The reduced GM-CSF priming of ROS production in granulocytes from patients with myelodysplasia is associated with an impaired lipid raft formation

Journal of Leukocyte Biology

Volumn 81, Issue 2, 2007, Pages 449-457

  Fuhler, Gwenny M ^a   Blom, Nel R ^a,b   Coffer, Paul J ^c   Drayer, A Lyndsay ^d   Vellenga, Edo ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^d Sanquin Bloedbank Regio Nordoost Groningen   (Netherlands)

Author keywords

MDS; NADPH; Signal transduction

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; METHYL BETA CYCLODEXTRIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; PROTEIN KINASE LYN; PROTEIN P22; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2;

ARTICLE; CONTROLLED STUDY; ELECTRON MICROSCOPY; GRANULOCYTE; HUMAN; LIPID ANALYSIS; LIPID RAFT; MYELODYSPLASIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

BETA-CYCLODEXTRINS; G(M1) GANGLIOSIDE; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; GRANULOCYTES; HUMANS; MEMBRANE MICRODOMAINS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; NEURAL TUBE DEFECTS; NEUTROPHILS; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33846705646     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0506311     Document Type: Article

References (50)

1. Babior, B. M. (1984) Oxidants from phagocytes: agents of defense and destruction. Blood 64, 959-966.
2. Weisbart, R. H., Kwan, L., Golde, D. W., Gasson, J. C. (1987) Human GM-CSF primes neutrophils for enhanced oxidative metabolism in response to the major physiological chemoattractants. Blood 69, 18-21.
3. Kitagawa, S., Yuo, A., Souza, L. M., Saito, M., Miura, Y., Takaku, F. (1987) Recombinant human granulocyte colony-stimulating factor enhances superoxide release in human granulocytes stimulated by the chemotactic peptide. Biochem. Biophys. Res. Commun. 144, 1143-1146.
4. Kouides, P. A., Bennett, J. M. (1996) Morphology and classification of the Myelodysplastic syndromes and their pathologic variants. Semin. Hematol. 33, 95-100.
5. Houwerzijl, E. J., Blom, N. R., van der Want, J. J., Louwes, H., Esselink, M. T., Smit, J. W., Vellenga, E., de Wolf, J. T. (2005) Increased peripheral platelet destruction and caspase-3-independent programmed cell death of bone marrow megakaryoctes in Myelodysplastic patients. Blood 105, 3472-3479.
6. Kouides, P. A., Bennett, J. M. (1997) Understanding the Myelodysplastic syndromes. Oncologist 2, 389-401.
7. Fuhler, G. M., Drayer, A. L., Vellenga, E. (2003) Decreased phosphorylation of protein kinase B (PKB/Akt) and extracellular signal-regulated kinase (ERK) in neutrophils from patients with Myelodysplasia. Blood 101, 1172-1180.
8. Zabernigg, A., Hilbe, W., Eisterer, W., Greil, R., Ludescher, C., Thaler, J. (1997) Cytokine priming of the granulocyte respiratory burst in Myelodysplastic syndromes. Leuk. Lymphoma 27, 137-143.
9. Ohsaka, A., Kitagawa, S., Yuo, A., Motoyoshi, K., Furusawa, S., Miura, Y., Takaku, F., Saito, M. (1993) Effects of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor on respiratory burst activity of neutrophils in patients with Myelodysplastic syndromes. Clin. Exp. Immunol. 91, 308-313.
10. Babior, B. M. (1999) NADPH oxidase: an update. Blood 93, 1464-1476.
11. Shao, D., Segal, A. W., Dekker, L. V. (2003) Lipid rafts determine efficiency of NADPH oxidase activation in neutrophils. FEBS Lett. 550, 101-106.
12. Vilhardt, F., Van Deurs, B. (2004) The phagocyte NADPH oxidase depends on cholesterol-enriched membrane microdomains for assembly. EMBO J. 23, 739-748.
13. Zajchowski, L. D., Robbins, S. M. (2002) Lipid rafts and little caves. Compartmentalized signaling in membrane microdomains. Eur. J. Biochem. 269, 737-752.
14. Zhan, Y., Virbasius, J. V., Song, X., Pomerleau, D. P., Zhou, G. W. (2002) The p40phox and p47phox PX domains of NADPH oxidase target cell membranes via direct and indirect recruitment by phosphoinositides. J. Biol. Chem. 277, 4512-4518.
15. Dewas, C., Fay, M., Gougerot-Pocidalo, M. A., El Benna, J. (2000) The mitogen-activated protein kinase extracellular signal-regulated kinase 1/2 pathway is involved in formyl-methionyl-leucyl-phenylalanine-induced p47phox phosphorylation in human neutrophils. J. Immunol. 165, 5238-5244.
