Effect of garlic on liver phosphatidate phosphohydrolase and plasma lipid levels in hyperlipidemic rats

Food and Chemical Toxicology

Volumn 49, Issue 5, 2011, Pages 1110-1114

  Heidarian, Esfandiar ^a   Jafari Dehkordi, Effat ^b   Seidkhani Nahal, Ali ^c  

^a SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c ILAM UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Garlic; Hyperlipidemia; Liver triglyceride; Phosphatidate phosphohydrolase; Plasma lipid

Indexed keywords

CHOLESTEROL; HERBACEOUS AGENT; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MALONALDEHYDE; PHOSPHATIDATE PHOSPHATASE; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; GARLIC; HYPERLIPIDEMIA; LIPID LIVER LEVEL; MALE; NONHUMAN; RAT; TRIACYLGLYCEROL BLOOD LEVEL; WISTAR RAT;

ANIMALS; ANTIOXIDANTS; CHOLESTEROL, DIETARY; CHOLESTEROL, LDL; CHOLESTEROL, VLDL; DIET; GARLIC; HYPERLIPIDEMIAS; LIPID PEROXIDATION; LIVER; MALE; OXIDATIVE STRESS; PHOSPHATIDATE PHOSPHATASE; PLANT OILS; RANDOM ALLOCATION; RATS; RATS, WISTAR; TRIGLYCERIDES;

ALLIUM SATIVUM; HELIANTHUS; RATTUS; RATTUS NORVEGICUS;

EID: 79953066732     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2011.02.001     Document Type: Article

References (49)

