang Z., Qian Y., Xiao H., et al. Interleukin-1 (IL-1)-induced TAK1-dependent versus MEKK3-dependent NFκB activation pathways bifurcate at IL-1-receptor associated kinase modification. J Biol Chem 282 (2007) 6075-6089