Redox regulation of the proteasome in T lymphocytes during aging

Free Radical Biology and Medicine

Volumn 42, Issue 4, 2007, Pages 541-551

  Das, Rupali ^a   Ponnappan, Subramaniam ^b,c   Ponnappan, Usha ^a,b,c  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^c CENTRAL ARKANSAS VETERANS HEALTHCARE SYSTEM   (United States)

Author keywords

Aging; GSH; Immune dysregulation; Immune senescence; Oxidative stress; Proteasome; ROS; T lymphocytes

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEASOME;

AGED; AGING; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME REGULATION; FEMALE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; STIMULUS; T LYMPHOCYTE;

ADENOSINE TRIPHOSPHATE; ADULT; AGED; AGED, 80 AND OVER; AGING; CATALYSIS; DOWN-REGULATION; GLUTATHIONE; HUMANS; I-KAPPA B PROTEINS; OXIDATION-REDUCTION; OXIDATIVE STRESS; PROTEASOME ENDOPEPTIDASE COMPLEX; REACTIVE OXYGEN SPECIES; T-LYMPHOCYTES; TUMOR NECROSIS FACTORS;

EID: 33846529983     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2006.11.020     Document Type: Article

References (52)

1. Fulop Jr. T., Douziech N., Larbi A., and Dupuis G. The role of lipid rafts in T lymphocyte signal transduction with aging. Ann. N. Y. Acad. Sci. 973 (2002) 302-304
2. Ginaldi L., De M.M., Modesti M., Loreto F., Corsi M.P., and Quaglino D. Immunophenotypical changes of T lymphocytes in the elderly. Gerontology 46 (2000) 242-248
3. Linton P.J., and Dorshkind K. Age-related changes in lymphocyte development and function. Nat. Immunol. 5 (2004) 133-139
4. Ponnappan U., Zhong M., and Trebilcock G.U. Decreased proteasome-mediated degradation in T cells from the elderly: a role in immune senescence. Cell. Immunol. 192 (1999) 167-174
5. Sadighi Akha A.A., and Miller R.A. Signal transduction in the aging immune system. Curr. Opin. Immunol. 17 (2005) 486-491
6. Tamir A., Eisenbraun M.D., Garcia G.G., and Miller R.A. Age-dependent alterations in the assembly of signal transduction complexes at the site of T cell/APC interaction. J. Immunol. 165 (2000) 1243-1251
7. Trebilcock G.U., and Ponnappan U. Nuclear factor-kappaB induction in CD45RO+ and CD45RA+ T cell subsets during aging. Mech. Ageing Dev. 102 (1998) 149-163
8. Whisler R.L., Karanfilov C.I., Newhouse Y.G., Fox C.C., Lakshmanan R.R., and Liu B. Phosphorylation and coupling of zeta-chains to activated T-cell receptor (TCR)/CD3 complexes from peripheral blood T-cells of elderly humans. Mech. Ageing Dev. 105 (1998) 115-135
9. Trebilcock G.U., and Ponnappan U. Evidence for lowered induction of nuclear factor kappa B in activated human T lymphocytes during aging. Gerontology 42 (1996) 137-146
10. Ponnappan U. Ubiquitin-proteasome pathway is compromised in CD45RO+ and CD45RA+ T lymphocyte subsets during aging. Exp. Gerontol. 37 (2002) 359-367
11. Coux O., Tanaka K., and Goldberg A.L. Structure and functions of the 20S and 26S proteasomes. Annu. Rev. Biochem. 65 (1996) 801-847
12. Djaballah H., Rowe A.J., Harding S.E., and Rivett A.J. The multicatalytic proteinase complex (proteasome): structure and conformational changes associated with changes in proteolytic activity. Biochem. J. 292 Pt. 3 (1993) 857-862
13. Rivett A.J. Proteasomes: multicatalytic proteinase complexes. Biochem. J. 291 Pt 1 (1993) 1-10
14. Davies K.J. Degradation of oxidized proteins by the 20S proteasome. Biochimie 83 (2001) 301-310
15. Grune T., Reinheckel T., and Davies K.J. Degradation of oxidized proteins in mammalian cells. FASEB J. 11 (1997) 526-534
16. Grune T., and Davies K.J. The proteasomal system and HNE-modified proteins. Mol. Aspects Med. 24 (2003) 195-204
