-
1
-
-
0025770646
-
A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations
-
Matthews W, Jordan CT, Wiegand GW, et al. A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations. Cell 1991;65:1143-52 (Pubitemid 121001328)
-
(1991)
Cell
, vol.65
, Issue.7
, pp. 1143-1152
-
-
Matthews, W.1
Jordan, C.T.2
Wiegand, G.W.3
Pardoll, D.4
Lemischka, I.R.5
-
2
-
-
0029798251
-
Regulatory roles of the ligand for Flk2/Flt3 tyrosine kinase receptor on human hematopoiesis
-
Namikawa R, Muench MO, Roncarolo MG. Regulatory roles of the ligand for Flk2/Flt3 tyrosine kinase receptor on human hematopoiesis. Stem Cells 1996;14:388-95 (Pubitemid 26286260)
-
(1996)
Stem Cells
, vol.14
, Issue.4
, pp. 388-395
-
-
Namikawa, R.1
Muench, M.O.2
Roncarolo, M.-G.3
-
3
-
-
0032030339
-
FLT3: Receptor and ligand. Biology and potential clinical application
-
DOI 10.1016/S1359-6101(97)00035-X, PII S135961019700035X
-
Shurin MR, Esche C, Lotze MT. FLT3: Receptor and ligand. Biology and potential clinical application. Cytokine Growth Factor Rev 1998;9:37-48 .A comprehensive review of the Flt3/FL system. (Pubitemid 28280535)
-
(1998)
Cytokine and Growth Factor Reviews
, vol.9
, Issue.1
, pp. 37-48
-
-
Shurin, M.R.1
Esche, C.2
Lotze, M.T.3
-
4
-
-
0030451722
-
Internal tandem duplication of the flt3 gene found in acute myeloid leukemia
-
Nakao M, Yokota S, Iwai T, et al. Internal tandem duplication of the flt3 gene found in acute myeloid leukemia. Leukemia 1996;10:1911-18 (Pubitemid 27019637)
-
(1996)
Leukemia
, vol.10
, Issue.12
, pp. 1911-1918
-
-
Nakao, M.1
Yokota, S.2
Iwai, T.3
Kaneko, H.4
Horiike, S.5
Kashima, K.6
Sonoda, Y.7
Fujimoto, T.8
Misawa, S.9
-
5
-
-
0031686409
-
Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product
-
Kiyoi H, Towatari M, Yokota S, et al. Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product. Leukemia 1998;12:1333-7 (Pubitemid 28442377)
-
(1998)
Leukemia
, vol.12
, Issue.9
, pp. 1333-1337
-
-
Kiyoi, H.1
Towatari, M.2
Yokota, S.3
Hamaguchi, M.4
Ohno, R.5
Saito, H.6
Naoe, T.7
-
6
-
-
0035871889
-
Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies
-
DOI 10.1182/blood.V97.8.2434
-
Yamamoto Y, Kiyoi H, Nakano Y, et al. Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. Blood 2001;97:2434-9 (Pubitemid 32291491)
-
(2001)
Blood
, vol.97
, Issue.8
, pp. 2434-2439
-
-
Yamamoto, Y.1
Kiyoi, H.2
Nakano, Y.3
Suzuki, R.4
Kodera, Y.5
Miyawaki, S.6
Asou, N.7
Kuriyama, K.8
Yagasaki, F.9
Shimazaki, C.10
Akiyama, H.11
Saito, K.12
Nishimura, M.13
Motoji, T.14
Shinagawa, K.15
Takeshita, A.16
Saito, H.17
Ueda, R.18
Ohno, R.19
Naoe, T.20
more..
-
7
-
-
15544389069
-
Advances in understanding the biology and genetics of acute myelocytic leukemia
-
Mckenzie SB. Advances in understanding the biology and genetics of acute myelocytic leukemia. Clin Lab Sci 2005;18:28-37
-
(2005)
Clin Lab Sci
, vol.18
, pp. 28-37
-
-
Mckenzie, S.B.1
-
9
-
-
77951111333
-
Novel agents and regimens for acute myeloid leukemia: 2009 ASH annual meeting highlights
-
Recent development of AML therapies.
-
Zhu X, Ma Y, Liu D. Novel agents and regimens for acute myeloid leukemia: 2009 ASH annual meeting highlights. J Hematol Oncol 2010;3:17 .Recent development of AML therapies.
-
(2010)
J Hematol Oncol
, vol.3
, pp. 17
-
-
Zhu, X.1
Ma, Y.2
Liu, D.3
-
10
-
-
0026457216
-
Expression of the FMS/KIT-like gene FLT3 in human acute leukemias of the myeloid and lymphoid lineages
-
Birg F, Courcoul M, Rosnet O, et al. Expression of the FMS/KIT-like gene FLT3 in human acute leukemias of the myeloid and lymphoid lineages. Blood 1992;80:2584-93
-
(1992)
Blood
, vol.80
, pp. 2584-2593
-
-
Birg, F.1
Courcoul, M.2
Rosnet, O.3
-
11
-
-
13344282746
-
Expression of the hematopoietic growth factor receptor FLT3 (STK-1/Flk2) in human leukemias
-
Carow CE, Levenstein M, Kaufmann SH, et al. Expression of the hematopoietic growth factor receptor FLT3 (STK-1/Flk2) in human leukemias. Blood 1996;87:1089-96 (Pubitemid 26043536)
-
(1996)
Blood
, vol.87
, Issue.3
, pp. 1089-1096
-
-
Carow, C.E.1
Levenstein, M.2
Kaufmann, S.H.3
Chen, J.4
Amin, S.5
Rockwell, P.6
Witte, L.7
Borowitz, M.J.8
Civin, C.I.9
Small, D.10
-
12
-
-
0035168677
-
Prevalence and prognostic significance of Flt3 internal tandem duplication in pediatric acute myeloid leukemia
-
DOI 10.1182/blood.V97.1.89
-
Meshinchi S, Woods WG, Stirewalt DL, et al. Prevalence and prognostic significance of Flt3 internal tandem duplication in pediatric acute myeloid leukemia. Blood 2001;97:89-94 (Pubitemid 32061246)
-
(2001)
Blood
, vol.97
, Issue.1
, pp. 89-94
-
-
Meshinchi, S.1
Woods, W.G.2
Stirewalt, D.L.3
Sweetser, D.A.4
Buckley, J.D.5
Tjoa, T.K.6
Bernstein, I.D.7
Radich, J.P.8
-
13
-
-
0035885955
-
The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: Analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials
-
Kottaridis PD, Gale RE, Frew ME, et al. The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: Analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials. Blood 2001;98:1752-9
-
(2001)
Blood
, vol.98
, pp. 1752-1759
-
-
Kottaridis, P.D.1
Gale, R.E.2
Frew, M.E.3
-
14
-
-
23744444913
-
Prognostic significance of FLT3 internal tandem duplication and tyrosine kinase domain mutations for acute myeloid leukemia: A meta-analysis
-
DOI 10.1038/sj.leu.2403838
-
Yanada M, Matsuo K, Suzuki T, et al. Prognostic significance of FLT3 internal tandem duplication and tyrosine kinase domain mutations for acute myeloid leukemia: A meta-analysis. Leukemia 2005;19:1345-9 (Pubitemid 41136326)
-
(2005)
Leukemia
, vol.19
, Issue.8
, pp. 1345-1349
-
-
Yanada, M.1
Matsuo, K.2
Suzuki, T.3
Kiyoi, H.4
Naoe, T.5
-
15
-
-
0036659931
-
Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: Correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease
-
DOI 10.1182/blood.V100.1.59
-
Schnittger S, Schoch C, Dugas M, et al. Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: Correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease. Blood 2002;100:59-66 (Pubitemid 35177429)
-
(2002)
Blood
, vol.100
, Issue.1
, pp. 59-66
-
-
Schnittger, S.1
Schoch, C.2
Dugas, M.3
Kern, W.4
Staib, P.5
Wuchter, C.6
Loffler, H.7
Sauerland, C.M.8
Serve, H.9
Buchner, T.10
Haferlach, T.11
Hiddemann, W.12
-
16
-
-
0037097716
-
Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: Association with FAB subtypes and identification of subgroups with poor prognosis
-
DOI 10.1182/blood.V99.12.4326
-
Thiede C, Steudel C, Mohr B, et al. Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: Association with FAB subtypes and identification of subgroups with poor prognosis. Blood 2002;99:4326-35 (Pubitemid 34627197)
-
(2002)
Blood
, vol.99
, Issue.12
, pp. 4326-4335
-
-
Thiede, C.1
Steudel, C.2
Mohr, B.3
Schaich, M.4
Schakel, U.5
