-
1
-
-
79955935868
-
Why are molecular mechanisms of immune activation important in IBD?
-
Monteleone G, Caprioli F. Why are molecular mechanisms of immune activation important in IBD? Inflamm Bowel Dis 2008; 14 Suppl 2: S106-S107
-
(2008)
Inflamm Bowel Dis
, vol.14
, Issue.SUPPL. 2
-
-
Monteleone, G.1
Caprioli, F.2
-
2
-
-
70949107842
-
Inflammatory bowel disease
-
Abraham C, Cho JH. Inflammatory bowel disease. N Engl J Med 2009; 361: 2066-2078
-
(2009)
N Engl J Med
, vol.361
, pp. 2066-2078
-
-
Abraham, C.1
Cho, J.H.2
-
4
-
-
34547176642
-
Unravelling the pathogenesis of inflammatory bowel disease
-
Xavier RJ, Podolsky DK. Unravelling the pathogenesis of inflammatory bowel disease. Nature 2007; 448: 427-434
-
(2007)
Nature
, vol.448
, pp. 427-434
-
-
Xavier, R.J.1
Podolsky, D.K.2
-
6
-
-
58149265605
-
Mucosal cytokine network in inflammatory bowel disease
-
Andoh A, Yagi Y, Shioya M, Nishida A, Tsujikawa T, Fujiyama Y. Mucosal cytokine network in inflammatory bowel disease. World J Gastroenterol 2008; 14: 5154-5161
-
(2008)
World J Gastroenterol
, vol.14
, pp. 5154-5161
-
-
Andoh, A.1
Yagi, Y.2
Shioya, M.3
Nishida, A.4
Tsujikawa, T.5
Fujiyama, Y.6
-
7
-
-
35848958662
-
New players in the cytokine orchestra of inflammatory bowel disease
-
Fantini MC, Monteleone G, Macdonald TT. New players in the cytokine orchestra of inflammatory bowel disease. Inflamm Bowel Dis 2007; 13: 1419-1423
-
(2007)
Inflamm Bowel Dis
, vol.13
, pp. 1419-1423
-
-
Fantini, M.C.1
Monteleone, G.2
Macdonald, T.T.3
-
8
-
-
70349919789
-
Beyond tumor necrosis factor: Next-generation biologic therapy for inflammatory bowel disease
-
Podolsky DK. Beyond tumor necrosis factor: next-generation biologic therapy for inflammatory bowel disease. Dig Dis 2009; 27: 366-369
-
(2009)
Dig Dis
, vol.27
, pp. 366-369
-
-
Podolsky, D.K.1
-
9
-
-
44649187924
-
Efficacy and safety of tumor necrosis factor antagonists in Crohn's disease: Meta-analysis of placebo-controlled trials
-
Peyrin-Biroulet L, Deltenre P, de Suray N, Branche J, Sandborn WJ, Colombel JF. Efficacy and safety of tumor necrosis factor antagonists in Crohn's disease: meta-analysis of placebo-controlled trials. Clin Gastroenterol Hepatol 2008; 6: 644-653
-
(2008)
Clin Gastroenterol Hepatol
, vol.6
, pp. 644-653
-
-
Peyrin-Biroulet, L.1
Deltenre, P.2
de Suray, N.3
Branche, J.4
Sandborn, W.J.5
Colombel, J.F.6
-
10
-
-
34248136828
-
Inflammatory bowel disease: Cause and immunobiology
-
Baumgart DC, Carding SR. Inflammatory bowel disease: cause and immunobiology. Lancet 2007; 369: 1627-1640
-
(2007)
Lancet
, vol.369
, pp. 1627-1640
-
-
Baumgart, D.C.1
Carding, S.R.2
-
11
-
-
33644774565
-
Evolving knowledge and therapy of inflammatory bowel disease
-
Korzenik JR, Podolsky DK. Evolving knowledge and therapy of inflammatory bowel disease. Nat Rev Drug Discov 2006; 5: 197-209
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 197-209
-
-
Korzenik, J.R.1
Podolsky, D.K.2
-
12
-
-
62949219864
-
Biological therapies for inflammatory bowel diseases
-
Rutgeerts P, Vermeire S, Van Assche G. Biological therapies for inflammatory bowel diseases. Gastroenterology 2009; 136: 1182-1197
-
(2009)
Gastroenterology
, vol.136
, pp. 1182-1197
-
-
Rutgeerts, P.1
Vermeire, S.2
van Assche, G.3
-
14
-
-
0030749419
-
Tumour necrosis factor and inflammatory bowel disease
-
Armstrong AM, Gardiner KR, Kirk SJ, Halliday MI, Rowlands BJ. Tumour necrosis factor and inflammatory bowel disease. Br J Surg 1997; 84: 1051-1058
-
(1997)
Br J Surg
, vol.84
, pp. 1051-1058
-
-
Armstrong, A.M.1
Gardiner, K.R.2
Kirk, S.J.3
Halliday, M.I.4
Rowlands, B.J.5
-
15
-
-
85047688069
-
Inflammatory bowel disease: Progress and current concepts of etiopathogenesis
-
Scaldaferri F, Fiocchi C. Inflammatory bowel disease: progress and current concepts of etiopathogenesis. J Dig Dis 2007; 8: 171-178
-
(2007)
J Dig Dis
, vol.8
, pp. 171-178
-
-
Scaldaferri, F.1
Fiocchi, C.2
-
16
-
-
23344446340
-
Defects in mucosal immunity leading to ulcerative colitis
-
Targan SR, Karp LC. Defects in mucosal immunity leading to ulcerative colitis. Immunol Rev 2005; 206: 296-305
-
(2005)
Immunol Rev
, vol.206
, pp. 296-305
-
-
Targan, S.R.1
Karp, L.C.2
-
17
-
-
34247343687
-
Crohn's disease intestinal CD4+ T cells have impaired interleukin-10 production which is not restored by probiotic bacteria
-
Hvas CL, Kelsen J, Agnholt J, Höllsberg P, Tvede M, Møller JK, Dahlerup JF. Crohn's disease intestinal CD4+ T cells have impaired interleukin-10 production which is not restored by probiotic bacteria. Scand J Gastroenterol 2007; 42: 592-601
-
(2007)
Scand J Gastroenterol
, vol.42
, pp. 592-601
-
-
Hvas, C.L.1
Kelsen, J.2
Agnholt, J.3
Höllsberg, P.4
Tvede, M.5
Møller, J.K.6
Dahlerup, J.F.7
-
18
-
-
36249014365
-
Characterization of FOXP3+CD4+ regulatory T cells in Crohn's disease
-
Saruta M, Yu QT, Fleshner PR, Mantel PY, Schmidt-Weber CB, Banham AH, Papadakis KA. Characterization of FOXP3+CD4+ regulatory T cells in Crohn's disease. Clin Immunol 2007; 125: 281-290
-
(2007)
Clin Immunol
, vol.125
, pp. 281-290
-
-
Saruta, M.1
Yu, Q.T.2
Fleshner, P.R.3
Mantel, P.Y.4
Schmidt-Weber, C.B.5
Banham, A.H.6
Papadakis, K.A.7
-
20
-
-
34547188748
-
IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
-
Zhou L, Ivanov II, Spolski R, Min R, Shenderov K, Egawa T, Levy DE, Leonard WJ, Littman DR. IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol 2007; 8: 967-974
-
(2007)
Nat Immunol
, vol.8
, pp. 967-974
-
-
Zhou, L.1
Ivanov, I.I.2
Spolski, R.3
Min, R.4
Shenderov, K.5
Egawa, T.6
Levy, D.E.7
Leonard, W.J.8
Littman, D.R.9
-
21
-
-
67650224449
-
Crohn's disease: Th1, Th17 or both? The change of a paradigm: New immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease
-
Brand S. Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease. Gut 2009; 58: 1152-1167
-
(2009)
Gut
, vol.58
, pp. 1152-1167
-
-
Brand, S.1
-
22
-
-
0026531017
-
Tumour necrosis factor alpha in stool as a marker of intestinal inflammation
-
