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Volumn 21, Issue 4, 2011, Pages 483-503

FMS-like tyrosine kinase 3 inhibitors: A patent review

Author keywords

Acute myeloid leukemia; cancer; Flt3; small molecule kinase inhibitor

Indexed keywords

BENZOXAZOLE DERIVATIVE; CD135 ANTIGEN; DASATINIB; FIBROBLAST GROWTH FACTOR RECEPTOR; INDOLE; LESTAURTINIB; MIDOSTAURIN; PLATELET DERIVED GROWTH FACTOR RECEPTOR; QUINOLINE; QUINOXALINE; SORAFENIB; STAUROSPORINE; SUNITINIB; THIOPHENE;

EID: 79952973352     PISSN: 13543776     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543776.2011.560115     Document Type: Review
Times cited : (4)

References (132)
  • 1
    • 0025770646 scopus 로고
    • A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations
    • Matthews W, Jordan CT, Wiegand GW, et al. A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations. Cell 1991;65:1143-52 (Pubitemid 121001328)
    • (1991) Cell , vol.65 , Issue.7 , pp. 1143-1152
    • Matthews, W.1    Jordan, C.T.2    Wiegand, G.W.3    Pardoll, D.4    Lemischka, I.R.5
  • 2
    • 0029798251 scopus 로고    scopus 로고
    • Regulatory roles of the ligand for Flk2/Flt3 tyrosine kinase receptor on human hematopoiesis
    • Namikawa R, Muench MO, Roncarolo MG. Regulatory roles of the ligand for Flk2/Flt3 tyrosine kinase receptor on human hematopoiesis. Stem Cells 1996;14:388-95 (Pubitemid 26286260)
    • (1996) Stem Cells , vol.14 , Issue.4 , pp. 388-395
    • Namikawa, R.1    Muench, M.O.2    Roncarolo, M.-G.3
  • 3
    • 0032030339 scopus 로고    scopus 로고
    • FLT3: Receptor and ligand. Biology and potential clinical application
    • DOI 10.1016/S1359-6101(97)00035-X, PII S135961019700035X
    • Shurin MR, Esche C, Lotze MT. FLT3: Receptor and ligand. Biology and potential clinical application. Cytokine Growth Factor Rev 1998;9:37-48 .A comprehensive review of the Flt3/FL system. (Pubitemid 28280535)
    • (1998) Cytokine and Growth Factor Reviews , vol.9 , Issue.1 , pp. 37-48
    • Shurin, M.R.1    Esche, C.2    Lotze, M.T.3
  • 5
    • 0031686409 scopus 로고    scopus 로고
    • Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product
    • Kiyoi H, Towatari M, Yokota S, et al. Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product. Leukemia 1998;12:1333-7 (Pubitemid 28442377)
    • (1998) Leukemia , vol.12 , Issue.9 , pp. 1333-1337
    • Kiyoi, H.1    Towatari, M.2    Yokota, S.3    Hamaguchi, M.4    Ohno, R.5    Saito, H.6    Naoe, T.7
  • 7
    • 15544389069 scopus 로고    scopus 로고
    • Advances in understanding the biology and genetics of acute myelocytic leukemia
    • Mckenzie SB. Advances in understanding the biology and genetics of acute myelocytic leukemia. Clin Lab Sci 2005;18:28-37
    • (2005) Clin Lab Sci , vol.18 , pp. 28-37
    • Mckenzie, S.B.1
  • 9
    • 77951111333 scopus 로고    scopus 로고
    • Novel agents and regimens for acute myeloid leukemia: 2009 ASH annual meeting highlights
    • Recent development of AML therapies.
    • Zhu X, Ma Y, Liu D. Novel agents and regimens for acute myeloid leukemia: 2009 ASH annual meeting highlights. J Hematol Oncol 2010;3:17 .Recent development of AML therapies.
    • (2010) J Hematol Oncol , vol.3 , pp. 17
    • Zhu, X.1    Ma, Y.2    Liu, D.3
  • 10
    • 0026457216 scopus 로고
    • Expression of the FMS/KIT-like gene FLT3 in human acute leukemias of the myeloid and lymphoid lineages
    • Birg F, Courcoul M, Rosnet O, et al. Expression of the FMS/KIT-like gene FLT3 in human acute leukemias of the myeloid and lymphoid lineages. Blood 1992;80:2584-93
    • (1992) Blood , vol.80 , pp. 2584-2593
    • Birg, F.1    Courcoul, M.2    Rosnet, O.3
  • 13
    • 0035885955 scopus 로고    scopus 로고
    • The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: Analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials
    • Kottaridis PD, Gale RE, Frew ME, et al. The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: Analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials. Blood 2001;98:1752-9
    • (2001) Blood , vol.98 , pp. 1752-1759
    • Kottaridis, P.D.1    Gale, R.E.2    Frew, M.E.3
  • 14
    • 23744444913 scopus 로고    scopus 로고
    • Prognostic significance of FLT3 internal tandem duplication and tyrosine kinase domain mutations for acute myeloid leukemia: A meta-analysis
    • DOI 10.1038/sj.leu.2403838
    • Yanada M, Matsuo K, Suzuki T, et al. Prognostic significance of FLT3 internal tandem duplication and tyrosine kinase domain mutations for acute myeloid leukemia: A meta-analysis. Leukemia 2005;19:1345-9 (Pubitemid 41136326)
    • (2005) Leukemia , vol.19 , Issue.8 , pp. 1345-1349
    • Yanada, M.1    Matsuo, K.2    Suzuki, T.3    Kiyoi, H.4    Naoe, T.5
  • 15
    • 0036659931 scopus 로고    scopus 로고
    • Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: Correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease
    • DOI 10.1182/blood.V100.1.59
    • Schnittger S, Schoch C, Dugas M, et al. Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: Correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease. Blood 2002;100:59-66 (Pubitemid 35177429)
    • (2002) Blood , vol.100 , Issue.1 , pp. 59-66
    • Schnittger, S.1    Schoch, C.2    Dugas, M.3    Kern, W.4    Staib, P.5    Wuchter, C.6    Loffler, H.7    Sauerland, C.M.8    Serve, H.9    Buchner, T.10    Haferlach, T.11    Hiddemann, W.12
  • 18
    • 41949090673 scopus 로고    scopus 로고
    • The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia
