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Volumn 11, Issue 1, 2011, Pages 68-75

Application of innate immune molecules for a new class of drugs: Infection, inflammation and beyond

Author keywords

Adjuvant; dsDNA; Innate immunity; Thyroid; Vaccine

Indexed keywords

ALPHA INTERFERON; ANTISENSE OLIGODEOXYNUCLEOTIDE; BCG VACCINE; CARBOXYMETHYLCELLULOSE POLYCYTIDYLIC POLYINOSINIC ACID POLYLYSINE; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; CPG OLIGODEOXYNUCLEOTIDE; DOUBLE STRANDED RNA; HELICASE; IMIQUIMOD; INFLUENZA VACCINE; LIPOPOLYSACCHARIDE; MATRIX METALLOPROTEINASE; MINOCYCLINE; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; PHOSPHORYL LIPID A; PNEUMOCOCCUS VACCINE; QS 21; RETINOIC ACID INDUCIBLE PROTEIN I; SM 360320; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; TOLL LIKE RECEPTOR AGONIST; UNCLASSIFIED DRUG; WART VIRUS VACCINE;

EID: 79952998026     PISSN: 18715303     EISSN: None     Source Type: Journal    
DOI: 10.2174/187153011794982077     Document Type: Review
Times cited : (2)

References (94)
  • 2
    • 34548700796 scopus 로고    scopus 로고
    • Unveiling the roles of autophagy in innate and adaptive immunity
    • Levine, B. and Deretic, V. (2007) Unveiling the roles of autophagy in innate and adaptive immunity. Nat. Rev. Immunol., 7, 767-777.
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 767-777
    • Levine, B.1    Deretic, V.2
  • 3
    • 1042278905 scopus 로고    scopus 로고
    • Proteasome and peptidase function in MHC-class-I-mediated antigen presentation
    • Kloetzel, P.M. and Ossendorp, F. (2004) Proteasome and peptidase function in MHC-class-I-mediated antigen presentation. Curr. Opin. Immunol., 16, 76-81.
    • (2004) Curr. Opin. Immunol. , vol.16 , pp. 76-81
    • Kloetzel, P.M.1    Ossendorp, F.2
  • 4
    • 56649108016 scopus 로고    scopus 로고
    • Engagement of TLR signaling as adjuvant: Towards smarter vaccine and beyond
    • Lahiri, A.; Das, P. and Chakravortty, D. (2008) Engagement of TLR signaling as adjuvant: towards smarter vaccine and beyond. Vaccine, 26, 6777-6783.
    • (2008) Vaccine , vol.26 , pp. 6777-6783
    • Lahiri, A.1    Das, P.2    Chakravortty, D.3
  • 5
    • 63849285296 scopus 로고    scopus 로고
    • Therapeutic applications of nucleic acids as ligands for Toll-like receptors
    • Panter, G.; Kuznik, A. and Jerala, R. (2009) Therapeutic applications of nucleic acids as ligands for Toll-like receptors. Curr. Opin. Mol. Ther., 11, 133-145.
    • (2009) Curr. Opin. Mol. Ther. , vol.11 , pp. 133-145
    • Panter, G.1    Kuznik, A.2    Jerala, R.3
  • 6
    • 3142779901 scopus 로고    scopus 로고
    • Therapeutics targeting the innate immune system
    • Ulevitch, R.J. (2004) Therapeutics targeting the innate immune system. Nat. Rev. Immunol., 4, 512-520.
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 512-520
    • Ulevitch, R.J.1
  • 7
    • 33947589836 scopus 로고    scopus 로고
    • Nucleic acid-based antiviral drugs against seasonal and avian influenza viruses
    • Wong, J.P.; Christopher, M.E.; Salazar, A.M.; Dale, R.M.; Sun, L.Q. and Wang, M. (2007) Nucleic acid-based antiviral drugs against seasonal and avian influenza viruses. Vaccine, 25, 3175-3178.
    • (2007) Vaccine , vol.25 , pp. 3175-3178
    • Wong, J.P.1    Christopher, M.E.2    Salazar, A.M.3    Dale, R.M.4    Sun, L.Q.5    Wang, M.6
  • 9
    • 43649101982 scopus 로고    scopus 로고
    • Human papilloma virus: Prevention and treatment
    • Diaz, M.L. (2008) Human papilloma virus: prevention and treatment. Obstet Gynecol Clin. North. Am., 35, 199-217, vii-viii.