Braegger CP, Nicholls S, Murch SH, Stephens S, MacDonald TT. Tumour necrosis factor alpha in stool as a marker of intestinal inflammation. Lancet 1992; 339: 89-91
-
(1992)
Lancet
, vol.339
, pp. 89-91
-
-
Braegger, C.P.1
Nicholls, S.2
Murch, S.H.3
Stephens, S.4
Macdonald, T.T.5
-
23
-
-
0028236232
-
Tumor necrosis factor alpha-producing cells in the intestinal mucosa of children with inflammatory bowel disease
-
Breese EJ, Michie CA, Nicholls SW, Murch SH, Williams CB, Domizio P, Walker-Smith JA, MacDonald TT. Tumor necrosis factor alpha-producing cells in the intestinal mucosa of children with inflammatory bowel disease. Gastroenterology 1994; 106: 1455-1466
-
(1994)
Gastroenterology
, vol.106
, pp. 1455-1466
-
-
Breese, E.J.1
Michie, C.A.2
Nicholls, S.W.3
Murch, S.H.4
Williams, C.B.5
Domizio, P.6
Walker-Smith, J.A.7
Macdonald, T.T.8
-
24
-
-
70350719371
-
TNF-alpha as a therapeutic target in inflammatory diseases, ischemia-reperfusion injury and trauma
-
Esposito E, Cuzzocrea S. TNF-alpha as a therapeutic target in inflammatory diseases, ischemia-reperfusion injury and trauma. Curr Med Chem 2009; 16: 3152-3167
-
(2009)
Curr Med Chem
, vol.16
, pp. 3152-3167
-
-
Esposito, E.1
Cuzzocrea, S.2
-
25
-
-
0027486125
-
Location of tumour necrosis factor alpha by immunohistochemistry in chronic inflammatory bowel disease
-
Murch SH, Braegger CP, Walker-Smith JA, MacDonald TT. Location of tumour necrosis factor alpha by immunohistochemistry in chronic inflammatory bowel disease. Gut 1993; 34: 1705-1709
-
(1993)
Gut
, vol.34
, pp. 1705-1709
-
-
Murch, S.H.1
Braegger, C.P.2
Walker-Smith, J.A.3
Macdonald, T.T.4
-
26
-
-
33745841186
-
Modulating TNF-alpha signaling with natural products
-
Paul AT, Gohil VM, Bhutani KK. Modulating TNF-alpha signaling with natural products. Drug Discov Today 2006; 11: 725-732
-
(2006)
Drug Discov Today
, vol.11
, pp. 725-732
-
-
Paul, A.T.1
Gohil, V.M.2
Bhutani, K.K.3
-
27
-
-
0023254162
-
Activation of cultured human endothelial cells by recombinant lymphotoxin: Comparison with tumor necrosis factor and interleukin 1 species
-
Pober JS, Lapierre LA, Stolpen AH, Brock TA, Springer TA, Fiers W, Bevilacqua MP, Mendrick DL, Gimbrone MA Jr. Activation of cultured human endothelial cells by recombinant lymphotoxin: comparison with tumor necrosis factor and interleukin 1 species. J Immunol 1987; 138: 3319-3324
-
(1987)
J Immunol
, vol.138
, pp. 3319-3324
-
-
Pober, J.S.1
Lapierre, L.A.2
Stolpen, A.H.3
Brock, T.A.4
Springer, T.A.5
Fiers, W.6
Bevilacqua, M.P.7
Mendrick, D.L.8
Gimbrone Jr., M.A.9
-
28
-
-
0027732688
-
Tumor necrosis factor activates human endothelial cells through the p55 tumor necrosis factor receptor but the p75 receptor contributes to activation at low tumor necrosis factor concentration
-
Slowik MR, De Luca LG, Fiers W, Pober JS. Tumor necrosis factor activates human endothelial cells through the p55 tumor necrosis factor receptor but the p75 receptor contributes to activation at low tumor necrosis factor concentration. Am J Pathol 1993; 143: 1724-1730
-
(1993)
Am J Pathol
, vol.143
, pp. 1724-1730
-
-
Slowik, M.R.1
de Luca, L.G.2
Fiers, W.3
Pober, J.S.4
-
29
-
-
0026779627
-
Nitric oxide mediates tumor necrosis factor-alpha cytotoxicity in endothelial cells
-
Estrada C, Gómez C, Martín C, Moncada S, González C. Nitric oxide mediates tumor necrosis factor-alpha cytotoxicity in endothelial cells. Biochem Biophys Res Commun 1992; 186: 475-482
-
(1992)
Biochem Biophys Res Commun
, vol.186
, pp. 475-482
-
-
Estrada, C.1
Gómez, C.2
Martín, C.3
Moncada, S.4
González, C.5
-
30
-
-
0027233868
-
Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life
-
Yoshizumi M, Perrella MA, Burnett JC Jr, Lee ME. Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life. Circ Res 1993; 73: 205-209
-
(1993)
Circ Res
, vol.73
, pp. 205-209
-
-
Yoshizumi, M.1
Perrella, M.A.2
Burnett Jr., J.C.3
Lee, M.E.4
-
31
-
-
0037043658
-
Inflammatory bowel disease
-
Podolsky DK. Inflammatory bowel disease. N Engl J Med 2002; 347: 417-429
-
(2002)
N Engl J Med
, vol.347
, pp. 417-429
-
-
Podolsky, D.K.1
-
32
-
-
43549087629
-
TL1A-DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease
-
Pappu BP, Borodovsky A, Zheng TS, Yang X, Wu P, Dong X, Weng S, Browning B, Scott ML, Ma L, Su L, Tian Q, Schneider P, Flavell RA, Dong C, Burkly LC. TL1A-DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease. J Exp Med 2008; 205: 1049-1062
-
(2008)
J Exp Med
, vol.205
, pp. 1049-1062
-
-
Pappu, B.P.1
Borodovsky, A.2
Zheng, T.S.3
Yang, X.4
Wu, P.5
Dong, X.6
Weng, S.7
Browning, B.8
Scott, M.L.9
Ma, L.10
Su, L.11
Tian, Q.12
Schneider, P.13
Flavell, R.A.14
Dong, C.15
Burkly, L.C.16
-
33
-
-
46049089270
-
Contribution of TNFSF15 gene variants to Crohn's disease susceptibility confirmed in UK population
-
Tremelling M, Berzuini C, Massey D, Bredin F, Price C, Dawson C, Bingham SA, Parkes M. Contribution of TNFSF15 gene variants to Crohn's disease susceptibility confirmed in UK population. Inflamm Bowel Dis 2008; 14: 733-737
-
(2008)
Inflamm Bowel Dis
, vol.14
, pp. 733-737
-
-
Tremelling, M.1
Berzuini, C.2
Massey, D.3
Bredin, F.4
Price, C.5
Dawson, C.6
Bingham, S.A.7
Parkes, M.8
-
34
-
-
27944464550
-
Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease
-
Yamazaki K, McGovern D, Ragoussis J, Paolucci M, Butler H, Jewell D, Cardon L, Takazoe M, Tanaka T, Ichimori T, Saito S, Sekine A, Iida A, Takahashi A, Tsunoda T, Lathrop M, Nakamura Y. Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease. Hum Mol Genet 2005; 14: 3499-3506
-
(2005)
Hum Mol Genet
, vol.14
, pp. 3499-3506
-
-
Yamazaki, K.1
McGovern, D.2
Ragoussis, J.3
Paolucci, M.4
Butler, H.5
Jewell, D.6
Cardon, L.7
Takazoe, M.8
Tanaka, T.9
Ichimori, T.10
Saito, S.11
Sekine, A.12
Iida, A.13
Takahashi, A.14
Tsunoda, T.15
Lathrop, M.16
Nakamura, Y.17
-
35
-
-
10744225786
-
Expression, localization, and functional activity of TL1A, a novel Th1-polarizing cytokine in inflammatory bowel disease
-
