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Volumn 45, Issue 11, 2008, Pages 3205-3212

Foxp3 induces IL-4 gene silencing by affecting nuclear translocation of NFκB and chromatin structure

Author keywords

Chromatin; Foxp3; IL 4; Regulatory T cell; Transcriptional regulation

Indexed keywords

HISTONE H3; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 4; TRANSCRIPTION FACTOR FOXP3;

EID: 43649084651     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2008.02.021     Document Type: Article
Times cited : (21)

References (47)
  • 1
    • 0033667895 scopus 로고    scopus 로고
    • Cell-type-restricted binding of the transcription factor NFAT to a distal IL-4 enhancer in vivo
    • Agarwal S., Avni O., and Rao A. Cell-type-restricted binding of the transcription factor NFAT to a distal IL-4 enhancer in vivo. Immunity 12 (2000) 643-652
    • (2000) Immunity , vol.12 , pp. 643-652
    • Agarwal, S.1    Avni, O.2    Rao, A.3
  • 2
    • 0032412441 scopus 로고    scopus 로고
    • Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation
    • Agarwal S., and Rao A. Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation. Immunity 9 (1998) 765-775
    • (1998) Immunity , vol.9 , pp. 765-775
    • Agarwal, S.1    Rao, A.2
  • 3
    • 33646196946 scopus 로고    scopus 로고
    • Regulation of Th2 differentiation and Il4 locus accessibility
    • Ansel K.M., Djuretic I., Tanasa B., and Rao A. Regulation of Th2 differentiation and Il4 locus accessibility. Annu. Rev. Immunol. 24 (2006) 607-656
    • (2006) Annu. Rev. Immunol. , vol.24 , pp. 607-656
    • Ansel, K.M.1    Djuretic, I.2    Tanasa, B.3    Rao, A.4
  • 4
    • 0036305450 scopus 로고    scopus 로고
    • TH cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes
    • Avni O., Lee D., Macian F., Szabo S.J., Glimcher L.H., and Rao A. TH cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes. Nat. Immunol. 3 (2002) 643-651
    • (2002) Nat. Immunol. , vol.3 , pp. 643-651
    • Avni, O.1    Lee, D.2    Macian, F.3    Szabo, S.J.4    Glimcher, L.H.5    Rao, A.6
  • 5
    • 3843060051 scopus 로고    scopus 로고
    • Chromatin landscape dynamics of the Il4-Il13 locus during T helper 1 and 2 development
    • Baguet A., and Bix M. Chromatin landscape dynamics of the Il4-Il13 locus during T helper 1 and 2 development. Proc. Natl. Acad. Sci. U.S.A. 101 (2004) 11410-11415
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 11410-11415
    • Baguet, A.1    Bix, M.2
  • 6
    • 34249299791 scopus 로고    scopus 로고
    • The complex language of chromatin regulation during transcription
    • Berger S.L. The complex language of chromatin regulation during transcription. Nature 447 (2007) 407
    • (2007) Nature , vol.447 , pp. 407
    • Berger, S.L.1
  • 7
    • 17044393922 scopus 로고    scopus 로고
    • Foxp3 interacts with nuclear factor of activated T cells and NF-{kappa}B to repress cytokine gene expression and effector functions of T helper cells
    • Bettelli E., Dastrange M., and Oukka M. Foxp3 interacts with nuclear factor of activated T cells and NF-{kappa}B to repress cytokine gene expression and effector functions of T helper cells. PNAS 102 (2005) 5138-5143
    • (2005) PNAS , vol.102 , pp. 5138-5143
    • Bettelli, E.1    Dastrange, M.2    Oukka, M.3
  • 8
    • 33846016948 scopus 로고    scopus 로고
    • Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylation
    • Chen C., Rowell E.A., Thomas R.M., Hancock W.W., and Wells A.D. Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylation. J. Biol. Chem. 281 (2006) 36828-36834
    • (2006) J. Biol. Chem. , vol.281 , pp. 36828-36834
    • Chen, C.1    Rowell, E.A.2    Thomas, R.M.3    Hancock, W.W.4    Wells, A.D.5
  • 9
    • 0035222187 scopus 로고    scopus 로고
    • A critical role for NF-κB in Gata3 expression and TH2 differentiation in allergic airway inflammation