    • (2008) Obstet Gynecol Clin. North. Am. , vol.35
    • Diaz, M.L.1
  • 10
    • 34447526800 scopus 로고    scopus 로고
    • Impact of the human papilloma vaccine on cervical cancer
    • Chan, J.K. and Berek, J.S. (2007) Impact of the human papilloma vaccine on cervical cancer. J Clin Oncol., 25, 2975-2982.
    • (2007) J Clin Oncol , vol.25 , pp. 2975-2982
    • Chan, J.K.1    Berek, J.S.2
  • 11
    • 35348988624 scopus 로고    scopus 로고
    • IC31 and IC30, novel types of vaccine adjuvant based on peptide delivery systems
    • Lingnau, K.; Riedl, K. and von Gabain, A. (2007) IC31 and IC30, novel types of vaccine adjuvant based on peptide delivery systems. Expert Rev. Vaccines, 6, 741-746.
    • (2007) Expert Rev. Vaccines , vol.6 , pp. 741-746
    • Lingnau, K.1    Riedl, K.2    von Gabain, A.3
  • 12
    • 57149086632 scopus 로고    scopus 로고
    • Prophylaxis with cationic liposome-DNA complexes protects hamsters from phleboviral disease: Importance of liposomal delivery and CpG motifs
    • Gowen, B.B.; Fairman, J.; Dow, S.; Troyer, R.; Wong, M.H.; Jung, K.H.; Melby, P.C. and Morrey, J.D. (2009) Prophylaxis with cationic liposome-DNA complexes protects hamsters from phleboviral disease: importance of liposomal delivery and CpG motifs. Antiviral Res., 81, 37-46.
    • (2009) Antiviral Res , vol.81 , pp. 37-46
    • Gowen, B.B.1    Fairman, J.2    Dow, S.3    Troyer, R.4    Wong, M.H.5    Jung, K.H.6    Melby, P.C.7    Morrey, J.D.8
  • 15
    • 42249108157 scopus 로고    scopus 로고
    • Human blood dendritic cells from allergic subjects have impaired capacity to produce interferon-alpha via Toll-like receptor 9
    • Tversky, J.R.; Le, T.V.; Bieneman, A.P.; Chichester, K.L.; Hamilton, R.G. and Schroeder, J.T. (2008) Human blood dendritic cells from allergic subjects have impaired capacity to produce interferon-alpha via Toll-like receptor 9. Clin. Exp. Allergy, 38, 781-788.
    • (2008) Clin. Exp. Allergy , vol.38 , pp. 781-788
    • Tversky, J.R.1    Le, T.V.2    Bieneman, A.P.3    Chichester, K.L.4    Hamilton, R.G.5    Schroeder, J.T.6
  • 16
    • 0024315910 scopus 로고
    • Induction of tumor cytotoxicity in murine bone marrow-derived macrophages by two synthetic lipopeptide analogues
    • Hoffmann, P.; Wiesmuller, K.H.; Metzger, J.; Jung, G. and Bessler, W.G. (1989) Induction of tumor cytotoxicity in murine bone marrow-derived macrophages by two synthetic lipopeptide analogues. Biol. Chem. Hoppe. Seyler., 370, 575-582.
    • (1989) Biol. Chem. Hoppe. Seyler. , vol.370 , pp. 575-582
    • Hoffmann, P.1    Wiesmuller, K.H.2    Metzger, J.3    Jung, G.4    Bessler, W.G.5
  • 18
    • 34548660856 scopus 로고    scopus 로고
    • Robust immune responses elicited by a fully synthetic threecomponent vaccine
    • Ingale, S.; Wolfert, M.A.; Gaekwad, J.; Buskas, T. and Boons, G.J. (2007) Robust immune responses elicited by a fully synthetic threecomponent vaccine. Nat. Chem. Biol., 3, 663-667.
    • (2007) Nat. Chem. Biol. , vol.3 , pp. 663-667
    • Ingale, S.1    Wolfert, M.A.2    Gaekwad, J.3    Buskas, T.4    Boons, G.J.5
  • 19
    • 60349111689 scopus 로고    scopus 로고
    • Increasing the antigenicity of synthetic tumor-associated carbohydrate antigens by targeting Toll-like receptors
    • Ingale, S.; Wolfert, M.A.; Buskas, T. and Boons, G.J. (2009) Increasing the antigenicity of synthetic tumor-associated carbohydrate antigens by targeting Toll-like receptors. Chem. Bio. Chem., 10, 455-463.
