메뉴 건너뛰기




Volumn 39, Issue 2, 2011, Pages 600-605

Cell-cycle-specific activators of the Mec1/ATR checkpoint kinase

Author keywords

Ataxia telangiectasia mutated and Rad3 related (ATR); Cell cycle; Checkpoint; DNA damage; DNA replication; Mec1

Indexed keywords

ATR PROTEIN;

EID: 79953176016     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST0390600     Document Type: Review
Times cited : (28)

References (43)
  • 1
    • 1542320702 scopus 로고    scopus 로고
    • Physical and functional interactions between nucleotide excision repair and DNA damage checkpoint
    • DOI 10.1038/sj.emboj.7600051
    • Giannattasio, M., Lazzaro, F., Longhese, M.P., Plevani, P. and Muzi-Falconi, M. (2004) Physical and functional interactions between nucleotide excision repair and DNA damage checkpoint. EMBO J. 23, 429-438 (Pubitemid 38294507)
    • (2004) EMBO Journal , vol.23 , Issue.2 , pp. 429-438
    • Giannattasio, M.1    Lazzaro, F.2    Longhese, M.P.3    Plevani, P.4    Muzi-Falconi, M.5
  • 2
    • 53649104599 scopus 로고    scopus 로고
    • Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing
    • Mimitou, E.P. and Symington, L.S. (2008) Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing. Nature 455, 770-774
    • (2008) Nature , vol.455 , pp. 770-774
    • Mimitou, E.P.1    Symington, L.S.2
  • 3
    • 51549095956 scopus 로고    scopus 로고
    • Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends
    • Zhu, Z., Chung, W.H., Shim, E.Y., Lee, S.E. and Ira, G. (2008) Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends. Cell 134, 981-994
    • (2008) Cell , vol.134 , pp. 981-994
    • Zhu, Z.1    Chung, W.H.2    Shim, E.Y.3    Lee, S.E.4    Ira, G.5
  • 4
    • 18244371925 scopus 로고    scopus 로고
    • Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint
    • DOI 10.1101/gad.1301205
    • Byun, T.S., Pacek, M., Yee, M.C., Walter, J.C. and Cimprich, K.A. (2005) Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint. Genes Dev. 19, 1040-1052 (Pubitemid 40632450)
    • (2005) Genes and Development , vol.19 , Issue.9 , pp. 1040-1052
    • Byun, T.S.1    Pacek, M.2    Yee, M.-C.3    Walter, J.C.4    Cimprich, K.A.5
  • 5
    • 0028882869 scopus 로고
    • Yeast checkpoint genes in DNA damage processing: Implications for repair and arrest
    • Lydall, D. and Weinert, T. (1995) Yeast checkpoint genes in DNA damage processing: implications for repair and arrest. Science 270, 1488-1491
    • (1995) Science , vol.270 , pp. 1488-1491
    • Lydall, D.1    Weinert, T.2
  • 6
    • 0035355342 scopus 로고    scopus 로고
    • Silent repair accounts for cell cycle specificity in the signaling of oxidative DNA lesions
    • DOI 10.1093/emboj/20.11.2896
    • Leroy, C., Mann, C. and Marsolier, M.C. (2001) Silent repair accounts for cell cycle specificity in the signaling of oxidative DNA lesions. EMBO J. 20, 2896-2906 (Pubitemid 32938572)
    • (2001) EMBO Journal , vol.20 , Issue.11 , pp. 2896-2906
    • Leroy, C.1    Mann, C.2    Marsolier, M.-C.3
  • 7
    • 0038730929 scopus 로고    scopus 로고
    • A central role for DNA replication forks in checkpoint activation and response
    • DOI 10.1016/S1097-2765(03)00169-2
    • Tercero, J.A., Longhese, M.P. and Diffley, J.F. (2003) A central role for DNA replication forks in checkpoint activation and response. Mol. Cell 11, 1323-1336 (Pubitemid 36645150)