    • Das J., Chen C.H., Yang L., Cohn L., Ray P., and Ray A. A critical role for NF-κB in Gata3 expression and TH2 differentiation in allergic airway inflammation. Nat. Immunol. 2 (2001) 45-50
    • (2001) Nat. Immunol. , vol.2 , pp. 45-50
    • Das, J.1    Chen, C.H.2    Yang, L.3    Cohn, L.4    Ray, P.5    Ray, A.6
  • 11
    • 0037100265 scopus 로고    scopus 로고
    • Cutting edge: changes in histone acetylation at the IL-4 and IFN-γ loci accompany Th1/Th2 differentiation
    • Fields P.E., Kim S.T., and Flavell R.A. Cutting edge: changes in histone acetylation at the IL-4 and IFN-γ loci accompany Th1/Th2 differentiation. J. Immunol. 169 (2002) 647-650
    • (2002) J. Immunol. , vol.169 , pp. 647-650
    • Fields, P.E.1    Kim, S.T.2    Flavell, R.A.3
  • 12
    • 8744258956 scopus 로고    scopus 로고
    • Chromatin-level regulation of the IL10 gene in T cells
    • Im S.H., Hueber A., Monticelli S., Kang K.H., and Rao A. Chromatin-level regulation of the IL10 gene in T cells. J. Biol. Chem. 279 (2004) 46818-46825
    • (2004) J. Biol. Chem. , vol.279 , pp. 46818-46825
    • Im, S.H.1    Hueber, A.2    Monticelli, S.3    Kang, K.H.4    Rao, A.5
  • 13
    • 0028209548 scopus 로고
    • Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases
    • Iwashima M., Irving B.A., van Oers N.S., Chan A.C., and Weiss A. Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases. Science 263 (1994) 1136-1139
    • (1994) Science , vol.263 , pp. 1136-1139
    • Iwashima, M.1    Irving, B.A.2    van Oers, N.S.3    Chan, A.C.4    Weiss, A.5
  • 14
    • 0042346231 scopus 로고    scopus 로고
    • Scurfin (FoxP3) controls T-dependent immune responses in vivo through regulation of CD4 + T cell effector function
    • Kasprowicz D.J., Smallwood P.S., Tyznik A.J., and Ziegler S.F. Scurfin (FoxP3) controls T-dependent immune responses in vivo through regulation of CD4 + T cell effector function. J. Immunol. 171 (2003) 1216-1223
    • (2003) J. Immunol. , vol.171 , pp. 1216-1223
    • Kasprowicz, D.J.1    Smallwood, P.S.2    Tyznik, A.J.3    Ziegler, S.F.4
  • 16
    • 0030463173 scopus 로고    scopus 로고
    • HMG I(Y) interferes with the DNA binding of NF-AT factors and the induction of the interleukin 4 promoter in T cells
    • Klein-Hessling S., Schneider G., Heinfling A., Chuvpilo S., and Serfling E. HMG I(Y) interferes with the DNA binding of NF-AT factors and the induction of the interleukin 4 promoter in T cells. Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 15311-15316
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 15311-15316
    • Klein-Hessling, S.1    Schneider, G.2    Heinfling, A.3    Chuvpilo, S.4    Serfling, E.5
  • 17
    • 0036532202 scopus 로고    scopus 로고
    • Histone methylation in transcriptional control
    • Kouzarides T. Histone methylation in transcriptional control. Curr. Opin. Genet. Develop. 12 (2002) 198-209
    • (2002) Curr. Opin. Genet. Develop. , vol.12 , pp. 198-209
    • Kouzarides, T.1
  • 18
    • 33847076849 scopus 로고    scopus 로고
    • Chromatin modifications and their function
    • Kouzarides T. Chromatin modifications and their function. Cell 128 (2007) 693-705
    • (2007) Cell , vol.128 , pp. 693-705
    • Kouzarides, T.1
  • 19
    • 0037672689 scopus 로고    scopus 로고
    • An epigenetic road map for histone lysine methylation
    • Lachner M., O'Sullivan R.J., and Jenuwein T. An epigenetic road map for histone lysine methylation. J. Cell Sci. 116 (2003) 2117-2124
    • (2003) J. Cell Sci. , vol.116 , pp. 2117-2124
    • Lachner, M.1    O'Sullivan, R.J.2    Jenuwein, T.3
  • 20
    • 0036279221 scopus 로고    scopus 로고
    • Th2 lineage commitment and efficient IL-4 production involves extended demethylation of the IL-4 gene
    • Lee D.U., Agarwal S., and Rao A. Th2 lineage commitment and efficient IL-4 production involves extended demethylation of the IL-4 gene. Immunity 16 (2002) 649-660
    • (2002) Immunity , vol.16 , pp. 649-660
    • Lee, D.U.1    Agarwal, S.2    Rao, A.3
  • 21