    • (2009) Chem. Bio. Chem. , vol.10 , pp. 455-463
    • Ingale, S.1    Wolfert, M.A.2    Buskas, T.3    Boons, G.J.4
  • 20
    • 33845352530 scopus 로고    scopus 로고
    • Lipid-containing mimetics of natural triggers of innate immunity as CTL-inducing influenza vaccines
    • Lau, Y.F.; Deliyannis, G.; Zeng, W.; Mansell, A.; Jackson, D.C. and Brown, L.E. (2006) Lipid-containing mimetics of natural triggers of innate immunity as CTL-inducing influenza vaccines. Int. Immunol., 18, 1801-1813.
    • (2006) Int. Immunol. , vol.18 , pp. 1801-1813
    • Lau, Y.F.1    Deliyannis, G.2    Zeng, W.3    Mansell, A.4    Jackson, D.C.5    Brown, L.E.6
  • 21
    • 63849167957 scopus 로고    scopus 로고
    • A critical role for direct TLR2-MyD88 signaling in CD8 T-cell clonal expansion and memory formation following vaccinia viral infection
    • Quigley, M.; Martinez, J.; Huang, X. and Yang, Y. (2009) A critical role for direct TLR2-MyD88 signaling in CD8 T-cell clonal expansion and memory formation following vaccinia viral infection. Blood, 113, 2256-2264.
    • (2009) Blood , vol.113 , pp. 2256-2264
    • Quigley, M.1    Martinez, J.2    Huang, X.3    Yang, Y.4
  • 22
    • 0027173808 scopus 로고
    • Lipopolysaccharide, lipid A, and liposomes containing lipid A as immunologic adjuvants
    • Alving, C.R. (1993) Lipopolysaccharide, lipid A, and liposomes containing lipid A as immunologic adjuvants. Immunobiology, 187, 430-446.
    • (1993) Immunobiology , vol.187 , pp. 430-446
    • Alving, C.R.1
  • 23
    • 0022354780 scopus 로고
    • The serologic response to Meth A sarcoma vaccines after cyclophosphamide treatment is additionally increased by various adjuvants
    • Livingston, P.O.; Jones, M.; Deleo, A.B.; Oettgen, H.F. and Old, L.J. (1985) The serologic response to Meth A sarcoma vaccines after cyclophosphamide treatment is additionally increased by various adjuvants. J. Immunol., 135, 1505-1509.
    • (1985) J. Immunol. , vol.135 , pp. 1505-1509
    • Livingston, P.O.1    Jones, M.2    Deleo, A.B.3    Oettgen, H.F.4    Old, L.J.5
  • 24
    • 0022544882 scopus 로고
    • Immunobiological activities of nontoxic lipid A: Enhancement of nonspecific resistance in combination with trehalose dimycolate against viral infection and adjuvant effects
    • Masihi, K.N.; Lange, W.; Brehmer, W. and Ribi, E. (1986) Immunobiological activities of nontoxic lipid A: enhancement of nonspecific resistance in combination with trehalose dimycolate against viral infection and adjuvant effects. Int. J. Immunopharmacol., 8, 339-345.
    • (1986) Int. J. Immunopharmacol. , vol.8 , pp. 339-345
    • Masihi, K.N.1    Lange, W.2    Brehmer, W.3    Ribi, E.4
  • 25
    • 0023234075 scopus 로고
    • Enumeration of T cells reactive with Mycobacterium tuberculosis organisms and specific for the recombinant mycobacterial 64-kDa protein
    • Kaufmann, S.H.; Vath, U.; Thole, J.E.; Van Embden, J.D. and Emmrich, F. (1987) Enumeration of T cells reactive with Mycobacterium tuberculosis organisms and specific for the recombinant mycobacterial 64-kDa protein. Eur. J. Immunol., 17, 351-357.
    • (1987) Eur. J. Immunol. , vol.17 , pp. 351-357
    • Kaufmann, S.H.1    Vath, U.2    Thole, J.E.3    van Embden, J.D.4    Emmrich, F.5
  • 27
    • 35349028297 scopus 로고    scopus 로고
    • GlaxoSmithKline Adjuvant Systems in vaccines: Concepts, achievements and perspectives
    • Garcon, N.; Chomez, P. and Van Mechelen, M. (2007) GlaxoSmithKline Adjuvant Systems in vaccines: concepts, achievements and perspectives. Expert Rev. Vaccines, 6, 723-739.