Bamias G, Martin C 3rd, Marini M, Hoang S, Mishina M, Ross WG, Sachedina MA, Friel CM, Mize J, Bickston SJ, Pizarro TT, Wei P, Cominelli F. Expression, localization, and functional activity of TL1A, a novel Th1-polarizing cytokine in inflammatory bowel disease. J Immunol 2003; 171: 4868-4874
-
(2003)
J Immunol
, vol.171
, pp. 4868-4874
-
-
Bamias, G.1
Martin, C.2
Marini, M.3
Hoang, S.4
Mishina, M.5
Ross, W.G.6
Sachedina, M.A.7
Friel, C.M.8
Mize, J.9
Bickston, S.J.10
Pizarro, T.T.11
Wei, P.12
Cominelli, F.13
-
36
-
-
48549106477
-
TL1A (TNFSF15) regulates the development of chronic colitis by modulating both T-helper 1 and T-helper 17 activation
-
Takedatsu H, Michelsen KS, Wei B, Landers CJ, Thomas LS, Dhall D, Braun J, Targan SR. TL1A (TNFSF15) regulates the development of chronic colitis by modulating both T-helper 1 and T-helper 17 activation. Gastroenterology 2008; 135: 552-567
-
(2008)
Gastroenterology
, vol.135
, pp. 552-567
-
-
Takedatsu, H.1
Michelsen, K.S.2
Wei, B.3
Landers, C.J.4
Thomas, L.S.5
Dhall, D.6
Braun, J.7
Targan, S.R.8
-
37
-
-
0030954732
-
A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease
-
Crohn's Disease cA2 Study Group
-
Targan SR, Hanauer SB, van Deventer SJ, Mayer L, Present DH, Braakman T, DeWoody KL, Schaible TF, Rutgeerts PJ. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease. Crohn's Disease cA2 Study Group. N Engl J Med 1997; 337: 1029-1035
-
(1997)
N Engl J Med
, vol.337
, pp. 1029-1035
-
-
Targan, S.R.1
Hanauer, S.B.2
van Deventer, S.J.3
Mayer, L.4
Present, D.H.5
Braakman, T.6
Dewoody, K.L.7
Schaible, T.F.8
Rutgeerts, P.J.9
-
38
-
-
32044451548
-
Human anti-tumor necrosis factor monoclonal antibody (adalimumab) in Crohn's disease: The CLASSIC-I trial
-
quiz 591
-
Hanauer SB, Sandborn WJ, Rutgeerts P, Fedorak RN, Lukas M, MacIntosh D, Panaccione R, Wolf D, Pollack P. Human anti-tumor necrosis factor monoclonal antibody (adalimumab) in Crohn's disease: the CLASSIC-I trial. Gastroenterology 2006; 130: 323-333; quiz 591
-
(2006)
Gastroenterology
, vol.130
, pp. 323-333
-
-
Hanauer, S.B.1
Sandborn, W.J.2
Rutgeerts, P.3
Fedorak, R.N.4
Lukas, M.5
Macintosh, D.6
Panaccione, R.7
Wolf, D.8
Pollack, P.9
-
39
-
-
33846242958
-
Adalimumab for maintenance of clinical response and remission in patients with Crohn's disease: The CHARM trial
-
Colombel JF, Sandborn WJ, Rutgeerts P, Enns R, Hanauer SB, Panaccione R, Schreiber S, Byczkowski D, Li J, Kent JD, Pollack PF. Adalimumab for maintenance of clinical response and remission in patients with Crohn's disease: the CHARM trial. Gastroenterology 2007; 132: 52-65
-
(2007)
Gastroenterology
, vol.132
, pp. 52-65
-
-
Colombel, J.F.1
Sandborn, W.J.2
Rutgeerts, P.3
Enns, R.4
Hanauer, S.B.5
Panaccione, R.6
Schreiber, S.7
Byczkowski, D.8
Li, J.9
Kent, J.D.10
Pollack, P.F.11
-
40
-
-
0037018761
-
Maintenance infliximab for Crohn's disease: The ACCENT I randomised trial
-
Hanauer SB, Feagan BG, Lichtenstein GR, Mayer LF, Schreiber S, Colombel JF, Rachmilewitz D, Wolf DC, Olson A, Bao W, Rutgeerts P. Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial. Lancet 2002; 359: 1541-1549
-
(2002)
Lancet
, vol.359
, pp. 1541-1549
-
-
Hanauer, S.B.1
Feagan, B.G.2
Lichtenstein, G.R.3
Mayer, L.F.4
Schreiber, S.5
Colombel, J.F.6
Rachmilewitz, D.7
Wolf, D.C.8
Olson, A.9
Bao, W.10
Rutgeerts, P.11
-
41
-
-
34447523749
-
Certolizumab pegol for the treatment of Crohn's disease
-
Sandborn WJ, Feagan BG, Stoinov S, Honiball PJ, Rutgeerts P, Mason D, Bloomfield R, Schreiber S. Certolizumab pegol for the treatment of Crohn's disease. N Engl J Med 2007; 357: 228-238
-
(2007)
N Engl J Med
, vol.357
, pp. 228-238
-
-
Sandborn, W.J.1
Feagan, B.G.2
Stoinov, S.3
Honiball, P.J.4
Rutgeerts, P.5
Mason, D.6
Bloomfield, R.7
Schreiber, S.8
-
42
-
-
34447515607
-
Maintenance therapy with certolizumab pegol for Crohn's disease
-
Schreiber S, Khaliq-Kareemi M, Lawrance IC, Thomsen OØ, Hanauer SB, McColm J, Bloomfield R, Sandborn WJ. Maintenance therapy with certolizumab pegol for Crohn's disease. N Engl J Med 2007; 357: 239-250
-
(2007)
N Engl J Med
, vol.357
, pp. 239-250
-
-
Schreiber, S.1
Khaliq-Kareemi, M.2
Lawrance, I.C.3
Thomsen, O.O.4
Hanauer, S.B.5
McColm, J.6
Bloomfield, R.7
Sandborn, W.J.8
-
43
-
-
0033529049
-
Infliximab for the treatment of fistulas in patients with Crohn's disease
-
Present DH, Rutgeerts P, Targan S, Hanauer SB, Mayer L, van Hogezand RA, Podolsky DK, Sands BE, Braakman T, DeWoody KL, Schaible TF, van Deventer SJ. Infliximab for the treatment of fistulas in patients with Crohn's disease. N Engl J Med 1999; 340: 1398-1405
-
(1999)
N Engl J Med
, vol.340
, pp. 1398-1405
-
-
Present, D.H.1
Rutgeerts, P.2
Targan, S.3
Hanauer, S.B.4
Mayer, L.5
van Hogezand, R.A.6
Podolsky, D.K.7
Sands, B.E.8
Braakman, T.9
Dewoody, K.L.10
Schaible, T.F.11
van Deventer, S.J.12
-
44
-
-
28844473957
-
Infliximab for induction and maintenance therapy for ulcerative colitis
-
Rutgeerts P, Sandborn WJ, Feagan BG, Reinisch W, Olson A, Johanns J, Travers S, Rachmilewitz D, Hanauer SB, Lichtenstein GR, de Villiers WJ, Present D, Sands BE, Colombel JF. Infliximab for induction and maintenance therapy for ulcerative colitis. N Engl J Med 2005; 353: 2462-2476
-
(2005)
N Engl J Med
, vol.353
, pp. 2462-2476
-
-
Rutgeerts, P.1
Sandborn, W.J.2
Feagan, B.G.3
Reinisch, W.4
Olson, A.5
Johanns, J.6
Travers, S.7
Rachmilewitz, D.8
Hanauer, S.B.9
Lichtenstein, G.R.10
de Villiers, W.J.11
Present, D.12
Sands, B.E.13
Colombel, J.F.14
-
45
-
-
33646147141
-
Serious infections and mortality in association with therapies for Crohn's disease: TREAT registry
-
Lichtenstein GR, Feagan BG, Cohen RD, Salzberg BA, Diamond RH, Chen DM, Pritchard ML, Sandborn WJ. Serious infections and mortality in association with therapies for Crohn's disease: TREAT registry. Clin Gastroenterol Hepatol 2006; 4: 621-630
-
(2006)
Clin Gastroenterol Hepatol
, vol.4
, pp. 621-630
-
-
Lichtenstein, G.R.1
Feagan, B.G.2
Cohen, R.D.3
Salzberg, B.A.4
Diamond, R.H.5
Chen, D.M.6
Pritchard, M.L.7
Sandborn, W.J.8