    • Gale RE, Green C, Allen C, et al. The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia. Blood 2008;111:2776-84
    • (2008) Blood , vol.111 , pp. 2776-2784
    • Gale, R.E.1    Green, C.2    Allen, C.3
  • 19
    • 41949087055 scopus 로고    scopus 로고
    • Prognostic relevance of FLT3-TKD mutations in AML: The combination matters-an analysis of 3082 patients
    • Bacher U, Haferlach C, Kern W, et al. Prognostic relevance of FLT3-TKD mutations in AML: The combination matters-an analysis of 3082 patients. Blood 2008;111:2527-37
    • (2008) Blood , vol.111 , pp. 2527-2537
    • Bacher, U.1    Haferlach, C.2    Kern, W.3
  • 21
    • 9144244169 scopus 로고    scopus 로고
    • FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy
    • DOI 10.1182/blood-2003-02-0418
    • Taketani T, Taki T, Sugita K, et al. FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy. Blood 2004;103:1085-8 (Pubitemid 38129575)
    • (2004) Blood , vol.103 , Issue.3 , pp. 1085-1088
    • Taketani, T.1    Taki, T.2    Sugita, K.3    Furuichi, Y.4    Ishii, E.5    Hanada, R.6    Tsuchida, M.7    Sugita, K.8    Ida, K.9    Hayashi, Y.10
  • 22
    • 1842420032 scopus 로고    scopus 로고
    • Single-agent CEP-701, a novel FLT3 inhibitor, shows biologic and clinical activity in patients with relapsed or refractory acute myeloid leukemia
    • DOI 10.1182/blood-2003-11-3775
    • Smith BD, Levis M, Beran M, et al. Single-agent CEP-701, a novel FLT3 inhibitor, shows biologic and clinical activity in patients with relapsed or refractory acute myeloid leukemia. Blood 2004;103:3669-76 (Pubitemid 38596280)
    • (2004) Blood , vol.103 , Issue.10 , pp. 3669-3676
    • Smith, B.D.1    Levis, M.2    Beran, M.3    Giles, F.4    Kantarjian, H.5    Berg, K.6    Murphy, K.M.7    Dauses, T.8    Allebach, J.9    Small, D.10
  • 23
    • 33751173636 scopus 로고    scopus 로고
    • A phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy
    • Knapper S, Burnett AK, Littlewood T, et al. A phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy. Blood 2006;108:3262-70
    • (2006) Blood , vol.108 , pp. 3262-3270
    • Knapper, S.1    Burnett, A.K.2    Littlewood, T.3
  • 24
    • 78049426367 scopus 로고    scopus 로고
    • Phase IIB trial of oral midostaurin (PKC412), the FMS-like tyrosine kinase 3 receptor (FLT3) and multi-targeted kinase inhibitor, in patients with acute myeloid leukemia and high-risk myelodysplastic syndrome with either wild-type or mutated FLT3
    • Fischer T, Stone RM, Deangelo DJ, et al. Phase IIB trial of oral midostaurin (PKC412), the FMS-like tyrosine kinase 3 receptor (FLT3) and multi-targeted kinase inhibitor, in patients with acute myeloid leukemia and high-risk myelodysplastic syndrome with either wild-type or mutated FLT3. J Clin Oncol 2010;28:4339-45
    • (2010) J Clin Oncol , vol.28 , pp. 4339-4345
    • Fischer, T.1    Stone, R.M.2    Deangelo, D.J.3
  • 26
    • 79952921384 scopus 로고    scopus 로고
    • Astex Therapeutics. Pharmaceutical combinations. WO2008001101
    • Astex Therapeutics. Pharmaceutical combinations. WO2008001101; 2008
    • (2008)
  • 27
    • 60549088370 scopus 로고    scopus 로고
    • Fragment-based discovery of the pyrazol-4-yl urea (AT9283), a multitargeted kinase inhibitor with potent aurora kinase activity
    • Howard S, Berdini V, Boulstridge JA, et al. Fragment-based discovery of the pyrazol-4-yl urea (AT9283), a multitargeted kinase inhibitor with potent aurora kinase activity. J Med Chem 2009;52:379-88
    • (2009) J Med Chem , vol.52 , pp. 379-388
    • Howard, S.1    Berdini, V.2    Boulstridge, J.A.3
  • 28
    • 47249087693 scopus 로고    scopus 로고
    • The kinase inhibitor LS104 induces apoptosis, enhances cytotoxic effects of chemotherapeutic drugs and is targeting the receptor tyrosine kinase FLT3 in acute myeloid leukemia
    • Kasper S, Breitenbuecher F, Hoehn Y, et al. The kinase inhibitor LS104 induces apoptosis, enhances cytotoxic effects of chemotherapeutic drugs and is targeting the receptor tyrosine kinase FLT3 in acute myeloid leukemia. Leuk Res 2008;32:1698-708
    • (2008) Leuk Res , vol.32 , pp. 1698-1708
    • Kasper, S.1    Breitenbuecher, F.2    Hoehn, Y.3
  • 30
    • 47249129126 scopus 로고    scopus 로고
    • LS104, a non-ATP-competitive small-molecule inhibitor of JAK2, is potently inducing apoptosis in JAK2V617F-positive cells
    • Lipka DB, Hoffmann LS, Heidel F, et al. LS104, a non-ATP-competitive small-molecule inhibitor of JAK2, is potently inducing apoptosis in JAK2V617F-positive cells. Mol Cancer Ther 2008;7:1176-84
    • (2008) Mol Cancer Ther , vol.7 , pp. 1176-1184
    • Lipka, D.B.1    Hoffmann, L.S.2    Heidel, F.3
  • 31
    • 72249087752 scopus 로고    scopus 로고
    • Identification of N-(5-tert-butylisoxazol- 3-yl)-N'-{4-[7-(2-morpholin-4- yl-ethoxy)imidazo[2 ,1-b][1,3] benzothiazol-2-yl]phenyl}urea dihydrochloride (AC220), a uniquely potent, selective, and efficacious FMS-like tyrosine kinase-3 (FLT3) inhibitor
    • Chao Q, Sprankle KG, Grotzfeld RM, et al. Identification of N-(5-tert-butylisoxazol- 3-yl)-N'-{4-[7-(2-morpholin-4- yl-ethoxy)imidazo[2 ,1-b][1,3] benzothiazol-2-yl]phenyl}urea dihydrochloride (AC220), a uniquely potent, selective, and efficacious FMS-like tyrosine kinase-3 (FLT3) inhibitor. J Med Chem 2009;52:7808-16
    • (2009) J Med Chem , vol.52 , pp. 7808-7816
    • Chao, Q.1    Sprankle, K.G.2    Grotzfeld, R.M.3
  • 32
    • 70449475105 scopus 로고    scopus 로고
    • AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML)
    • Second generation Flt3 inhibitor.
