-
1
-
-
58149269422
-
The influence of educational level on polypharmacy and inappropriate drug use: A register-based study of more than 600 000 older people
-
Haider SI et al. The influence of educational level on polypharmacy and inappropriate drug use: a register-based study of more than 600 000 older people. J Am Geriatr Soc 2009; 57: 62-69.
-
(2009)
J Am Geriatr Soc
, vol.57
, pp. 62-69
-
-
Haider, S.I.1
-
2
-
-
67449107180
-
Polypharmacy in the elderly: Focus on drug interactions and adherence in hypertension
-
Cooney D, Pascuzzi K. Polypharmacy in the elderly: focus on drug interactions and adherence in hypertension. Clin Geriatr Med 2009; 25: 221-233.
-
(2009)
Clin Geriatr Med
, vol.25
, pp. 221-233
-
-
Cooney, D.1
Pascuzzi, K.2
-
3
-
-
33748751561
-
Kinetics of human serum butyrylcholinesterase and its inhibition by a novel experimental Alzheimer therapeutic, bisnorcymserine
-
Kamal MA et al. Kinetics of human serum butyrylcholinesterase and its inhibition by a novel experimental Alzheimer therapeutic, bisnorcymserine. J Alzheimers Dis 2006; 10: 43-51. (Pubitemid 44401365)
-
(2006)
Journal of Alzheimer's Disease
, vol.10
, Issue.1
, pp. 43-51
-
-
Kamal, M.A.1
Klein, P.2
Yu, Q.-S.3
Tweedie, D.4
Li, Y.5
Holloway, H.W.6
Greig, N.H.7
-
4
-
-
0036257075
-
The clinical benefits of rivastigmine may reflect its dual inhibitory mode of action: An hypothesis
-
Bullock R. The clinical benefits of rivastigmine may reflect its dual inhibitory mode of action: an hypothesis. Int J Clin Pract 2002; 56: 206-214. (Pubitemid 34477205)
-
(2002)
International Journal of Clinical Practice
, vol.56
, Issue.3
, pp. 206-214
-
-
Bullock, R.1
-
5
-
-
13844251864
-
Empirical evidence of neuroprotection by dual cholinesterase inhibition in Alzheimer's disease
-
DOI 10.1097/00001756-200502080-00006
-
Venneri A et al. Empirical evidence of neuroprotection by dual cholinesterase inhibition in Alzheimer's disease. Neuroreport 2005; 16: 107-110. (Pubitemid 40250379)
-
(2005)
NeuroReport
, vol.16
, Issue.2
, pp. 107-110
-
-
Venneri, A.1
McGeown, W.J.2
Shanks, M.F.3
-
6
-
-
0036363671
-
Advances in the treatment of Alzheimer's disease: Benefits of dual cholinesterase inhibition
-
Ballard CG. Advances in the treatment of Alzheimer's disease: benefits of dual cholinesterase inhibition. Eur Neurol 2002; 47: 64-70.
-
(2002)
Eur Neurol
, vol.47
, pp. 64-70
-
-
Ballard, C.G.1
-
7
-
-
27944457858
-
Effects of switching from an AChE inhibitor to a dual AChE-BuChE inhibitor in patients with Alzheimer's disease
-
Bartorelli L et al. Effects of switching from an AChE inhibitor to a dual AChE-BuChE inhibitor in patients with Alzheimer's disease. Curr Med Res Opin 2005; 21: 1809-1818.
-
(2005)
Curr Med Res Opin
, vol.21
, pp. 1809-1818
-
-
Bartorelli, L.1
-
8
-
-
15444378025
-
Synthesis and pharmacological evaluation of huprine-tacrine heterodimers: Subnanomolar dual binding site acetylcholinesterase inhibitors
-
DOI 10.1021/jm0496741
-
Camps P et al. Synthesis and pharmacological evaluation of huprine-tacrine heterodimers: subnanomolar dual binding site acetylcholinesterase inhibitors. J Med Chem 2005; 48: 1701-1704. (Pubitemid 40396300)
-
(2005)
Journal of Medicinal Chemistry
, vol.48
, Issue.6
, pp. 1701-1704
-
-
Camps, P.1
Formosa, X.2
Munoz-Torrero, D.3
Petrignet, J.4
Badia, A.5
Clos, M.V.6
-
9
-
-
74949109750
-
Methylacridinium and its cholinergic properties
-
Soukup O et al. Methylacridinium and its cholinergic properties. Neurotox Res 2009; 16: 372-377.
-
(2009)
Neurotox Res
, vol.16
, pp. 372-377
-
-
Soukup, O.1
-
10
-
-
44849113496
-
Design, synthesis and evaluation of isaindigotone derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors
-
DOI 10.1016/j.bmcl.2008.05.039, PII S0960894X08005374
-
Pan L et al. Design, synthesis and evaluation of isaindigotone derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors. Bioorg Med Chem Lett 2008; 18: 3790-3793. (Pubitemid 351794508)
-
(2008)
Bioorganic and Medicinal Chemistry Letters
, vol.18
, Issue.13
, pp. 3790-3793
-
-
Pan, L.1
Tan, J.-H.2
Hou, J.-Q.3
Huang, S.-L.4
Gu, L.-Q.5
Huang, Z.-S.6
-
11
-
-
16644370991
-
Effects of metabolites of mangrove fungus Xylaria sp. from South China Sea Coast on the activity of acetylcholinesterase in vitro
-
Jinghui L et al. Effects of metabolites of mangrove fungus Xylaria sp. from South China Sea Coast on the activity of acetylcholinesterase in vitro. Zhong Yao Cai 2004; 27: 261-264.
