JunB and c-Rel cooperatively enhance Foxp3 expression during induced regulatory T cell differentiation

Biochemical and Biophysical Research Communications

Volumn 407, Issue 1, 2011, Pages 141-147

  Son, Jun Seock ^a   Sahoo, Anupama ^a   Chae, Chang Suk ^a   Hwang, Ji Sun ^a   Park, Zee Yong ^a   Im, Sin Hyeog ^a  

^a Gwangju Institute of Science and Technology (GIST)   (South Korea)

Author keywords

C Rel; Epigenetics; Foxp3; IL 2; JunB; TCR; TGF ; Transcription

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 2; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR JUNB; TRANSCRIPTION FACTOR REL; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; CD4+ T LYMPHOCYTE; CHROMATIN STRUCTURE; CONTROLLED STUDY; GENE EXPRESSION PROFILING; GENE OVEREXPRESSION; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION;

ANIMALS; CELL DIFFERENTIATION; CHROMATIN; EPIGENOMICS; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-JUN; PROTO-ONCOGENE PROTEINS C-REL; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA;

EID: 79953161326     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.02.126     Document Type: Article

References (22)

1. + regulatory T cells: more of the same or a division of labor?. Immunity 2009, 30:626-635.
2. Hori S., Nomura T., Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003, 299:1057-1061.
3. + regulatory T cells. Nat. Immunol. 2003, 4:330-336.
4. + regulatory T cells. Int. Immunol. 2004, 16:1643-1656.
5. Fontenot J.D., Rasmussen J.P., Williams L.M., Dooley J.L., Farr A.G., Rudensky A.Y. Regulatory T Cell lineage specification by the forkhead transcription factor Foxp3. Immunity 2005, 22:329-341.
6. + T regulatory cells. Nat. Immunol. 2003, 4:337-342.
7. + T cells. Eur. J. Immunol. 2007, 37:129-138.
8. Zheng Y., Rudensky A.Y. Foxp3 in control of the regulatory T cell lineage. Nat. Immunol. 2007, 8:457-462.
9. Josefowicz S.Z., Rudensky A. Control of Regulatory T cell lineage commitment and maintenance. Immunity 2009, 30:616-625.
10. Mantel P.-Y., Ouaked N., Ruckert B., Karagiannidis C., Welz R., Blaser K., Schmidt-Weber C.B. Molecular mechanisms underlying FOXP3 induction in human T cells. J. Immunol. 2006, 176:3593-3602.
11. Selvaraj R.K., Geiger T.L., Kinetic A. Dynamic analysis of Foxp3 induced in T cells by TGF-beta. J. Immunol. 2007, 178:7667-7677.
12. Bennett B.L., Sasaki D.T., Murray B.W., O'Leary E.C., Sakata S.T., Xu W., Leisten J.C., Motiwala A., Pierce S., Satoh Y., Bhagwat S.S., Manning A.M., Anderson D.W. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc. Natl. Acad. Sci. USA 2001, 98:13681-13686.
13. Nasu K., Nishida M., Ueda T., Yuge A., Takai N., Narahara H. Application of the nuclear factor-kB inhibitor BAY 11-7085 for the treatment of endometriosis: an in vitro study. Am. J. Physiol. Cell Physiol. Endocrinol. Metab. 2007, 293:E16-E23.
14. Kwon H.-K., So J.-S., Lee C.-G., Sahoo A., Yi H.-J., Park J.-N., Lim S.-Y., Hwang K.-C., Jun C.-D., Chun J.-S., Im S.-H. Foxp3 induces IL-4 gene silencing by affecting nuclear translocation of NF[kappa]B and chromatin structure. Mol, Immunol. 2008, 45:3205-3212.
15. Lee C.-G., Kang K.-H., So J.-S., Kwon H.-K., Son J.-S., Song M.-K., Sahoo A., Yi H.-J., Hwang K.-C., Matsuyama T., Yui K., Im S.-H. A distal cis-regulatory element, CNS-9, controls NFAT1 and IRF4-mediated IL-10 gene activation in T helper cells. Mol. Immunol. 2009, 46:613-621.
16. Rao S., Procko E., Shannon M.F. Chromatin remodeling, measured by a novel real-time polymerase chain reaction assay, across the proximal promoter region of the IL-2 gene. J. Immunol. 2001, 167:4494-4503.
17. Long M., Park S.-G., Strickland I., Hayden M.S., Ghosh S. Nuclear factor-[kappa]B modulates regulatory T Cell development by directly regulating expression of Foxp3 transcription factor. Immunity 2009, 31:921-931.
18. Ruan Q., Kameswaran V., Tone Y., Li L., Liou H.-C., Greene M.I., Tone M., Chen Y.H. Development of Foxp3+ regulatory T cells is driven by the c-Rel Enhanceosome. Immunity 2009, 31:932-940.
19. + regulatory T cells: differentiation specification, subphenotypes. Nat. Immunol. 2009, 10:689-695.
20. Floess S., Freyer J., Siewert C., Baron U., Olek S., Polansky J., Schlawe K., Chang H.-D., Bopp T., Schmitt E., Klein-Hessling S., Serfling E., Hamann A., Huehn J. Epigenetic control of the foxp3 locus in regulatory T cells. PLoS Biol. 2007, 5:e38.
21. Ponticos M., Harvey C., Ikeda T., Abraham D., Bou-Gharios G. JunB mediates enhancer/promoter activity of COL1A2 following TGF-b induction. Nucleic Acids Res. 2009, 37:5378-5389.
22. Srikanta J., Parthav J., Dipica H., Jill W., Sanja G., William G., Manoj M., Renren W., Demin W., Calvin B.W., Soumitra G. The role of NF-kappaB and Smad3 in TGF-beta-mediated Foxp3 expression. Eur. J.Immunol. 2009, 39:2571-2583.