    • 3843148505 scopus 로고    scopus 로고
    • NF-κB synergizes with NF-AT and NF-IL6 in activation of the IL-4 gene in T cells
    • Li-Weber M., Giaisi M., Baumann S., Pálfi K., and Krammer P.H. NF-κB synergizes with NF-AT and NF-IL6 in activation of the IL-4 gene in T cells. Eur. J. Immunol. 34 (2004) 1111-1118
    • (2004) Eur. J. Immunol. , vol.34 , pp. 1111-1118
    • Li-Weber, M.1    Giaisi, M.2    Baumann, S.3    Pálfi, K.4    Krammer, P.H.5
  • 22
    • 0032483991 scopus 로고    scopus 로고
    • Involvement of Jun and Rel proteins in up-regulation of interleukin-4 gene activity by the T cell accessory molecule CD28
    • Li-Weber M., Giasi M., and Krammer P.H. Involvement of Jun and Rel proteins in up-regulation of interleukin-4 gene activity by the T cell accessory molecule CD28. J. Biol. Chem. 273 (1998) 32460-32466
    • (1998) J. Biol. Chem. , vol.273 , pp. 32460-32466
    • Li-Weber, M.1    Giasi, M.2    Krammer, P.H.3
  • 23
    • 0142197612 scopus 로고    scopus 로고
    • Regulation of IL4 gene expression by T cells and therapeutic perspectives
    • Li-Weber M., and Krammer P.H. Regulation of IL4 gene expression by T cells and therapeutic perspectives. Nat. Rev. Immunol. 3 (2003) 534-543
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 534-543
    • Li-Weber, M.1    Krammer, P.H.2
  • 26
    • 0036781052 scopus 로고    scopus 로고
    • Erratum: NF-κB regulation in the immune system
    • Li Q., and Verma I.M. Erratum: NF-κB regulation in the immune system. Nat. Rev. Immunol. 2 (2002) 725-734
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 725-734
    • Li, Q.1    Verma, I.M.2
  • 27
    • 25444497719 scopus 로고    scopus 로고
    • Cutting edge: direct suppression of B cells by CD4 + CD25+ regulatory T cells
    • Lim H.W., Hillsamer P., Banham A.H., and Kim C.H. Cutting edge: direct suppression of B cells by CD4 + CD25+ regulatory T cells. J. Immunol. 175 (2005) 4180-4183
    • (2005) J. Immunol. , vol.175 , pp. 4180-4183
    • Lim, H.W.1    Hillsamer, P.2    Banham, A.H.3    Kim, C.H.4
  • 30
    • 0036738755 scopus 로고    scopus 로고
    • Vitamin E inhibits IL-4 gene expression in peripheral blood T cells
    • Min Li-Weber M.G.M.T.P.K. Vitamin E inhibits IL-4 gene expression in peripheral blood T cells. Eur. J. Immunol. 32 (2002) 2401-2408
    • (2002) Eur. J. Immunol. , vol.32 , pp. 2401-2408
    • Min Li-Weber, M.G.M.T.P.1
  • 31
    • 0036885067 scopus 로고    scopus 로고
    • The lineage decisions of helper T cells
    • Murphy K.M., and Reiner S.L. The lineage decisions of helper T cells. Nat. Rev. Immunol. 2 (2002) 933-944
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 933-944
    • Murphy, K.M.1    Reiner, S.L.2
  • 33
    • 0029030775 scopus 로고
    • Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene
    • Rooney J.W., Hoey T., and Glimcher L.H. Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene. Immunity 2 (1995) 473-483
    • (1995) Immunity , vol.2 , pp. 473-483
    • Rooney, J.W.1    Hoey, T.2    Glimcher, L.H.3
  • 34
    • 16844378209 scopus 로고    scopus 로고
    • Natural regulatory T cells and self-tolerance
    • Schwartz R.H. Natural regulatory T cells and self-tolerance. Nat. Immunol. 6 (2005) 327-330
    • (2005) Nat. Immunol. , vol.6 , pp. 327-330
    • Schwartz, R.H.1
  • 35
    • 0028201726 scopus 로고
    • Acquisition of lymphokine-producing phenotype by CD4+ T cells
    • Seder R.A., and Paul W.E. Acquisition of lymphokine-producing phenotype by CD4+ T cells. Annu. Rev. Immunol. 12 (1994) 635-673
    • (1994) Annu. Rev. Immunol. , vol.12 , pp. 635-673
    • Seder, R.A.1    Paul, W.E.2
  • 36
    • 0034284190 scopus 로고    scopus 로고
    • MHC Class II transactivator inhibits IL-4 gene transcription by competing with NF-AT to bind the coactivator CREB binding protein (CBP)/p300
    • Sisk T.J., Gourley T., Roys S., and Chang C.-H. MHC Class II transactivator inhibits IL-4 gene transcription by competing with NF-AT to bind the coactivator CREB binding protein (CBP)/p300. J. Immunol. 165 (2000) 2511-2517