    • (2007) Expert Rev. Vaccines , vol.6 , pp. 723-739
    • Garcon, N.1    Chomez, P.2    van Mechelen, M.3
  • 28
    • 58149112511 scopus 로고    scopus 로고
    • Analysis of adverse events of potential autoimmune aetiology in a large integrated safety database of AS04 adjuvanted vaccines
    • Verstraeten, T.; Descamps, D.; David, M.P.; Zahaf, T.; Hardt, K.; Izurieta, P.; Dubin, G. and Breuer, T. (2008) Analysis of adverse events of potential autoimmune aetiology in a large integrated safety database of AS04 adjuvanted vaccines. Vaccine, 26, 6630-6638.
    • (2008) Vaccine , vol.26 , pp. 6630-6638
    • Verstraeten, T.1    Descamps, D.2    David, M.P.3    Zahaf, T.4    Hardt, K.5    Izurieta, P.6    Dubin, G.7    Breuer, T.8
  • 29
    • 35349002727 scopus 로고    scopus 로고
    • E6020: A synthetic Tolllike receptor 4 agonist as a vaccine adjuvant
    • Ishizaka, S.T. and Hawkins, L.D. (2007) E6020: a synthetic Tolllike receptor 4 agonist as a vaccine adjuvant. Expert. Rev. Vaccines, 6, 773-784.
    • (2007) Expert. Rev. Vaccines , vol.6 , pp. 773-784
    • Ishizaka, S.T.1    Hawkins, L.D.2
  • 32
    • 48449092989 scopus 로고    scopus 로고
    • Immunization with a Toll-like receptor 7 and/or 8 agonist vaccine adjuvant increases protective immunity against Leishmania major in BALB/c mice
    • Zhang, W.W. and Matlashewski, G. (2008) Immunization with a Toll-like receptor 7 and/or 8 agonist vaccine adjuvant increases protective immunity against Leishmania major in BALB/c mice. Infect. Immun., 76, 3777-3783.
    • (2008) Infect. Immun. , vol.76 , pp. 3777-3783
    • Zhang, W.W.1    Matlashewski, G.2
  • 36
    • 35348932070 scopus 로고    scopus 로고
    • Intracellular NOD-like receptors in host defense and disease
    • Kanneganti, T.D.; Lamkanfi, M. and Nunez, G. (2007) Intracellular NOD-like receptors in host defense and disease. Immunity., 27, 549-559.
    • (2007) Immunity. , vol.27 , pp. 549-559
    • Kanneganti, T.D.1    Lamkanfi, M.2    Nunez, G.3
  • 38
    • 34248342698 scopus 로고    scopus 로고
    • Evidence for correlation between the intensities of adjuvant effects and NOD2 activation by monomeric, dimeric and lipophylic derivatives of N-acetylglucosaminyl-Nacetylmuramyl peptides
    • Meshcheryakova, E.; Makarov, E.; Philpott, D.; Andronova, T. and Ivanov, V. (2007) Evidence for correlation between the intensities of adjuvant effects and NOD2 activation by monomeric, dimeric and lipophylic derivatives of N-acetylglucosaminyl-Nacetylmuramyl peptides. Vaccine, 25, 4515-4520.
    • (2007) Vaccine , vol.25 , pp. 4515-4520
    • Meshcheryakova, E.1    Makarov, E.2    Philpott, D.3    Andronova, T.4    Ivanov, V.5
  • 39
    • 38849163741 scopus 로고    scopus 로고
    • Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis
    • Watanabe, T.; Asano, N.; Murray, P.J.; Ozato, K.; Tailor, P.; Fuss, I.J.; Kitani, A. and Strober, W. (2008) Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis. J. Clin. Invest., 118, 545-559.
    • (2008) J. Clin. Invest. , vol.118 , pp. 545-559
    • Watanabe, T.1    Asano, N.2    Murray, P.J.3    Ozato, K.4    Tailor, P.5    Fuss, I.J.6    Kitani, A.7    Strober, W.8
  • 40
    • 66949138341 scopus 로고    scopus 로고
    • Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2
    • Bertrand, M.J.; Doiron, K.; Labbe, K.; Korneluk, R.G.; Barker, P.A. and Saleh, M. (2009) Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2. Immunity, 30, 789-801.