    • Zarrinkar PP, Gunawardane RN, Cramer MD, et al. AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML). Blood 2009;114:2984-92 .Second generation Flt3 inhibitor.
    • (2009) Blood , vol.114 , pp. 2984-2992
    • Zarrinkar, P.P.1    Gunawardane, R.N.2    Cramer, M.D.3
  • 34
    • 76749105773 scopus 로고    scopus 로고
    • Dasatinib inhibits the growth of molecularly heterogeneous myeloid leukemias
    • Guerrouahen BS, Futami M, Vaklavas C, et al. Dasatinib inhibits the growth of molecularly heterogeneous myeloid leukemias. Clin Cancer Res 2010;16:1149-58
    • (2010) Clin Cancer Res , vol.16 , pp. 1149-1158
    • Guerrouahen, B.S.1    Futami, M.2    Vaklavas, C.3
  • 35
    • 33847195060 scopus 로고    scopus 로고
    • Antitumor activity of sorafenib in FLT3-driven leukemic cells
    • Auclair D, Miller D, Yatsula V, et al. Antitumor activity of sorafenib in FLT3-driven leukemic cells. Leukemia 2007;21:439-45
    • (2007) Leukemia , vol.21 , pp. 439-445
    • Auclair, D.1    Miller, D.2    Yatsula, V.3
  • 36
    • 77951645227 scopus 로고    scopus 로고
    • Phase I/II study of combination therapy with sorafenib, idarubicin, and cytarabine in younger patients with acute myeloid leukemia
    • Ravandi F, Cortes JE, Jones D, et al. Phase I/II study of combination therapy with sorafenib, idarubicin, and cytarabine in younger patients with acute myeloid leukemia. J Clin Oncol 2010;28:1856-62
    • (2010) J Clin Oncol , vol.28 , pp. 1856-1862
    • Ravandi, F.1    Cortes, J.E.2    Jones, D.3
  • 37
    • 79952954873 scopus 로고    scopus 로고
    • Sugen. Indolinone compounds for the treatment of disease. WO1996040116
    • Sugen. Indolinone compounds for the treatment of disease. WO1996040116; 1996
    • (1996)
  • 38
    • 0037108298 scopus 로고    scopus 로고
    • SU5416 and SU5614 inhibit kinase activity of wild-type and mutant FLT3 receptor tyrosine kinase
    • Yee KW, O'farrell AM, Smolich BD, et al. SU5416 and SU5614 inhibit kinase activity of wild-type and mutant FLT3 receptor tyrosine kinase. Blood 2002;100:2941-9
    • (2002) Blood , vol.100 , pp. 2941-299
    • Yee, K.W.1    O'farrell, A.M.2    Smolich, B.D.3
  • 41
    • 79952933619 scopus 로고    scopus 로고
    • Sugen. Pyrrole substituted 2-indolinone protein kinase inhibitors. WO2001060814
    • Sugen. Pyrrole substituted 2-indolinone protein kinase inhibitors. WO2001060814; 2001
    • (2001)
  • 42
    • 79952966310 scopus 로고    scopus 로고
    • Yamanouchi Pharmaceutical. Pharmaceutical composition containing 3-quinolin-2(1h)-ylidene indolin-2-one derivative as active component. JP2005145928
    • Yamanouchi Pharmaceutical. Pharmaceutical composition containing 3-quinolin-2(1h)-ylidene indolin-2-one derivative as active component. JP2005145928; 2005
    • (2005)
  • 43
    • 33645077600 scopus 로고    scopus 로고
    • YM-359445, an orally bioavailable vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor, has highly potent antitumor activity against established tumors
    • Amino N, Ideyama Y, Yamano M, et al. YM-359445, an orally bioavailable vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor, has highly potent antitumor activity against established tumors. Clin Cancer Res 2006;12:1630-8
    • (2006) Clin Cancer Res , vol.12 , pp. 1630-1608
    • Amino, N.1    Ideyama, Y.2    Yamano, M.3
  • 44
    • 79952973990 scopus 로고    scopus 로고
    • Anygen. Indirubin derivatives having anticancer property against human cancer cell me. WO2005070416
    • Anygen. Indirubin derivatives having anticancer property against human cancer cell me. WO2005070416; 2005
    • (2005)
  • 45
    • 77549087807 scopus 로고    scopus 로고
    • Indirubin derivatives as potent FLT3 inhibitors with anti-proliferative activity of acute myeloid leukemic cells
    • Choi SJ, Moon MJ, Lee SD, et al. Indirubin derivatives as potent FLT3 inhibitors with anti-proliferative activity of acute myeloid leukemic cells. Bioorg Med Chem Lett 2010;20:2033-7
    • (2010) Bioorg Med Chem Lett , vol.20 , pp. 2033-2037
    • Choi, S.J.1    Moon, M.J.2    Lee, S.D.3
  • 46
    • 79952936894 scopus 로고    scopus 로고
    • Research Institute Azulene compounds EP1918277
    • Industrial Technology Research Institute. Azulene compounds. EP1918277; 2008
    • (2008) Industrial Technology
  • 48
    • 79952981309 scopus 로고    scopus 로고
    • Johannes-Gutenberg Universitat Mainz. Use of 3-(indolyl)- or 3-(azaindolyl)-4- arylmaleimide derivatives in leukemia management. WO2009071620
    • Johannes-Gutenberg Universitat Mainz. Use of 3-(indolyl)- or 3-(azaindolyl)-4- arylmaleimide derivatives in leukemia management. WO2009071620; 2009
    • (2009)
  • 49
    • 0035984518 scopus 로고    scopus 로고
    • Bis(1H-2-indolyl)-1-methanones as inhibitors of the hematopoietic tyrosine kinase Flt3
