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Volumn 17, Issue 5, 2011, Pages 547-556

Recent advances in cytokines: Therapeutic implications for inflammatory bowel diseases

Author keywords

Biological therapy; Crohn's disease; Cytokine; Inflammatory bowel disease; Pathophysiology; Ulcerative colitis

Indexed keywords

ADALIMUMAB; APILIMOD; BASILIXIMAB; BETA1A INTERFERON; BRIAKINUMAB; CERTOLIZUMAB PEGOL; CYTOKINE; DACLIZUMAB; FONTOLIZUMAB; INFLIXIMAB; INTERLEUKIN 1; INTERLEUKIN 11; INTERLEUKIN 23; INTERLEUKIN 3; INTERLEUKIN 6; PEGINTERFERON ALPHA; PROTEIN P40; RECOMBINANT HUMAN INSULIN; RECOMBINANT INTERLEUKIN 10; TOCILIZUMAB; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR ALPHA; USTEKINUMAB;

EID: 79952781337     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v17.i5.547     Document Type: Article
Times cited : (59)

References (104)
  • 1
    • 79955935868 scopus 로고    scopus 로고
    • Why are molecular mechanisms of immune activation important in IBD?
    • Monteleone G, Caprioli F. Why are molecular mechanisms of immune activation important in IBD? Inflamm Bowel Dis 2008; 14 Suppl 2: S106-S107
    • (2008) Inflamm Bowel Dis , vol.14 , Issue.SUPPL. 2
    • Monteleone, G.1    Caprioli, F.2
  • 2
    • 70949107842 scopus 로고    scopus 로고
    • Inflammatory bowel disease
    • Abraham C, Cho JH. Inflammatory bowel disease. N Engl J Med 2009; 361: 2066-2078
    • (2009) N Engl J Med , vol.361 , pp. 2066-2078
    • Abraham, C.1    Cho, J.H.2
  • 4
    • 34547176642 scopus 로고    scopus 로고
    • Unravelling the pathogenesis of inflammatory bowel disease
    • Xavier RJ, Podolsky DK. Unravelling the pathogenesis of inflammatory bowel disease. Nature 2007; 448: 427-434
    • (2007) Nature , vol.448 , pp. 427-434
    • Xavier, R.J.1    Podolsky, D.K.2
  • 5
    • 33644873228 scopus 로고    scopus 로고
    • New concepts in the pathophysiology of inflammatory bowel disease
    • Bamias G, Nyce MR, De La Rue SA, Cominelli F. New concepts in the pathophysiology of inflammatory bowel disease. Ann Intern Med 2005; 143: 895-904
    • (2005) Ann Intern Med , vol.143 , pp. 895-904
    • Bamias, G.1    Nyce, M.R.2    de la Rue, S.A.3    Cominelli, F.4
  • 7
    • 35848958662 scopus 로고    scopus 로고
    • New players in the cytokine orchestra of inflammatory bowel disease
    • Fantini MC, Monteleone G, Macdonald TT. New players in the cytokine orchestra of inflammatory bowel disease. Inflamm Bowel Dis 2007; 13: 1419-1423
    • (2007) Inflamm Bowel Dis , vol.13 , pp. 1419-1423
    • Fantini, M.C.1    Monteleone, G.2    Macdonald, T.T.3
  • 8
    • 70349919789 scopus 로고    scopus 로고
    • Beyond tumor necrosis factor: Next-generation biologic therapy for inflammatory bowel disease
    • Podolsky DK. Beyond tumor necrosis factor: next-generation biologic therapy for inflammatory bowel disease. Dig Dis 2009; 27: 366-369
    • (2009) Dig Dis , vol.27 , pp. 366-369
    • Podolsky, D.K.1
  • 10
    • 34248136828 scopus 로고    scopus 로고
    • Inflammatory bowel disease: Cause and immunobiology
    • Baumgart DC, Carding SR. Inflammatory bowel disease: cause and immunobiology. Lancet 2007; 369: 1627-1640
    • (2007) Lancet , vol.369 , pp. 1627-1640
    • Baumgart, D.C.1    Carding, S.R.2
  • 11
    • 33644774565 scopus 로고    scopus 로고
    • Evolving knowledge and therapy of inflammatory bowel disease
    • Korzenik JR, Podolsky DK. Evolving knowledge and therapy of inflammatory bowel disease. Nat Rev Drug Discov 2006; 5: 197-209
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 197-209
    • Korzenik, J.R.1    Podolsky, D.K.2