17. Rivett A.J. Preferential degradation of the oxidatively modified form of glutamine synthetase by intracellular mammalian proteases. J. Biol. Chem. 260 (1985) 300-305
18. Sitte N., Merker K., Von Z.T., and Grune T. Protein oxidation and degradation during proliferative senescence of human MRC-5 fibroblasts. Free Radic. Biol. Med. 28 (2000) 701-708
19. Stadtman E.R. Protein oxidation in aging and age-related diseases. Ann. N. Y. Acad. Sci. 928 (2001) 22-38
20. Bardag-Gorce F., Farout L., Veyrat-Durebex C., Briand Y., and Briand M. Changes in 20S proteasome activity during ageing of the LOU rat. Mol. Biol. Rep. 26 (1999) 89-93
21. Bulteau A.L., Lundberg K.C., Humphries K.M., Sadek H.A., Szweda P.A., Friguet B., and Szweda L.I. Oxidative modification and inactivation of the proteasome during coronary occlusion/reperfusion. J. Biol. Chem. 276 (2001) 30057-30063
22. Carrard G., Dieu M., Raes M., Toussaint O., and Friguet B. Impact of ageing on proteasome structure and function in human lymphocytes. Int. J. Biochem. Cell Biol. 35 (2003) 728-739
23. Chondrogianni N., Stratford F.L., Trougakos I.P., Friguet B., Rivett A.J., and Gonos E.S. Central role of the proteasome in senescence and survival of human fibroblasts: induction of a senescence-like phenotype upon its inhibition and resistance to stress upon its activation. J. Biol. Chem. 278 (2003) 28026-28037
24. Chondrogianni N., Tzavelas C., Pemberton A.J., Nezis I.P., Rivett A.J., and Gonos E.S. Overexpression of proteasome beta5 assembled subunit increases the amount of proteasome and confers ameliorated response to oxidative stress and higher survival rates. J. Biol. Chem. 280 (2005) 11840-11850
25. Cemerski S., van Meerwijk J.P., and Romagnoli P. Oxidative-stress-induced T lymphocyte hyporesponsiveness is caused by structural modification rather than proteasomal degradation of crucial TCR signaling molecules. Eur. J. Immunol. 33 (2003) 2178-2185
26. Ermak G., and Davies K.J. Calcium and oxidative stress: from cell signaling to cell death. Mol. Immunol. 38 (2002) 713-721
27. Ginn-Pease M.E., and Whisler R.L. Optimal NF kappa B mediated transcriptional responses in Jurkat T cells exposed to oxidative stress are dependent on intracellular glutathione and costimulatory signals. Biochem. Biophys. Res. Commun. 226 (1996) 695-702
28. Kanner S.B., Kavanagh T.J., Grossmann A., Hu S.L., Bolen J.B., Rabinovitch P.S., and Ledbetter J.A. Sulfhydryl oxidation down-regulates T-cell signaling and inhibits tyrosine phosphorylation of phospholipase C gamma 1. Proc. Natl. Acad. Sci. USA 89 (1992) 300-304
29. Kavanagh T.J., Grossmann A., Jaecks E.P., Jinneman J.C., Eaton D.L., Martin G.M., and Rabinovitch P.S. Proliferative capacity of human peripheral blood lymphocytes sorted on the basis of glutathione content. J. Cell. Physiol. 145 (1990) 472-480
30. Harman D. The aging process. Proc. Natl. Acad. Sci. USA 78 (1981) 7124-7128
31. Lin S.C., Yamate T., Taguchi Y., Borba V.Z., Girasole G., O'Brien C.A., Bellido T., Abe E., and Manolagas S.C. Regulation of the gp80 and gp130 subunits of the IL-6 receptor by sex steroids in the murine bone marrow. J. Clin. Invest. 100 (1997) 1980-1990
32. Ponnappan U., Trebilcock G.U., and Zheng M.Z. Studies into the effect of tyrosine phosphatase inhibitor phenylarsine oxide on NFkappaB activation in T lymphocytes during aging: evidence for altered IkappaB-alpha phosphorylation and degradation. Exp. Gerontol. 34 (1999) 95-107