    • (2009) Immunity , vol.30 , pp. 789-801
    • Bertrand, M.J.1    Doiron, K.2    Labbe, K.3    Korneluk, R.G.4    Barker, P.A.5    Saleh, M.6
  • 41
    • 0026535382 scopus 로고
    • Protective effects of immunoactive peptide, FK565 against systemic and local infections with herpes simplex virus and murine cytomegalovirus and respiratory tract infection with influenza virus in mice
    • Yokota, Y.; Watanabe, Y.; Wakai, Y. and Mine, Y. (1992) Protective effects of immunoactive peptide, FK565 against systemic and local infections with herpes simplex virus and murine cytomegalovirus and respiratory tract infection with influenza virus in mice. J. Antibiot. (Tokyo), 45, 258-264.
    • (1992) J. Antibiot. (Tokyo) , vol.45 , pp. 258-264
    • Yokota, Y.1    Watanabe, Y.2    Wakai, Y.3    Mine, Y.4
  • 42
    • 0026755301 scopus 로고
    • Effect of immunostimulant therapy on acute viral myocarditis in an animal model
    • Sato, Y.; Maruyama, S.; Kawai, C. and Matsumori, A. (1992) Effect of immunostimulant therapy on acute viral myocarditis in an animal model. Am. Heart. J., 124, 428-434.
    • (1992) Am. Heart. J. , vol.124 , pp. 428-434
    • Sato, Y.1    Maruyama, S.2    Kawai, C.3    Matsumori, A.4
  • 43
    • 69949105157 scopus 로고    scopus 로고
    • The NLRP3 inflammasome: A sensor of immune danger signals
    • Cassel, S.L.; Joly, S. and Sutterwala, F.S. (2009) The NLRP3 inflammasome: a sensor of immune danger signals. Semin. Immunol., 21, 194-198.
    • (2009) Semin. Immunol. , vol.21 , pp. 194-198
    • Cassel, S.L.1    Joly, S.2    Sutterwala, F.S.3
  • 44
    • 67049173026 scopus 로고    scopus 로고
    • Immunology of TLR-independent vaccine adjuvants
    • De Gregorio, E.; D'Oro, U. and Wack, A. (2009) Immunology of TLR-independent vaccine adjuvants. Curr. Opin. Immunol., 21, 339-345.
    • (2009) Curr. Opin. Immunol. , vol.21 , pp. 339-345
    • de Gregorio, E.1    D'oro, U.2    Wack, A.3
  • 45
    • 32044457700 scopus 로고    scopus 로고
    • MasterCARD: A priceless link to innate immunity
    • Hiscott, J.; Lin, R.; Nakhaei, P. and Paz, S. (2006) MasterCARD: a priceless link to innate immunity. Trends. Mol. Med., 12, 53-56.
    • (2006) Trends. Mol. Med. , vol.12 , pp. 53-56
    • Hiscott, J.1    Lin, R.2    Nakhaei, P.3    Paz, S.4
  • 48
    • 60549088603 scopus 로고    scopus 로고
    • Attenuated expression of A20 markedly increases the efficacy of doublestranded RNA-activated dendritic cells as an anti-cancer vaccine
    • Breckpot, K.; Aerts-Toegaert, C.; Heirman, C.; Peeters, U.; Beyaert, R.; Aerts, J.L. and Thielemans, K. (2009) Attenuated expression of A20 markedly increases the efficacy of doublestranded RNA-activated dendritic cells as an anti-cancer vaccine. J. Immunol., 182, 860-870.
    • (2009) J. Immunol. , vol.182 , pp. 860-870
    • Breckpot, K.1    Aerts-Toegaert, C.2    Heirman, C.3    Peeters, U.4    Beyaert, R.5    Aerts, J.L.6    Thielemans, K.7
  • 49
    • 47249092785 scopus 로고    scopus 로고
    • Development of TLR inhibitors for the treatment of autoimmune diseases
    • Barrat, F.J. and Coffman, R.L. (2008) Development of TLR inhibitors for the treatment of autoimmune diseases. Immunol. Rev., 223, 271-283.
    • (2008) Immunol. Rev. , vol.223 , pp. 271-283
    • Barrat, F.J.1    Coffman, R.L.2
  • 50
    • 34548443465 scopus 로고    scopus 로고
    • Targeting toll-like receptors for drug development: A summary of commercial approaches
    • Gearing, A.J. (2007) Targeting toll-like receptors for drug development: a summary of commercial approaches. Immunol. Cell. Biol., 85, 490-494.
    • (2007) Immunol. Cell. Biol. , vol.85 , pp. 490-494
    • Gearing, A.J.1
  • 51
    • 70349342913 scopus 로고    scopus 로고
    • Identification and characterization of oligonucleotides that inhibit Toll-like receptor 2-associated immune responses
    • Chang, Y.C.; Kao, W.C.; Wang, W.Y.; Wang, W.Y.; Yang, R.B. and Peck, K. (2009) Identification and characterization of oligonucleotides that inhibit Toll-like receptor 2-associated immune responses. FASEB J., 23, 3078-3088.