-
46
-
-
9644252669
-
New cytokine therapeutics for inflammatory bowel disease
-
Stokkers PC, Hommes DW. New cytokine therapeutics for inflammatory bowel disease. Cytokine 2004; 28: 167-173
-
(2004)
Cytokine
, vol.28
, pp. 167-173
-
-
Stokkers, P.C.1
Hommes, D.W.2
-
47
-
-
0031943618
-
The interleukin-12/interleukin-12-receptor system: Role in normal and pathologic immune responses
-
Gately MK, Renzetti LM, Magram J, Stern AS, Adorini L, Gubler U, Presky DH. The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses. Annu Rev Immunol 1998; 16: 495-521
-
(1998)
Annu Rev Immunol
, vol.16
, pp. 495-521
-
-
Gately, M.K.1
Renzetti, L.M.2
Magram, J.3
Stern, A.S.4
Adorini, L.5
Gubler, U.6
Presky, D.H.7
-
48
-
-
0031937388
-
Proinflammatory and immunoregulatory functions of interleukin-12
-
Trinchieri G. Proinflammatory and immunoregulatory functions of interleukin-12. Int Rev Immunol 1998; 16: 365-396
-
(1998)
Int Rev Immunol
, vol.16
, pp. 365-396
-
-
Trinchieri, G.1
-
49
-
-
8344284998
-
Anti-interleukin-12 antibody for active Crohn's disease
-
Mannon PJ, Fuss IJ, Mayer L, Elson CO, Sandborn WJ, Present D, Dolin B, Goodman N, Groden C, Hornung RL, Quezado M, Yang Z, Neurath MF, Salfeld J, Veldman GM, Schwertschlag U, Strober W. Anti-interleukin-12 antibody for active Crohn's disease. N Engl J Med 2004; 351: 2069-2079
-
(2004)
N Engl J Med
, vol.351
, pp. 2069-2079
-
-
Mannon, P.J.1
Fuss, I.J.2
Mayer, L.3
Elson, C.O.4
Sandborn, W.J.5
Present, D.6
Dolin, B.7
Goodman, N.8
Groden, C.9
Hornung, R.L.10
Quezado, M.11
Yang, Z.12
Neurath, M.F.13
Salfeld, J.14
Veldman, G.M.15
Schwertschlag, U.16
Strober, W.17
-
50
-
-
0030995575
-
Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells
-
Monteleone G, Biancone L, Marasco R, Morrone G, Marasco O, Luzza F, Pallone F. Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells. Gastroenterology 1997; 112: 1169-1178
-
(1997)
Gastroenterology
, vol.112
, pp. 1169-1178
-
-
Monteleone, G.1
Biancone, L.2
Marasco, R.3
Morrone, G.4
Marasco, O.5
Luzza, F.6
Pallone, F.7
-
51
-
-
0031057872
-
Type 1 T-helper cell predominance and interleukin-12 expression in the gut of patients with Crohn's disease
-
Parronchi P, Romagnani P, Annunziato F, Sampognaro S, Becchio A, Giannarini L, Maggi E, Pupilli C, Tonelli F, Romagnani S. Type 1 T-helper cell predominance and interleukin-12 expression in the gut of patients with Crohn's disease. Am J Pathol 1997; 150: 823-832
-
(1997)
Am J Pathol
, vol.150
, pp. 823-832
-
-
Parronchi, P.1
Romagnani, P.2
Annunziato, F.3
Sampognaro, S.4
Becchio, A.5
Giannarini, L.6
Maggi, E.7
Pupilli, C.8
Tonelli, F.9
Romagnani, S.10
-
52
-
-
33646560950
-
Transforming growth factor-beta induces development of the T(H)17 lineage
-
Mangan PR, Harrington LE, O'Quinn DB, Helms WS, Bullard DC, Elson CO, Hatton RD, Wahl SM, Schoeb TR, Weaver CT. Transforming growth factor-beta induces development of the T(H)17 lineage. Nature 2006; 441: 231-234
-
(2006)
Nature
, vol.441
, pp. 231-234
-
-
Mangan, P.R.1
Harrington, L.E.2
O'Quinn, D.B.3
Helms, W.S.4
Bullard, D.C.5
Elson, C.O.6
Hatton, R.D.7
Wahl, S.M.8
Schoeb, T.R.9
Weaver, C.T.10
-
53
-
-
39449110445
-
The link between IL-23 and Th17 cell-mediated immune pathologies
-
McGeachy MJ, Cua DJ. The link between IL-23 and Th17 cell-mediated immune pathologies. Semin Immunol 2007; 19: 372-376
-
(2007)
Semin Immunol
, vol.19
, pp. 372-376
-
-
McGeachy, M.J.1
Cua, D.J.2
-
54
-
-
48349136889
-
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
-
Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD, Brant SR, Silverberg MS, Taylor KD, Barmada MM, Bitton A, Dassopoulos T, Datta LW, Green T, Griffiths AM, Kistner EO, Murtha MT, Regueiro MD, Rotter JI, Schumm LP, Steinhart AH, Targan SR, Xavier RJ, Libioulle C, Sandor C, Lathrop M, Belaiche J, Dewit O, Gut I, Heath S, Laukens D, Mni M, Rutgeerts P, Van Gossum A, Zelenika D, Franchimont D, Hugot JP, de Vos M, Vermeire S, Louis E, Cardon LR, Anderson CA, Drummond H, Nimmo E, Ahmad T, Prescott NJ, Onnie CM, Fisher SA, Marchini J, Ghori J, Bumpstead S, Gwilliam R, Tremelling M, Deloukas P, Mansfield J, Jewell D, Satsangi J, Mathew CG, Parkes M, Georges M, Daly MJ. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet 2008; 40: 955-962
-
(2008)
Nat Genet
, vol.40
, pp. 955-962
-
-
Barrett, J.C.1
Hansoul, S.2
Nicolae, D.L.3
Cho, J.H.4
Duerr, R.H.5
Rioux, J.D.6
Brant, S.R.7
Silverberg, M.S.8
Taylor, K.D.9
Barmada, M.M.10
Bitton, A.11
Dassopoulos, T.12
Datta, L.W.13
Green, T.14
Griffiths, A.M.15
Kistner, E.O.16
Murtha, M.T.17
Regueiro, M.D.18
Rotter, J.I.19
Schumm, L.P.20
Steinhart, A.H.21
Targan, S.R.22
Xavier, R.J.23
Libioulle, C.24
Sandor, C.25
Lathrop, M.26
Belaiche, J.27
Dewit, O.28
Gut, I.29
Heath, S.30
Laukens, D.31
Mni, M.32
Rutgeerts, P.33
van Gossum, A.34
Zelenika, D.35
Franchimont, D.36
Hugot, J.P.37
de Vos, M.38
Vermeire, S.39
Louis, E.40
Cardon, L.R.41
Anderson, C.A.42
Drummond, H.43
Nimmo, E.44
Ahmad, T.45
Prescott, N.J.46
Onnie, C.M.47
Fisher, S.A.48
Marchini, J.49
Ghori, J.50
Bumpstead, S.51
Gwilliam, R.52
Tremelling, M.53
Deloukas, P.54
Mansfield, J.55
Jewell, D.56
Satsangi, J.57
Mathew, C.G.58
Parkes, M.59
Georges, M.60
Daly, M.J.61
more..
-
55
-
-
33845340501
-
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
-
Duerr RH, Taylor KD, Brant SR, Rioux JD, Silverberg MS, Daly MJ, Steinhart AH, Abraham C, Regueiro M, Griffiths A, Dassopoulos T, Bitton A, Yang H, Targan S, Datta LW, Kistner EO, Schumm LP, Lee AT, Gregersen PK, Barmada MM, Rotter JI, Nicolae DL, Cho JH. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 2006; 314: 1461-1463
-
(2006)
Science
, vol.314
, pp. 1461-1463
-
-
Duerr, R.H.1
Taylor, K.D.2
Brant, S.R.3
Rioux, J.D.4
Silverberg, M.S.5
Daly, M.J.6
Steinhart, A.H.7
Abraham, C.8
Regueiro, M.9
Griffiths, A.10
Dassopoulos, T.11
Bitton, A.12
Yang, H.13
Targan, S.14
Datta, L.W.15
Kistner, E.O.16
Schumm, L.P.17
Lee, A.T.18
Gregersen, P.K.19
Barmada, M.M.20
Rotter, J.I.21
Nicolae, D.L.22
Cho, J.H.23
more..