16. McLeish, K. R., Knall, C., Ward, R. A., Gerwins, P., Coxon, P. Y., Klein, J. B., Johnson, G. L. (1998) Activation of mitogen-activated protein kinase cascades during priming of human neutrophils by TNF-α and GM-CSF. J. Leukoc. Biol. 64, 537-545.
17. Djerdjouri, B., Lenoir, M., Giroud, J. P., Perianin, A. (1999) Contribution of mitogen-activated protein kinase to stimulation of phospholipase D by the chemotactic peptide fMet-Leu-Phe in human neutrophils. Biochem. Biophys. Res. Commun. 264, 371-375.
18. Coxon, P. Y., Rane, M. J., Uriarte, S., Powell, D. W., Singh, S., Butt, W., Chen, Q., McLeish, K. R. (2003) MAPK-activated protein kinase-2 participates in p38 MAPK-dependent and ERK-dependent functions in human neutrophils. Cell. Signal. 15, 993-1001.
19. Condliffe, A. M., Hawkins, P. T., Stephens, L. R., Haslett, C., Chilvers, E. R. (1998) Priming of human neutrophil superoxide generation by tumor necrosis factor-α is signaled by enhanced phosphatidylinositol 3,4,5-triphosphate but not inositol 1,4,5-triphosphate accumulation. FEBS Lett. 439, 147-151.
20. Kodama, T., Hazeki, K., Hazeki, O., Okada, T., Ui, M. (1999) Enhancement of chemotactic peptide-induced activation of phosphoinositide 3-kinase by granulocyte-macrophage colony-stimulating factor and its relation to the cytokine-mediated priming of neutrophil superoxide-anion production. Biochem. J. 337, 201-209.
21. Tuluc, F., Meshki, J., Kunapuli, S. P. (2003) Membrane lipid microdomains differentially regulate intracellular signaling events in human neutrophils. Int. Immunopharmacol. 3, 1775-1790.
22. Navratil, A. M., Bliss, S. P., Berghorn, K. A., Haughian, J. M., Farmerie, T. A., Graham, J. K., Clay, C. M., Roberson, M. S. (2003) Constitutive localization of the gonadotropin-releasing hormone (GnRH) receptor to low density membrane microdomains is necessary for GnRH signaling to ERK. J. Biol. Chem. 278, 31593-31602.
23. Peres, C., Yart, A., Perret, B., Salles, J. P., Raynal, P. (2003) Modulation of phosphoinositide 3-kinase activation by cholesterol level suggests a novel positive role for lipid rafts in lysophosphatidic acid signaling. FEBS Lett. 534, 164-168.
24. Decker, L., ffrench-Constant, C. (2004) Lipid rafts and integrin activation regulate oligodendrocyte survival. J. Neurosci. 24, 3816-3825.
25. Remacle-Bonnet, M., Garrouste, F., Baillat, G., Andre, F., Marvaldi, J., Pommier, G. (2005) Membrane rafts segregate pro- from anti-apoptotic insulin-like growth factor-I receptor signaling in colon carcinoma cells stimulated by members of the tumor necrosis factor superfamily. Am. J. Pathol. 167, 761-773.
26. Yang, N., Huang, Y., Jiang, J., Frank, S. J. (2004) Caveolar and lipid raft localization of the growth hormone receptor and its signaling elements: impact on growth hormone signaling. J. Biol. Chem. 279, 20898-20905.
27. Fuhler, G. M., Cadwallader, K. A., Knol, G. J., Chilvers, E. R., Drayer, A. L., Vellenga, E. (2004) Disturbed granulocyte macrophage-colony stimulating factor priming of phosphatidylinositol 3,4,5-trisphosphate accumulation and Rac activation in fMLP-stimulated neutrophils from patients with Myelodysplasia. J. Leukoc. Biol. 76, 254-262.
28. Bennett, J. M., Catovsky, D., Daniel, M. T., Flandrin, G., Galton, D. A., Gralnick, H. R., Sultan, C. (1982) Proposals for the classification of the Myelodysplastic syndromes. Br. J. Haematol. 51, 189-199.
29. Fuhler, G. M., Hooijenga, F., Drayer, A. L., Vellenga, E. (2003) Reduced expression of flavocytochrome b558, a component of the NADPH oxidase complex, in neutrophils from patients with Myelodysplasia. Exp. Hematol. 31, 752-759.
30. Bligh, E. G., Dyer, W. J. (1959) A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37, 911-917.
31. Kovar, K. A., El Yazbi, F. (1983) Determination of cholesterol in sera. Clin. Chim. Acta 132, 257-265.
32. Harder, T., Scheiffele, P., Verkade, P., Simons, K. (1998) Lipid domain structure of the plasma membrane revealed by patching of membrane components. J. Cell Biol. 141, 929-942.