    • Teller S, Kramer D, Bohmer SA, et al. Bis(1H-2-indolyl)-1-methanones as inhibitors of the hematopoietic tyrosine kinase Flt3. Leukemia 2002;16:1528-34
    • (2002) Leukemia , vol.16 , pp. 1528-1534
    • Teller, S.1    Kramer, D.2    Bohmer, S.A.3
  • 50
    • 79952955620 scopus 로고    scopus 로고
    • Kyowa Hakko Kogyo. Indazole derivatives. WO2005012257
    • Kyowa Hakko Kogyo. Indazole derivatives. WO2005012257; 2005
    • (2005)
  • 51
    • 70349566478 scopus 로고    scopus 로고
    • KW-2449, a novel multikinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation
    • Shiotsu Y, Kiyoi H, Ishikawa Y, et al. KW-2449, a novel multikinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation. Blood 2009;114:1607-17
    • (2009) Blood , vol.114 , pp. 1607-1617
    • Shiotsu, Y.1    Kiyoi, H.2    Ishikawa, Y.3
  • 53
    • 62949087552 scopus 로고    scopus 로고
    • A pharmacodynamic study of the FLT3 inhibitor KW-2449 yields insight into the basis for clinical response
    • Pratz KW, Cortes J, Roboz GJ, et al. A pharmacodynamic study of the FLT3 inhibitor KW-2449 yields insight into the basis for clinical response. Blood 2009;113:3938-46
    • (2009) Blood , vol.113 , pp. 3938-3946
    • Pratz, K.W.1    Cortes, J.2    Roboz, G.J.3
  • 54
    • 79952913602 scopus 로고    scopus 로고
    • Abbott. Indazole benzisoxazole and benzisothiazole kinase inhibitors. WO2004113304
    • Abbott. Indazole, benzisoxazole, and benzisothiazole kinase inhibitors. WO2004113304; 2004
    • (2004)
  • 55
    • 69249142285 scopus 로고    scopus 로고
    • ABT-869, a promising multi-targeted tyrosine kinase inhibitor: From bench to bedside
    • Zhou J, Goh BC, Albert DH, Chen CS. ABT-869, a promising multi-targeted tyrosine kinase inhibitor: From bench to bedside. J Hematol Oncol 2009;2:33
    • (2009) J Hematol Oncol , vol.2 , pp. 33
    • Zhou, J.1    Goh, B.C.2    Albert, D.H.3    Chen, C.S.4
  • 56
    • 38349075768 scopus 로고    scopus 로고
    • Synergistic antileukemic effects between ABT-869 and chemotherapy involve downregulation of cell cycle-regulated genes and c-Mos-mediated MAPK pathway
    • Zhou J, Pan M, Xie Z, et al. Synergistic antileukemic effects between ABT-869 and chemotherapy involve downregulation of cell cycle-regulated genes and c-Mos-mediated MAPK pathway. Leukemia 2008;22:138-46
    • (2008) Leukemia , vol.22 , pp. 138-146
    • Zhou, J.1    Pan, M.2    Xie, Z.3
  • 57
    • 79952969639 scopus 로고    scopus 로고
    • Bristol-Myers Squibb. Pyrrolotriazine kinase inhibitors. WO2007061882
    • Bristol-Myers Squibb. Pyrrolotriazine kinase inhibitors. WO2007061882; 2007
    • (2007)
  • 58
    • 79952913167 scopus 로고    scopus 로고
    • SuperGen. Imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine derivatives and their use as protein kinase inhibitors. WO2008058126
    • SuperGen. Imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine derivatives and their use as protein kinase inhibitors. WO2008058126; 2008
    • (2008)
  • 59
    • 77950538522 scopus 로고    scopus 로고
    • Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells
    • Chen LS, Redkar S, Bearss D, et al. Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells. Blood 2009;114:4150-7
    • (2009) Blood , vol.114 , pp. 4150-4157
    • Chen, L.S.1    Redkar, S.2    Bearss, D.3
  • 60
    • 79952931878 scopus 로고    scopus 로고
    • Ariad Pharmaceuticals. Bicyclic heteroaryl compounds. WO2007075869
    • Ariad Pharmaceuticals. Bicyclic heteroaryl compounds. WO2007075869; 2007
    • (2007)
  • 61
    • 79952944645 scopus 로고    scopus 로고
    • Amphora. Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof. WO2005033102
    • Amphora. Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof. WO2005033102; 2005
    • (2005)
  • 62
    • 79952956055 scopus 로고    scopus 로고
    • The Pfahl Family Trust. Substituted biarylheterocycle derivatives as protein kinase inhibitors for the treatment of cancer and other diseases. WO2006130613
    • The Pfahl Family Trust. Substituted biarylheterocycle derivatives as protein kinase inhibitors for the treatment of cancer and other diseases. WO2006130613; 2006
    • (2006)
  • 63
    • 79952914466 scopus 로고    scopus 로고
    • Novartis. Thiazole and pyrazole derivatives as Flt-3 kinase inhibitors. WO2005047273
    • Novartis. Thiazole and pyrazole derivatives as Flt-3 kinase inhibitors. WO2005047273; 2005
    • (2005)
  • 64
    • 79952925828 scopus 로고    scopus 로고
    • IRM. Compounds and compositions as protein kinase inhibitors. WO2006081172
    • IRM. Compounds and compositions as protein kinase inhibitors. WO2006081172; 2006
    • (2006)
  • 65
    • 79952950043 scopus 로고    scopus 로고
    • Sugen. Treatment of platelet derived growth factor related disorders such as cancers. US5990141
    • Sugen. Treatment of platelet derived growth factor related disorders such as cancers. US5990141; 1999
    • (1999)