Platzbecker, U.6
Wermke, M.7
Bornhauser, M.8
Ritter, M.9
Neubauer, A.10
Ehninger, G.11
Illmer, T.12
-
17
-
-
42949142189
-
Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia
-
DOI 10.1056/NEJMoa074306
-
Schlenk RF, Dohner K, Krauter J, et al. Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia. N Engl J Med 2008;358:1909-18 (Pubitemid 351620111)
-
(2008)
New England Journal of Medicine
, vol.358
, Issue.18
, pp. 1909-1918
-
-
Schlenk, R.F.1
Dohner, K.2
Krauter, J.3
Frohling, S.4
Corbacioglu, A.5
Bullinger, L.6
Habdank, M.7
Spath, D.8
Morgan, M.9
Benner, A.10
Schlegelberger, B.11
Heil, G.12
Ganser, A.13
Dohner, H.14
-
18
-
-
41949090673
-
The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia
-
Gale RE, Green C, Allen C, et al. The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia. Blood 2008;111:2776-84
-
(2008)
Blood
, vol.111
, pp. 2776-2784
-
-
Gale, R.E.1
Green, C.2
Allen, C.3
-
19
-
-
41949087055
-
Prognostic relevance of FLT3-TKD mutations in AML: The combination matters-an analysis of 3082 patients
-
Bacher U, Haferlach C, Kern W, et al. Prognostic relevance of FLT3-TKD mutations in AML: The combination matters-an analysis of 3082 patients. Blood 2008;111:2527-37
-
(2008)
Blood
, vol.111
, pp. 2527-2537
-
-
Bacher, U.1
Haferlach, C.2
Kern, W.3
-
20
-
-
16944366584
-
Tandem duplications of the FLT3 receptor gene are associated with leukemic transformation of myelodysplasia
-
Horiike S, Yokota S, Nakao M, et al. Tandem duplications of the FLT3 receptor gene are associated with leukemic transformation of myelodysplasia. Leukemia 1997;11:1442-6 (Pubitemid 27404382)
-
(1997)
Leukemia
, vol.11
, Issue.9
, pp. 1442-1446
-
-
Horiike, S.1
Yokota, S.2
Nakao, M.3
Iwai, T.4
Sasai, Y.5
Kaneko, H.6
Taniwaki, M.7
Kashima, K.8
Fujii, H.9
Abe, T.10
Misawa, S.11
-
21
-
-
9144244169
-
FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy
-
DOI 10.1182/blood-2003-02-0418
-
Taketani T, Taki T, Sugita K, et al. FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy. Blood 2004;103:1085-8 (Pubitemid 38129575)
-
(2004)
Blood
, vol.103
, Issue.3
, pp. 1085-1088
-
-
Taketani, T.1
Taki, T.2
Sugita, K.3
Furuichi, Y.4
Ishii, E.5
Hanada, R.6
Tsuchida, M.7
Sugita, K.8
Ida, K.9
Hayashi, Y.10
-
22
-
-
1842420032
-
Single-agent CEP-701, a novel FLT3 inhibitor, shows biologic and clinical activity in patients with relapsed or refractory acute myeloid leukemia
-
DOI 10.1182/blood-2003-11-3775
-
Smith BD, Levis M, Beran M, et al. Single-agent CEP-701, a novel FLT3 inhibitor, shows biologic and clinical activity in patients with relapsed or refractory acute myeloid leukemia. Blood 2004;103:3669-76 (Pubitemid 38596280)
-
(2004)
Blood
, vol.103
, Issue.10
, pp. 3669-3676
-
-
Smith, B.D.1
Levis, M.2
Beran, M.3
Giles, F.4
Kantarjian, H.5
Berg, K.6
Murphy, K.M.7
Dauses, T.8
Allebach, J.9
Small, D.10
-
23
-
-
33751173636
-
A phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy
-
Knapper S, Burnett AK, Littlewood T, et al. A phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy. Blood 2006;108:3262-70
-
(2006)
Blood
, vol.108
, pp. 3262-3270
-
-
Knapper, S.1
Burnett, A.K.2
Littlewood, T.3
-
24
-
-
78049426367
-
Phase IIB trial of oral midostaurin (PKC412), the FMS-like tyrosine kinase 3 receptor (FLT3) and multi-targeted kinase inhibitor, in patients with acute myeloid leukemia and high-risk myelodysplastic syndrome with either wild-type or mutated FLT3
-
Fischer T, Stone RM, Deangelo DJ, et al. Phase IIB trial of oral midostaurin (PKC412), the FMS-like tyrosine kinase 3 receptor (FLT3) and multi-targeted kinase inhibitor, in patients with acute myeloid leukemia and high-risk myelodysplastic syndrome with either wild-type or mutated FLT3. J Clin Oncol 2010;28:4339-45
-
(2010)
J Clin Oncol
, vol.28
, pp. 4339-4345
-
-
Fischer, T.1
Stone, R.M.2
Deangelo, D.J.3
-
26
-
-
79952921384
-
-
Astex Therapeutics. Pharmaceutical combinations. WO2008001101
-
Astex Therapeutics. Pharmaceutical combinations. WO2008001101; 2008
-
(2008)
-
-
-
27
-
-
60549088370
-
Fragment-based discovery of the pyrazol-4-yl urea (AT9283), a multitargeted kinase inhibitor with potent aurora kinase activity
-
Howard S, Berdini V, Boulstridge JA, et al. Fragment-based discovery of the pyrazol-4-yl urea (AT9283), a multitargeted kinase inhibitor with potent aurora kinase activity. J Med Chem 2009;52:379-88
-
(2009)
J Med Chem
, vol.52
, pp. 379-388
-
-
Howard, S.1
Berdini, V.2
Boulstridge, J.A.3
-
28
-
-
47249087693
-
The kinase inhibitor LS104 induces apoptosis, enhances cytotoxic effects of chemotherapeutic drugs and is targeting the receptor tyrosine kinase FLT3 in acute myeloid leukemia
-
Kasper S, Breitenbuecher F, Hoehn Y, et al. The kinase inhibitor LS104 induces apoptosis, enhances cytotoxic effects of chemotherapeutic drugs and is targeting the receptor tyrosine kinase FLT3 in acute myeloid leukemia. Leuk Res 2008;32:1698-708
-
(2008)
Leuk Res
, vol.32
, pp. 1698-1708
-
-
Kasper, S.1
Breitenbuecher, F.2
Hoehn, Y.3
-
29
-
-
0344394472
-
Inhibition of acute lymphoblastic and myeloid leukemias by a novel kinase inhibitor
-
DOI 10.1182/blood-2003-03-0860
-
Grunberger T, Demin P, Rounova O, et al. Inhibition of acute lymphoblastic and myeloid leukemias by a novel kinase inhibitor. Blood 2003;102:4153-8 (Pubitemid 37487002)
-
(2003)
Blood
, vol.102
, Issue.12
, pp. 4153-4158
-
-
Grunberger, T.1
Demin, P.2
Rounova, O.3
Sharfe, N.4
Cimpean, L.5
Dadi, H.6
Freywald, A.7
Estrov, Z.8
Roifman, C.M.9
-
30
-
-
47249129126
-
LS104, a non-ATP-competitive small-molecule inhibitor of JAK2, is potently inducing apoptosis in JAK2V617F-positive cells
-
Lipka DB, Hoffmann LS, Heidel F, et al. LS104, a non-ATP-competitive small-molecule inhibitor of JAK2, is potently inducing apoptosis in JAK2V617F-positive cells. Mol Cancer Ther 2008;7:1176-84
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 1176-1184
-
-
Lipka, D.B.1
Hoffmann, L.S.2
Heidel, F.3
-
31
-
-
72249087752
-
Identification of N-(5-tert-butylisoxazol- 3-yl)-N'-{4-[7-(2-morpholin-4- yl-ethoxy)imidazo[2 ,1-b][1,3] benzothiazol-2-yl]phenyl}urea dihydrochloride (AC220), a uniquely potent, selective, and efficacious FMS-like tyrosine kinase-3 (FLT3) inhibitor
-
Chao Q, Sprankle KG, Grotzfeld RM, et al. Identification of N-(5-tert-butylisoxazol- 3-yl)-N'-{4-[7-(2-morpholin-4- yl-ethoxy)imidazo[2 ,1-b][1,3] benzothiazol-2-yl]phenyl}urea dihydrochloride (AC220), a uniquely potent, selective, and efficacious FMS-like tyrosine kinase-3 (FLT3) inhibitor. J Med Chem 2009;52:7808-16
-
(2009)
J Med Chem
, vol.52
, pp. 7808-7816
-
-
Chao, Q.1
Sprankle, K.G.2
Grotzfeld, R.M.3
-
32
-
-
70449475105
-
AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML)
-
Second generation Flt3 inhibitor.