  • 12
    • 62949219864 scopus 로고    scopus 로고
    • Biological therapies for inflammatory bowel diseases
    • Rutgeerts P, Vermeire S, Van Assche G. Biological therapies for inflammatory bowel diseases. Gastroenterology 2009; 136: 1182-1197
    • (2009) Gastroenterology , vol.136 , pp. 1182-1197
    • Rutgeerts, P.1    Vermeire, S.2    van Assche, G.3
  • 15
    • 85047688069 scopus 로고    scopus 로고
    • Inflammatory bowel disease: Progress and current concepts of etiopathogenesis
    • Scaldaferri F, Fiocchi C. Inflammatory bowel disease: progress and current concepts of etiopathogenesis. J Dig Dis 2007; 8: 171-178
    • (2007) J Dig Dis , vol.8 , pp. 171-178
    • Scaldaferri, F.1    Fiocchi, C.2
  • 16
    • 23344446340 scopus 로고    scopus 로고
    • Defects in mucosal immunity leading to ulcerative colitis
    • Targan SR, Karp LC. Defects in mucosal immunity leading to ulcerative colitis. Immunol Rev 2005; 206: 296-305
    • (2005) Immunol Rev , vol.206 , pp. 296-305
    • Targan, S.R.1    Karp, L.C.2
  • 17
    • 34247343687 scopus 로고    scopus 로고
    • Crohn's disease intestinal CD4+ T cells have impaired interleukin-10 production which is not restored by probiotic bacteria
    • Hvas CL, Kelsen J, Agnholt J, Höllsberg P, Tvede M, Møller JK, Dahlerup JF. Crohn's disease intestinal CD4+ T cells have impaired interleukin-10 production which is not restored by probiotic bacteria. Scand J Gastroenterol 2007; 42: 592-601
    • (2007) Scand J Gastroenterol , vol.42 , pp. 592-601
    • Hvas, C.L.1    Kelsen, J.2    Agnholt, J.3    Höllsberg, P.4    Tvede, M.5    Møller, J.K.6    Dahlerup, J.F.7
  • 21
    • 67650224449 scopus 로고    scopus 로고
    • Crohn's disease: Th1, Th17 or both? The change of a paradigm: New immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease
    • Brand S. Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease. Gut 2009; 58: 1152-1167
    • (2009) Gut , vol.58 , pp. 1152-1167
    • Brand, S.1
  • 22
    • 0026531017 scopus 로고
    • Tumour necrosis factor alpha in stool as a marker of intestinal inflammation
    • Braegger CP, Nicholls S, Murch SH, Stephens S, MacDonald TT. Tumour necrosis factor alpha in stool as a marker of intestinal inflammation. Lancet 1992; 339: 89-91
    • (1992) Lancet , vol.339 , pp. 89-91
    • Braegger, C.P.1    Nicholls, S.2    Murch, S.H.3    Stephens, S.4    Macdonald, T.T.5
  • 24
    • 70350719371 scopus 로고    scopus 로고
    • TNF-alpha as a therapeutic target in inflammatory diseases, ischemia-reperfusion injury and trauma
    • Esposito E, Cuzzocrea S. TNF-alpha as a therapeutic target in inflammatory diseases, ischemia-reperfusion injury and trauma. Curr Med Chem 2009; 16: 3152-3167
    • (2009) Curr Med Chem , vol.16 , pp. 3152-3167
    • Esposito, E.1    Cuzzocrea, S.2
  • 25
    • 0027486125 scopus 로고
    • Location of tumour necrosis factor alpha by immunohistochemistry in chronic inflammatory bowel disease
    • Murch SH, Braegger CP, Walker-Smith JA, MacDonald TT. Location of tumour necrosis factor alpha by immunohistochemistry in chronic inflammatory bowel disease. Gut 1993; 34: 1705-1709
    • (1993) Gut , vol.34 , pp. 1705-1709
    • Murch, S.H.1    Braegger, C.P.2    Walker-Smith, J.A.3    Macdonald, T.T.4
  • 26
    • 33745841186 scopus 로고    scopus 로고
    • Modulating TNF-alpha signaling with natural products
    • Paul AT, Gohil VM, Bhutani KK. Modulating TNF-alpha signaling with natural products. Drug Discov Today 2006; 11: 725-732
    • (2006) Drug Discov Today , vol.11 , pp. 725-732
    • Paul, A.T.1    Gohil, V.M.2    Bhutani, K.K.3