  • 66
    • 0034895025 scopus 로고    scopus 로고
    • Inhibition of FLT3-mediated transformation by use of a tyrosine kinase inhibitor
    • DOI 10.1038/sj.leu.2402199
    • Tse KF, Novelli E, Civin CI, et al. Inhibition of FLT3-mediated transformation by use of a tyrosine kinase inhibitor. Leukemia 2001;15:1001-10 (Pubitemid 32717268)
    • (2001) Leukemia , vol.15 , Issue.7 , pp. 1001-1010
    • Tse, K.-F.1    Novelli, E.2    Civin, C.I.3    Bohmer, F.D.4    Small, D.5
  • 67
    • 0035437140 scopus 로고    scopus 로고
    • A FLT3 tyrosine kinase inhibitor is selectively cytotoxic to acute myeloid leukemia blasts harboring FLT3 internal tandem duplication mutations
    • Levis M, Tse KF, Smith BD, et al. A FLT3 tyrosine kinase inhibitor is selectively cytotoxic to acute myeloid leukemia blasts harboring FLT3 internal tandem duplication mutations. Blood 2001;98:885-7
    • (2001) Blood , vol.98 , pp. 885-887
    • Levis, M.1    Tse, K.F.2    Smith, B.D.3
  • 68
    • 0029899585 scopus 로고    scopus 로고
    • Tyrphostins. 5. Potent inhibitors of platelet-derived growth factor receptor tyrosine kinase: Structure-activity relationships in quinoxalines, quinolines, and indole tyrphostins
    • Gazit A, App H, Mcmahon G, et al. Tyrphostins. 5. Potent inhibitors of platelet-derived growth factor receptor tyrosine kinase: Structure-activity relationships in quinoxalines, quinolines, and indole tyrphostins. J Med Chem 1996;39:2170-7
    • (1996) J Med Chem , vol.39 , pp. 2170-2717
    • Gazit, A.1    App, H.2    Mcmahon, G.3
  • 69
    • 0024434810 scopus 로고
    • Tyrphostins I: Synthesis and biological activity of protein tyrosine kinase inhibitors
    • Gazit A, Yaish P, Gilon C, Levitzki A. Tyrphostins I: Synthesis and biological activity of protein tyrosine kinase inhibitors. J Med Chem 1989;32:2344-52 (Pubitemid 19245898)
    • (1989) Journal of Medicinal Chemistry , vol.32 , Issue.10 , pp. 2344-2352
    • Gazit, A.1    Yaish, P.2    Gilon, C.3    Levitzki, A.4
  • 70
    • 0036799356 scopus 로고    scopus 로고
    • Inhibition of the transforming activity of FLT3 internal tandem duplication mutants from AML patients by a tyrosine kinase inhibitor
    • DOI 10.1038/sj.leu.2402674
    • Tse KF, Allebach J, Levis M, et al. Inhibition of the transforming activity of FLT3 internal tandem duplication mutants from AML patients by a tyrosine kinase inhibitor. Leukemia 2002;16:2027-36 (Pubitemid 35203445)
    • (2002) Leukemia , vol.16 , Issue.10 , pp. 2027-2036
    • Tse, K.-F.1    Allebach, J.2    Levis, M.3    Smith, B.D.4    Bohmer, F.D.5    Small, D.6
  • 71
    • 79952959738 scopus 로고    scopus 로고
    • Yissum Research Development Company of the Hebrew University of Jerusalem. PDGF receptor kinase inhibitory compounds, their preparation, purification and pharmaceutical compositions including same. WO2001034607
    • Yissum Research Development Company of the Hebrew University of Jerusalem. PDGF receptor kinase inhibitory compounds, their preparation, purification and pharmaceutical compositions including same. WO2001034607; 2001
    • (2001)
  • 73
    • 79952947472 scopus 로고    scopus 로고
    • Cor Therapeutics and Kyowa Hakko Kogyo. Quinazoline derivatives as kinase inhibitors. WO2002016351
    • Cor Therapeutics and Kyowa Hakko Kogyo. Quinazoline derivatives as kinase inhibitors. WO2002016351; 2002
    • (2002)
  • 77
    • 7244251613 scopus 로고    scopus 로고
    • Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518
    • DOI 10.1182/blood-2003-12-4446
    • Clark JJ, Cools J, Curley DP, et al. Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518. Blood 2004;104:2867-72 .Study revealing the cause for inherent resistance to tandutinib. (Pubitemid 39434973)
    • (2004) Blood , vol.104 , Issue.9 , pp. 2867-2872
    • Clark, J.J.1    Cools, J.2    Curley, D.P.3    Yu, J.-C.4    Lokker, N.A.5    Giese, N.A.6    Gilliland, D.G.7
  • 78
    • 79952915394 scopus 로고    scopus 로고
    • Astrazeneca. Combination therapy for the treatment of cancer. WO2007132215
    • Astrazeneca. Combination therapy for the treatment of cancer. WO2007132215; 2007
    • (2007)
  • 79
    • 66249093516 scopus 로고    scopus 로고
    • AZD1152 rapidly and negatively affects the growth and survival of human acute myeloid leukemia cells in vitro and in vivo
    • Oke A, Pearce D, Wilkinson RW, et al. AZD1152 rapidly and negatively affects the growth and survival of human acute myeloid leukemia cells in vitro and in vivo. Cancer Res 2009;69:4150-8
    • (2009) Cancer Res , vol.69 , pp. 4150-4158
    • Oke, A.1    Pearce, D.2    Wilkinson, R.W.3
  • 80
    • 77949693761 scopus 로고    scopus 로고
    • The FLT3 internal tandem duplication mutation is a secondary target of the aurora B kinase inhibitor AZD1152-HQPA in acute myelogenous leukemia cells