-
Zarrinkar PP, Gunawardane RN, Cramer MD, et al. AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML). Blood 2009;114:2984-92 .Second generation Flt3 inhibitor.
-
(2009)
Blood
, vol.114
, pp. 2984-2992
-
-
Zarrinkar, P.P.1
Gunawardane, R.N.2
Cramer, M.D.3
-
33
-
-
79952971535
-
-
[abstract 636]. 51st American society of hematology (ASH) annual meeting and exposition 5 -8 December New Orleans, USA
-
Cortes J, Foran J, Ghirdaladze D, et al. AC220, a potent, selective, second generation FLT3 receptor tyrosine kinase (RTK) inhibitor, in a first-in-human (FIH) phase 1 AML study [abstract 636]. 51st American society of hematology (ASH) annual meeting and exposition; 5 - 8 December 2009; New Orleans, USA
-
(2009)
AC220, a Potent, Selective, Second Generation FLT3 Receptor Tyrosine Kinase (RTK) Inhibitor, in a First-In-Human (FIH) Phase 1 AML study
-
-
Cortes, J.1
Foran, J.2
Ghirdaladze, D.3
-
34
-
-
76749105773
-
Dasatinib inhibits the growth of molecularly heterogeneous myeloid leukemias
-
Guerrouahen BS, Futami M, Vaklavas C, et al. Dasatinib inhibits the growth of molecularly heterogeneous myeloid leukemias. Clin Cancer Res 2010;16:1149-58
-
(2010)
Clin Cancer Res
, vol.16
, pp. 1149-1158
-
-
Guerrouahen, B.S.1
Futami, M.2
Vaklavas, C.3
-
35
-
-
33847195060
-
Antitumor activity of sorafenib in FLT3-driven leukemic cells
-
Auclair D, Miller D, Yatsula V, et al. Antitumor activity of sorafenib in FLT3-driven leukemic cells. Leukemia 2007;21:439-45
-
(2007)
Leukemia
, vol.21
, pp. 439-445
-
-
Auclair, D.1
Miller, D.2
Yatsula, V.3
-
36
-
-
77951645227
-
Phase I/II study of combination therapy with sorafenib, idarubicin, and cytarabine in younger patients with acute myeloid leukemia
-
Ravandi F, Cortes JE, Jones D, et al. Phase I/II study of combination therapy with sorafenib, idarubicin, and cytarabine in younger patients with acute myeloid leukemia. J Clin Oncol 2010;28:1856-62
-
(2010)
J Clin Oncol
, vol.28
, pp. 1856-1862
-
-
Ravandi, F.1
Cortes, J.E.2
Jones, D.3
-
37
-
-
79952954873
-
-
Sugen. Indolinone compounds for the treatment of disease. WO1996040116
-
Sugen. Indolinone compounds for the treatment of disease. WO1996040116; 1996
-
(1996)
-
-
-
38
-
-
0037108298
-
SU5416 and SU5614 inhibit kinase activity of wild-type and mutant FLT3 receptor tyrosine kinase
-
Yee KW, O'farrell AM, Smolich BD, et al. SU5416 and SU5614 inhibit kinase activity of wild-type and mutant FLT3 receptor tyrosine kinase. Blood 2002;100:2941-9
-
(2002)
Blood
, vol.100
, pp. 2941-299
-
-
Yee, K.W.1
O'farrell, A.M.2
Smolich, B.D.3
-
39
-
-
0141993064
-
A phase 2 clinical study of SU5416 in patients with refractory acute myeloid leukemia
-
DOI 10.1182/blood-2002-10-2998
-
Fiedler W, Mesters R, Tinnefeld H, et al. A phase 2 clinical study of SU5416 in patients with refractory acute myeloid leukemia. Blood 2003;102:2763-7 (Pubitemid 37248845)
-
(2003)
Blood
, vol.102
, Issue.8
, pp. 2763-2767
-
-
Fiedler, W.1
Mesters, R.2
Tinnefeld, H.3
Loges, S.4
Staib, P.5
Duhrsen, U.6
Flasshove, M.7
Ottmann, O.G.8
Jung, W.9
Cavalli, F.10
Kuse, R.11
Thomalla, J.12
Serve, H.13
O'Farrell, A.M.14
Jacobs, M.15
Brega, N.M.16
Scigalla, P.17
Hossfeld, D.K.18
Berdel, W.E.19
-
40
-
-
33748293111
-
SU14813: A novel multiple receptor tyrosine kinase inhibitor with potent antiangiogenic and antitumor activity
-
DOI 10.1158/1535-7163.MCT-05-0333
-
Patyna S, Laird AD, Mendel DB, et al. SU14813: A novel multiple receptor tyrosine kinase inhibitor with potent antiangiogenic and antitumor activity. Mol Cancer Ther 2006;5:1774-82 (Pubitemid 44323245)
-
(2006)
Molecular Cancer Therapeutics
, vol.5
, Issue.7
, pp. 1774-1782
-
-
Patyna, S.1
Laird, A.D.2
Mendel, D.B.3
O'Farrell, A.-M.4
Liang, C.5
Guan, H.6
Vojkovsky, T.7
Vasile, S.8
Wang, X.9
Chen, J.10
Grazzini, M.11
Yang, C.Y.12
Haznedar, J.O.13
Sukbuntherng, J.14
Zhong, W.-Z.15
Cherrington, J.M.16
Hu-Lowe, D.17
-
41
-
-
79952933619
-
-
Sugen. Pyrrole substituted 2-indolinone protein kinase inhibitors. WO2001060814
-
Sugen. Pyrrole substituted 2-indolinone protein kinase inhibitors. WO2001060814; 2001
-
(2001)
-
-
-
42
-
-
79952966310
-
-
Yamanouchi Pharmaceutical. Pharmaceutical composition containing 3-quinolin-2(1h)-ylidene indolin-2-one derivative as active component. JP2005145928
-
Yamanouchi Pharmaceutical. Pharmaceutical composition containing 3-quinolin-2(1h)-ylidene indolin-2-one derivative as active component. JP2005145928; 2005
-
(2005)
-
-
-
43
-
-
33645077600
-
YM-359445, an orally bioavailable vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor, has highly potent antitumor activity against established tumors
-
Amino N, Ideyama Y, Yamano M, et al. YM-359445, an orally bioavailable vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor, has highly potent antitumor activity against established tumors. Clin Cancer Res 2006;12:1630-8
-
(2006)
Clin Cancer Res
, vol.12
, pp. 1630-1608
-
-
Amino, N.1
Ideyama, Y.2
Yamano, M.3
-
44
-
-
79952973990
-
-
Anygen. Indirubin derivatives having anticancer property against human cancer cell me. WO2005070416
-
Anygen. Indirubin derivatives having anticancer property against human cancer cell me. WO2005070416; 2005
-
(2005)
-
-
-
45
-
-
77549087807
-
Indirubin derivatives as potent FLT3 inhibitors with anti-proliferative activity of acute myeloid leukemic cells
-
Choi SJ, Moon MJ, Lee SD, et al. Indirubin derivatives as potent FLT3 inhibitors with anti-proliferative activity of acute myeloid leukemic cells. Bioorg Med Chem Lett 2010;20:2033-7
-
(2010)
Bioorg Med Chem Lett
, vol.20
, pp. 2033-2037
-
-
Choi, S.J.1
Moon, M.J.2
Lee, S.D.3
-
46
-
-
79952936894
-
-
Research Institute Azulene compounds EP1918277
-
Industrial Technology Research Institute. Azulene compounds. EP1918277; 2008
-
(2008)
Industrial Technology
-
-
-
47
-
-
79952957348
-
-
[abstract LB-219]. AACR Annual Meeting; 18 - 22 April 2009; Denver, USA
-
Ko CH, Chen CH, Lee O, et al. K01109, a potent, novel selective FLT-3 inhibitor for the treatment of acute myelogenous leukemia [abstract LB-219]. 2009 AACR Annual Meeting; 18 - 22 April 2009; Denver, USA
-
(2009)
K01109, a Potent, Novel Selective FLT-3 Inhibitor for the Treatment of Acute Myelogenous Leukemia
-
-
Ko, C.H.1
Chen, C.H.2
Lee, O.3
-
48
-
-
79952981309
-
-
Johannes-Gutenberg Universitat Mainz. Use of 3-(indolyl)- or 3-(azaindolyl)-4- arylmaleimide derivatives in leukemia management. WO2009071620
-