-
56
-
-
53049091561
-
A randomized trial of Ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn's disease
-
Sandborn WJ, Feagan BG, Fedorak RN, Scherl E, Fleisher MR, Katz S, Johanns J, Blank M, Rutgeerts P. A randomized trial of Ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn's disease. Gastroenterology 2008; 135: 1130-1141
-
(2008)
Gastroenterology
, vol.135
, pp. 1130-1141
-
-
Sandborn, W.J.1
Feagan, B.G.2
Fedorak, R.N.3
Scherl, E.4
Fleisher, M.R.5
Katz, S.6
Johanns, J.7
Blank, M.8
Rutgeerts, P.9
-
57
-
-
77953693548
-
Randomized, double-blind, placebo-controlled trial of the oral interleukin-12/23 inhibitor apilimod mesylate for treatment of active Crohn's disease
-
Sands BE, Jacobson EW, Sylwestrowicz T, Younes Z, Dryden G, Fedorak R, Greenbloom S. Randomized, double-blind, placebo-controlled trial of the oral interleukin-12/23 inhibitor apilimod mesylate for treatment of active Crohn's disease. Inflamm Bowel Dis 2010; 16: 1209-1218
-
(2010)
Inflamm Bowel Dis
, vol.16
, pp. 1209-1218
-
-
Sands, B.E.1
Jacobson, E.W.2
Sylwestrowicz, T.3
Younes, Z.4
Dryden, G.5
Fedorak, R.6
Greenbloom, S.7
-
58
-
-
0024360388
-
The biology of interleukin-6
-
Kishimoto T. The biology of interleukin-6. Blood 1989; 74: 1-10
-
(1989)
Blood
, vol.74
, pp. 1-10
-
-
Kishimoto, T.1
-
59
-
-
67349104400
-
Interleukin-6 as a key player in systemic inflammation and joint destruction
-
Fonseca JE, Santos MJ, Canhão H, Choy E. Interleukin-6 as a key player in systemic inflammation and joint destruction. Autoimmun Rev 2009; 8: 538-542
-
(2009)
Autoimmun Rev
, vol.8
, pp. 538-542
-
-
Fonseca, J.E.1
Santos, M.J.2
Canhão, H.3
Choy, E.4
-
61
-
-
0029147155
-
Toxicity and efficacy of escalating dosages of recombinant human interleukin-6 after chemotherapy in patients with breast cancer or non-small-cell lung cancer
-
Veldhuis GJ, Willemse PH, Sleijfer DT, van der Graaf WT, Groen HJ, Limburg PC, Mulder NH, de Vries EG. Toxicity and efficacy of escalating dosages of recombinant human interleukin-6 after chemotherapy in patients with breast cancer or non-small-cell lung cancer. J Clin Oncol 1995; 13: 2585-2593
-
(1995)
J Clin Oncol
, vol.13
, pp. 2585-2593
-
-
Veldhuis, G.J.1
Willemse, P.H.2
Sleijfer, D.T.3
van der Graaf, W.T.4
Groen, H.J.5
Limburg, P.C.6
Mulder, N.H.7
de Vries, E.G.8
-
62
-
-
18344410191
-
Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: Evidence in crohn disease and experimental colitis in vivo
-
Atreya R, Mudter J, Finotto S, Müllberg J, Jostock T, Wirtz S, Schütz M, Bartsch B, Holtmann M, Becker C, Strand D, Czaja J, Schlaak JF, Lehr HA, Autschbach F, Schürmann G, Nishimoto N, Yoshizaki K, Ito H, Kishimoto T, Galle PR, Rose-John S, Neurath MF. Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo. Nat Med 2000; 6: 583-588
-
(2000)
Nat Med
, vol.6
, pp. 583-588
-
-
Atreya, R.1
Mudter, J.2
Finotto, S.3
Müllberg, J.4
Jostock, T.5
Wirtz, S.6
Schütz, M.7
Bartsch, B.8
Holtmann, M.9
Becker, C.10
Strand, D.11
Czaja, J.12
Schlaak, J.F.13
Lehr, H.A.14
Autschbach, F.15
Schürmann, G.16
Nishimoto, N.17
Yoshizaki, K.18
Ito, H.19
Kishimoto, T.20
Galle, P.R.21
Rose-John, S.22
Neurath, M.F.23
more..
-
63
-
-
37249013895
-
Serum interleukin-6, soluble interleukin-6 receptor and Crohn's disease activity
-
Nancey S, Hamzaoui N, Moussata D, Graber I, Bienvenu J, Flourie B. Serum interleukin-6, soluble interleukin-6 receptor and Crohn's disease activity. Dig Dis Sci 2008; 53: 242-247
-
(2008)
Dig Dis Sci
, vol.53
, pp. 242-247
-
-
Nancey, S.1
Hamzaoui, N.2
Moussata, D.3
Graber, I.4
Bienvenu, J.5
Flourie, B.6
-
64
-
-
11144358366
-
A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease
-
discussion 947
-
Ito H, Takazoe M, Fukuda Y, Hibi T, Kusugami K, Andoh A, Matsumoto T, Yamamura T, Azuma J, Nishimoto N, Yoshizaki K, Shimoyama T, Kishimoto T. A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease. Gastroenterology 2004; 126: 989-996; discussion 947
-
(2004)
Gastroenterology
, vol.126
, pp. 989-996
-
-
Ito, H.1
Takazoe, M.2
Fukuda, Y.3
Hibi, T.4
Kusugami, K.5
Andoh, A.6
Matsumoto, T.7
Yamamura, T.8
Azuma, J.9
Nishimoto, N.10
Yoshizaki, K.11
Shimoyama, T.12
Kishimoto, T.13
-
65
-
-
42449088420
-
Successful treatment of a patient with Takayasu arteritis using a humanized anti-interleukin-6 receptor antibody
-
Nishimoto N, Nakahara H, Yoshio-Hoshino N, Mima T. Successful treatment of a patient with Takayasu arteritis using a humanized anti-interleukin-6 receptor antibody. Arthritis Rheum 2008; 58: 1197-1200
-
(2008)
Arthritis Rheum
, vol.58
, pp. 1197-1200
-
-
Nishimoto, N.1
Nakahara, H.2
Yoshio-Hoshino, N.3
Mima, T.4
-
66
-
-
33746146891
-
Interfering with interferons in inflammatory bowel disease
-
Ghosh S, Chaudhary R, Carpani M, Playford R. Interfering with interferons in inflammatory bowel disease. Gut 2006; 55: 1071-1073
-
(2006)
Gut
, vol.55
, pp. 1071-1073
-
-
Ghosh, S.1
Chaudhary, R.2
Carpani, M.3
Playford, R.4
-
67
-
-
0038781673
-
Gamma interferon augments the intracellular pathway for lipopolysaccharide (LPS) recognition in human intestinal epithelial cells through coordinated up-regulation of LPS uptake and expression of the intracellular Toll-like receptor 4-MD-2 complex
-
Suzuki M, Hisamatsu T, Podolsky DK. Gamma interferon augments the intracellular pathway for lipopolysaccharide (LPS) recognition in human intestinal epithelial cells through coordinated up-regulation of LPS uptake and expression of the intracellular Toll-like receptor 4-MD-2 complex. Infect Immun 2003; 71: 3503-3511
-
(2003)
Infect Immun
, vol.71
, pp. 3503-3511
-
-
Suzuki, M.1
Hisamatsu, T.2
Podolsky, D.K.3
-
68
-
-
33746176176
-
Fontolizumab, a humanised anti-interferon gamma antibody, demonstrates safety and clinical activity in patients with moderate to severe Crohn's disease
-
Hommes DW, Mikhajlova TL, Stoinov S, Stimac D, Vucelic B, Lonovics J, Zákuciová M, D'Haens G, Van Assche G, Ba S, Lee S, Pearce T. Fontolizumab, a humanised anti-interferon gamma antibody, demonstrates safety and clinical activity in patients with moderate to severe Crohn's disease. Gut 2006; 55: 1131-1137
-
(2006)
Gut
, vol.55
, pp. 1131-1137
-
-
Hommes, D.W.1
Mikhajlova, T.L.2
Stoinov, S.3
Stimac, D.4
Vucelic, B.5
Lonovics, J.6
Zákuciová, M.7
D'haens, G.8
van Assche, G.9
Ba, S.10
Lee, S.11
Pearce, T.12
-
69
-
-
73949092345
-
Fontolizumab in moderate to severe Crohn's disease: A phase 2, randomized, double-blind, placebo-controlled, multipledose study
-
Reinisch W, de Villiers W, Bene L, Simon L, Rácz I, Katz S, Altorjay I, Feagan B, Riff D, Bernstein CN, Hommes D, Rutgeerts P, Cortot A, Gaspari M, Cheng M, Pearce T, Sands BE. Fontolizumab in moderate to severe Crohn's disease: a phase 2, randomized, double-blind, placebo-controlled, multipledose study. Inflamm Bowel Dis 2010; 16: 233-242