    • Grundy M, Seedhouse C, Shang S, et al. The FLT3 internal tandem duplication mutation is a secondary target of the aurora B kinase inhibitor AZD1152-HQPA in acute myelogenous leukemia cells. Mol Cancer Ther 2010;9:661-72
    • (2010) Mol Cancer Ther , vol.9 , pp. 661-672
    • Grundy, M.1    Seedhouse, C.2    Shang, S.3
  • 81
    • 79952931046 scopus 로고    scopus 로고
    • Janssen. Synergistic modulation of Flt3 kinase using alkylquinolines and alkylquinazolines. WO2006135629
    • Janssen. Synergistic modulation of Flt3 kinase using alkylquinolines and alkylquinazolines. WO2006135629; 2006
    • (2006)
  • 82
    • 79952958522 scopus 로고    scopus 로고
    • Signal Pharmaceuticals. Quinazoline analogs and related compounds and methods for treating inflammatory conditions. US5939421
    • Signal Pharmaceuticals. Quinazoline analogs and related compounds and methods for treating inflammatory conditions. US5939421; 1999
    • (1999)
  • 85
    • 79952934340 scopus 로고    scopus 로고
    • Kirin. Quinoline and quinazoline derivatives and drugs containing the same. WO2001047890
    • Kirin. Quinoline and quinazoline derivatives and drugs containing the same. WO2001047890; 2001
    • (2001)
  • 86
    • 79952967565 scopus 로고    scopus 로고
    • Kirin. Quinoline derivatives and quinazoline derivatives inhibiting autophosphorylation of Flt3 and medicinal compositions containing the same. WO2004039782
    • Kirin. Quinoline derivatives and quinazoline derivatives inhibiting autophosphorylation of Flt3 and medicinal compositions containing the same. WO2004039782; 2004
    • (2004)
  • 87
    • 46749115588 scopus 로고    scopus 로고
    • Ki11502, a novel multitargeted receptor tyrosine kinase inhibitor, induces growth arrest and apoptosis of human leukemia cells in vitro and in vivo
    • Nishioka C, Ikezoe T, Yang J, et al. Ki11502, a novel multitargeted receptor tyrosine kinase inhibitor, induces growth arrest and apoptosis of human leukemia cells in vitro and in vivo. Blood 2008;111:5086-92
    • (2008) Blood , vol.111 , pp. 5086-5092
    • Nishioka, C.1    Ikezoe, T.2    Yang, J.3
  • 90
    • 79952945470 scopus 로고    scopus 로고
    • Array Biopharma Imidazo[1,2-a]pyridine compounds as receptor tyrosine kinase inhibitors WO2008121687
    • Array Biopharma. Imidazo[1,2-a]pyridine compounds as receptor tyrosine kinase inhibitors. WO2008121687; 2008
    • (2008)
  • 92
    • 79952982173 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors. WO2003020699
    • Merck. Tyrosine kinase inhibitors. WO2003020699; 2003
    • (2003)
    • Merck1
  • 93
    • 79952982624 scopus 로고    scopus 로고
    • Orally active salts with tyrosine kinase activity. WO2002032861
    • Merck. Orally active salts with tyrosine kinase activity. WO2002032861; 2002
    • (2002)
    • Merck1
  • 94
    • 79952941209 scopus 로고    scopus 로고
    • BASF. Tricyclic pyrazole derivatives. WO2000027822
    • BASF. Tricyclic pyrazole derivatives. WO2000027822; 2000
    • (2000)
  • 95
    • 0042357316 scopus 로고    scopus 로고
    • Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosine kinase 3 (FLT3)
    • Murata K, Kumagai H, Kawashima T, et al. Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosine kinase 3 (FLT3). J Biol Chem 2003;278:32892-8
    • (2003) J Biol Chem , vol.278 , pp. 32892-3288
    • Murata, K.1    Kumagai, H.2    Kawashima, T.3
  • 96
    • 79952944187 scopus 로고    scopus 로고
    • SuperGen. Pharmaceutical formulations comprising salts of a protein kinase inhibitor and methods of using same. US20080226747
    • SuperGen. Pharmaceutical formulations comprising salts of a protein kinase inhibitor and methods of using same. US20080226747; 2008
    • (2008)
  • 97
    • 79952920014 scopus 로고    scopus 로고
    • Xanthus Pharmaceuticals. Imidazoacridine compounds for treating FLT3-mediated disorders. WO2008016665
    • Xanthus Pharmaceuticals. Imidazoacridine compounds for treating FLT3-mediated disorders. WO2008016665; 2008
    • (2008)
  • 98
    • 79952910424 scopus 로고    scopus 로고
    • Kinetek. Heteropolycyclic inhibitors of protein kinases. US6514972
    • Kinetek. Heteropolycyclic inhibitors of protein kinases. US6514972; 2003
    • (2003)
  • 99
    • 33645728920 scopus 로고    scopus 로고
    • Simultaneous inhibition of PDK1/AKT and Fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia
    • Zeng Z, Samudio IJ, Zhang W, et al. Simultaneous inhibition of PDK1/AKT and Fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia. Cancer Res 2006;66:3737-46
    • (2006) Cancer Res , vol.66 , pp. 3737-3746
    • Zeng, Z.1    Samudio, I.J.2    Zhang, W.3
  • 100
    • 79952973574 scopus 로고    scopus 로고
    • Novartis. Diaryl urea derivatives useful for the treatment of protein kinase dependent diseases. WO2003099771
    • Novartis. Diaryl urea derivatives useful for the treatment of protein kinase dependent diseases. WO2003099771; 2003