  • 28
    • 0027732688 scopus 로고
    • Tumor necrosis factor activates human endothelial cells through the p55 tumor necrosis factor receptor but the p75 receptor contributes to activation at low tumor necrosis factor concentration
    • Slowik MR, De Luca LG, Fiers W, Pober JS. Tumor necrosis factor activates human endothelial cells through the p55 tumor necrosis factor receptor but the p75 receptor contributes to activation at low tumor necrosis factor concentration. Am J Pathol 1993; 143: 1724-1730
    • (1993) Am J Pathol , vol.143 , pp. 1724-1730
    • Slowik, M.R.1    de Luca, L.G.2    Fiers, W.3    Pober, J.S.4
  • 30
    • 0027233868 scopus 로고
    • Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life
    • Yoshizumi M, Perrella MA, Burnett JC Jr, Lee ME. Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life. Circ Res 1993; 73: 205-209
    • (1993) Circ Res , vol.73 , pp. 205-209
    • Yoshizumi, M.1    Perrella, M.A.2    Burnett Jr., J.C.3    Lee, M.E.4
  • 31
    • 0037043658 scopus 로고    scopus 로고
    • Inflammatory bowel disease
    • Podolsky DK. Inflammatory bowel disease. N Engl J Med 2002; 347: 417-429
    • (2002) N Engl J Med , vol.347 , pp. 417-429
    • Podolsky, D.K.1
  • 46
    • 9644252669 scopus 로고    scopus 로고
    • New cytokine therapeutics for inflammatory bowel disease
    • Stokkers PC, Hommes DW. New cytokine therapeutics for inflammatory bowel disease. Cytokine 2004; 28: 167-173
    • (2004) Cytokine , vol.28 , pp. 167-173
    • Stokkers, P.C.1    Hommes, D.W.2
  • 48
    • 0031937388 scopus 로고    scopus 로고
    • Proinflammatory and immunoregulatory functions of interleukin-12
    • Trinchieri G. Proinflammatory and immunoregulatory functions of interleukin-12. Int Rev Immunol 1998; 16: 365-396
    • (1998) Int Rev Immunol , vol.16 , pp. 365-396
    • Trinchieri, G.1
  • 50
    • 0030995575 scopus 로고    scopus 로고
    • Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells
    • Monteleone G, Biancone L, Marasco R, Morrone G, Marasco O, Luzza F, Pallone F. Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells. Gastroenterology 1997; 112: 1169-1178
    • (1997) Gastroenterology , vol.112 , pp. 1169-1178
    • Monteleone, G.1    Biancone, L.2    Marasco, R.3    Morrone, G.4    Marasco, O.5    Luzza, F.6    Pallone, F.7
  • 53
    • 39449110445 scopus 로고    scopus 로고
    • The link between IL-23 and Th17 cell-mediated immune pathologies
    • McGeachy MJ, Cua DJ. The link between IL-23 and Th17 cell-mediated immune pathologies. Semin Immunol 2007; 19: 372-376
    • (2007) Semin Immunol , vol.19 , pp. 372-376
    • McGeachy, M.J.1    Cua, D.J.2
  • 57
    • 77953693548 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled trial of the oral interleukin-12/23 inhibitor apilimod mesylate for treatment of active Crohn's disease
    • Sands BE, Jacobson EW, Sylwestrowicz T, Younes Z, Dryden G, Fedorak R, Greenbloom S. Randomized, double-blind, placebo-controlled trial of the oral interleukin-12/23 inhibitor apilimod mesylate for treatment of active Crohn's disease. Inflamm Bowel Dis 2010; 16: 1209-1218
    • (2010) Inflamm Bowel Dis , vol.16 , pp. 1209-1218
    • Sands, B.E.1    Jacobson, E.W.2    Sylwestrowicz, T.3    Younes, Z.4    Dryden, G.5    Fedorak, R.6    Greenbloom, S.7
  • 58
    • 0024360388 scopus 로고
    • The biology of interleukin-6
    • Kishimoto T. The biology of interleukin-6. Blood 1989; 74: 1-10
    • (1989) Blood , vol.74 , pp. 1-10
    • Kishimoto, T.1
  • 59
    • 67349104400 scopus 로고    scopus 로고
    • Interleukin-6 as a key player in systemic inflammation and joint destruction