    • (2009) FASEB J , vol.23 , pp. 3078-3088
    • Chang, Y.C.1    Kao, W.C.2    Wang, W.Y.3    Wang, W.Y.4    Yang, R.B.5    Peck, K.6
  • 53
  • 55
    • 29144462494 scopus 로고    scopus 로고
    • Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity
    • Li, X.D.; Sun, L.; Seth, R.B.; Pineda, G. and Chen, Z.J. (2005) Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity. Proc. Natl. Acad. Sci. USA, 102, 17717-17722.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 17717-17722
    • Li, X.D.1    Sun, L.2    Seth, R.B.3    Pineda, G.4    Chen, Z.J.5
  • 57
    • 37649005234 scopus 로고    scopus 로고
    • Autophagy in the pathogenesis of disease
    • Levine, B. and Kroemer, G. (2008) Autophagy in the pathogenesis of disease. Cell, 132, 27-42.
    • (2008) Cell , vol.132 , pp. 27-42
    • Levine, B.1    Kroemer, G.2
  • 58
    • 62049084947 scopus 로고    scopus 로고
    • Autophagy enhances the efficacy of BCG vaccine by increasing peptide presentation in mouse dendritic cells
    • Jagannath, C.; Lindsey, D.R.; Dhandayuthapani, S.; Xu, Y.; Hunter, R.L.Jr. and Eissa, N.T. (2009) Autophagy enhances the efficacy of BCG vaccine by increasing peptide presentation in mouse dendritic cells. Nat. Med., 15, 267-276.
    • (2009) Nat. Med. , vol.15 , pp. 267-276
    • Jagannath, C.1    Lindsey, D.R.2    Dhandayuthapani, S.3    Xu, Y.4    Hunter Jr., R.L.5    Eissa, N.T.6
  • 61
    • 59249084491 scopus 로고    scopus 로고
    • The proteasome: Overview of structure and functions
    • Tanaka, K. (2009) The proteasome: overview of structure and functions. Proc. Jpn. Acad. Ser. B. Phys. Biol. Sci., 85, 12-36.
    • (2009) Proc. Jpn. Acad. Ser. B. Phys. Biol. Sci. , vol.85 , pp. 12-36
    • Tanaka, K.1
  • 63
    • 50249092779 scopus 로고    scopus 로고
    • Development of proteasome inhibitors in oncology and autoimmune diseases
    • Bennett, M.K. and Kirk, C.J. (2008) Development of proteasome inhibitors in oncology and autoimmune diseases. Curr. Opin. Drug. Discov. Dev., 11, 616-625.
    • (2008) Curr. Opin. Drug. Discov. Dev. , vol.11 , pp. 616-625
    • Bennett, M.K.1    Kirk, C.J.2
  • 65
    • 66549099025 scopus 로고    scopus 로고
    • Targeted inhibition of the immunoproteasome is a potent strategy against models of multiple myeloma that overcomes resistance to conventional drugs and nonspecific proteasome inhibitors
    • Kuhn, D.J.; Hunsucker, S.A.; Chen, Q.; Voorhees, P.M.; Orlowski, M. and Orlowski, R.Z. (2009) Targeted inhibition of the immunoproteasome is a potent strategy against models of multiple myeloma that overcomes resistance to conventional drugs and nonspecific proteasome inhibitors. Blood, 113, 4667-4676.
    • (2009) Blood , vol.113 , pp. 4667-4676
    • Kuhn, D.J.1    Hunsucker, S.A.2    Chen, Q.3    Voorhees, P.M.4    Orlowski, M.5    Orlowski, R.Z.6
  • 66
    • 41149111580 scopus 로고    scopus 로고
    • Chemokines and their receptors: Drug targets in immunity and inflammation
    • Viola, A. and Luster, A.D. (2008) Chemokines and their receptors: drug targets in immunity and inflammation. Annu. Rev. Pharmacol. Toxicol., 48, 171-197.
    • (2008) Annu. Rev. Pharmacol. Toxicol. , vol.48 , pp. 171-197
    • Viola, A.1    Luster, A.D.2
  • 69
    • 66749134594 scopus 로고    scopus 로고
    • Targeting innate immunity protein kinase signalling in inflammation
    • Gaestel, M.; Kotlyarov, A. and Kracht, M. (2009) Targeting innate immunity protein kinase signalling in inflammation. Nat. Rev. Drug. Discov., 8, 480-499.
