Analysis of gene expression in a human-derived glial cell line exposed to 2.45 GHz continuous radiofrequency electromagnetic fields

Journal of Radiation Research

Volumn 52, Issue 2, 2011, Pages 185-192

  Sakurai, Tomonori ^a   Kiyokawa, Tomoko ^b   Narita, Eijiro ^a   Suzuki, Yukihisa ^c   Taki, Masao ^c   Miyakoshi, Junji ^a  

^a KYOTO UNIVERSITY   (Japan)

^b HIROSAKI UNIVERSITY   (Japan)

^c TOKYO METROPOLITAN UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ELECTROMAGNETIC FIELD EFFECTS; ELECTROMAGNETIC FIELDS; HEALTH RISKS; POLYMERASE CHAIN REACTION; TRANSCRIPTION;

CELL LINES; CONTINUOUS WAVE; EXPOSED TO; GENE SPOTS; GENES EXPRESSION; GLIAL CELLS; POTENTIAL HEALTH RISKS; PUBLIC CONCERN; RADIO FREQUENCY FIELDS; RADIOFREQUENCY ELECTROMAGNETIC FIELD;

CELL CULTURE;

EID: 79953146931     PISSN: 04493060     EISSN: 13499157     Source Type: Journal    
DOI: 10.1269/jrr.10116     Document Type: Article

References (30)

1. ICNIRP (2009) II Review of experimental studies of RF biological effects (100 kHz-300 GHz) In: Exposure to high frequency electromagnetic fields, biological effects and health consequences (100 kHz-300 GHz). ICNIRP 16/2009. pp. 90-303. International Commission on Non-Ionizing Radiation Protection.
2. Tice RR, et al (2002) Genotoxicity of radiofrequency signals. I. Investigation of DNA damage and micronuclei induction in cultured human blood cells. Bioelectromagnetics 23: 113-126.
3. Sun L, et al (2006) Effects of 1.8 GHz radiofrequency field on DNA damage and expression of heat shock protein 70 in human lens epithelial cells. Mutat Res 602: 135-142.
4. Vijayalaxmi, et al (2000) Primary DNA damage in human blood lymphocytes exposued in vitro to 2450 MHz radiofrequency radiation. Radiat Res 153: 479-486.
5. McNamee JP, et al (2003) No evidence for genotoxic effects from 24 h exposure of human leukocytes to 1.9 GHz radiofrequency fields. Radiat Res 159: 693-697.
6. Sakuma N, et al (2006) DNA strand breaks are not induced in human cells exposed to 2.1425 GHz band CW and W-CDMA modulated radiofrequency fields allocated to mobile radio base stations. Bioelectromagnetics 27: 51-57.
7. McNamee JP and Chauhan V (2009) Radiofrequency radiation and gene/protein expression: A review. Radiat Res 172: 265-287.
8. Fritze K, et al (1997) Effect of global system for mobile communication microwave exposure on the genomic response of the rat brain. Neuroscience 81: 627-639.
9. Chauhan V, et al (2006) Analysis of proto-oncogene and heat-shock protein gene expression in human derived cell-lines exposed in vitro to an intermittent 1.9 GHz pulse-modulated radiofrequency field. Int Radiat Biol 82: 347-354.
10. Simkó M, et al (2006) Hsp70 expression and free radical release after exposure to non-thermal radio-frequency electromagnetic fields and ultrafine particles in human Mono Mac 6 cells. Toxicol Lett 161: 73-82.
11. Hirose H, et al (2007) Mobile phone base station-emitted radiation dose not induce phosphorylation of hsp27. Bioelectromagnetics 28: 99-108.
12. Goswami PC, et al (1999) Proto-oncogene mRNA levels and activities of multiple transcription factors in C3H 10T1/2 murine embryonic fibroblasts exposed to 835.62 and 847.74 MHz cellular phone communication frequency radiation. Radiat Res 151: 300-309.
13. Leszczynski D, et al (2002) Non-thermal activation of the hsp27/p38MAPK stress pathway by mobile phone radiation in human endothelial cells: molecular mechanism for cancer- and blood-brain barrier-related effects. Differentiation 70: 120-129.
14. Czyz J, et al (2004) High frequency electromagnetic fields (GSM signals) affect gene expression levels in tumor suppressor p53-deficient embryonic stem cells. Bioelectromagnetics 25: 296-307.
15. Whitehead TD, et al (2005) Expression of the proto-oncogene Fos after exposure to radiofrequency radiation relevant to wireless communications. Radiat Res 164: 420-430.
16. Vanderstraeten J and Verschaeve L (2008) Gene and protein expression following exposure to radiofrequency fields from mobile phones. Environ. Health Perspect 116: 1131-1135.
17. Nylund R and Leszczynski D (2006) Mobile phone radiation causes changes in gene and protein expression in human endothelial cell lines and the response seems to be genome- and proteome-dependent. Proteomics 6: 4769-4780.
18. Zhao R, et al (2007) Studying gene expression profile of rat neuron exposed to 1800 MHz radiofrequency electromagnetic fields with cDNA microarray. Toxicology 235: 167-175.
19. Grurislk E, et al (2006) An in vitro study of the effects of exposure to a GSM signal in two human cell line: monocytic U937 and neuroblastoma SK-N-SH. Cell Biol Int 30: 793-799.
20. Zeng Q, et al (2006) Effects of global system for mobile communications 1800 MHz radiofrequency electromagnetic fields on gene and protein expression in MCF-7 cells. Proteomics 6: 4732-4738.
21. Chauhan V, et al (2007) Analysis of gene expression in two human-derived cell lines exposed in vitro to a 1.9 GHz pulse-modulated radiofrequency field. Proteomics 7: 3896-3905.
22. Major EO, et al (1885) Establishment of line of human fetal glial cells the supports JC virus multiplication. Proc Natl Acad Sci USA 82: 1257-1261.
23. Sonoda T, et al (2005) Electromagnetic and thermal dosimetry of a cylindrical waveguide-type in vitro exposure apparatus. IEICE Trans Commun E88-B: 3287-3293.
24. Bennett L, et al (2003) Interferon and granulopoiesis in systemic lupus erythematosus blood. J Exp Med 197: 711-723.
25. Ponnampalam AP, et al (2004) Molecular classification of human endometrial cycle stages by transcriptional profiling. Mol Hum Reprod 10: 879-893.
26. Yin H-Q, et al (2007) Differential gene expression and lipid metabolism in fatty liver induced by acute ethanol treatment in mice. Toxicol Appl Pharmacol 223: 225-233.
27. Pacini S, et al (2002) Exposure to global system for mobile communication (GSM) cellular phone radiofrequency alters gene expression, proliferation, and morphology of human skin fibroblasts. Oncol Res 13: 19-24.
28. Chilakapati J, et al (2010) Genome-wide analysis of BEAS-2B cells exposed to trivalent arsenicals and dimethylthioarsinic acid. Toxicology 268: 31-39.
29. Martin-Requena V, et al (2009) PreP+07: improvements of a user friendly tool to preprocess and analyse microarray data. BMC Bioinformatics 10: 16.
30. Kim JH, Shin DM and Lee YS (2002) Effect of local background intensities in the normalization of cDNA microarray data with a skewed expression profiles. Exp Mol Med 34: 224-232.