Johannes-Gutenberg Universitat Mainz. Use of 3-(indolyl)- or 3-(azaindolyl)-4- arylmaleimide derivatives in leukemia management. WO2009071620; 2009
-
(2009)
-
-
-
49
-
-
0035984518
-
Bis(1H-2-indolyl)-1-methanones as inhibitors of the hematopoietic tyrosine kinase Flt3
-
Teller S, Kramer D, Bohmer SA, et al. Bis(1H-2-indolyl)-1-methanones as inhibitors of the hematopoietic tyrosine kinase Flt3. Leukemia 2002;16:1528-34
-
(2002)
Leukemia
, vol.16
, pp. 1528-1534
-
-
Teller, S.1
Kramer, D.2
Bohmer, S.A.3
-
50
-
-
79952955620
-
-
Kyowa Hakko Kogyo. Indazole derivatives. WO2005012257
-
Kyowa Hakko Kogyo. Indazole derivatives. WO2005012257; 2005
-
(2005)
-
-
-
51
-
-
70349566478
-
KW-2449, a novel multikinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation
-
Shiotsu Y, Kiyoi H, Ishikawa Y, et al. KW-2449, a novel multikinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation. Blood 2009;114:1607-17
-
(2009)
Blood
, vol.114
, pp. 1607-1617
-
-
Shiotsu, Y.1
Kiyoi, H.2
Ishikawa, Y.3
-
52
-
-
79952925827
-
-
6-9 December San Francisco, USA
-
Cortes J, Roboz GJ, Kantarjian H, et al. A phase i dose escalation study of KW-2449, an oral multi-kinase inhibitor against FLT3, Abl, FGFR1 and aurora in patients with relapsed/refractory AML, ALL and MDS or resistant/intolerant CML [abstract 2967]. 50th American society of hematology (ASH) annual meeting and exposition; 6 - 9 December 2008; San Francisco, USA
-
(2008)
A phase i Dose Escalation Study of KW-2449, an Oral Multi-Kinase Inhibitor Against FLT3, Abl, FGFR1 and Aurora In Patients With Relapsed/Refractory Aml, All And Mds Or Resistant/Intolerant Cml [Abstract 2967]. 50Th American Society of Hematology (ASH) Annual Meeting and Exposition
-
-
Cortes, J.1
Roboz, G.J.2
Kantarjian, H.3
-
53
-
-
62949087552
-
A pharmacodynamic study of the FLT3 inhibitor KW-2449 yields insight into the basis for clinical response
-
Pratz KW, Cortes J, Roboz GJ, et al. A pharmacodynamic study of the FLT3 inhibitor KW-2449 yields insight into the basis for clinical response. Blood 2009;113:3938-46
-
(2009)
Blood
, vol.113
, pp. 3938-3946
-
-
Pratz, K.W.1
Cortes, J.2
Roboz, G.J.3
-
54
-
-
79952913602
-
-
Abbott. Indazole benzisoxazole and benzisothiazole kinase inhibitors. WO2004113304
-
Abbott. Indazole, benzisoxazole, and benzisothiazole kinase inhibitors. WO2004113304; 2004
-
(2004)
-
-
-
55
-
-
69249142285
-
ABT-869, a promising multi-targeted tyrosine kinase inhibitor: From bench to bedside
-
Zhou J, Goh BC, Albert DH, Chen CS. ABT-869, a promising multi-targeted tyrosine kinase inhibitor: From bench to bedside. J Hematol Oncol 2009;2:33
-
(2009)
J Hematol Oncol
, vol.2
, pp. 33
-
-
Zhou, J.1
Goh, B.C.2
Albert, D.H.3
Chen, C.S.4
-
56
-
-
38349075768
-
Synergistic antileukemic effects between ABT-869 and chemotherapy involve downregulation of cell cycle-regulated genes and c-Mos-mediated MAPK pathway
-
Zhou J, Pan M, Xie Z, et al. Synergistic antileukemic effects between ABT-869 and chemotherapy involve downregulation of cell cycle-regulated genes and c-Mos-mediated MAPK pathway. Leukemia 2008;22:138-46
-
(2008)
Leukemia
, vol.22
, pp. 138-146
-
-
Zhou, J.1
Pan, M.2
Xie, Z.3
-
57
-
-
79952969639
-
-
Bristol-Myers Squibb. Pyrrolotriazine kinase inhibitors. WO2007061882
-
Bristol-Myers Squibb. Pyrrolotriazine kinase inhibitors. WO2007061882; 2007
-
(2007)
-
-
-
58
-
-
79952913167
-
-
SuperGen. Imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine derivatives and their use as protein kinase inhibitors. WO2008058126
-
SuperGen. Imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine derivatives and their use as protein kinase inhibitors. WO2008058126; 2008
-
(2008)
-
-
-
59
-
-
77950538522
-
Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells
-
Chen LS, Redkar S, Bearss D, et al. Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells. Blood 2009;114:4150-7
-
(2009)
Blood
, vol.114
, pp. 4150-4157
-
-
Chen, L.S.1
Redkar, S.2
Bearss, D.3
-
60
-
-
79952931878
-
-
Ariad Pharmaceuticals. Bicyclic heteroaryl compounds. WO2007075869
-
Ariad Pharmaceuticals. Bicyclic heteroaryl compounds. WO2007075869; 2007
-
(2007)
-
-
-
61
-
-
79952944645
-
-
Amphora. Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof. WO2005033102
-
Amphora. Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof. WO2005033102; 2005
-
(2005)
-
-
-
62
-
-
79952956055
-
-
The Pfahl Family Trust. Substituted biarylheterocycle derivatives as protein kinase inhibitors for the treatment of cancer and other diseases. WO2006130613
-
The Pfahl Family Trust. Substituted biarylheterocycle derivatives as protein kinase inhibitors for the treatment of cancer and other diseases. WO2006130613; 2006
-
(2006)
-
-
-
63
-
-
79952914466
-
-
Novartis. Thiazole and pyrazole derivatives as Flt-3 kinase inhibitors. WO2005047273
-
Novartis. Thiazole and pyrazole derivatives as Flt-3 kinase inhibitors. WO2005047273; 2005
-
(2005)
-
-
-
64
-
-
79952925828
-
-
IRM. Compounds and compositions as protein kinase inhibitors. WO2006081172
-
IRM. Compounds and compositions as protein kinase inhibitors. WO2006081172; 2006
-
(2006)
-
-
-
65
-
-
79952950043
-
-
Sugen. Treatment of platelet derived growth factor related disorders such as cancers. US5990141
-
Sugen. Treatment of platelet derived growth factor related disorders such as cancers. US5990141; 1999
-
(1999)
-
-
-
66
-
-
0034895025
-
Inhibition of FLT3-mediated transformation by use of a tyrosine kinase inhibitor
-
DOI 10.1038/sj.leu.2402199
-
Tse KF, Novelli E, Civin CI, et al. Inhibition of FLT3-mediated transformation by use of a tyrosine kinase inhibitor. Leukemia 2001;15:1001-10 (Pubitemid 32717268)
-
(2001)
Leukemia
, vol.15
, Issue.7
, pp. 1001-1010
-
-
Tse, K.-F.1
Novelli, E.2
Civin, C.I.3
Bohmer, F.D.4
Small, D.5
-
67
-
-
0035437140
-
A FLT3 tyrosine kinase inhibitor is selectively cytotoxic to acute myeloid leukemia blasts harboring FLT3 internal tandem duplication mutations
-
Levis M, Tse KF, Smith BD, et al. A FLT3 tyrosine kinase inhibitor is selectively cytotoxic to acute myeloid leukemia blasts harboring FLT3 internal tandem duplication mutations. Blood 2001;98:885-7
-
(2001)
Blood
, vol.98
, pp. 885-887
-
-
Levis, M.1
Tse, K.F.2
Smith, B.D.3
-
68
-
-
0029899585
-
Tyrphostins. 5. Potent inhibitors of platelet-derived growth factor receptor tyrosine kinase: Structure-activity relationships in quinoxalines, quinolines, and indole tyrphostins
-