    • (2003)
  • 101
    • 79952981758 scopus 로고    scopus 로고
    • Novartis. Diaryl urea derivatives in the treatment of protein kinase dependent diseases. WO2005051366
    • Novartis. Diaryl urea derivatives in the treatment of protein kinase dependent diseases. WO2005051366; 2005
    • (2005)
  • 102
    • 58149104523 scopus 로고    scopus 로고
    • Antileukemic effects of the novel, mutant FLT3 inhibitor NVP-AST487: Effects on PKC412-sensitive and -resistant FLT3-expressing cells
    • Weisberg E, Roesel J, Bold G, et al. Antileukemic effects of the novel, mutant FLT3 inhibitor NVP-AST487: Effects on PKC412-sensitive and -resistant FLT3-expressing cells. Blood 2008;112:5161-70
    • (2008) Blood , vol.112 , pp. 5161-5170
    • Weisberg, E.1    Roesel, J.2    Bold, G.3
  • 103
    • 79952948323 scopus 로고    scopus 로고
    • Targe Gen Bi-aryl meta-pyrimidine inhibitors of kinases. WO2007053452
    • TargeGen. Bi-aryl meta-pyrimidine inhibitors of kinases. WO2007053452; 2007
    • (2007)
  • 105
    • 79952936488 scopus 로고    scopus 로고
    • Celltech. 5-cyano-2-aminopyrimidine derivatives. WO2000078731
    • Celltech. 5-cyano-2-aminopyrimidine derivatives. WO2000078731; 2000
    • (2000)
  • 107
    • 79952966746 scopus 로고    scopus 로고
    • Aminopyrimidines as kinase modulators. WO2006135719
    • Janssen. Aminopyrimidines as kinase modulators. WO2006135719; 2006
    • (2006)
    • Janssen1
  • 108
    • 34547519745 scopus 로고    scopus 로고
    • 4-Amino-6-piperazin-1-yl-pyrimidine-5- carbaldehyde oximes as potent FLT-3 inhibitors
    • Gaul MD, Xu G, Kirkpatrick J, et al. 4-Amino-6-piperazin-1-yl-pyrimidine- 5- carbaldehyde oximes as potent FLT-3 inhibitors. Bioorg Med Chem Lett 2007;17:4861-5
    • (2007) Bioorg Med Chem Lett , vol.17 , pp. 4861-485
    • Gaul, M.D.1    Xu, G.2    Kirkpatrick, J.3
  • 109
    • 79952965422 scopus 로고    scopus 로고
    • Kyowa Hakko Kogyo. Protein kinase inhibitors. WO2007032445
    • Kyowa Hakko Kogyo. Protein kinase inhibitors. WO2007032445; 2007
    • (2007)
  • 110
    • 79952967146 scopus 로고    scopus 로고
    • Kyowa Hakko Kogyo. Anti-tumor agent. WO2005095382
    • Kyowa Hakko Kogyo. Anti-tumor agent. WO2005095382; 2005
    • (2005)
  • 111
    • 53349162182 scopus 로고    scopus 로고
    • Novel and orally active 5-(1,3,4-oxadiazol-2-yl)pyrimidine derivatives as selective FLT3 inhibitors
    • Ishida H, Isami S, Matsumura T, et al. Novel and orally active 5-(1,3,4-oxadiazol-2-yl)pyrimidine derivatives as selective FLT3 inhibitors. Bioorg Med Chem Lett 2008;18:5472-7
    • (2008) Bioorg Med Chem Lett , vol.18 , pp. 5472-5477
    • Ishida, H.1    Isami, S.2    Matsumura, T.3
  • 112
    • 34547673146 scopus 로고    scopus 로고
    • A novel FLT3 inhibitor FI-700 selectively suppresses the growth of leukemia cells with FLT3 mutations
    • Kiyoi H, Shiotsu Y, Ozeki K, et al. A novel FLT3 inhibitor FI-700 selectively suppresses the growth of leukemia cells with FLT3 mutations. Clin Cancer Res 2007;13:4575-82
    • (2007) Clin Cancer Res , vol.13 , pp. 4575-45782
    • Kiyoi, H.1    Shiotsu, Y.2    Ozeki, K.3
  • 113
    • 79952960989 scopus 로고    scopus 로고
    • Rigel Pharmaceuticals. Cycloalkyl substituted pyrimidinediamine compounds and their uses. WO2005118544
    • Rigel Pharmaceuticals. Cycloalkyl substituted pyrimidinediamine compounds and their uses. WO2005118544; 2005
    • (2005)
  • 114
    • 71449112904 scopus 로고    scopus 로고
    • Preclinical characterization of Aurora kinase inhibitor R763/AS703569 identified through an image-based phenotypic screen
    • Mclaughlin J, Markovtsov V, Li H, et al. Preclinical characterization of Aurora kinase inhibitor R763/AS703569 identified through an image-based phenotypic screen. J Cancer Res Clin Oncol 2010;136:99-113
    • (2010) J Cancer Res Clin Oncol , vol.136 , pp. 99-113
    • Mclaughlin, J.1    Markovtsov, V.2    Li, H.3
  • 115
    • 79952967931 scopus 로고    scopus 로고
    • S.*Bio. Heterocycloalkyl substituted pyrimidine derivatives. WO2008140421
    • S.*Bio. Heterocycloalkyl substituted pyrimidine derivatives. WO2008140421; 2008
    • (2008)
  • 116
    • 79952933157 scopus 로고    scopus 로고
    • Substituted 7, 8-dihydro-1hpyrimido [4,5-b] [1,4] diazepin-4-amines as kinase inhibitors. WO2006124813
    • Abbott. Substituted 7, 8-dihydro-1hpyrimido [4,5-b] [1,4] diazepin-4-amines as kinase inhibitors. WO2006124813; 2006
    • (2006)
    • Abbott1
  • 118
    • 79952983002 scopus 로고    scopus 로고
    • Ambit Biosciences. Urea derivatives as kinase modulators. WO2005048948
    • Ambit Biosciences. Urea derivatives as kinase modulators. WO2005048948; 2005
    • (2005)
  • 119
    • 79952963169 scopus 로고    scopus 로고
    • Method of inhibiting FLT3 kinase. WO2007048088
    • Janssen. Method of inhibiting FLT3 kinase. WO2007048088; 2007
    • (2007)
