Tricyclic quinoxalines as potent kinase inhibitors of PDGFR kinase, Flt3 and Kit

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 9, 2003, Pages 2007-2018

  Gazit, Aviv ^a   Yee, Kevin ^b   Uecker, Andrea ^c   Böhmer, Frank D ^c   Sjöblom, Tobias ^d   Östman, Arne ^d   Waltenberger, Johannes ^g   Golomb, Gershon ^e   Banai, Shmuel ^f   Heinrich, Michael C ^b   Levitzki, Alexander ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^d LUDWIG INSTITUTE FOR CANCER RESEARCH   (Sweden)

^e HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^f BIKUR CHOLIM HOSPITAL   (Israel)

^g NONE

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DIMETHYL 6 (2 THIOPHENE)IMIDAZOLO[5,4 G]QUINOXALINE; 1,2 DIMETHYL 6 FERROCENE IMIDAZOLO[5,4 G]QUINOXALINE; 1,2 DIMETHYL 6 PHENYLIMIDAZOLO[5,4 G]QUINOXALINE; 1,2 DIMETHYL 7 (2 THIOPHENE)IMIDAZOLO[5,4 G]QUINOXALINE; 1,2 DIMETHYL 7 PHENYLIMIDAZOLO[5,4 G]QUINOXALINE; 2 THIOPHENE 6,7 DIMETHYLQUINOXALINE; 3 FERROCENE 6,7 DIMETHYLQUINOXALINE; AGL 1295; AGL 1296; AGL 1385; AGL 1989; AGL 1990; AGL 1991; AGL 2033; AGL 2034; AGL 2043; AGL 2044; FLT3 LIGAND; PLATELET DERIVED GROWTH FACTOR RECEPTOR; QUINOXALINE DERIVATIVE; RECEPTOR BLOCKING AGENT; STEM CELL FACTOR RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOAVAILABILITY; CELL GROWTH; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG EFFICACY; DRUG POTENCY; DRUG SOLUBILITY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; HYDROPHOBICITY; MITOSIS INHIBITION; NONHUMAN; SMOOTH MUSCLE FIBER; STRUCTURE ANALYSIS; SWINE; X RAY CRYSTALLOGRAPHY;

SUS SCROFA;

EID: 0037401818     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(03)00048-8     Document Type: Article

References (23)

1. Levitzki A. Pharmacol. Ther. 82:1999;231.
2. Gazit A., App H., McMahon G., Chen J., Levitzki A., Böhmer F.D. J. Med. Chem. 39:1996;2170.
3. Kovalenko M., Gazit A., Böhmer A., Rorsman C., Ronnstrand L., Heldin C.H., Waltenberger J., Böhmer F.D., Levitzki A. Cancer Res. 54:1994;6106.
4. Lipson K.E., Pang L., Huber L.J., Chen C., Tsai J.M., Hirth P., Gazit A., Levitzki A., McMahon J. J. Pharm. Exp. Therapeutics. 285:1998;844.
5. Waltenberger J., Uecker A., Kroll J., Frank H., Mayr U., Bjorge J.D., Fujita D., Gazit A., Hombach V., Levitzki A., Böhmer F.D. Circulation Res. 85:1999;12.
6. Kovalenko M., Ronnstrand L., Heldin C.H., Loubtchenkov M., Gazit A., Levitzki A., Böhmer F.D. Biochemistry. 36:1997;6260.
7. Banai S., Wolf Y., Golomb G., Pearle A., Waltenberger J., Fishbein I., Schneider A., Gazit A., Perez L., Huber R., Lazarovichi G., Rabinovich L., Levitzki A., Gertz D. Circulation. 97:1998;1960.
8. Karck M., Meliss M.R., Hestermann M., Mengel M., Pethig K., Levitzki A., Banai S., Golomb G., Fishbein I., Chorny M., Haverich A. Transplantation. 74:2002;1335.
9. George D. Semin. Oncol. 5(Suppl. 17):2001;27.
10. Gilliland D.G., Griffin J.D. Blood. 100:2002;1532.
11. Heinrich M.C., Rubin B.P., Longley B.J., Fletcher J.A. Hum. Pathol. 33:2002;484.
12. Schindler T., Sicheri F., Pico A., Gazit A., Levitzki A., Kuriyan J. Mol. Cell. 3:1999;639.
13. Zhu X., Kim J.L., Newcomb J.R., Rose P.E., Stover D.R., Toledo L.M., Zhao H., Morgenstern K.A. Struct. Fold Des. 7:1999;651.
14. Traxler P., Green J., Mett H., Sequin U., Furet P. J. Med. Chem. 42:1999;1018.
15. Kikugawa Y. Synthesis. 3:1981;124.
16. Kronke F., Borner E. Berichte. 69:1936;2006.
17. Karni, R.; Mizrachi, S.; Reiss-Sklan, E.; Gazit, A.; Livnah, O.; Levitzki, A. FEBS Lett. 2003, in press.
18. Ortu G., Ben-David I., Rozen Y., Freedman N.M., Chisin R., Levitzki A., Mishani E. Int. J. Cancer. 101:2002;360.
19. Blum G., Gazit A., Levitzki A. Biochemistry. 39:2000;15705.
20. Reuveni H., Livnah N., Geiger T., Klein S., Ohne O., Cohen I., Benhar M., Gellerman G., Levitzki A. Biochemistry. 41:2002;10304.
21. Eriksson A., Siobhan A., Westermark B., Heldin C.H., Claesson-Welsh L. EMBO J. 11:1992;543.
22. Josses C., Carron C., Boureux A., Quang C.T., Oury C., Dusanter-Fourt I., Charon M., Levin J., Bernard O., Ghysdael A. EMBO J. 16:1997;69.
23. Claesson-Welsh L., Eriksson A., Morén A., Severinsson L., Östman A., Betsholtz C., Heldin C.H. Mol. Cell. Biol. 8:1998;3476.