    • (2003) Molecular Cell , vol.11 , Issue.5 , pp. 1323-1336
    • Tercero, J.A.1    Longhese, M.P.2    Diffley, J.F.X.3
  • 8
    • 0036948433 scopus 로고    scopus 로고
    • Toward maintaining the genome: DNA damage and replication checkpoints
    • Nyberg, K.A., Michelson, R.J., Putnam, C.W. and Weinert, T.A. (2002) Toward maintaining the genome: DNA damage and replication checkpoints. Annu. Rev. Genet. 36, 617-656
    • (2002) Annu. Rev. Genet. , vol.36 , pp. 617-656
    • Nyberg, K.A.1    Michelson, R.J.2    Putnam, C.W.3    Weinert, T.A.4
  • 9
    • 0036241880 scopus 로고    scopus 로고
    • Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo
    • DOI 10.1016/S1097-2765(02)00507-5
    • Rouse, J. and Jackson, S.P. (2002) Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo. Mol. Cell 9, 857-869 (Pubitemid 34454895)
    • (2002) Molecular Cell , vol.9 , Issue.4 , pp. 857-869
    • Rouse, J.1    Jackson, S.P.2
  • 10
    • 0037567268 scopus 로고    scopus 로고
    • Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
    • DOI 10.1126/science.1083430
    • Zou, L. and Elledge, S.J. (2003) Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 300, 1542-1548 (Pubitemid 36682880)
    • (2003) Science , vol.300 , Issue.5625 , pp. 1542-1548
    • Zou, L.1    Elledge, S.J.2
  • 11
    • 67649111979 scopus 로고    scopus 로고
    • Crystal structure of the Rad9-Rad1-Hus1 DNA damage checkpoint complex: Implications for clamp loading and regulation
    • Dore, A.S., Kilkenny, M.L., Rzechorzek, N.J. and Pearl, L.H. (2009) Crystal structure of the Rad9-Rad1-Hus1 DNA damage checkpoint complex: implications for clamp loading and regulation. Mol. Cell 34, 735-745
    • (2009) Mol. Cell , vol.34 , pp. 735-745
    • Dore, A.S.1    Kilkenny, M.L.2    Rzechorzek, N.J.3    Pearl, L.H.4
  • 12
    • 67449103064 scopus 로고    scopus 로고
    • Crystal structure of the human Rad9-Hus1-Rad1 clamp
    • Sohn, S.Y. and Cho, Y. (2009) Crystal structure of the human Rad9-Hus1-Rad1 clamp. J. Mol. Biol. 390, 490-502
    • (2009) J. Mol. Biol. , vol.390 , pp. 490-502
    • Sohn, S.Y.1    Cho, Y.2
  • 13
    • 0037418195 scopus 로고    scopus 로고
    • Yeast Rad17/Mec3/Ddc1: A sliding clamp for the DNA damage checkpoint
    • Majka, J. and Burgers, P.M. (2003) Yeast Rad17/Mec3/Ddc1: a sliding clamp for the DNA damage checkpoint. Proc. Natl. Acad. Sci. U.S.A. 100, 2249-2254
    • (2003) Proc. Natl. Acad. Sci. U.S.A. , vol.100 , pp. 2249-2254
    • Majka, J.1    Burgers, P.M.2
  • 14
    • 4243156107 scopus 로고    scopus 로고
    • Biochemical characterization of DNA damage checkpoint complexes: Clamp loader and clamp complexes with specificity for 5′ recessed DNA
    • Ellison, V. and Stillman, B. (2003) Biochemical characterization of DNA damage checkpoint complexes: clamp loader and clamp complexes with specificity for 5′ recessed DNA. PLoS Biol. 1, 231-243
    • (2003) PLoS Biol. , vol.1 , pp. 231-243
    • Ellison, V.1    Stillman, B.2
  • 15
    • 0345564858 scopus 로고    scopus 로고
    • Replication protein A-mediated recruitment and activation of Rad17 complexes
    • Zou, L., Liu, D. and Elledge, S.J. (2003) Replication protein A-mediated recruitment and activation of Rad17 complexes. Proc. Natl. Acad. Sci. U.S.A. 100, 13827-13832
    • (2003) Proc. Natl. Acad. Sci. U.S.A. , vol.100 , pp. 13827-13832