    • (2009) Nat. Rev. Drug. Discov. , vol.8 , pp. 480-499
    • Gaestel, M.1    Kotlyarov, A.2    Kracht, M.3
  • 73
    • 0034027425 scopus 로고    scopus 로고
    • Genetic immunization of outbred mice with thyrotropin receptor cDNA provides a model of Graves' disease
    • Costagliola, S.; Many, M.C.; Denef, J.F.; Pohlenz, J.; Refetoff, S. and Vassart, G. (2000) Genetic immunization of outbred mice with thyrotropin receptor cDNA provides a model of Graves' disease. J. Clin. Invest., 105, 803-811.
    • (2000) J. Clin. Invest. , vol.105 , pp. 803-811
    • Costagliola, S.1    Many, M.C.2    Denef, J.F.3    Pohlenz, J.4    Refetoff, S.5    Vassart, G.6
  • 75
    • 41449102471 scopus 로고    scopus 로고
    • Taking a toll on the bones: Regulation of bone metabolism by innate immune regulators
    • Bar-Shavit, Z. (2008) Taking a toll on the bones: regulation of bone metabolism by innate immune regulators. Autoimmunity, 41, 195-203.
    • (2008) Autoimmunity , vol.41 , pp. 195-203
    • Bar-Shavit, Z.1
  • 76
    • 33947583822 scopus 로고    scopus 로고
    • Osteoimmunology: Shared mechanisms and crosstalk between the immune and bone systems
    • Takayanagi, H. (2007) Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. Nat. Rev. Immunol., 7, 292-304.
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 292-304
    • Takayanagi, H.1
  • 77
    • 33750584214 scopus 로고    scopus 로고
    • TLR4 links innate immunity and fatty acid-induced insulin resistance
    • Shi, H.; Kokoeva, M.V.; Inouye, K.; Tzameli, I.; Yin, H. and Flier, J.S. (2006) TLR4 links innate immunity and fatty acid-induced insulin resistance. J. Clin. Invest., 116, 3015-3025.
    • (2006) J. Clin. Invest. , vol.116 , pp. 3015-3025
    • Shi, H.1    Kokoeva, M.V.2    Inouye, K.3    Tzameli, I.4    Yin, H.5    Flier, J.S.6
  • 78
    • 44449110675 scopus 로고    scopus 로고
    • Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat
    • Davis, J.E.; Gabler, N.K.; Walker-Daniels, J. and Spurlock, M.E. (2008) Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat. Obesity (Silver Spring), 16, 1248-1255.
    • (2008) Obesity (Silver Spring) , vol.16 , pp. 1248-1255
    • Davis, J.E.1    Gabler, N.K.2    Walker-Daniels, J.3    Spurlock, M.E.4
  • 82
    • 33748998485 scopus 로고    scopus 로고
    • Toll-like receptor expression and response to specific stimulation in adipocytes and preadipocytes: On the role of fat in inflammation
    • Pietsch, J.; Batra, A.; Stroh, T.; Fedke, I.; Glauben, R.; Okur, B.; Zeitz, M. and Siegmund, B. (2006) Toll-like receptor expression and response to specific stimulation in adipocytes and preadipocytes: on the role of fat in inflammation. Ann. NY Acad. Sci., 1072, 407-409.
    • (2006) Ann. NY Acad. Sci. , vol.1072 , pp. 407-409
    • Pietsch, J.1    Batra, A.2    Stroh, T.3    Fedke, I.4    Glauben, R.5    Okur, B.6    Zeitz, M.7    Siegmund, B.8
  • 85
    • 63049112908 scopus 로고    scopus 로고
    • Innate immunity and adipocyte function: Ligand-specific activation of multiple Toll-like receptors modulates cytokine, adipokine, and chemokine secretion in adipocytes
    • Kopp, A.; Buechler, C.; Neumeier, M.; Weigert, J.; Aslanidis, C.; Scholmerich, J. and Schaffler, A. (2009) Innate immunity and adipocyte function: ligand-specific activation of multiple Toll-like receptors modulates cytokine, adipokine, and chemokine secretion in adipocytes. Obesity (Silver Spring), 17, 648-656.
