Derivatives of aryl amines containing the cytotoxic 1,4-dioxo-2-butenyl pharmacophore

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 5, 2010, Pages 1510-1515

  Jha, Amitabh ^a   Mukherjee, Chandrani ^a,b   Prasad, Ashok K ^b   Parmar, Virinder S ^b   Vadaparti, Manjula ^a   Das, Umashankar ^c   De Clercq, Erik ^d   Balzarini, Jan ^d   Stables, James P ^e   Shrivastav, Anuraag ^f   Sharma, Rajendra K ^f   Dimmock, Jonathan R ^c  

^a ACADIA UNIVERSITY   (Canada)

^b UNIVERSITY OF DELHI   (India)

^c UNIVERSITY OF SASKATCHEWAN   (Canada)

^d REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^e NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^f UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

1,4 Dioxo 2 butenyl; Cytotoxicity; Molecular modeling; N Arylfumaramates; N Arylisomaleimides; N Arylmaleamates; N Arylmaleimides; Structure activity relationships

Indexed keywords

1,4 DIOXO 2 BUTENYL DERIVATIVE; ANTINEOPLASTIC AGENT; AROMATIC AMINE; CYTOTOXIC AGENT; CYTOTOXIN; ELECTROPHILE; IMIDE; MELPHALAN; METHYL GROUP; METHYL N (3,4 DICHLOROPHENYL)FUMARAMATE; METHYL N ARYLFUMARAMATE DERIVATIVE; METHYL N ARYLMALEAMATE DERIVATIVE; N ARYLISOMALEIMIDE DERIVATIVE; N ARYLMALEIMIDE DERIVATIVE; PROTEIN N MYRISTOYLTRANSFERASE; THIOBENZYL ALCOHOL; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; DRUG TOLERABILITY; HUMAN; HUMAN CELL; ISOMER; MOLECULAR MODEL; MOUSE; NONHUMAN; PHARMACOPHORE; PRACTICE GUIDELINE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; T LYMPHOCYTE; THIOLATION;

ACYLTRANSFERASES; ALDEHYDES; AMINES; ANIMALS; CELL LINE; ENZYME INHIBITORS; HUMANS; MICE; MODELS, MOLECULAR; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

MURINAE; MUS;

EID: 76649096984     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.01.098     Document Type: Article

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