1. Abdalla F.H., Bellé L.P., De Bona K.S., Bitencourt P.E., Pigatto A.S., Moretto M.B. Allium sativum L. extract prevents methyl mercury-induced cytotoxicity in peripheral blood leukocytes (LS). Food Chem. Toxicol. 2009, 48:417-421.
2. Agarwal K. Therapeutic actions of garlic constituents. Med. Res. Rev. 1996, 16:111-124.
3. Ali M., Al-Qattan K.K., Al-Enezi F., Khanafer R.M., Mustafa T. Effect of allicin from garlic powder on serum lipids and blood pressure in rats fed with a high cholesterol diet. Prostaglandins Leukot. Essent. Fatty Acids 2000, 62:253-259.
4. Amagase H., Petesch B., Matsuura H., Kasuga S., Itakura Y. Intake of garlic and its bioactive components. J. Nutr. 2001, 131:955-962.
5. Avci A., Atli T., Erguder I.B., Varli M., Devrim E., Aras S., Durak I. Effects of garlic consumption on plasma and erythrocyte antioxidant parameters in elderly subjects. Gerontology 2008, 54:173-176.
6. Aviello G., Abenavoli L., Borrelli F., Capasso R., Izzo A., Lembo F., Romano B., Capasso F. Garlic: empiricism or science?. Nat. Prod. Commun. 2009, 4:1785-1796.
7. Azuma K., Minami Y., Ippoushi K., Terao J. Lowering effects of onion intake on oxidative stress biomarkers in streptozotocin-induced diabetic rats. J. Clin. Biochem. Nutr. 2007, 40:131-140.
8. Benzie I.F., Strain J.J. The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. Anal. Biochem. 1996, 239:70-76.
9. Bradford M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72:248-254.
10. Brindley D.N. Lipid phosphate phosphatases and related proteins: signaling functions in development, cell division, and cancer. J. Cell. Biochem. 2004, 92:900-912.
11. Carman G.M., Han G.S. Roles of phosphatidate phosphatase enzymes in lipid metabolism. Trends Biochem. Sci. 2006, 31:694-699.
12. 2) displays diacylglycerol pyrophosphate phosphatase activity. J. Biol. Chem. 1997, 272:10361-10366.
13. Durak I., Kavutcu M., Aytaç B., Avci A., Devrim E., Özbek H., Öztürk H.S. Effects of garlic extract consumption on blood lipid and oxidant/antioxidant parameters in humans with high blood cholesterol. J. Nutr. Biochem. 2004, 15:373-377.
14. Eilat S., Oestraicher Y., Rabinkov A., Ohad D., Mirelman D., Battler A., Eldar M., Vered Z. Alteration of lipid profile in hyperlipidemic rabbits by allicin, an active constituent of garlic. Coron. Artery Dis. 1995, 6:985-990.
15. Elabbadi N., Day C.P., Gamouh A., Zyad A., Yeaman S.J. Relationship between the inhibition of phosphatidic acid phosphohydrolase-1 by oleate and oleoyl-CoA ester and its apparent translocation. Biochimie 2005, 87:437-443.
16. 2) from rat liver. Biochem. J. 1995, 308:983-989.
17. Friedewald W.T., Levy R.I., Fredrickson D.s. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem. 1972, 18:499-502.
18. Gebhardt R. Inhibition of cholesterol biosynthesis by a water-soluble garlic extract in primary cultures of rat hepatocytes. Arzneimittelforschung 1991, 41:800-804.
19. Gebhardt R., Beck H. Differential inhibitory effects of garlic-derived organosulfur compounds on cholesterol biosynthesis in primary rat hepatocyte cultures. Lipids 1996, 31:1269-1276.
20. Gorinstein S., Jastrzebski Z., Namiesnik J., Leontowicz H., Leontowicz M., Trakhtenberg S. The atherosclerotic heart disease and protecting properties of garlic: contemporary data. Mol. Nutr. Food Res. 2007, 51:1365-1381.
21. Gorinstein S., Leontowicz H., Leontowicz M., Drzewiecki J., Najman K., Katrich E., Barasch D., Yamamoto K., Trakhtenberg S. Raw and boiled garlic enhances plasma antioxidant activity and improves plasma lipid metabolism in cholesterol-fed rats. Life Sci. 2006, 78:655-663.
22. Haghighi B., Honarjou S. The effects of hydrazine on the phosphatidate phosphohydrolase activity in rat liver. Biochem. Pharmacol. 1987, 36:1163-1165.
23. Hegele R.A., Pollex R.L. Genetic and physiological insights into the metabolic syndrome. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2005, 289:R663-R669.
24. Hegsted D.M., McGandy R.B., Myers M.L., Stare F.J. Quantitative effects of dietary fat on serum cholesterol in man. Am. J. Clin. Nutr. 1965, 17:281-295.
25. 2) from rat liver. Iran. J. Sci. Technol. A 2008, 32:117-122.
26. Iciek M., Kwiecien I., Wlodek L. Biological properties of garlic and garlic-derived organosulfur compounds. Environ. Mol. Mutagen. 2009, 50:247-265.
27. Kanoh H., Imai S.I., Yamada K., Sakane F. Purification and properties of phosphatidic acid phosphatase from porcine thymus membranes. J. Biol. Chem. 1992, 267:25309-25314.
28. Lau B. Suppression of LDL oxidation by garlic compounds is a possible mechanism of cardiovascular health benefit. J. Nutr. 2006, 136:765S-768S.
29. Lebovitz H.E. Insulin resistance. Definition and consequences. Exp. Clin. Endocrinol. Diabetes 2001, 109:S135-S148.
30. Lykkesfeldt J. Malondialdehyde as biomarker of oxidative damage to lipids caused by smoking. Clin. Chim. Acta 2007, 380:50-58.
31. Mahmoodi M., Islami M.R., Asadi K., Khaksari M., Sahebghadam L., Hajizadeh M., Mirzaee M. Study of the effects of raw garlic consumption on the level of lipids and other blood biochemical factors in hyperlipidemic individuals. Pak. J. Pharm. Sci. 2006, 19:295-298.
32. McKenney J.M. Pharmacotherapy of dyslipidemia. Cardiovasc. Drugs Ther. 2001, 15:413-422.
33. Nanjundan M., Possmayer F. Pulmonary phosphatidic acid phosphatase and lipid phosphate phosphohydrolase. Am. J. Physiol. Lung Cell. Mol. Physiol. 2003, 284:L1-23.
34. Norman S.R. Preparation of lipid extracts. Methods of Enzymology 1969, vol. 14. Academic Press, London.
35. Ohkawa H., Ohishi N., Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 1979, 95:351-358.
36. Ortega R., Palencia A., López-Sobaler A. Improvement of cholesterol levels and reduction of cardiovascular risk via the consumption of phytosterols. Br. J. Nutr. 2007, 96:S89-93.
37. Petersen K.F., Shulman G.I. Etiology of insulin resistance. Am. J. Med. 2006, 119:S10-S16.
38. Reue K., Phan J. Metabolic consequences of lipodystrophy in mouse models. Curr. Opin. Clin. Nutr. Metab. Care 2006, 9:436-441.
39. Roberts R., Sciorra V.A., Morris A.J. Human type 2 phosphatidic acid phosphohydrolases. J. Biol. Chem. 1998, 273:22059-22067.
40. Romero F.J., Bosch-Morell F., Romero M.J., Jareño E.J., Romero B., Marín N., Romá J. Lipid peroxidation products and antioxidants in human disease. Environ. Health Perspect. 1998, 106:1229-1234.
41. Ryu K., Ide N., Matsuura H., Itakura Y. N alpha-(1-deoxy-d-fructos-1-yl)-l-arginine, an antioxidant compound identified in aged garlic extract. J. Nutr. 2001, 131:972S-976S.
42. Sciorra V.A., Morris A.J. Roles for lipid phosphate phosphatases in regulation of cellular signaling. Biochim. Biophys. Acta 2002, 1582:45-51.
43. Sharma V., Sharma A., Kansal L. The effect of oral administration of Allium sativum extracts on lead nitrate induced toxicity in male mice. Food Chem. Toxicol. 2010, 48:928-936.
44. Singh D.K., Porter T.D. Inhibition of sterol 4α-methyl oxidase is the principal mechanism by which garlic decreases cholesterol synthesis. J. Nutr. 2006, 136:759S-764S.
45. Sumioka I., Hayama M., Shimokawa Y., Shiraishi S., Tokunaga A. Lipid-lowering effect of monascus garlic fermented extract (MGFE) in hyperlipidemic subjects. Hiroshima J. Med. Sci. 2006, 55:59-64.
46. Thomson M., Al-Qattan K.K., Bordia T., Ali M. Including garlic in the diet may help lower blood glucose, cholesterol, and triglycerides. J. Nutr. 2006, 136:800S-802S.
47. Yanagita T., Han S.Y., Wang Y.M., Tsuruta Y., Anno T. Cycloalliin, a cyclic sulfur imino acid, reduces serum triacylglycerol in rats. Nutrition 2003, 19:140-143.
48. Yanardag R., Peksel A., Yesilyaprak B., Mutluhan Doger M.M., Arisan-Atac I. Effects of a combination of niacin and chromium (III)-chloride on the skin and lungs of hyperlipemic rats. Biol. Trace Elem. Res. 2005, 103:249-260.
49. Yeh Y.Y., Yeh S.M. Garlic reduces plasma lipids by inhibiting hepatic cholesterol and triacylglycerol synthesis. Lipids 1994, 29:189-193.