Gazit A, App H, Mcmahon G, et al. Tyrphostins. 5. Potent inhibitors of platelet-derived growth factor receptor tyrosine kinase: Structure-activity relationships in quinoxalines, quinolines, and indole tyrphostins. J Med Chem 1996;39:2170-7
-
(1996)
J Med Chem
, vol.39
, pp. 2170-2717
-
-
Gazit, A.1
App, H.2
Mcmahon, G.3
-
69
-
-
0024434810
-
Tyrphostins I: Synthesis and biological activity of protein tyrosine kinase inhibitors
-
Gazit A, Yaish P, Gilon C, Levitzki A. Tyrphostins I: Synthesis and biological activity of protein tyrosine kinase inhibitors. J Med Chem 1989;32:2344-52 (Pubitemid 19245898)
-
(1989)
Journal of Medicinal Chemistry
, vol.32
, Issue.10
, pp. 2344-2352
-
-
Gazit, A.1
Yaish, P.2
Gilon, C.3
Levitzki, A.4
-
70
-
-
0036799356
-
Inhibition of the transforming activity of FLT3 internal tandem duplication mutants from AML patients by a tyrosine kinase inhibitor
-
DOI 10.1038/sj.leu.2402674
-
Tse KF, Allebach J, Levis M, et al. Inhibition of the transforming activity of FLT3 internal tandem duplication mutants from AML patients by a tyrosine kinase inhibitor. Leukemia 2002;16:2027-36 (Pubitemid 35203445)
-
(2002)
Leukemia
, vol.16
, Issue.10
, pp. 2027-2036
-
-
Tse, K.-F.1
Allebach, J.2
Levis, M.3
Smith, B.D.4
Bohmer, F.D.5
Small, D.6
-
71
-
-
79952959738
-
-
Yissum Research Development Company of the Hebrew University of Jerusalem. PDGF receptor kinase inhibitory compounds, their preparation, purification and pharmaceutical compositions including same. WO2001034607
-
Yissum Research Development Company of the Hebrew University of Jerusalem. PDGF receptor kinase inhibitory compounds, their preparation, purification and pharmaceutical compositions including same. WO2001034607; 2001
-
(2001)
-
-
-
72
-
-
0037401818
-
Tricyclic quinoxalines as potent kinase inhibitors of PDGFR kinase, Flt3 and Kit
-
DOI 10.1016/S0968-0896(03)00048-8
-
Gazit A, Yee K, Uecker A, et al. Tricyclic quinoxalines as potent kinase inhibitors of PDGFR kinase, Flt3 and Kit. Bioorg Med Chem 2003;11:2007-18 (Pubitemid 36379018)
-
(2003)
Bioorganic and Medicinal Chemistry
, vol.11
, Issue.9
, pp. 2007-2018
-
-
Gazit, A.1
Yee, K.2
Uecker, A.3
Bohmer, F.-D.4
Sjoblom, T.5
Ostman, A.6
Waltenberger, J.7
Golomb, G.8
Banai, S.9
Heinrich, M.C.10
Levitzki, A.11
-
73
-
-
79952947472
-
-
Cor Therapeutics and Kyowa Hakko Kogyo. Quinazoline derivatives as kinase inhibitors. WO2002016351
-
Cor Therapeutics and Kyowa Hakko Kogyo. Quinazoline derivatives as kinase inhibitors. WO2002016351; 2002
-
(2002)
-
-
-
74
-
-
0013102301
-
CT53518, a novel selective FLT3 antagonist for the treatment of acute myelogenous leukemia (AML)
-
DOI 10.1016/S1535-6108(02)00070-3
-
Kelly LM, Yu JC, Boulton CL, et al. CT53518, a novel selective FLT3 antagonist for the treatment of acute myelogenous leukemia (AML). Cancer Cell 2002;1:421-32 (Pubitemid 41039123)
-
(2002)
Cancer Cell
, vol.1
, Issue.5
, pp. 421-432
-
-
Kelly, L.M.1
Yu, J.-C.2
Boulton, C.L.3
Apatira, M.4
Li, J.5
Sullivan, C.M.6
Williams, I.7
Amaral, S.M.8
Curley, D.P.9
Duclos, N.10
Neuberg, D.11
Scarborough, R.M.12
Pandey, A.13
Hollenbach, S.14
Abe, K.15
Lokker, N.A.16
Gilliland, D.G.17
Giese, N.A.18
-
75
-
-
0037103166
-
Identification of orally active, potent, and selective 4-piperazinylquinazolines as antagonists of the platelet-derived growth factor receptor tyrosine kinase family
-
DOI 10.1021/jm020143r
-
Pandey A, Volkots DL, Seroogy JM, et al. Identification of orally active, potent, and selective 4-piperazinylquinazolines as antagonists of the platelet-derived growth factor receptor tyrosine kinase family. J Med Chem 2002;45:3772-93 (Pubitemid 34856116)
-
(2002)
Journal of Medicinal Chemistry
, vol.45
, Issue.17
, pp. 3772-3793
-
-
Pandey, A.1
Volkots, D.L.2
Seroogy, J.M.3
Rose, J.W.4
Yu, J.-C.5
Lambing, J.L.6
Hutchaleelaha, A.7
Hollenbach, S.J.8
Abe, K.9
Giese, N.A.10
Scarborough, R.M.11
-
76
-
-
33845240584
-
Phase 1 clinical results with tandutinib (MLN518), a novel FLT3 antagonist, in patients with acute myelogenous leukemia or high-risk myelodysplastic syndrome: Safety, pharmacokinetics, and pharmacodynamics
-
DOI 10.1182/blood-2006-02-005702
-
Deangelo DJ, Stone RM, Heaney ML, et al. Phase 1 clinical results with tandutinib (MLN518), a novel FLT3 antagonist, in patients with acute myelogenous leukemia or high-risk myelodysplastic syndrome: Safety, pharmacokinetics, and pharmacodynamics. Blood 2006;108:3674-81 (Pubitemid 44864544)
-
(2006)
Blood
, vol.108
, Issue.12
, pp. 3674-3681
-
-
DeAngelo, D.J.1
Stone, R.M.2
Heaney, M.L.3
Nimer, S.D.4
Paquette, R.L.5
Klisovic, R.B.6
Caligiuri, M.A.7
Cooper, M.R.8
Lecerf, J.-M.9
Karol, M.D.10
Sheng, S.11
Holford, N.12
Curtin, P.T.13
Druker, B.J.14
Heinrich, M.C.15
-
77
-
-
7244251613
-
Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518
-
DOI 10.1182/blood-2003-12-4446
-
Clark JJ, Cools J, Curley DP, et al. Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518. Blood 2004;104:2867-72 .Study revealing the cause for inherent resistance to tandutinib. (Pubitemid 39434973)
-
(2004)
Blood
, vol.104
, Issue.9
, pp. 2867-2872
-
-
Clark, J.J.1
Cools, J.2
Curley, D.P.3
Yu, J.-C.4
Lokker, N.A.5
Giese, N.A.6
Gilliland, D.G.7
-
78
-
-
79952915394
-
-
Astrazeneca. Combination therapy for the treatment of cancer. WO2007132215
-
Astrazeneca. Combination therapy for the treatment of cancer. WO2007132215; 2007
-
(2007)
-
-
-
79
-
-
66249093516
-
AZD1152 rapidly and negatively affects the growth and survival of human acute myeloid leukemia cells in vitro and in vivo
-
Oke A, Pearce D, Wilkinson RW, et al. AZD1152 rapidly and negatively affects the growth and survival of human acute myeloid leukemia cells in vitro and in vivo. Cancer Res 2009;69:4150-8
-
(2009)
Cancer Res
, vol.69
, pp. 4150-4158
-
-
Oke, A.1
Pearce, D.2
Wilkinson, R.W.3
-
80
-
-
77949693761
-
The FLT3 internal tandem duplication mutation is a secondary target of the aurora B kinase inhibitor AZD1152-HQPA in acute myelogenous leukemia cells
-
Grundy M, Seedhouse C, Shang S, et al. The FLT3 internal tandem duplication mutation is a secondary target of the aurora B kinase inhibitor AZD1152-HQPA in acute myelogenous leukemia cells. Mol Cancer Ther 2010;9:661-72
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 661-672
-
-
Grundy, M.1
Seedhouse, C.2
Shang, S.3
-
81
-
-
79952931046
-
-
Janssen. Synergistic modulation of Flt3 kinase using alkylquinolines and alkylquinazolines. WO2006135629