    • (2000) J. Immunol. , vol.165 , pp. 2511-2517
    • Sisk, T.J.1    Gourley, T.2    Roys, S.3    Chang, C.-H.4
  • 37
    • 0037164741 scopus 로고    scopus 로고
    • Gene-specific targeting of H3K9 methylation is sufficient for initiating repression in vivo
    • Snowden A.W., Gregory P.D., Case C.C., and Pabo C.O. Gene-specific targeting of H3K9 methylation is sufficient for initiating repression in vivo. Curr. Biol. 12 (2002) 2159-2166
    • (2002) Curr. Biol. , vol.12 , pp. 2159-2166
    • Snowden, A.W.1    Gregory, P.D.2    Case, C.C.3    Pabo, C.O.4
  • 38
    • 33748460087 scopus 로고    scopus 로고
    • Foxp3-dependent and -independent molecules specific for CD25+CD4+ natural regulatory T cells revealed by DNA microarray analysis
    • Sugimoto N., Oida T., Hirota K., Nakamura K., Nomura T., Uchiyama T., and Sakaguchi S. Foxp3-dependent and -independent molecules specific for CD25+CD4+ natural regulatory T cells revealed by DNA microarray analysis. Int. Immunol. 18 (2006) 1197-1209
    • (2006) Int. Immunol. , vol.18 , pp. 1197-1209
    • Sugimoto, N.1    Oida, T.2    Hirota, K.3    Nakamura, K.4    Nomura, T.5    Uchiyama, T.6    Sakaguchi, S.7
  • 39
    • 0025083185 scopus 로고
    • IL-4 induces allergic-like inflammatory disease and alters T cell development in transgenic mice
    • Tepper R.I., Levinson D.A., Stanger B.Z., Campos-Torres J., Abbas A.K., and Leder P. IL-4 induces allergic-like inflammatory disease and alters T cell development in transgenic mice. Cell 62 (1990) 457-467
    • (1990) Cell , vol.62 , pp. 457-467
    • Tepper, R.I.1    Levinson, D.A.2    Stanger, B.Z.3    Campos-Torres, J.4    Abbas, A.K.5    Leder, P.6
  • 41
    • 0028014460 scopus 로고
    • Signal transduction by lymphocyte antigen receptors
    • Weiss A., and Littman D.R. Signal transduction by lymphocyte antigen receptors. Cell 76 (1994) 263-274
    • (1994) Cell , vol.76 , pp. 263-274
    • Weiss, A.1    Littman, D.R.2
  • 42
    • 34247271308 scopus 로고    scopus 로고
    • Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3
    • Williams L.M., and Rudensky A.Y. Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3. Nat. Immunol. 8 (2007) 277-284
    • (2007) Nat. Immunol. , vol.8 , pp. 277-284
    • Williams, L.M.1    Rudensky, A.Y.2
  • 44
    • 37449018934 scopus 로고    scopus 로고
    • Cinnamaldehyde suppresses toll-like receptor 4 activation mediated through the inhibition of receptor oligomerization
    • Youn H.S., Lee J.K., Choi Y.J., Saitoh S.I., Miyake K., Hwang D.H., and Lee J.Y. Cinnamaldehyde suppresses toll-like receptor 4 activation mediated through the inhibition of receptor oligomerization. Biochem. Pharmacol. 75 (2008) 494-502
    • (2008) Biochem. Pharmacol. , vol.75 , pp. 494-502
    • Youn, H.S.1    Lee, J.K.2    Choi, Y.J.3    Saitoh, S.I.4    Miyake, K.5    Hwang, D.H.6    Lee, J.Y.7
  • 45
    • 0032498231 scopus 로고    scopus 로고
    • LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation
    • Zhang W., Sloan-Lancaster J., Kitchen J., Trible R.P., and Samelson L.E. LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell 92 (1998) 83-92
    • (1998) Cell , vol.92 , pp. 83-92
    • Zhang, W.1    Sloan-Lancaster, J.2    Kitchen, J.3    Trible, R.P.4    Samelson, L.E.5
  • 46
    • 34247277666 scopus 로고    scopus 로고
    • Foxp3 in control of the regulatory T cell lineage
    • Zheng Y., and Rudensky A.Y. Foxp3 in control of the regulatory T cell lineage. Nat. Immunol. 8 (2007) 457-462
    • (2007) Nat. Immunol. , vol.8 , pp. 457-462
    • Zheng, Y.1    Rudensky, A.Y.2
  • 47
    • 33646168597 scopus 로고    scopus 로고
    • FOXP3: of mice and men
    • Ziegler S.F. FOXP3: of mice and men. Annu. Rev. Immunol. 24 (2006) 209-226
    • (2006) Annu. Rev. Immunol. , vol.24 , pp. 209-226
    • Ziegler, S.F.1


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