Inhibition of sterol 4α-methyl oxidase is the principal mechanism by which garlic decreases cholesterol synthesis

Journal of Nutrition

Volumn 136, Issue 3, 2006, Pages

  Singh, Dev K ^a   Porter, Todd D ^a  

^a University of Kentucky   (United States)

Author keywords

Cholesterol synthesis; Diallyl disulfide; Garlic; Lanosterol; Sterol 4 methyl oxidase

Indexed keywords

2 PROPENE 1 THIOL; 4,4' DIMETHYLZYMOSTEROL; ACETIC ACID; CARBON 14; CHOLESTEROL; DIALLYL DISULFIDE; DIALLYL TRISULFIDE; GARLIC EXTRACT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LANOSTEROL SYNTHASE; MEVALONIC ACID; OXIDOREDUCTASE; SQUALENE; STEROL 4ALPHA METHYL OXIDASE; STEROL DERIVATIVE; THIOL DERIVATIVE; UNCLASSIFIED DRUG; 4 METHYL STEROL DEMETHYLASE; 4-METHYL STEROL DEMETHYLASE; ENZYME INHIBITOR; HYPOCHOLESTEROLEMIC AGENT; LANOSTEROL; MULTIENZYME COMPLEX; PLANT EXTRACT;

ANIMAL CELL; CHOLESTEROL SYNTHESIS; CONFERENCE PAPER; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INHIBITION; GAS CHROMATOGRAPHY; HEPATOMA CELL; ISOTOPE LABELING; NONHUMAN; RAT; ANIMAL; ARTICLE; BIOSYNTHESIS; BLOOD; DRUG ANTAGONISM; GARLIC; LIVER TUMOR; METABOLISM; PHYTOTHERAPY; TUMOR CELL LINE;

ALLIUM SATIVUM; ANIMALIA;

ANIMALS; ANTICHOLESTEREMIC AGENTS; CELL LINE, TUMOR; CHOLESTEROL; ENZYME INHIBITORS; GARLIC; LANOSTEROL; LIVER NEOPLASMS, EXPERIMENTAL; MULTIENZYME COMPLEXES; OXIDOREDUCTASES; PHYTOTHERAPY; PLANT EXTRACTS; RATS; SQUALENE;

EID: 33644840885     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.1093/jn/136.3.759s     Document Type: Conference Paper

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