    • (2009) Obesity (Silver Spring) , vol.17 , pp. 648-656
    • Kopp, A.1    Buechler, C.2    Neumeier, M.3    Weigert, J.4    Aslanidis, C.5    Scholmerich, J.6    Schaffler, A.7
  • 86
    • 65649117802 scopus 로고    scopus 로고
    • Unexpected trafficking of immune cells within the adipose tissue during the onset of obesity
    • Duffaut, C.; Galitzky, J.; Lafontan, M. and Bouloumie, A. (2009) Unexpected trafficking of immune cells within the adipose tissue during the onset of obesity. Biochem. Biophys. Res. Commun., 384, 482-485.
    • (2009) Biochem. Biophys. Res. Commun. , vol.384 , pp. 482-485
    • Duffaut, C.1    Galitzky, J.2    Lafontan, M.3    Bouloumie, A.4
  • 88
    • 34347253595 scopus 로고    scopus 로고
    • Toll-like receptor-MyD88 and Fc receptor pathways of mast cells mediate the thyroid dysfunctions observed during nonthyroidal illness
    • Rocchi, R.; Kimura, H.; Tzou, S.C.; Suzuki, K.; Rose, N.R.; Pinchera, A.; Ladenson, P.W. and Caturegli, P. (2007) Toll-like receptor-MyD88 and Fc receptor pathways of mast cells mediate the thyroid dysfunctions observed during nonthyroidal illness. Proc. Natl. Acad. Sci. USA, 104, 6019-6024.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 6019-6024
    • Rocchi, R.1    Kimura, H.2    Tzou, S.C.3    Suzuki, K.4    Rose, N.R.5    Pinchera, A.6    Ladenson, P.W.7    Caturegli, P.8
  • 90
    • 34347255396 scopus 로고    scopus 로고
    • Suppression of iodide uptake and thyroid hormone synthesis with stimulation of the type I interferon system by double-stranded ribonucleic acid in cultured human thyroid follicles
    • Yamazaki, K.; Suzuki, K.; Yamada, E.; Yamada, T.; Takeshita, F.; Matsumoto, M.; Mitsuhashi, T.; Obara, T.; Takano, K. and Sato, K. (2007) Suppression of iodide uptake and thyroid hormone synthesis with stimulation of the type I interferon system by double-stranded ribonucleic acid in cultured human thyroid follicles. Endocrinology, 148, 3226-3235.
    • (2007) Endocrinology , vol.148 , pp. 3226-3235
    • Yamazaki, K.1    Suzuki, K.2    Yamada, E.3    Yamada, T.4    Takeshita, F.5    Matsumoto, M.6    Mitsuhashi, T.7    Obara, T.8    Takano, K.9    Sato, K.10
  • 91
    • 17844410902 scopus 로고    scopus 로고
    • Thyrocytes express a functional toll-like receptor 3: Overexpression can be induced by viral infection and reversed by phenylmethimazole and is associated with Hashimoto's autoimmune thyroiditis
    • Harii, N.; Lewis, C.J.; Vasko, V.; McCall, K.; Benavides-Peralta, U.; Sun, X.; Ringel, M.D.; Saji, M.; Giuliani, C.; Napolitano, G.; Goetz, D.J. and Kohn, L.D. (2005) Thyrocytes express a functional toll-like receptor 3: overexpression can be induced by viral infection and reversed by phenylmethimazole and is associated with Hashimoto's autoimmune thyroiditis. Mol. Endocrinol., 19, 1231-1250.
    • (2005) Mol. Endocrinol. , vol.19 , pp. 1231-1250
    • Harii, N.1    Lewis, C.J.2    Vasko, V.3    McCall, K.4    Benavides-Peralta, U.5    Sun, X.6    Ringel, M.D.7    Saji, M.8    Giuliani, C.9    Napolitano, G.10    Goetz, D.J.11    Kohn, L.D.12
  • 92
    • 34548265278 scopus 로고    scopus 로고
    • Autophagy and human disease
    • Huang, J. and Klionsky, D.J. (2007) Autophagy and human disease. Cell Cycle, 6, 1837-1849.
    • (2007) Cell Cycle , vol.6 , pp. 1837-1849
    • Huang, J.1    Klionsky, D.J.2
  • 94
    • 50249179101 scopus 로고    scopus 로고
    • Vitamin effects on the immune system: Vitamins A and D take centre stage
    • Moro, J.R.; Iwata, M. and von Andriano, U.H. (2008) Vitamin effects on the immune system: vitamins A and D take centre stage. Nat. Rev. Immunol., 8, 685-698.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 685-698
    • Moro, J.R.1    Iwata, M.2    von Andriano, U.H.3


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