    • Zou, L.1    Liu, D.2    Elledge, S.J.3
  • 16
    • 0030804309 scopus 로고    scopus 로고
    • The novel DNA damage checkpoint protein Ddc1p is phosphorylated periodically during the cell cycle and in response to DNA damage in budding yeast
    • DOI 10.1093/emboj/16.17.5216
    • Longhese, M.P., Paciotti, V., Fraschini, R., Zaccarini, R., Plevani, P. and Lucchini, G. (1997) The novel DNA damage checkpoint protein ddc1p is phosphorylated periodically during the cell cycle and in response to DNA damage in budding yeast. EMBO J. 16, 5216-5226 (Pubitemid 27380130)
    • (1997) EMBO Journal , vol.16 , Issue.17 , pp. 5216-5226
    • Longhese, M.P.1    Paciotti, V.2    Fraschini, R.3    Zaccarini, R.4    Plevani, P.5    Lucchini, G.6
  • 17
    • 0033570894 scopus 로고    scopus 로고
    • Activation of Rad53 kinase in response to DNA damage and its effect in modulating phosphorylation of the lagging strand DNA polymerase
    • Pellicioli, A., Lucca, C., Liberi, G., Marini, F., Lopes, M., Plevani, P., Romano, A., Di Fiore, P.P. and Foiani, M. (1999) Activation of Rad53 kinase in response to DNA damage and its effect in modulating phosphorylation of the lagging strand DNA polymerase. EMBO J. 18, 6561-6572
    • (1999) EMBO J. , vol.18 , pp. 6561-6572
    • Pellicioli, A.1    Lucca, C.2    Liberi, G.3    Marini, F.4    Lopes, M.5    Plevani, P.6    Romano, A.7    Di Fiore, P.P.8    Foiani, M.9
  • 18
    • 71149093704 scopus 로고    scopus 로고
    • The unstructured C-terminal tail of the 9-1-1 clamp subunit Ddc1 activates Mec1/ATR via two distinct mechanisms
    • Navadgi-Patil, V.M. and Burgers, P.M. (2009) The unstructured C-terminal tail of the 9-1-1 clamp subunit Ddc1 activates Mec1/ATR via two distinct mechanisms. Mol. Cell 36, 743-753
    • (2009) Mol. Cell , vol.36 , pp. 743-753
    • Navadgi-Patil, V.M.1    Burgers, P.M.2
  • 19
    • 2542478964 scopus 로고    scopus 로고
    • Redundancy, insult-specific sensors and thresholds: Unlocking the S-phase checkpoint response
    • Cobb, J.A., Shimada, K. and Gasser, S.M. (2004) Redundancy, insult-specific sensors and thresholds: unlocking the S-phase checkpoint response. Curr. Opin. Genet. Dev. 14, 292-300
    • (2004) Curr. Opin. Genet. Dev. , vol.14 , pp. 292-300
    • Cobb, J.A.1    Shimada, K.2    Gasser, S.M.3
  • 20
    • 33751419716 scopus 로고    scopus 로고
    • Surviving the breakup: The DNA damage checkpoint
    • Harrison, J.C. and Haber, J.E. (2006) Surviving the breakup: the DNA damage checkpoint. Annu. Rev. Genet. 40, 209-235
    • (2006) Annu. Rev. Genet. , vol.40 , pp. 209-235
    • Harrison, J.C.1    Haber, J.E.2
  • 21
  • 22
    • 33748780358 scopus 로고    scopus 로고
    • Replication protein A directs loading of the DNA damage checkpoint clamp to 5′-DNA junctions
    • Majka, J., Binz, S.K., Wold, M.S. and Burgers, P.M. (2006) Replication protein A directs loading of the DNA damage checkpoint clamp to 5′-DNA junctions. J. Biol. Chem. 281, 27855-27861
    • (2006) J. Biol. Chem. , vol.281 , pp. 27855-27861
    • Majka, J.1    Binz, S.K.2    Wold, M.S.3    Burgers, P.M.4
  • 23
    • 33845607102 scopus 로고    scopus 로고
    • The Checkpoint Clamp Activates Mec1 Kinase during Initiation of the DNA Damage Checkpoint
    • DOI 10.1016/j.molcel.2006.11.027, PII S1097276506008239