    • Janssen1
  • 120
    • 70949104409 scopus 로고    scopus 로고
    • JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/ FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia
    • Manthey CL, Johnson DL, Illig CR, et al. JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/ FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia. Mol Cancer Ther 2009;8:3151-61
    • (2009) Mol Cancer Ther , vol.8 , pp. 3151-3161
    • Manthey, C.L.1    Johnson, D.L.2    Illig, C.R.3
  • 121
    • 79952931045 scopus 로고    scopus 로고
    • Akinion Pharmaceuticals. Pyrazine derivatives and their use as protein kinase inhibitors. WO2009095399
    • Akinion Pharmaceuticals. Pyrazine derivatives and their use as protein kinase inhibitors. WO2009095399; 2009
    • (2009)
  • 122
    • 77957017186 scopus 로고    scopus 로고
    • Identification of AKN-032, a novel 2-aminopyrazine tyrosine kinase inhibitor, with significant preclinical activity in acute myeloid leukemia
    • Eriksson A, Hoglund M, Lindhagen E, et al. Identification of AKN-032, a novel 2-aminopyrazine tyrosine kinase inhibitor, with significant preclinical activity in acute myeloid leukemia. Biochem Pharmacol 2010;80:1507-16
    • (2010) Biochem Pharmacol , vol.80 , pp. 1507-1516
    • Eriksson, A.1    Hoglund, M.2    Lindhagen, E.3
  • 123
    • 0036595322 scopus 로고    scopus 로고
    • Finding the next Gleevec: FLT3 targeted kinase inhibitor therapy for acute myeloid leukemia
    • DOI 10.1016/S1535-6108(02)00080-6
    • Sawyers CL. Finding the next Gleevec: FLT3 targeted kinase inhibitor therapy for acute myeloid leukemia. Cancer Cell 2002;1:413-15 (Pubitemid 41039121)
    • (2002) Cancer Cell , vol.1 , Issue.5 , pp. 413-415
    • Sawyers, C.L.1
  • 124
    • 0033614446 scopus 로고    scopus 로고
    • Chronic myeloid leukemia
    • DOI 10.1056/NEJM199904293401706
    • Sawyers CL. Chronic myeloid leukemia. N Engl J Med 1999;340:1330-40 (Pubitemid 29196596)
    • (1999) New England Journal of Medicine , vol.340 , Issue.17 , pp. 1330-1340
    • Sawyers, C.L.1
  • 125
    • 0036146806 scopus 로고    scopus 로고
    • Comprehensive genotypic analysis of leukemia: Clinical and therapeutic implications
    • DOI 10.1097/00001622-200201000-00003
    • Kelly L, Clark J, Gilliland DG. Comprehensive genotypic analysis of leukemia: Clinical and therapeutic implications. Curr Opin Oncol 2002;14:10-18 .Two-hit hypothesis. (Pubitemid 34072957)
    • (2002) Current Opinion in Oncology , vol.14 , Issue.1 , pp. 10-18
    • Kelly, L.1    Clark, J.2    Gilliland, D.G.3
  • 126
    • 0036093475 scopus 로고    scopus 로고
    • FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model
    • Kelly LM, Liu Q, Kutok JL, et al. FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model. Blood 2002;99:310-18
    • (2002) Blood , vol.99 , pp. 310-318
    • Kelly, L.M.1    Liu, Q.2    Kutok, J.L.3
  • 127
    • 0035800507 scopus 로고    scopus 로고
    • Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
    • DOI 10.1126/science.1062538
    • Gorre ME, Mohammed M, Ellwood K, et al. Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science 2001;293:876-80 (Pubitemid 32743979)
    • (2001) Science , vol.293 , Issue.5531 , pp. 876-880
    • Gorre, M.E.1    Mohammed, M.2    Ellwood, K.3    Hsu, N.4    Paquette, R.5    Nagesh Rao, P.6    Sawyers, C.L.7
  • 129
    • 66149152278 scopus 로고    scopus 로고
    • FMS-like tyrosine kinase 3-internal tandem duplication tyrosine kinase inhibitors display a nonoverlapping profile of resistance mutations in vitro
    • Von Bubnoff N, Engh RA, Aberg E, et al. FMS-like tyrosine kinase 3-internal tandem duplication tyrosine kinase inhibitors display a nonoverlapping profile of resistance mutations in vitro. Cancer Res 2009;69:3032-41
    • (2009) Cancer Res , vol.69 , pp. 3032-3041
    • Von Bubnoff, N.1    Engh, R.A.2    Aberg, E.3
  • 130
    • 4644240387 scopus 로고    scopus 로고
    • Prediction of resistance to small molecule FLT3 inhibitors: Implications for molecularly targeted therapy of acute leukemia
    • Cools J, Mentens N, Furet P, et al. Prediction of resistance to small molecule FLT3 inhibitors: Implications for molecularly targeted therapy of acute leukemia. Cancer Res 2004;64:6385-9
    • (2004) Cancer Res , vol.64 , pp. 6385-639
    • Cools, J.1    Mentens, N.2    Furet, P.3
  • 132
    • 77954243603 scopus 로고    scopus 로고
    • Emergence of orphan drugs in the United States: A quantitative assessment of the first 25 years
    • Braun MM, Farag-El-Massah S, Xu K, Cote TR. Emergence of orphan drugs in the United States: A quantitative assessment of the first 25 years. Nat Rev Drug Discov 2010;9:519-22
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 519-522
    • Braun, M.M.1    Farag-El-Massah, S.2    Xu, K.3    Cote, T.R.4


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