-
Janssen. Synergistic modulation of Flt3 kinase using alkylquinolines and alkylquinazolines. WO2006135629; 2006
-
(2006)
-
-
-
82
-
-
79952958522
-
-
Signal Pharmaceuticals. Quinazoline analogs and related compounds and methods for treating inflammatory conditions. US5939421
-
Signal Pharmaceuticals. Quinazoline analogs and related compounds and methods for treating inflammatory conditions. US5939421; 1999
-
(1999)
-
-
-
83
-
-
19944427042
-
Targeting NF-κB activation via pharmacologic inhibition of IKK2-induced apoptosis of human acute myeloid leukemia cells
-
DOI 10.1182/blood-2004-04-1463
-
Frelin C, Imbert V, Griessinger E, et al. Targeting NF-kappaB activation via pharmacologic inhibition of IKK2-induced apoptosis of human acute myeloid leukemia cells. Blood 2005;105:804-11 (Pubitemid 40070768)
-
(2005)
Blood
, vol.105
, Issue.2
, pp. 804-811
-
-
Frelin, C.1
Imbert, V.2
Griessinger, E.3
Peyron, A.-C.4
Rochet, N.5
Philip, P.6
Dageville, C.7
Sirvent, A.8
Hummelsberger, M.9
Berard, E.10
Dreano, M.11
Sirvent, N.12
Peyron, J.-F.13
-
84
-
-
34247609952
-
AS602868, a dual inhibitor of IKK2 and FLT3 to target AML cells
-
DOI 10.1038/sj.leu.2404614, PII 2404614
-
Griessinger E, Imbert V, Lagadec P, et al. AS602868, a dual inhibitor of IKK2 and FLT3 to target AML cells. Leukemia 2007;21:877-85 (Pubitemid 46672062)
-
(2007)
Leukemia
, vol.21
, Issue.5
, pp. 877-885
-
-
Griessinger, E.1
Imbert, V.2
Lagadec, P.3
Gonthier, N.4
Dubreuil, P.5
Romanelli, A.6
Dreano, M.7
Peyron, J.-F.8
-
85
-
-
79952934340
-
-
Kirin. Quinoline and quinazoline derivatives and drugs containing the same. WO2001047890
-
Kirin. Quinoline and quinazoline derivatives and drugs containing the same. WO2001047890; 2001
-
(2001)
-
-
-
86
-
-
79952967565
-
-
Kirin. Quinoline derivatives and quinazoline derivatives inhibiting autophosphorylation of Flt3 and medicinal compositions containing the same. WO2004039782
-
Kirin. Quinoline derivatives and quinazoline derivatives inhibiting autophosphorylation of Flt3 and medicinal compositions containing the same. WO2004039782; 2004
-
(2004)
-
-
-
87
-
-
46749115588
-
Ki11502, a novel multitargeted receptor tyrosine kinase inhibitor, induces growth arrest and apoptosis of human leukemia cells in vitro and in vivo
-
Nishioka C, Ikezoe T, Yang J, et al. Ki11502, a novel multitargeted receptor tyrosine kinase inhibitor, induces growth arrest and apoptosis of human leukemia cells in vitro and in vivo. Blood 2008;111:5086-92
-
(2008)
Blood
, vol.111
, pp. 5086-5092
-
-
Nishioka, C.1
Ikezoe, T.2
Yang, J.3
-
88
-
-
20844431698
-
Identification of Ki23819, a highly potent inhibitor of kinase activity of mutant FLT3 receptor tyrosine kinase
-
DOI 10.1038/sj.leu.2403736
-
Komeno Y, Kurokawa M, Imai Y, et al. Identification of Ki23819, a highly potent inhibitor of kinase activity of mutant FLT3 receptor tyrosine kinase. Leukemia 2005;19:930-5 (Pubitemid 40862002)
-
(2005)
Leukemia
, vol.19
, Issue.6
, pp. 930-935
-
-
Komeno, Y.1
Kurokawa, M.2
Imai, Y.3
Takeshita, M.4
Matsumura, T.5
Kubo, K.6
Yoshino, T.7
Nishiyama, U.8
Kuwaki, T.9
Kubo, K.10
Osawa, T.11
Ogawa, S.12
Chiba, S.13
Miwa, A.14
Hirai, H.15
-
89
-
-
33750030177
-
Antineoplastic effect of a single oral dose of the novel Flt3 inhibitor KRN383 on xenografted human leukemic cells harboring Flt3-activating mutations
-
DOI 10.1016/j.leukres.2006.02.028, PII S0145212606000944
-
Nishiyama U, Yoshino T, Ozai M, et al. Antineoplastic effect of a single oral dose of the novel Flt3 inhibitor KRN383 on xenografted human leukemic cells harboring Flt3-activating mutations. Leuk Res 2006;30:1541-6 (Pubitemid 44573480)
-
(2006)
Leukemia Research
, vol.30
, Issue.12
, pp. 1541-1546
-
-
Nishiyama, U.1
Yoshino, T.2
Ozai, M.3
Yoshioka, R.4
Fujisawa, M.5
Ogasawara, Y.6
Kitahori, M.7
Yoshioka, E.8
Kubo, K.9
Komeno, Y.10
Kurokawa, M.11
Ogawa, S.12
Chiba, S.13
Osawa, T.14
Kuwaki, T.15
Hirai, H.16
Miwa, A.17
-
90
-
-
79952945470
-
-
Array Biopharma Imidazo[1,2-a]pyridine compounds as receptor tyrosine kinase inhibitors WO2008121687
-
Array Biopharma. Imidazo[1,2-a]pyridine compounds as receptor tyrosine kinase inhibitors. WO2008121687; 2008
-
(2008)
-
-
-
91
-
-
22344453138
-
CHIR-258: A potent inhibitor of FLT3 kinase in experimental tumor xenograft models of human acute myelogenous leukemia
-
DOI 10.1158/1078-0432.CCR-05-0358
-
Lopes De Menezes DE, Peng J, Garrett EN, et al. CHIR-258: A potent inhibitor of FLT3 kinase in experimental tumor xenograft models of human acute myelogenous leukemia. Clin Cancer Res 2005;11:5281-91 (Pubitemid 41003717)
-
(2005)
Clinical Cancer Research
, vol.11
, Issue.14
, pp. 5281-5291
-
-
Lopes De Menezes, D.E.1
Peng, J.2
Garrett, E.N.3
Louie, S.G.4
Lee, S.H.5
Wiesmann, M.6
Tang, Y.7
Shephard, L.8
Goldbeck, C.9
Oei, Y.10
Ye, H.11
Aukerman, S.L.12
Heise, C.13
-
92
-
-
79952982173
-
-
Tyrosine kinase inhibitors. WO2003020699
-
Merck. Tyrosine kinase inhibitors. WO2003020699; 2003
-
(2003)
-
-
Merck1
-
93
-
-
79952982624
-
-
Orally active salts with tyrosine kinase activity. WO2002032861
-
Merck. Orally active salts with tyrosine kinase activity. WO2002032861; 2002
-
(2002)
-
-
Merck1
-
94
-
-
79952941209
-
-
BASF. Tricyclic pyrazole derivatives. WO2000027822
-
BASF. Tricyclic pyrazole derivatives. WO2000027822; 2000
-
(2000)
-
-
-
95
-
-
0042357316
-
Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosine kinase 3 (FLT3)
-
Murata K, Kumagai H, Kawashima T, et al. Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosine kinase 3 (FLT3). J Biol Chem 2003;278:32892-8
-
(2003)
J Biol Chem
, vol.278
, pp. 32892-3288
-
-
Murata, K.1
Kumagai, H.2
Kawashima, T.3
-
96
-
-
79952944187
-
-
SuperGen. Pharmaceutical formulations comprising salts of a protein kinase inhibitor and methods of using same. US20080226747
-
SuperGen. Pharmaceutical formulations comprising salts of a protein kinase inhibitor and methods of using same. US20080226747; 2008
-
(2008)
-
-
-
97
-
-
79952920014
-
-
Xanthus Pharmaceuticals. Imidazoacridine compounds for treating FLT3-mediated disorders. WO2008016665
-
Xanthus Pharmaceuticals. Imidazoacridine compounds for treating FLT3-mediated disorders. WO2008016665; 2008
-
(2008)
-
-
-
98
-
-
79952910424
-
-
Kinetek. Heteropolycyclic inhibitors of protein kinases. US6514972
-
Kinetek. Heteropolycyclic inhibitors of protein kinases. US6514972; 2003
-
(2003)
-
-
-
99
-
-
33645728920
-