    • Majka, J., Niedziela-Majka, A. and Burgers, P.M. (2006) The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage checkpoint. Mol. Cell 24, 891-901 (Pubitemid 44960097)
    • (2006) Molecular Cell , vol.24 , Issue.6 , pp. 891-901
    • Majka, J.1    Niedziela-Majka, A.2    Burgers, P.M.J.3
  • 24
    • 42949130159 scopus 로고    scopus 로고
    • Colocalization of Sensors Is Sufficient to Activate the DNA Damage Checkpoint in the Absence of Damage
    • DOI 10.1016/j.molcel.2008.03.023, PII S1097276508002943
    • Bonilla, C.Y., Melo, J.A. and Toczyski, D.P. (2008) Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage. Mol. Cell 30, 267-276 (Pubitemid 351615321)
    • (2008) Molecular Cell , vol.30 , Issue.3 , pp. 267-276
    • Bonilla, C.Y.1    Melo, J.A.2    Toczyski, D.P.3
  • 26
    • 33846328709 scopus 로고    scopus 로고
    • Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast
    • DOI 10.1038/nature05432, PII NATURE05432
    • Zegerman, P. and Diffley, J.F. (2007) Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast. Nature 445, 281-285 (Pubitemid 46122811)
    • (2007) Nature , vol.445 , Issue.7125 , pp. 281-285
    • Zegerman, P.1    Diffley, J.F.X.2
  • 27
    • 33846330909 scopus 로고    scopus 로고
    • CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast
    • DOI 10.1038/nature05465, PII NATURE05465
    • Tanaka, S., Umemori, T., Hirai, K., Muramatsu, S., Kamimura, Y. and Araki, H. (2007) CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast. Nature 445, 328-332 (Pubitemid 46122821)
    • (2007) Nature , vol.445 , Issue.7125 , pp. 328-332
    • Tanaka, S.1    Umemori, T.2    Hirai, K.3    Muramatsu, S.4    Kamimura, Y.5    Araki, H.6
  • 28
    • 33644757806 scopus 로고    scopus 로고
    • TopBP1 activates the ATR-ATRIP complex
    • DOI 10.1016/j.cell.2005.12.041, PII S0092867406001723
    • Kumagai, A., Lee, J., Yoo, H.Y. and Dunphy, W.G. (2006) TopBP1 activates the ATR-ATRIP complex. Cell 124, 943-955 (Pubitemid 43344235)
    • (2006) Cell , vol.124 , Issue.5 , pp. 943-955
    • Kumagai, A.1    Lee, J.2    Yoo, H.Y.3    Dunphy, W.G.4
  • 29
    • 34548060929 scopus 로고    scopus 로고
    • Reconstitution of a human ATR-mediated checkpoint response to damaged DNA
    • Choi, J.H., Lindsey-Boltz, L.A. and Sancar, A. (2007) Reconstitution of a human ATR-mediated checkpoint response to damaged DNA. Proc. Natl. Acad. Sci. U.S.A. 104, 13301-13306
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 13301-13306
    • Choi, J.H.1    Lindsey-Boltz, L.A.2    Sancar, A.3
  • 30
    • 58149102035 scopus 로고    scopus 로고
    • Yeast DNA replication protein Dpb11 activates the Mec1/ATR checkpoint kinase
    • Navadgi-Patil, V.M. and Burgers, P.M. (2008) Yeast DNA replication protein Dpb11 activates the Mec1/ATR checkpoint kinase. J. Biol. Chem. 283, 35853-35859
    • (2008) J. Biol. Chem. , vol.283 , pp. 35853-35859
    • Navadgi-Patil, V.M.1    Burgers, P.M.2
  • 34
    • 2442646547 scopus 로고    scopus 로고
    • TOPBP1
    • DOI 10.1101/gad.291104
    • Furuya, K., Poitelea, M., Guo, L., Caspari, T. and Carr, A.M. (2004) Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-terminal BRCT domains of Rad4TOPBP1. Genes Dev. 18, 1154-1164 (Pubitemid 38669036)
    • (2004) Genes and Development , vol.18 , Issue.10 , pp. 1154-1164
    • Furuya, K.1    Poitelea, M.2    Guo, L.3    Caspari, T.4    Carr, A.M.5
