Antigen-dependent suppression of alloresponses by Foxp3-induced regulatory T cells in transplantation

European Journal of Immunology

Volumn 35, Issue 9, 2005, Pages 2598-2607

  Albert, Michael H ^a,c   Liu, Yan ^b   Anasetti, Claudio ^a,b,d   Yu, Xue Zhong ^a,b,d  

^a Fred Hutchinson Cancer Research Center   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^d H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

Foxp3; GVHD; Regulatory T cells; Transplantation

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR FOXP3;

ADOPTIVE TRANSFER; ALLOIMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN SPECIFICITY; ARTICLE; CELL CLONING; CONTROLLED STUDY; EFFECTOR CELL; FEASIBILITY STUDY; GENETIC TRANSDUCTION; GRAFT VERSUS HOST REACTION; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH1 CELL; TRANSPLANTATION; WILD TYPE;

ANIMALS; ANTIGENS, CD4; CD4-POSITIVE T-LYMPHOCYTES; CROSSES, GENETIC; DNA-BINDING PROTEINS; EPITOPES, T-LYMPHOCYTE; FLOW CYTOMETRY; FORKHEAD TRANSCRIPTION FACTORS; GRAFT VS HOST DISEASE; IMMUNOTHERAPY, ADOPTIVE; ISOANTIGENS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC; RECEPTORS, INTERLEUKIN-2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TH1 CELLS; TRANSDUCTION, GENETIC;

EID: 26044458206     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200526077     Document Type: Article

References (38)