33. Sheriff, A., Gaipl, U. S., Franz, S., Heyder, P., Voll, R. E., Kalden, J. R., Herrmann, M. (2004) Loss of GM1 surface expression precedes annexin V-phycoerythrin binding of neutrophils undergoing spontaneous apoptosis during in vitro aging. Cytometry A 62, 75-80.
34. Tokuyasu, K. T. (1973) A technique for ultracryotomy of cell suspensions and tissues. J. Cell Biol. 57, 551-565.
35. Tewary, P., Veena, K., Pucadyil, T. J., Chattopadhyay, A., Madhubala, R. (2006) The sterol-binding antibiotic nystatin inhibits entry of non-opsonized Leishmania donovani into macrophages. Biochem. Biophys. Res. Commun. 339, 661-666.
36. Radeva, G., Sharom, F. J. (2004) Isolation and characterization of lipid rafts with different properties from RBL-2H3 (rat basophilic leukaemia) cells. Biochem. J. 380, 219-230.
37. Fuhler, G. M., Knol, G. J., Drayer, A. L., Vellenga, E. (2005) Impaired interleukin-8- and GROα-induced phosphorylation of extracellular signal-regulated kinase result in decreased migration of neutrophils from patients with Myelodysplasia. J. Leukoc. Biol. 77, 257-266.
38. Ricevuti, G., Mazzone, A., Pasotti, D., Fossati, G., Mazzucchelli, I., Notario, A. (1993) The role of integrins in granulocyte dysfunction in Myelodysplastic syndrome. Leuk. Res. 17, 609-619.
39. Gomez-Mouton, C., Abad, J. L., Mira, E., Lacalle, R. A., Gallardo, E., Jimenez-Baranda, S., Illa, I., Bernad, A., Manes, S., Martinez, A. (2001) Segregation of leading-edge and uropod components into specific lipid rafts during T cell polarization. Proc. Natl. Acad. Sci. USA 98, 9642-9647.
40. Pierini, L. M., Eddy, R. J., Fuortes, M., Seveau, S., Casulo, C., Maxfield, F. R. (2003) Membrane lipid organization is critical for human neutrophil polarization. J. Biol. Chem. 278, 10831-10841.
41. Guichard, C., Pedruzzi, E., Dewas, C., Fay, M., Pouzet, C., Bens, M., Vandewalle, A., Ogier-Denis, E., Gougerot-Pocidalo, M. A., Elbim, C. (2005) Interleukin-8-induced priming of neutrophil oxidative burst requires sequential recruitment of NADPH oxidase components into lipid rafts. J. Biol. Chem. 280, 37021-37032.
42. Kaldi, K., Kalocsai, A., Rada, B. K., Mezo, G., Molnar, G. Z., Bathori, G., Ligeti, E. (2003) Degranulation and superoxide production depend on cholesterol in PLB-985 cells. Biochem. Biophys. Res. Commun. 310, 1241-1246.
43. David, A., Fridlich, R., Aviram, I. (2005) The presence of membrane proteinase 3 in neutrophil lipid rafts and its colocalisation with FcγRIIIb and cytochrome b558. Exp. Cell Res. 308, 156-165.
44. Itoh, Y., Kuratsuji, T., Aizawa, S., Sai, M., Ohyashiki, K., Toyama, K. (1991) Superoxide anion production and expression of cytochrome b 558 by neutrophils are impaired in some patients with Myelodysplastic syndrome. Ann. Hematol. 63, 270-275.
45. Del Pozo, M. A., Alderson, N. B., Kiosses, W. B., Chiang, H. H., Anderson, R. G., Schwartz, M. A. (2004) Integrins regulate Rac targeting by internalization of membrane domains. Science 303, 839-842.
46. Niggli, V., Meszaros, A. V., Oppliger, C., Tornay, S. (2004) Impact of cholesterol depletion on shape changes, actin reorganization, and signal transduction in neutrophil-like HL-60 cells. Exp. Cell Res. 296, 358-368.
47. Xue, M., Vines, C. M., Buranda, T., Cimino, D. F., Bennett, T. A., Prossnitz, E. R. (2004) N-formyl peptide receptors cluster in an active raft-associated state prior to phosphorylation. J. Biol. Chem. 279, 45175-45184.
48. Liu, P., Anderson, R. G. (1999) Spatial organization of EGF receptor transmodulation by PDGF. Biochem. Biophys. Res. Commun. 261, 695-700.
49. Paccani, S. R., Boncristiano, M., Patrussi, L., Ulivieri, C., Wack, A., Valensin, S., Hirst, T. R., Amedei, A., Del Prete, G., Telford, J. L., D'Elios, M. M., Baldari, C. T. (2005) Defective Vav expression and impaired F-actin reorganization in a subset of patients with common variable immunodeficiency characterized by T-cell defects. Blood 106, 626-634.
50. Tani-ichi, S., Maruyama, K., Kondo, N., Nagafuku, M., Kabayama, K., Inokuchi, J., Shimada, Y., Ohno-Iwashita, Y., Yagita, H., Kawano, S., Kosugi, A. (2005) Structure and function of lipid rafts in human activated T cells. Int. Immunol. 17, 749-758.