  • 35
    • 34948889415 scopus 로고    scopus 로고
    • The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR
    • Lee, J., Kumagai, A. and Dunphy, W.G. (2007) The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR. J. Biol. Chem. 282, 28036-28044
    • (2007) J. Biol. Chem. , vol.282 , pp. 28036-28044
    • Lee, J.1    Kumagai, A.2    Dunphy, W.G.3
  • 36
    • 34250705797 scopus 로고    scopus 로고
    • The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1
    • DOI 10.1101/gad.1547007
    • Delacroix, S., Wagner, J.M., Kobayashi, M., Yamamoto, K. and Karnitz, L.M. (2007) The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1. Genes Dev. 21, 1472-1477 (Pubitemid 46955719)
    • (2007) Genes and Development , vol.21 , Issue.12 , pp. 1472-1477
    • Delacroix, S.1    Wagner, J.M.2    Kobayashi, M.3    Yamamoto, K.-I.4    Karnitz, L.M.5
  • 37
    • 11144266855 scopus 로고    scopus 로고
    • The PCNA-RFC families of DNA clamps and clamp loaders
    • Majka, J. and Burgers, P.M. (2004) The PCNA-RFC families of DNA clamps and clamp loaders. Prog. Nucleic Acid Res. Mol. Biol. 78, 227-260
    • (2004) Prog. Nucleic Acid Res. Mol. Biol. , vol.78 , pp. 227-260
    • Majka, J.1    Burgers, P.M.2
  • 38
    • 24944495500 scopus 로고    scopus 로고
    • Function of Rad17/Mec3/Ddc1 and its partial complexes in the DNA damage checkpoint
    • DOI 10.1016/j.dnarep.2005.07.008, PII S1568786405001990
    • Majka, J. and Burgers, P.M. (2005) Function of Rad17/Mec3/Ddc1 and its partial complexes in the DNA damage checkpoint. DNA Repair 4, 1189-1194 (Pubitemid 41316596)
    • (2005) DNA Repair , vol.4 , Issue.10 , pp. 1189-1194
    • Majka, J.1    Burgers, P.M.2
  • 40
    • 0031036995 scopus 로고    scopus 로고
    • Rad9, Rad17, and Rad24 are required for S phase regulation in Saccharomyces cerevisiae in response to DNA damage
    • Paulovich, A.G., Margulies, R.U., Garvik, B.M. and Hartwell, L.H. (1997) Rad9, Rad17, and Rad24 are required for S phase regulation in Saccharomyces cerevisiae in response to DNA damage. Genetics 145, 45-62
    • (1997) Genetics , vol.145 , pp. 45-62
    • Paulovich, A.G.1    Margulies, R.U.2    Garvik, B.M.3    Hartwell, L.H.4
  • 41
    • 0029859168 scopus 로고    scopus 로고
    • RAD9 and DNA polymerase epsilon form parallel sensory branches for transducing the DNA damage checkpoint signal in Saccharomyces cerevisiae
    • Navas, T.A., Sanchez, Y. and Elledge, S.J. (1996) Rad9 and DNA polymerase epsilon form parallel sensory branches for transducing the DNA damage checkpoint signal in Saccharomyces cerevisiae. Genes Dev. 10, 2632-2643 (Pubitemid 26357229)
    • (1996) Genes and Development , vol.10 , Issue.20 , pp. 2632-2643
    • Navas, T.A.1    Sanchez, Y.2    Elledge, S.J.3
  • 42
    • 0033957793 scopus 로고    scopus 로고
    • The yeast Sgs1p helicase acts upstream of Rad53p in the DNA replication checkpoint and colocalizes with Rad53p in S-phase-specific foci
    • Frei, C. and Gasser, S.M. (2000) The yeast Sgs1p helicase acts upstream of Rad53p in the DNA replication checkpoint and colocalizes with Rad53p in S-phase-specific foci. Genes Dev. 14, 81-96 (Pubitemid 30051581)
    • (2000) Genes and Development , vol.14 , Issue.1 , pp. 81-96
    • Frei, C.1    Gasser, S.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.