Simultaneous inhibition of PDK1/AKT and Fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia
-
Zeng Z, Samudio IJ, Zhang W, et al. Simultaneous inhibition of PDK1/AKT and Fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia. Cancer Res 2006;66:3737-46
-
(2006)
Cancer Res
, vol.66
, pp. 3737-3746
-
-
Zeng, Z.1
Samudio, I.J.2
Zhang, W.3
-
100
-
-
79952973574
-
-
Novartis. Diaryl urea derivatives useful for the treatment of protein kinase dependent diseases. WO2003099771
-
Novartis. Diaryl urea derivatives useful for the treatment of protein kinase dependent diseases. WO2003099771; 2003
-
(2003)
-
-
-
101
-
-
79952981758
-
-
Novartis. Diaryl urea derivatives in the treatment of protein kinase dependent diseases. WO2005051366
-
Novartis. Diaryl urea derivatives in the treatment of protein kinase dependent diseases. WO2005051366; 2005
-
(2005)
-
-
-
102
-
-
58149104523
-
Antileukemic effects of the novel, mutant FLT3 inhibitor NVP-AST487: Effects on PKC412-sensitive and -resistant FLT3-expressing cells
-
Weisberg E, Roesel J, Bold G, et al. Antileukemic effects of the novel, mutant FLT3 inhibitor NVP-AST487: Effects on PKC412-sensitive and -resistant FLT3-expressing cells. Blood 2008;112:5161-70
-
(2008)
Blood
, vol.112
, pp. 5161-5170
-
-
Weisberg, E.1
Roesel, J.2
Bold, G.3
-
103
-
-
79952948323
-
-
Targe Gen Bi-aryl meta-pyrimidine inhibitors of kinases. WO2007053452
-
TargeGen. Bi-aryl meta-pyrimidine inhibitors of kinases. WO2007053452; 2007
-
(2007)
-
-
-
104
-
-
41249099841
-
Efficacy of TG101348, a Selective JAK2 Inhibitor, in Treatment of a Murine Model of JAK2V617F-Induced Polycythemia Vera
-
DOI 10.1016/j.ccr.2008.02.009, PII S1535610808000457
-
Wernig G, Kharas MG, Okabe R, et al. Efficacy of TG101348, a selective JAK2 inhibitor, in treatment of a murine model of JAK2V617F-induced polycythemia vera. Cancer Cell 2008;13:311-20 (Pubitemid 351446195)
-
(2008)
Cancer Cell
, vol.13
, Issue.4
, pp. 311-320
-
-
Wernig, G.1
Kharas, M.G.2
Okabe, R.3
Moore, S.A.4
Leeman, D.S.5
Cullen, D.E.6
Gozo, M.7
McDowell, E.P.8
Levine, R.L.9
Doukas, J.10
Mak, C.C.11
Noronha, G.12
Martin, M.13
Ko, Y.D.14
Lee, B.H.15
Soll, R.M.16
Tefferi, A.17
Hood, J.D.18
Gilliland, D.G.19
-
105
-
-
79952936488
-
-
Celltech. 5-cyano-2-aminopyrimidine derivatives. WO2000078731
-
Celltech. 5-cyano-2-aminopyrimidine derivatives. WO2000078731; 2000
-
(2000)
-
-
-
106
-
-
4944227798
-
A vascular endothelial growth factor receptor-2 kinase inhibitor potentiates the activity of the conventional chemotherapeutic agents paclitaxel and doxorubicin in tumor xenograft models
-
DOI 10.1124/mol.104.000638
-
Emanuel S, Gruninger RH, Fuentes-Pesquera A, et al. A vascular endothelial growth factor receptor-2 kinase inhibitor potentiates the activity of the conventional chemotherapeutic agents paclitaxel and doxorubicin in tumor xenograft models. Mol Pharmacol 2004;66:635-47 (Pubitemid 39329263)
-
(2004)
Molecular Pharmacology
, vol.66
, Issue.3
, pp. 635-647
-
-
Emanuel, S.1
Gruninger, R.H.2
Fuentes-Pesquera, A.3
Connolly, P.J.4
Seamon, J.A.5
Hazel, S.6
Tominovich, R.7
Hollister, B.8
Napier, C.9
D'Andrea, M.R.10
Reuman, M.11
Bignan, G.12
Tuman, R.13
Johnson, D.14
Moffatt, D.15
Batchelor, M.16
Foley, A.17
O'Connell, J.18
Allen, R.19
Perry, M.20
Jolliffe, L.21
Middleton, S.A.22
more..
-
107
-
-
79952966746
-
-
Aminopyrimidines as kinase modulators. WO2006135719
-
Janssen. Aminopyrimidines as kinase modulators. WO2006135719; 2006
-
(2006)
-
-
Janssen1
-
108
-
-
34547519745
-
4-Amino-6-piperazin-1-yl-pyrimidine-5- carbaldehyde oximes as potent FLT-3 inhibitors
-
Gaul MD, Xu G, Kirkpatrick J, et al. 4-Amino-6-piperazin-1-yl-pyrimidine- 5- carbaldehyde oximes as potent FLT-3 inhibitors. Bioorg Med Chem Lett 2007;17:4861-5
-
(2007)
Bioorg Med Chem Lett
, vol.17
, pp. 4861-485
-
-
Gaul, M.D.1
Xu, G.2
Kirkpatrick, J.3
-
109
-
-
79952965422
-
-
Kyowa Hakko Kogyo. Protein kinase inhibitors. WO2007032445
-
Kyowa Hakko Kogyo. Protein kinase inhibitors. WO2007032445; 2007
-
(2007)
-
-
-
110
-
-
79952967146
-
-
Kyowa Hakko Kogyo. Anti-tumor agent. WO2005095382
-
Kyowa Hakko Kogyo. Anti-tumor agent. WO2005095382; 2005
-
(2005)
-
-
-
111
-
-
53349162182
-
Novel and orally active 5-(1,3,4-oxadiazol-2-yl)pyrimidine derivatives as selective FLT3 inhibitors
-
Ishida H, Isami S, Matsumura T, et al. Novel and orally active 5-(1,3,4-oxadiazol-2-yl)pyrimidine derivatives as selective FLT3 inhibitors. Bioorg Med Chem Lett 2008;18:5472-7
-
(2008)
Bioorg Med Chem Lett
, vol.18
, pp. 5472-5477
-
-
Ishida, H.1
Isami, S.2
Matsumura, T.3
-
112
-
-
34547673146
-
A novel FLT3 inhibitor FI-700 selectively suppresses the growth of leukemia cells with FLT3 mutations
-
Kiyoi H, Shiotsu Y, Ozeki K, et al. A novel FLT3 inhibitor FI-700 selectively suppresses the growth of leukemia cells with FLT3 mutations. Clin Cancer Res 2007;13:4575-82
-
(2007)
Clin Cancer Res
, vol.13
, pp. 4575-45782
-
-
Kiyoi, H.1
Shiotsu, Y.2
Ozeki, K.3
-
113
-
-
79952960989
-
-
Rigel Pharmaceuticals. Cycloalkyl substituted pyrimidinediamine compounds and their uses. WO2005118544
-
Rigel Pharmaceuticals. Cycloalkyl substituted pyrimidinediamine compounds and their uses. WO2005118544; 2005
-
(2005)
-
-
-
114
-
-
71449112904
-
Preclinical characterization of Aurora kinase inhibitor R763/AS703569 identified through an image-based phenotypic screen
-
Mclaughlin J, Markovtsov V, Li H, et al. Preclinical characterization of Aurora kinase inhibitor R763/AS703569 identified through an image-based phenotypic screen. J Cancer Res Clin Oncol 2010;136:99-113
-
(2010)
J Cancer Res Clin Oncol
, vol.136
, pp. 99-113
-
-
Mclaughlin, J.1
Markovtsov, V.2
Li, H.3
-
115
-
-
79952967931
-
-
S.*Bio. Heterocycloalkyl substituted pyrimidine derivatives. WO2008140421
-
S.*Bio. Heterocycloalkyl substituted pyrimidine derivatives. WO2008140421; 2008
-
(2008)
-
-
-
116
-
-
79952933157
-
-
Substituted 7, 8-dihydro-1hpyrimido [4,5-b] [1,4] diazepin-4-amines as kinase inhibitors. WO2006124813
-
Abbott. Substituted 7, 8-dihydro-1hpyrimido [4,5-b] [1,4] diazepin-4-amines as kinase inhibitors. WO2006124813; 2006
-
(2006)
-
-
Abbott1
-
117
-
-
41849136167
-
Scaffold oriented synthesis. Part 2: Design, synthesis and biological evaluation of pyrimido-diazepines as receptor tyrosine kinase inhibitors
-
DOI 10.1016/j.bmcl.2008.03.021, PII S0960894X08002965
-