-
(2010)
Inflamm Bowel Dis
, vol.16
, pp. 233-242
-
-
Reinisch, W.1
de Villiers, W.2
Bene, L.3
Simon, L.4
Rácz, I.5
Katz, S.6
Altorjay, I.7
Feagan, B.8
Riff, D.9
Bernstein, C.N.10
Hommes, D.11
Rutgeerts, P.12
Cortot, A.13
Gaspari, M.14
Cheng, M.15
Pearce, T.16
Sands, B.E.17
-
70
-
-
33746132472
-
A dose escalating, placebo controlled, double blind, single dose and multidose, safety and tolerability study of fontolizumab, a humanised anti-interferon gamma antibody, in patients with moderate to severe Crohn's disease
-
Reinisch W, Hommes DW, Van Assche G, Colombel JF, Gendre JP, Oldenburg B, Teml A, Geboes K, Ding H, Zhang L, Tang M, Cheng M, van Deventer SJ, Rutgeerts P, Pearce T. A dose escalating, placebo controlled, double blind, single dose and multidose, safety and tolerability study of fontolizumab, a humanised anti-interferon gamma antibody, in patients with moderate to severe Crohn's disease. Gut 2006; 55: 1138-1144
-
(2006)
Gut
, vol.55
, pp. 1138-1144
-
-
Reinisch, W.1
Hommes, D.W.2
van Assche, G.3
Colombel, J.F.4
Gendre, J.P.5
Oldenburg, B.6
Teml, A.7
Geboes, K.8
Ding, H.9
Zhang, L.10
Tang, M.11
Cheng, M.12
van Deventer, S.J.13
Rutgeerts, P.14
Pearce, T.15
-
71
-
-
0013851832
-
A lymphocyte-stimulating factor produced in vitro
-
Gordon J, MacLean LD. A lymphocyte-stimulating factor produced in vitro. Nature 1965; 208: 795-796
-
(1965)
Nature
, vol.208
, pp. 795-796
-
-
Gordon, J.1
Maclean, L.D.2
-
72
-
-
73849109835
-
Pharmacologic administration of interleukin-2
-
Chavez AR, Buchser W, Basse PH, Liang X, Appleman LJ, Maranchie JK, Zeh H, de Vera ME, Lotze MT. Pharmacologic administration of interleukin-2. Ann N Y Acad Sci 2009; 1182: 14-27
-
(2009)
Ann N Y Acad Sci
, vol.1182
, pp. 14-27
-
-
Chavez, A.R.1
Buchser, W.2
Basse, P.H.3
Liang, X.4
Appleman, L.J.5
Maranchie, J.K.6
Zeh, H.7
de Vera, M.E.8
Lotze, M.T.9
-
73
-
-
0028292007
-
Cyclosporine in severe ulcerative colitis refractory to steroid therapy
-
Lichtiger S, Present DH, Kornbluth A, Gelernt I, Bauer J, Galler G, Michelassi F, Hanauer S. Cyclosporine in severe ulcerative colitis refractory to steroid therapy. N Engl J Med 1994; 330: 1841-1845
-
(1994)
N Engl J Med
, vol.330
, pp. 1841-1845
-
-
Lichtiger, S.1
Present, D.H.2
Kornbluth, A.3
Gelernt, I.4
Bauer, J.5
Galler, G.6
Michelassi, F.7
Hanauer, S.8
-
74
-
-
0036784616
-
IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response
-
Strengell M, Sareneva T, Foster D, Julkunen I, Matikainen S. IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response. J Immunol 2002; 169: 3600-3605
-
(2002)
J Immunol
, vol.169
, pp. 3600-3605
-
-
Strengell, M.1
Sareneva, T.2
Foster, D.3
Julkunen, I.4
Matikainen, S.5
-
75
-
-
41349121555
-
Regulation of gut inflammation and th17 cell response by interleukin-21
-
Fina D, Sarra M, Fantini MC, Rizzo A, Caruso R, Caprioli F, Stolfi C, Cardolini I, Dottori M, Boirivant M, Pallone F, Macdonald TT, Monteleone G. Regulation of gut inflammation and th17 cell response by interleukin-21. Gastroenterology 2008; 134: 1038-1048
-
(2008)
Gastroenterology
, vol.134
, pp. 1038-1048
-
-
Fina, D.1
Sarra, M.2
Fantini, M.C.3
Rizzo, A.4
Caruso, R.5
Caprioli, F.6
Stolfi, C.7
Cardolini, I.8
Dottori, M.9
Boirivant, M.10
Pallone, F.11
Macdonald, T.T.12
Monteleone, G.13
-
76
-
-
10744232542
-
Basiliximab (anti-CD25) in combination with steroids may be an effective new treatment for steroid-resistant ulcerative colitis
-
Creed TJ, Norman MR, Probert CS, Harvey RF, Shaw IS, Smithson J, Anderson J, Moorghen M, Gupta J, Shepherd NA, Dayan CM, Hearing SD. Basiliximab (anti-CD25) in combination with steroids may be an effective new treatment for steroid-resistant ulcerative colitis. Aliment Pharmacol Ther 2003; 18: 65-75
-
(2003)
Aliment Pharmacol Ther
, vol.18
, pp. 65-75
-
-
Creed, T.J.1
Norman, M.R.2
Probert, C.S.3
Harvey, R.F.4
Shaw, I.S.5
Smithson, J.6
Anderson, J.7
Moorghen, M.8
Gupta, J.9
Shepherd, N.A.10
Dayan, C.M.11
Hearing, S.D.12
-
77
-
-
33646232018
-
Basiliximab for the treatment of steroid-resistant ulcerative colitis: Further experience in moderate and severe disease
-
Creed TJ, Probert CS, Norman MN, Moorghen M, Shepherd NA, Hearing SD, Dayan CM. Basiliximab for the treatment of steroid-resistant ulcerative colitis: further experience in moderate and severe disease. Aliment Pharmacol Ther 2006; 23: 1435-1442
-
(2006)
Aliment Pharmacol Ther
, vol.23
, pp. 1435-1442
-
-
Creed, T.J.1
Probert, C.S.2
Norman, M.N.3
Moorghen, M.4
Shepherd, N.A.5
Hearing, S.D.6
Dayan, C.M.7
-
78
-
-
0037285975
-
A pilot study on the use of the humanized anti-interleukin-2 receptor antibody daclizumab in active ulcerative colitis
-
Van Assche G, Dalle I, Noman M, Aerden I, Swijsen C, Asnong K, Maes B, Ceuppens J, Geboes K, Rutgeerts P. A pilot study on the use of the humanized anti-interleukin-2 receptor antibody daclizumab in active ulcerative colitis. Am J Gastroenterol 2003; 98: 369-376
-
(2003)
Am J Gastroenterol
, vol.98
, pp. 369-376
-
-
van Assche, G.1
Dalle, I.2
Noman, M.3
Aerden, I.4
Swijsen, C.5
Asnong, K.6
Maes, B.7
Ceuppens, J.8
Geboes, K.9
Rutgeerts, P.10
-
79
-
-
33750343050
-
Daclizumab, a humanised monoclonal antibody to the interleukin 2 receptor (CD25), for the treatment of moderately to severely active ulcerative colitis: A randomised, double blind, placebo controlled, dose ranging trial
-
Van Assche G, Sandborn WJ, Feagan BG, Salzberg BA, Silvers D, Monroe PS, Pandak WM, Anderson FH, Valentine JF, Wild GE, Geenen DJ, Sprague R, Targan SR, Rutgeerts P, Vexler V, Young D, Shames RS. Daclizumab, a humanised monoclonal antibody to the interleukin 2 receptor (CD25), for the treatment of moderately to severely active ulcerative colitis: a randomised, double blind, placebo controlled, dose ranging trial. Gut 2006; 55: 1568-1574
-
(2006)
Gut
, vol.55
, pp. 1568-1574
-
-
van Assche, G.1
Sandborn, W.J.2
Feagan, B.G.3
Salzberg, B.A.4
Silvers, D.5
Monroe, P.S.6
Pandak, W.M.7
Anderson, F.H.8
Valentine, J.F.9
Wild, G.E.10
Geenen, D.J.11
Sprague, R.12
Targan, S.R.13
Rutgeerts, P.14
Vexler, V.15
Young, D.16
Shames, R.S.17
-
81
-
-
0027521572
-
Interleukin-10-deficient mice develop chronic enterocolitis
-
Kühn R, Löhler J, Rennick D, Rajewsky K, Müller W. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 1993; 75: 263-274
-
(1993)
Cell
, vol.75
, pp. 263-274
-
-
Kühn, R.1
Löhler, J.2
Rennick, D.3
Rajewsky, K.4
Müller, W.5
-
82
-
-
0032536530
-
The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptor
-
Spencer SD, Di Marco F, Hooley J, Pitts-Meek S, Bauer M, Ryan AM, Sordat B, Gibbs VC, Aguet M. The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptor. J Exp Med 1998; 187: 571-578
-
(1998)
J Exp Med
, vol.187
, pp. 571-578
-
-
Spencer, S.D.1
di Marco, F.2
Hooley, J.3
Pitts-Meek, S.4
Bauer, M.5