    • Fonseca JE, Santos MJ, Canhão H, Choy E. Interleukin-6 as a key player in systemic inflammation and joint destruction. Autoimmun Rev 2009; 8: 538-542
    • (2009) Autoimmun Rev , vol.8 , pp. 538-542
    • Fonseca, J.E.1    Santos, M.J.2    Canhão, H.3    Choy, E.4
  • 60
    • 0027421831 scopus 로고
    • Interleukin-6 in biology and medicine
    • Akira S, Taga T, Kishimoto T. Interleukin-6 in biology and medicine. Adv Immunol 1993; 54: 1-78
    • (1993) Adv Immunol , vol.54 , pp. 1-78
    • Akira, S.1    Taga, T.2    Kishimoto, T.3
  • 61
    • 0029147155 scopus 로고
    • Toxicity and efficacy of escalating dosages of recombinant human interleukin-6 after chemotherapy in patients with breast cancer or non-small-cell lung cancer
    • Veldhuis GJ, Willemse PH, Sleijfer DT, van der Graaf WT, Groen HJ, Limburg PC, Mulder NH, de Vries EG. Toxicity and efficacy of escalating dosages of recombinant human interleukin-6 after chemotherapy in patients with breast cancer or non-small-cell lung cancer. J Clin Oncol 1995; 13: 2585-2593
    • (1995) J Clin Oncol , vol.13 , pp. 2585-2593
    • Veldhuis, G.J.1    Willemse, P.H.2    Sleijfer, D.T.3    van der Graaf, W.T.4    Groen, H.J.5    Limburg, P.C.6    Mulder, N.H.7    de Vries, E.G.8
  • 65
    • 42449088420 scopus 로고    scopus 로고
    • Successful treatment of a patient with Takayasu arteritis using a humanized anti-interleukin-6 receptor antibody
    • Nishimoto N, Nakahara H, Yoshio-Hoshino N, Mima T. Successful treatment of a patient with Takayasu arteritis using a humanized anti-interleukin-6 receptor antibody. Arthritis Rheum 2008; 58: 1197-1200
    • (2008) Arthritis Rheum , vol.58 , pp. 1197-1200
    • Nishimoto, N.1    Nakahara, H.2    Yoshio-Hoshino, N.3    Mima, T.4
  • 66
    • 33746146891 scopus 로고    scopus 로고
    • Interfering with interferons in inflammatory bowel disease
    • Ghosh S, Chaudhary R, Carpani M, Playford R. Interfering with interferons in inflammatory bowel disease. Gut 2006; 55: 1071-1073
    • (2006) Gut , vol.55 , pp. 1071-1073
    • Ghosh, S.1    Chaudhary, R.2    Carpani, M.3    Playford, R.4
  • 67
    • 0038781673 scopus 로고    scopus 로고
    • Gamma interferon augments the intracellular pathway for lipopolysaccharide (LPS) recognition in human intestinal epithelial cells through coordinated up-regulation of LPS uptake and expression of the intracellular Toll-like receptor 4-MD-2 complex
    • Suzuki M, Hisamatsu T, Podolsky DK. Gamma interferon augments the intracellular pathway for lipopolysaccharide (LPS) recognition in human intestinal epithelial cells through coordinated up-regulation of LPS uptake and expression of the intracellular Toll-like receptor 4-MD-2 complex. Infect Immun 2003; 71: 3503-3511
    • (2003) Infect Immun , vol.71 , pp. 3503-3511
    • Suzuki, M.1    Hisamatsu, T.2    Podolsky, D.K.3
  • 71
    • 0013851832 scopus 로고
    • A lymphocyte-stimulating factor produced in vitro
    • Gordon J, MacLean LD. A lymphocyte-stimulating factor produced in vitro. Nature 1965; 208: 795-796
    • (1965) Nature , vol.208 , pp. 795-796
    • Gordon, J.1    Maclean, L.D.2
  • 74
    • 0036784616 scopus 로고    scopus 로고
    • IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response
    • Strengell M, Sareneva T, Foster D, Julkunen I, Matikainen S. IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response. J Immunol 2002; 169: 3600-3605
    • (2002) J Immunol , vol.169 , pp. 3600-3605
    • Strengell, M.1    Sareneva, T.2    Foster, D.3    Julkunen, I.4    Matikainen, S.5
  • 81