33. Kamencic H., Lyon A., Paterson P.G., and Juurlink B.H. Monochlorobimane fluorometric method to measure tissue glutathione. Anal. Biochem. 286 (2000) 35-37
34. Lahdenpohja N., Savinainen K., and Hurme M. Pre-exposure to oxidative stress decreases the nuclear factor-kappa B-dependent transcription in T lymphocytes. J. Immunol. 160 (1998) 1354-1358
35. Berkers C.R., Verdoes M., Lichtman E., Fiebiger E., Kessler B.M., Anderson K.C., Ploegh H.L., Ovaa H., and Galardy P.J. Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib. Nat. Methods 2 (2005) 357-362
36. Lohmiller J.J., Roellich K.M., Toledano A., Rabinovitch P.S., Wolf N.S., and Grossmann A. Aged murine T-lymphocytes are more resistant to oxidative damage due to the predominance of the cells possessing the memory phenotype. J. Gerontol. A Biol. Sci. Med. Sci. 51 (1996) B132-B140
37. Sakon S., Xue X., Takekawa M., Sasazuki T., Okazaki T., Kojima Y., Piao J.H., Yagita H., Okumura K., Doi T., and Nakano H. NF-kappaB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death. EMBO J. 22 (2003) 3898-3909
38. Bulteau A.L., Petropoulos I., and Friguet B. Age-related alterations of proteasome structure and function in aging epidermis. Exp. Gerontol. 35 (2000) 767-777
39. Grune T., Reinheckel T., and Davies K.J. Degradation of oxidized proteins in K562 human hematopoietic cells by proteasome. J. Biol. Chem. 271 (1996) 15504-15509
40. Pajonk F., Riess K., Sommer A., and McBride W.H. N-Acetyl-L-cysteine inhibits 26S proteasome function: implications for effects on NF-kappaB activation. Free Radic. Biol. Med. 32 (2002) 536-543
41. Shibatani T., Nazir M., and Ward W.F. Alteration of rat liver 20S proteasome activities by age and food restriction. J. Gerontol. A Biol. Sci. Med. Sci. 51 (1996) B316-B322
42. Reinheckel T., Sitte N., Ullrich O., Kuckelkorn U., Davies K.J., and Grune T. Comparative resistance of the 20S and 26S proteasome to oxidative stress. Biochem. J. 335 Pt 3 (1998) 637-642
43. Conconi M., Szweda L.I., Levine R.L., Stadtman E.R., and Friguet B. Age-related decline of rat liver multicatalytic proteinase activity and protection from oxidative inactivation by heat-shock protein 90. Arch. Biochem. Biophys. 331 (1996) 232-240
44. Ghosh S., May M.J., and Kopp E.B. NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol. 16 (1998) 225-260
45. Ginn-Pease M.E., and Whisler R.L. Redox signals and NF-kappaB activation in T cells. Free Radic. Biol. Med. 25 (1998) 346-361
46. Schreck R., Rieber P., and Baeuerle P.A. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappaB transcription factor and HIV-1. EMBO J. 10 (1991) 2247-2258
47. Janssen-Heininger Y.M., Poynter M.E., and Baeuerle P.A. Recent advances towards understanding redox mechanisms in the activation of nuclear factor kappaB. Free Radic. Biol. Med. 28 (2000) 1317-1327
48. Li Q., and Verma I.M. NF-kappaB regulation in the immune system. Nat. Rev. Immunol. 2 (2002) 725-734
49. Naujokat C., and Hoffmann S. Role and function of the 26S proteasome in proliferation and apoptosis. Lab. Invest. 82 (2002) 965-980
50. Gupta S., Bi R., Kim C., Chiplunkar S., Yel L., and Gollapudi S. Role of NF-kappaB signaling pathway in increased tumor necrosis factor-alpha-induced apoptosis of lymphocytes in aged humans. Cell Death Differ. 12 (2005) 177-183
51. Williams M.S., and Kwon J. T cell receptor stimulation, reactive oxygen species, and cell signaling. Free Radic. Biol. Med. 37 (2004) 1144-1151
52. Hadzic T., Li L., Cheng N., Walsh S.A., Spitz D.R., and Knudson C.M. The role of low molecular weight thiols in T lymphocyte proliferation and IL-2 secretion. J. Immunol. 175 (2005) 7965-7972