Ryan, A.M.6
Sordat, B.7
Gibbs, V.C.8
Aguet, M.9
-
83
-
-
0028907439
-
Immunoregulatory role of interleukin 10 in patients with inflammatory bowel disease
-
Schreiber S, Heinig T, Thiele HG, Raedler A. Immunoregulatory role of interleukin 10 in patients with inflammatory bowel disease. Gastroenterology 1995; 108: 1434-1444
-
(1995)
Gastroenterology
, vol.108
, pp. 1434-1444
-
-
Schreiber, S.1
Heinig, T.2
Thiele, H.G.3
Raedler, A.4
-
84
-
-
70949107956
-
Interleukin-10 in inflammatory bowel disease
-
Kelsall B. Interleukin-10 in inflammatory bowel disease. N Engl J Med 2009; 361: 2091-2093
-
(2009)
N Engl J Med
, vol.361
, pp. 2091-2093
-
-
Kelsall, B.1
-
85
-
-
0000234094
-
Safety and tolerance of rHuIL-10 treatment in patients with mild/moderate active ulcerative colitis
-
the Ulcerative Colitis IL-10 Cooperative Study Group
-
Schreiber S, Fedorak RN, Wild G, Gangl A, Targan S, Jacyna M, Wright JP, Kilian A, Cohard M, Lebeaut A, Tremaine WJ, the Ulcerative Colitis IL-10 Cooperative Study Group. Safety and tolerance of rHuIL-10 treatment in patients with mild/moderate active ulcerative colitis. Gastroenterology 1998; 114: A1080-A1081
-
(1998)
Gastroenterology
, vol.114
-
-
Schreiber, S.1
Fedorak, R.N.2
Wild, G.3
Gangl, A.4
Targan, S.5
Jacyna, M.6
Wright, J.P.7
Kilian, A.8
Cohard, M.9
Lebeaut, A.10
Tremaine, W.J.11
-
86
-
-
0034464148
-
Safety and efficacy of recombinant human interleukin 10 in chronic active Crohn's disease
-
Crohn's Disease IL-10 Cooperative Study Group
-
Schreiber S, Fedorak RN, Nielsen OH, Wild G, Williams CN, Nikolaus S, Jacyna M, Lashner BA, Gangl A, Rutgeerts P, Isaacs K, van Deventer SJ, Koningsberger JC, Cohard M, Le-Beaut A, Hanauer SB. Safety and efficacy of recombinant human interleukin 10 in chronic active Crohn's disease. Crohn's Disease IL-10 Cooperative Study Group. Gastroenterology 2000; 119: 1461-1472
-
(2000)
Gastroenterology
, vol.119
, pp. 1461-1472
-
-
Schreiber, S.1
Fedorak, R.N.2
Nielsen, O.H.3
Wild, G.4
Williams, C.N.5
Nikolaus, S.6
Jacyna, M.7
Lashner, B.A.8
Gangl, A.9
Rutgeerts, P.10
Isaacs, K.11
van Deventer, S.J.12
Koningsberger, J.C.13
Cohard, M.14
Le-Beaut, A.15
Hanauer, S.B.16
-
87
-
-
0034956334
-
Interleukin 10 (Tenovil) in the prevention of postoperative recurrence of Crohn's disease
-
Colombel JF, Rutgeerts P, Malchow H, Jacyna M, Nielsen OH, Rask-Madsen J, Van Deventer S, Ferguson A, Desreumaux P, Forbes A, Geboes K, Melani L, Cohard M. Interleukin 10 (Tenovil) in the prevention of postoperative recurrence of Crohn's disease. Gut 2001; 49: 42-46
-
(2001)
Gut
, vol.49
, pp. 42-46
-
-
Colombel, J.F.1
Rutgeerts, P.2
Malchow, H.3
Jacyna, M.4
Nielsen, O.H.5
Rask-Madsen, J.6
van Deventer, S.7
Ferguson, A.8
Desreumaux, P.9
Forbes, A.10
Geboes, K.11
Melani, L.12
Cohard, M.13
-
88
-
-
0034714188
-
Treatment of murine colitis by Lactococcus lactis secreting interleukin-10
-
Steidler L, Hans W, Schotte L, Neirynck S, Obermeier F, Falk W, Fiers W, Remaut E. Treatment of murine colitis by Lactococcus lactis secreting interleukin-10. Science 2000; 289: 1352-1355
-
(2000)
Science
, vol.289
, pp. 1352-1355
-
-
Steidler, L.1
Hans, W.2
Schotte, L.3
Neirynck, S.4
Obermeier, F.5
Falk, W.6
Fiers, W.7
Remaut, E.8
-
89
-
-
0030917254
-
Interleukin-11: Review of molecular, cell biology, and clinical use
-
Du X, Williams DA. Interleukin-11: review of molecular, cell biology, and clinical use. Blood 1997; 89: 3897-3908
-
(1997)
Blood
, vol.89
, pp. 3897-3908
-
-
Du, X.1
Williams, D.A.2
-
90
-
-
33645455612
-
Randomized, double blind controlled trial of subcutaneous recombinant human interleukin-11 vs prednisolone in active Crohn's disease
-
Herrlinger KR, Witthoeft T, Raedler A, Bokemeyer B, Krummenerl T, Schulzke JD, Boerner N, Kueppers B, Emmrich J, Mescheder A, Schwertschlag U, Shapiro M, Stange EF. Randomized, double blind controlled trial of subcutaneous recombinant human interleukin-11 vs prednisolone in active Crohn's disease. Am J Gastroenterol 2006; 101: 793-797
-
(2006)
Am J Gastroenterol
, vol.101
, pp. 793-797
-
-
Herrlinger, K.R.1
Witthoeft, T.2
Raedler, A.3
Bokemeyer, B.4
Krummenerl, T.5
Schulzke, J.D.6
Boerner, N.7
Kueppers, B.8
Emmrich, J.9
Mescheder, A.10
Schwertschlag, U.11
Shapiro, M.12
Stange, E.F.13
-
91
-
-
0031229726
-
Interleukin-11 inhibits macrophage interleukin-12 production
-
Leng SX, Elias JA. Interleukin-11 inhibits macrophage interleukin-12 production. J Immunol 1997; 159: 2161-2168
-
(1997)
J Immunol
, vol.159
, pp. 2161-2168
-
-
Leng, S.X.1
Elias, J.A.2
-
92
-
-
0033404492
-
Interleukin-11 therapy selectively downregulates type I cytokine proinflammatory pathways in psoriasis lesions
-
Trepicchio WL, Ozawa M, Walters IB, Kikuchi T, Gilleaudeau P, Bliss JL, Schwertschlag U, Dorner AJ, Krueger JG. Interleukin-11 therapy selectively downregulates type I cytokine proinflammatory pathways in psoriasis lesions. J Clin Invest 1999; 104: 1527-1537
-
(1999)
J Clin Invest
, vol.104
, pp. 1527-1537
-
-
Trepicchio, W.L.1
Ozawa, M.2
Walters, I.B.3
Kikuchi, T.4
Gilleaudeau, P.5
Bliss, J.L.6
Schwertschlag, U.7
Dorner, A.J.8
Krueger, J.G.9
-
93
-
-
12144285844
-
Functional expression of the interleukin-11 receptor alpha-chain and evidence of antiapoptotic effects in human colonic epithelial cells
-
Kiessling S, Muller-Newen G, Leeb SN, Hausmann M, Rath HC, Strater J, Spottl T, Schlottmann K, Grossmann J, Montero-Julian FA, Scholmerich J, Andus T, Buschauer A, Heinrich PC, Rogler G. Functional expression of the interleukin-11 receptor alpha-chain and evidence of antiapoptotic effects in human colonic epithelial cells. J Biol Chem 2004; 279: 10304-10315
-
(2004)
J Biol Chem
, vol.279
, pp. 10304-10315
-
-
Kiessling, S.1
Muller-Newen, G.2
Leeb, S.N.3
Hausmann, M.4
Rath, H.C.5
Strater, J.6
Spottl, T.7
Schlottmann, K.8
Grossmann, J.9
Montero-Julian, F.A.10
Scholmerich, J.11
Andus, T.12
Buschauer, A.13
Heinrich, P.C.14
Rogler, G.15
-
94
-
-
0032989443
-
Preliminary evaluation of safety and activity of recombinant human interleukin 11 in patients with active Crohn's disease
-
Sands BE, Bank S, Sninsky CA, Robinson M, Katz S, Singleton JW, Miner PB, Safdi MA, Galandiuk S, Hanauer SB, Varilek GW, Buchman AL, Rodgers VD, Salzberg B, Cai B, Loewy J, DeBruin MF, Rogge H, Shapiro M, Schwertschlag US. Preliminary evaluation of safety and activity of recombinant human interleukin 11 in patients with active Crohn's disease. Gastroenterology 1999; 117: 58-64
-
(1999)
Gastroenterology
, vol.117
, pp. 58-64
-
-
Sands, B.E.1
Bank, S.2
Sninsky, C.A.3
Robinson, M.4
Katz, S.5
Singleton, J.W.6
Miner, P.B.7
Safdi, M.A.8
Galandiuk, S.9
Hanauer, S.B.10
Varilek, G.W.11
Buchman, A.L.12
Rodgers, V.D.13
Salzberg, B.14
Cai, B.15
Loewy, J.16
Debruin, M.F.17
Rogge, H.18
Shapiro, M.19
Schwertschlag, U.S.20
more..
