Intrathecal delivery of IFN-γ protects C57BL/6 mice from chronic-progressive experimental autoimmune encephalomyelitis by increasing apoptosis of central nervous system-infiltrating lymphocytes

Journal of Immunology

Volumn 167, Issue 3, 2001, Pages 1821-1829

  Furlan, R ^a   Brambilla, E ^a   Ruffini, F ^a   Poliani, P L ^a   Bergami, A ^a   Marconi, P C ^a   Franciotta, D M ^a   Penna, G ^a   Comi, G ^a   Adorini, L ^a   Martino, G ^a  

^a SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; VIRUS VECTOR;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; GENE TARGETING; GENE THERAPY; HERPES SIMPLEX VIRUS 1; IMMUNIZATION; LYMPHOCYTIC INFILTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0035423415     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.3.1821     Document Type: Article

References (38)

1. Immunopathogenesis of multiple sclerosis: The role of T cells
2. Effector pathways in immune mediated central nervous system demyelination
3. Biotechnological agents for the immunotherapy of multiple sclerosis: Principles, problems and perspectives
4. Phase 1 trial of transforming growth factor β2 in chronic progressive MS
5. TNF neutralization in MS: Results of a randomized, placebo-controlled multicenter study
6. Interferon β-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial
7. Multiple sclerosis: Comparison of copolymer-1-reactive T cell lines from treated and untreated subjects reveals cytokine shift from T helper 1 to T helper 2 cells
8. Cladribine and progressive MS: Clinical and MRI outcomes of a multicenter controlled trial
9. Monoclonal antibody treatment exposes three mechanisms underlying the clinical course of multiple sclerosis
10. Predictive value of gadolinium-enhanced magnetic resonance imaging for relapse rate and changes in disability or impairment in multiple sclerosis: A meta-analysis
11. Enhancement of experimental allergic encephalomyelitis in mice by antibodies against IFN-γ
12. Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: A neuroprotective role of inflammation?
13. Regulation of T cell responses by central nervous system antigen presenting cells: Different roles for microglia and astrocytes
14. Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy
15. Modulation of mucosal and systemic immunity by enteric administration of nonreplicating herpes simplex virus expressing cytokines
16. Central nervous system delivery of interleukin-4 by a non replicative herpes simplex type I viral vector ameliorates autoimmune demyelination
17. Central nervous system gene therapy with interleukin-4 inhibits progression of ongoing relapsing-remitting autoimmune encephalomyelitis in Biozzi AB/H mice
18. 1 α,25-dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activation
19. Delivery of a non-replicative herpes simplex type-I vector engineered with the IL-4 gene to the central nervous system protects rhesus monkeys from hyperacute autoimmune encephalomyelitis
20. Exacerbation of multiple sclerosis in patients treated with γ interferon
21. Increased transforming growth factor-β, interleukin-4, and interferon-γ in multiple sclerosis
22. Interferon-β treatment in multiple sclerosis patients decreases the number of circulating cells producing IFN-γ and IL-4
23. IFN-γ shapes immune invasion of the central nervous system via regulation of chemokines
24. Kinetics and cellular origin of cytokines in the central nervous system: Insight into mechanisms of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis
25. Differential role of TNF-α and IFN-γ in the brain of rats with chronic relapsing autoimmune encephalomyelitis
26. IFN-γ plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis
27. Interferon-γ confers resistance to experimental allergic encephalomyelitis
28. Interferon-γ in progression to chronic demyelination and neurological deficit following acute EAE
29. Caspase-1 regulates the inflammatory process leading to autoimmune demyelination
30. IFN-γ mediates a novel antiviral activity through dynamic modulation of TRAIL and TRAIL receptor expression
31. Interferon-γ rescues TNF-α-induced apoptosis mediated by upregulation of TNFR2 on EoL-1 cells
32. Interferon-γ and tumor necrosis factor-α induce synergistic cytolytic effects in ovarian cancer cell lines; roles of the TR60 and TR80 tumor necrosis factor receptors
33. Induction of apoptosis in mature T cells by tumor necrosis factor
34. Impairment of TNF-receptor-1 signaling but not Fas signaling diminishes T-cell apoptosis in myelin oligodendrocyte glycoprotein peptide-induced chronic demyelinating autoimmune encephalomyelitis
35. TNFRI signalling is critical for the development of demyelination and the limitation of T-cell responses during immune-mediated CNS disease
36. TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination
37. Regulation of autoimmunity by proinflammatory cytokines
38. Nitric oxide suppresses human T lymphocyte proliferation through IFN-γ-dependent and IFN-γ-independent induction of apoptosis