    • 0027521572 scopus 로고
    • Interleukin-10-deficient mice develop chronic enterocolitis
    • Kühn R, Löhler J, Rennick D, Rajewsky K, Müller W. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 1993; 75: 263-274
    • (1993) Cell , vol.75 , pp. 263-274
    • Kühn, R.1    Löhler, J.2    Rennick, D.3    Rajewsky, K.4    Müller, W.5
  • 83
    • 0028907439 scopus 로고
    • Immunoregulatory role of interleukin 10 in patients with inflammatory bowel disease
    • Schreiber S, Heinig T, Thiele HG, Raedler A. Immunoregulatory role of interleukin 10 in patients with inflammatory bowel disease. Gastroenterology 1995; 108: 1434-1444
    • (1995) Gastroenterology , vol.108 , pp. 1434-1444
    • Schreiber, S.1    Heinig, T.2    Thiele, H.G.3    Raedler, A.4
  • 84
    • 70949107956 scopus 로고    scopus 로고
    • Interleukin-10 in inflammatory bowel disease
    • Kelsall B. Interleukin-10 in inflammatory bowel disease. N Engl J Med 2009; 361: 2091-2093
    • (2009) N Engl J Med , vol.361 , pp. 2091-2093
    • Kelsall, B.1
  • 89
    • 0030917254 scopus 로고    scopus 로고
    • Interleukin-11: Review of molecular, cell biology, and clinical use
    • Du X, Williams DA. Interleukin-11: review of molecular, cell biology, and clinical use. Blood 1997; 89: 3897-3908
    • (1997) Blood , vol.89 , pp. 3897-3908
    • Du, X.1    Williams, D.A.2
  • 91
    • 0031229726 scopus 로고    scopus 로고
    • Interleukin-11 inhibits macrophage interleukin-12 production
    • Leng SX, Elias JA. Interleukin-11 inhibits macrophage interleukin-12 production. J Immunol 1997; 159: 2161-2168
    • (1997) J Immunol , vol.159 , pp. 2161-2168
    • Leng, S.X.1    Elias, J.A.2
  • 99
    • 62049083383 scopus 로고    scopus 로고
    • Loss of response and requirement of infliximab dose intensification in Crohn's disease: A review
    • Gisbert JP, Panés J. Loss of response and requirement of infliximab dose intensification in Crohn's disease: a review. Am J Gastroenterol 2009; 104: 760-767
    • (2009) Am J Gastroenterol , vol.104 , pp. 760-767
    • Gisbert, J.P.1    Panés, J.2
  • 100
    • 41149115774 scopus 로고    scopus 로고
    • A humanized tumor necrosis factor receptor 1 (TNFR1)-specific antagonistic antibody for selective inhibition of tumor necrosis factor (TNF) action
    • Kontermann RE, Münkel S, Neumeyer J, Müller D, Branschädel M, Scheurich P, Pfizenmaier K. A humanized tumor necrosis factor receptor 1 (TNFR1)-specific antagonistic antibody for selective inhibition of tumor necrosis factor (TNF) action. J Immunother 2008; 31: 225-234
    • (2008) J Immunother , vol.31 , pp. 225-234
    • Kontermann, R.E.1    Münkel, S.2    Neumeyer, J.3    Müller, D.4    Branschädel, M.5    Scheurich, P.6    Pfizenmaier, K.7
  • 102
    • 8344258233 scopus 로고    scopus 로고
    • Cytokine-based therapies for Crohn's disease--new paradigms
    • Cominelli F. Cytokine-based therapies for Crohn's disease--new paradigms. N Engl J Med 2004; 351: 2045-2048
    • (2004) N Engl J Med , vol.351 , pp. 2045-2048
    • Cominelli, F.1
  • 103
    • 0028226982 scopus 로고
    • Synergy between anti-CD4 and anti-tumor necrosis factor in the amelioration of established collagen-induced arthritis
    • Williams RO, Mason LJ, Feldmann M, Maini RN. Synergy between anti-CD4 and anti-tumor necrosis factor in the amelioration of established collagen-induced arthritis. Proc Natl Acad Sci USA 1994; 91: 2762-2766
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 2762-2766
    • Williams, R.O.1    Mason, L.J.2    Feldmann, M.3    Maini, R.N.4


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