-
95
-
-
0036186051
-
Randomized, controlled trial of recombinant human interleukin-11 in patients with active Crohn's disease
-
Sands BE, Winston BD, Salzberg B, Safdi M, Barish C, Wruble L, Wilkins R, Shapiro M, Schwertschlag US. Randomized, controlled trial of recombinant human interleukin-11 in patients with active Crohn's disease. Aliment Pharmacol Ther 2002; 16: 399-406
-
(2002)
Aliment Pharmacol Ther
, vol.16
, pp. 399-406
-
-
Sands, B.E.1
Winston, B.D.2
Salzberg, B.3
Safdi, M.4
Barish, C.5
Wruble, L.6
Wilkins, R.7
Shapiro, M.8
Schwertschlag, U.S.9
-
96
-
-
49849103846
-
Clinical trial: A multicentre, randomized, double-blind, placebo-controlled, dose-finding, phase II study of subcutaneous interferon-beta-1a in moderately active ulcerative colitis
-
Pena-Rossi C, Schreiber S, Golubovic G, Mertz-Nielsen A, Panes J, Rachmilewitz D, Shieh MJ, Simanenkov VI, Stanton D, Graffner H. Clinical trial: a multicentre, randomized, double-blind, placebo-controlled, dose-finding, phase II study of subcutaneous interferon-beta-1a in moderately active ulcerative colitis. Aliment Pharmacol Ther 2008; 28: 758-767
-
(2008)
Aliment Pharmacol Ther
, vol.28
, pp. 758-767
-
-
Pena-Rossi, C.1
Schreiber, S.2
Golubovic, G.3
Mertz-Nielsen, A.4
Panes, J.5
Rachmilewitz, D.6
Shieh, M.J.7
Simanenkov, V.I.8
Stanton, D.9
Graffner, H.10
-
97
-
-
10744225116
-
A randomised placebo controlled trial of pegylated interferon alpha in active ulcerative colitis
-
Tilg H, Vogelsang H, Ludwiczek O, Lochs H, Kaser A, Colombel JF, Ulmer H, Rutgeerts P, Krüger S, Cortot A, D'Haens G, Harrer M, Gasche C, Wrba F, Kuhn I, Reinisch W. A randomised placebo controlled trial of pegylated interferon alpha in active ulcerative colitis. Gut 2003; 52: 1728-1733
-
(2003)
Gut
, vol.52
, pp. 1728-1733
-
-
Tilg, H.1
Vogelsang, H.2
Ludwiczek, O.3
Lochs, H.4
Kaser, A.5
Colombel, J.F.6
Ulmer, H.7
Rutgeerts, P.8
Krüger, S.9
Cortot, A.10
D'haens, G.11
Harrer, M.12
Gasche, C.13
Wrba, F.14
Kuhn, I.15
Reinisch, W.16
-
98
-
-
63849101007
-
Long-term outcome of treatment with infliximab in 614 patients with Crohn's disease: Results from a single-centre cohort
-
Schnitzler F, Fidder H, Ferrante M, Noman M, Arijs I, Van Assche G, Hoffman I, Van Steen K, Vermeire S, Rutgeerts P. Long-term outcome of treatment with infliximab in 614 patients with Crohn's disease: results from a single-centre cohort. Gut 2009; 58: 492-500
-
(2009)
Gut
, vol.58
, pp. 492-500
-
-
Schnitzler, F.1
Fidder, H.2
Ferrante, M.3
Noman, M.4
Arijs, I.5
van Assche, G.6
Hoffman, I.7
van Steen, K.8
Vermeire, S.9
Rutgeerts, P.10
-
99
-
-
62049083383
-
Loss of response and requirement of infliximab dose intensification in Crohn's disease: A review
-
Gisbert JP, Panés J. Loss of response and requirement of infliximab dose intensification in Crohn's disease: a review. Am J Gastroenterol 2009; 104: 760-767
-
(2009)
Am J Gastroenterol
, vol.104
, pp. 760-767
-
-
Gisbert, J.P.1
Panés, J.2
-
100
-
-
41149115774
-
A humanized tumor necrosis factor receptor 1 (TNFR1)-specific antagonistic antibody for selective inhibition of tumor necrosis factor (TNF) action
-
Kontermann RE, Münkel S, Neumeyer J, Müller D, Branschädel M, Scheurich P, Pfizenmaier K. A humanized tumor necrosis factor receptor 1 (TNFR1)-specific antagonistic antibody for selective inhibition of tumor necrosis factor (TNF) action. J Immunother 2008; 31: 225-234
-
(2008)
J Immunother
, vol.31
, pp. 225-234
-
-
Kontermann, R.E.1
Münkel, S.2
Neumeyer, J.3
Müller, D.4
Branschädel, M.5
Scheurich, P.6
Pfizenmaier, K.7
-
101
-
-
27744586067
-
Small-molecule inhibition of TNF-alpha
-
He MM, Smith AS, Oslob JD, Flanagan WM, Braisted AC, Whitty A, Cancilla MT, Wang J, Lugovskoy AA, Yoburn JC, Fung AD, Farrington G, Eldredge JK, Day ES, Cruz LA, Cachero TG, Miller SK, Friedman JE, Choong IC, Cunningham BC. Small-molecule inhibition of TNF-alpha. Science 2005; 310: 1022-1025
-
(2005)
Science
, vol.310
, pp. 1022-1025
-
-
He, M.M.1
Smith, A.S.2
Oslob, J.D.3
Flanagan, W.M.4
Braisted, A.C.5
Whitty, A.6
Cancilla, M.T.7
Wang, J.8
Lugovskoy, A.A.9
Yoburn, J.C.10
Fung, A.D.11
Farrington, G.12
Eldredge, J.K.13
Day, E.S.14
Cruz, L.A.15
Cachero, T.G.16
Miller, S.K.17
Friedman, J.E.18
Choong, I.C.19
Cunningham, B.C.20
more..
-
102
-
-
8344258233
-
Cytokine-based therapies for Crohn's disease--new paradigms
-
Cominelli F. Cytokine-based therapies for Crohn's disease--new paradigms. N Engl J Med 2004; 351: 2045-2048
-
(2004)
N Engl J Med
, vol.351
, pp. 2045-2048
-
-
Cominelli, F.1
-
103
-
-
0028226982
-
Synergy between anti-CD4 and anti-tumor necrosis factor in the amelioration of established collagen-induced arthritis
-
Williams RO, Mason LJ, Feldmann M, Maini RN. Synergy between anti-CD4 and anti-tumor necrosis factor in the amelioration of established collagen-induced arthritis. Proc Natl Acad Sci USA 1994; 91: 2762-2766
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 2762-2766
-
-
Williams, R.O.1
Mason, L.J.2
Feldmann, M.3
Maini, R.N.4
-
104
-
-
33846184129
-
Safety and tolerability of concurrent natalizumab treatment for patients with Crohn's disease not in remission while receiving infliximab
-
Sands BE, Kozarek R, Spainhour J, Barish CF, Becker S, Goldberg L, Katz S, Goldblum R, Harrigan R, Hilton D, Hanauer SB. Safety and tolerability of concurrent natalizumab treatment for patients with Crohn's disease not in remission while receiving infliximab. Inflamm Bowel Dis 2007; 13: 2-11
-
(2007)
Inflamm Bowel Dis
, vol.13
, pp. 2-11
-
-
Sands, B.E.1
Kozarek, R.2
Spainhour, J.3
Barish, C.F.4
Becker, S.5
Goldberg, L.6
Katz, S.7
Goldblum, R.8
Harrigan, R.9
Hilton, D.10
Hanauer, S.B.11
|