1. Appelbaum, F. R., Haematopoietic cell transplantation as immunotherapy. Nature 2001. 411: 385-389.
2. Hansen, J. A., Gooley, T. A., Martin, P. J., Appelbaum, F., Chauncey, T. R., Clift, R. A., Petersdorf, E. W. et al., Bone marrow transplants from unrelated donors for patients with chronic myeloid leukemia. N. Engl. J. Med. 1998. 338: 962-968.
3. Hansen, J. A., Petersdorf, E., Martin, P. J. and Anasetti, C., Hematopoietic stem cell transplants from unrelated donors. Immunol. Rev. 1997. 157: 141-151.
4. Shevach, E. M., Certified professionals: CD4(+)CD25(+) suppressor T cells. J. Exp. Med. 2001. 193: F41-46.
5. Hara, M., Kingsley, C. L, Niimi, M., Read, S., Turvey, S. E., Bushell, A. R., Morris, P. J. et al., IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo. J. Immunol. 2001. 166: 3789-3796.
6. Sanchez-Fueyo, A., Weber, M., Domenig, C., Strom, T. B. and Zheng, X. X., Tracking the immunoregulatory mechanisms active during allograft tolerance. J. Immunol. 2002. 168: 2274-2281.
7. Cohen, J. L., Trenado, A., Vasey, D., Klatzmann, D. and Salomon, B. L., CD4(+)CD25(+) immunoregulatory T cells: new therapeutics for graft-versus-host disease. J. Exp. Med. 2002. 196: 401-406.
8. Hoffmann, P., Ermann, J., Edinger, M., Fathman, C. G. and Strober, S., Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation. J. Exp. Med. 2002. 196: 389-399.
9. Taylor, P. A., Lees, C. J. and Blazar, B. R., The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality. Blood 2002. 99: 3493-3499.
10. Taylor, P. A., Noelle, R. J. and Blazar, B. R., CD4(+)CD25(+) immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade. J. Exp. Med. 2001. 193: 1311-1318.
11. Jones, S. C., Murphy, G. F. and Korngold, R., Post-hematopoietic cell transplantation control of graft-versus-host disease by donor CD425 T cells to allow an effective graft-versus-leukemia response. Biol. Blood Marrow Transplant. 2003. 9: 243-256.
12. + regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus-leukemia. J. Clin. Invest. 2003. 112: 1688-1696.
13. + T-regulatory cells are potent inhibitors of GVHD and BM graft rejection. Blood 2004. 104: 3804-3812.
14. + regulatory T cells protects from lethal acute GVHD. Blood 2005. 105: 2220-2226.
15. Wood, K. J. and Sakaguchi, S., Regulatory T cells in transplantation tolerance. Nat. Rev. Immunol. 2003. 3: 199-210.
16. + regulatory T cells. Nat. Immunol. 2003. 4: 330-336.
17. Hori, S., Nomura, T. and Sakaguchi, S., Control of regulatory T cell development by the transcription factor Foxp3. Science 2003. 299: 1057-1061.
18. Khattri, R., Cox, T., Yasayko, S. A. and Ramsdell, F., An essential role for Scurfin in CD4+CD25 + T regulatory cells. Nat. Immunol. 2003. 4: 337-342.
19. Coffer, P. J. and Burgering, B. M., Forkhead-box transcription factors and their role in the immune system. Nat. Rev. Immunol. 2004. 4: 889-899.
20. high regulatory cells in human peripheral blood. J. Immunol. 2001. 167: 1245-1253.
21. Dieckmann, D., Plottner, H., Berchtold, S., Berger, T. and Schuler, G., Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood. J. Exp. Med. 2001. 193: 1303-1310.
22. Jonuleit, H., Schmitt, E., Stassen, M., Tuettenberg, A., Knop, J. and Enk, A. H., Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood. J. Exp. Med. 2001. 193: 1285-1294.
23. Ng, W. F., Duggan, P. J., Ponchel, F., Matarese, G., Lombardi, G., Edwards, A. D., Isaacs, J. D. and Lechler, R. I., Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells. Blood 2001. 98: 2736-2744.
24. -T cells. J. Clin. Invest. 2003. 112: 1437-1443.
25. Miura, Y., Thoburn, C. J., Bright, E. C., Phelps, M. L., Shin, T., Matsui, E. C., Matsui, W. H. et al., Association of Foxp3 regulatory gene expression with graft-versus-host disease. Blood 2004. 104: 2187-2193.
26. + immunoregulatory T cells is antigen nonspecific. J. Immunol. 2000. 164: 183-190.
27. + T cells as immunoregulatory T cells in vitro. Eur. J. Immunol. 2002. 32: 2365-2375.
28. + naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int. Immunol. 1998. 10: 1969-1980.
29. + T lymphocytes. Blood 2004. 103: 4216-4221.
30. Tang, Q., Henriksen, K. J., Bi, M., Finger, E. B., Szot, G., Ye, J., Masteller, E. L. et al., In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes. J. Exp. Med. 2004. 199: 1455-1465.
31. Clark, J. G., Madtes, D. K., Hackman, R. C., Chen, W., Cheever, M. A. and Martin, P. J., Lung injury induced by alloreactive Th1 cells is characterized by host-derived mononuclear cell inflammation and activation of alveolar macrophages. J. Immunol. 1998. 161: 1913-1920.
32. Chen, W., Chatta, G. S., Rubin, W. D., Clark, J. G., Hackman, R. C., Madtes, D. K., Ligitt, D. H. et al., T cells specific for a polymorphic segment of CD45 induce graft-versus-host disease with predominant pulmonary vasculitis. J. Immunol. 1998. 161: 909-918.
33. Hacein-Bey-Abina, S., von Kalle, C., Schmidt, M., Le Deist, F., Wulffraat, N., McIntyre, E., Radford, I. et al., A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency. N. Engl. J. Med. 2003. 348: 255-256.
34. Yu, X., Carpenter, P. and Anasetti, C., Advances in transplantation tolerance. Lancet 2001. 357: 1959-1963.
35. Yu, X. Z., Martin, P. J. and Anasetti, C., Role of CD28 in acute graft-versus-host disease. Blood 1998. 92: 2963-2970.
36. Yu, X. Z., Bidwell, S. J., Martin, P. J. and Anasetti, C., CD28-specific antibody prevents graft-versus-host disease in mice. J. Immunol. 2000. 164: 4564-4568.
37. Pear, W. S., Miller, J. P., Xu, L., Pui, J. C., Soffer, B., Quackenbush, R. C., Pendergast, A. M. et al., Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow. Blood 1998. 92: 3780-3792.
38. Walter, R. B., Raden, B. W., Thompson, J., Flowers, D. A., Kien, H.-P., Bernstein, I. D. and Linenberger, M. L., Breast cancer resistance protein (BRCP/ABCG2) does not confer resistance to gentuzumab 030gamicin and calicheamicin-gamma1 in acute myeloid leukemia cells. Leukemia 2004. 18: 1914-1917.