Gracias V, Ji Z, Akritopoulou-Zanze I, et al. Scaffold oriented synthesis. Part 2: Design, synthesis and biological evaluation of pyrimido-diazepines as receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett 2008;18:2691-5 (Pubitemid 351503877)
-
(2008)
Bioorganic and Medicinal Chemistry Letters
, vol.18
, Issue.8
, pp. 2691-2695
-
-
Gracias, V.1
Ji, Z.2
Akritopoulou-Zanze, I.3
Abad-Zapatero, C.4
Huth, J.R.5
Song, D.6
Hajduk, P.J.7
Johnson, E.F.8
Glaser, K.B.9
Marcotte, P.A.10
Pease, L.11
Soni, N.B.12
Stewart, K.D.13
Davidsen, S.K.14
Michaelides, M.R.15
Djuric, S.W.16
-
118
-
-
79952983002
-
-
Ambit Biosciences. Urea derivatives as kinase modulators. WO2005048948
-
Ambit Biosciences. Urea derivatives as kinase modulators. WO2005048948; 2005
-
(2005)
-
-
-
119
-
-
79952963169
-
-
Method of inhibiting FLT3 kinase. WO2007048088
-
Janssen. Method of inhibiting FLT3 kinase. WO2007048088; 2007
-
(2007)
-
-
Janssen1
-
120
-
-
70949104409
-
JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/ FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia
-
Manthey CL, Johnson DL, Illig CR, et al. JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/ FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia. Mol Cancer Ther 2009;8:3151-61
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 3151-3161
-
-
Manthey, C.L.1
Johnson, D.L.2
Illig, C.R.3
-
121
-
-
79952931045
-
-
Akinion Pharmaceuticals. Pyrazine derivatives and their use as protein kinase inhibitors. WO2009095399
-
Akinion Pharmaceuticals. Pyrazine derivatives and their use as protein kinase inhibitors. WO2009095399; 2009
-
(2009)
-
-
-
122
-
-
77957017186
-
Identification of AKN-032, a novel 2-aminopyrazine tyrosine kinase inhibitor, with significant preclinical activity in acute myeloid leukemia
-
Eriksson A, Hoglund M, Lindhagen E, et al. Identification of AKN-032, a novel 2-aminopyrazine tyrosine kinase inhibitor, with significant preclinical activity in acute myeloid leukemia. Biochem Pharmacol 2010;80:1507-16
-
(2010)
Biochem Pharmacol
, vol.80
, pp. 1507-1516
-
-
Eriksson, A.1
Hoglund, M.2
Lindhagen, E.3
-
123
-
-
0036595322
-
Finding the next Gleevec: FLT3 targeted kinase inhibitor therapy for acute myeloid leukemia
-
DOI 10.1016/S1535-6108(02)00080-6
-
Sawyers CL. Finding the next Gleevec: FLT3 targeted kinase inhibitor therapy for acute myeloid leukemia. Cancer Cell 2002;1:413-15 (Pubitemid 41039121)
-
(2002)
Cancer Cell
, vol.1
, Issue.5
, pp. 413-415
-
-
Sawyers, C.L.1
-
124
-
-
0033614446
-
Chronic myeloid leukemia
-
DOI 10.1056/NEJM199904293401706
-
Sawyers CL. Chronic myeloid leukemia. N Engl J Med 1999;340:1330-40 (Pubitemid 29196596)
-
(1999)
New England Journal of Medicine
, vol.340
, Issue.17
, pp. 1330-1340
-
-
Sawyers, C.L.1
-
125
-
-
0036146806
-
Comprehensive genotypic analysis of leukemia: Clinical and therapeutic implications
-
DOI 10.1097/00001622-200201000-00003
-
Kelly L, Clark J, Gilliland DG. Comprehensive genotypic analysis of leukemia: Clinical and therapeutic implications. Curr Opin Oncol 2002;14:10-18 .Two-hit hypothesis. (Pubitemid 34072957)
-
(2002)
Current Opinion in Oncology
, vol.14
, Issue.1
, pp. 10-18
-
-
Kelly, L.1
Clark, J.2
Gilliland, D.G.3
-
126
-
-
0036093475
-
FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model
-
Kelly LM, Liu Q, Kutok JL, et al. FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model. Blood 2002;99:310-18
-
(2002)
Blood
, vol.99
, pp. 310-318
-
-
Kelly, L.M.1
Liu, Q.2
Kutok, J.L.3
-
127
-
-
0035800507
-
Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
-
DOI 10.1126/science.1062538
-
Gorre ME, Mohammed M, Ellwood K, et al. Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science 2001;293:876-80 (Pubitemid 32743979)
-
(2001)
Science
, vol.293
, Issue.5531
, pp. 876-880
-
-
Gorre, M.E.1
Mohammed, M.2
Ellwood, K.3
Hsu, N.4
Paquette, R.5
Nagesh Rao, P.6
Sawyers, C.L.7
-
128
-
-
13844317894
-
EGFR mutation and resistance of non-small-cell lung cancer to gefitinib
-
DOI 10.1056/NEJMoa044238
-
Kobayashi S, Boggon TJ, Dayaram T, et al. EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. N Engl J Med 2005;352:786-92 (Pubitemid 40271173)
-
(2005)
New England Journal of Medicine
, vol.352
, Issue.8
, pp. 786-792
-
-
Kobayashi, S.1
Boggon, T.J.2
Dayaram, T.3
Janne, P.A.4
Kocher, O.5
Meyerson, M.6
Johnson, B.E.7
Eck, M.J.8
Tenen, D.G.9
Halmos, B.10
-
129
-
-
66149152278
-
FMS-like tyrosine kinase 3-internal tandem duplication tyrosine kinase inhibitors display a nonoverlapping profile of resistance mutations in vitro
-
Von Bubnoff N, Engh RA, Aberg E, et al. FMS-like tyrosine kinase 3-internal tandem duplication tyrosine kinase inhibitors display a nonoverlapping profile of resistance mutations in vitro. Cancer Res 2009;69:3032-41
-
(2009)
Cancer Res
, vol.69
, pp. 3032-3041
-
-
Von Bubnoff, N.1
Engh, R.A.2
Aberg, E.3
-
130
-
-
4644240387
-
Prediction of resistance to small molecule FLT3 inhibitors: Implications for molecularly targeted therapy of acute leukemia
-
Cools J, Mentens N, Furet P, et al. Prediction of resistance to small molecule FLT3 inhibitors: Implications for molecularly targeted therapy of acute leukemia. Cancer Res 2004;64:6385-9
-
(2004)
Cancer Res
, vol.64
, pp. 6385-639
-
-
Cools, J.1
Mentens, N.2
Furet, P.3
-
131
-
-
30144432781
-
Clinical resistance to the kinase inhibitor PKC412 in acute myeloid leukemia by mutation of Asn-676 in the FLT3 tyrosine kinase domain
-
DOI 10.1182/blood-2005-06-2469
-
Heidel F, Solem FK, Breitenbuecher F, et al. Clinical resistance to the kinase inhibitor PKC412 in acute myeloid leukemia by mutation of Asn-676 in the FLT3 tyrosine kinase domain. Blood 2006;107:293-300 .Clinical importance of secondary mutation of Flt3. (Pubitemid 43053554)
-
(2006)
Blood
, vol.107
, Issue.1
, pp. 293-300
-
-
Heidel, F.1
Solem, F.K.2
Breitenbuecher, F.3
Lipka, D.B.4
Kasper, S.5
Thiede, M.H.6
Brandts, C.7
Serve, H.8
Roesel, J.9
Giles, F.10
Feldman, E.11
Ehninger, G.12
Schiller, G.J.13
Nimer, S.14
Stone, R.M.15
Wang, Y.16
Kindler, T.17
Cohen, P.S.18
Huber, C.19
Fischer, T.20
more..
-
132
-
-
77954243603
-
Emergence of orphan drugs in the United States: A quantitative assessment of the first 25 years
-
Braun MM, Farag-El-Massah S, Xu K, Cote TR. Emergence of orphan drugs in the United States: A quantitative assessment of the first 25 years. Nat Rev Drug Discov 2010;9:519-22
-
(2010)
Nat Rev Drug Discov
, vol.9
, pp. 519-522
-
-
Braun, M.M.1
Farag-El-Massah, S.2
Xu, K.3
Cote, T.R.4
|