Structural and functional comparison of the RING domains of two p53 E3 ligases, Mdm2 and Pirh2

Journal of Biological Chemistry

Volumn 286, Issue 6, 2011, Pages 4796-4808

  Shloush, Jonathan ^a   Vlassov, John E ^a   Engson, Ian ^a   Duan, Shili ^b   Saridakis, Vivian ^a   Dhe paganon, Sirano ^c   Raught, Brian ^b   Sheng, Yi ^a   Arrowsmith, Cheryl H ^b,d  

^a YORK UNIVERSITY   (Canada)

^b PRINCESS MARGARET HOSPITAL   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d TMDT   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; CELL-CYCLE ARREST; COMPREHENSIVE ANALYSIS; COORDINATION SCHEME; E3 LIGASE; GENOME STABILITY; LIGASES; OLIGOMERIC STATE; PROTEASOMAL DEGRADATION; TERMINAL RESIDUES; TUMOR SUPPRESSORS; UBIQUITIN;

CELL DEATH; OLIGOMERS;

ENZYMES;

LIGASE; OLIGOMER; PROTEIN MDM2; PROTEIN P53; PROTEIN PIRH2; UNCLASSIFIED DRUG; MDM2 PROTEIN, HUMAN; RCHY1 PROTEIN, HUMAN; UBIQUITIN PROTEIN LIGASE;

ALPHA HELIX; ARTICLE; BINDING SITE; COMPARATIVE STUDY; CONTROLLED STUDY; DIMERIZATION; ENZYME ACTIVITY; ENZYME REGULATION; HUMAN; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; STRUCTURE ANALYSIS; UBIQUITINATION; CHEMISTRY; GENETICS; METABOLISM; NUCLEAR MAGNETIC RESONANCE; PROTEIN MULTIMERIZATION; RING FINGER MOTIF; STRUCTURE ACTIVITY RELATION;

BINDING SITES; HUMANS; MUTAGENESIS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN MULTIMERIZATION; PROTO-ONCOGENE PROTEINS C-MDM2; RING FINGER DOMAINS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN-PROTEIN LIGASES;

EID: 79953009006     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.157669     Document Type: Article

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