-
(2004)
Zhong Yao Cai
, vol.27
, pp. 261-264
-
-
Jinghui, L.1
-
12
-
-
0035855832
-
Coumarins derivatives as dual inhibitors of acetylcholinesterase and monoamine oxidase
-
DOI 10.1021/jm010894d
-
Brühlmann C et al. Coumarins derivatives as dual inhibitors of acetylcholinesterase and monoamine oxidase. J Med Chem 2001; 44: 3195-3198. (Pubitemid 32862350)
-
(2001)
Journal of Medicinal Chemistry
, vol.44
, Issue.19
, pp. 3195-3198
-
-
Bruhlmann, C.1
Ooms, F.2
Carrupt, P.-A.3
Testa, B.4
Catto, M.5
Leonetti, F.6
Altomare, C.7
Carotti, A.8
-
13
-
-
19544390899
-
1-N-Substituted thiocarbamoyl-3-phenyl-5-thienyl-2-pyrazolines: A novel cholinesterase and selective monoamine oxidase B inhibitors for the treatment of Parkinson's and Alzheimer's diseases
-
DOI 10.1016/j.neulet.2005.03.028, PII S0304394005003216
-
Ucar G et al. 1-N-Substituted thiocarbamoyl-3-phenyl-5- thienyl-2-pyrazolines: a novel cholinesterase and selective monoamine oxidase B inhibitors for the treatment of Parkinson's and Alzheimer's diseases. Neurosci Lett 2005; 382: 327-331. (Pubitemid 40733646)
-
(2005)
Neuroscience Letters
, vol.382
, Issue.3
, pp. 327-331
-
-
Ucar, G.1
Gokhan, N.2
Yesilada, A.3
Bilgin, A.A.4
-
14
-
-
25844529207
-
Screening of non-alkaloidal natural compounds as acetylcholinesterase inhibitors
-
Brühlmann C et al. Screening of non-alkaloidal natural compounds as acetylcholinesterase inhibitors. Chem Biodivers 2004; 1: 819-829.
-
(2004)
Chem Biodivers
, vol.1
, pp. 819-829
-
-
Brühlmann, C.1
-
15
-
-
79952732518
-
Dual inhibitors of acetylcholinesterase and serotonin transporter targeting potential agents for Alzheimer's disease
-
Chan AP, ed. New York: Nova Sci publishers
-
Toda N et al. Dual inhibitors of acetylcholinesterase and serotonin transporter targeting potential agents for Alzheimer's disease. In: Chan AP, ed. Alzheimer's Disease Research Trends. New York: Nova Sci publishers, 2008: 57-89.
-
(2008)
Alzheimer's Disease Research Trends
, pp. 57-89
-
-
Toda, N.1
-
16
-
-
12444257779
-
3-(4-{[benzyl(methyl)amino]methyl}-phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation: A dual function lead for Alzheimer's disease therapy
-
DOI 10.1021/jm0340602
-
Piazzi L et al. 3-(4-[[Benzyl(methyl)amino]methyl]phenyl)- 6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation: a dual function lead for Alzheimer's disease therapy. J Med Chem 2003; 46: 2279-2282. (Pubitemid 36637912)
-
(2003)
Journal of Medicinal Chemistry
, vol.46
, Issue.12
, pp. 2279-2282
-
-
Piazzi, L.1
Rampa, A.2
Bisi, A.3
Gobbi, S.4
Belluti, F.5
Cavalli, A.6
Bartolini, M.7
Andrisano, V.8
Valenti, P.9
Recanatini, M.10
-
18
-
-
12144257246
-
Propidium-based polyamine ligands as potent inhibitors of acetylcholinesterase and acetylcholinesterase-induced amyloid-beta aggregation
-
DOI 10.1021/jm049156q
-
Bolognesi ML et al. Propidium-based polyamine ligands as potent inhibitors of acetylcholinesterase and acetylcholinesterase-induced amyloid-beta aggregation. J Med Chem 2005; 48: 24-27. (Pubitemid 40105245)
-
(2005)
Journal of Medicinal Chemistry
, vol.48
, Issue.1
, pp. 24-27
-
-
Bolognesi, M.L.1
Andrisano, V.2
Bartolini, M.3
Banzi, R.4
Melchiorre, C.5
-
19
-
-
65649142161
-
Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease
-
Marco-Contelles J et al. Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease. J Med Chem 2009; 52: 2724-2732.
-
(2009)
J Med Chem
, vol.52
, pp. 2724-2732
-
-
Marco-Contelles, J.1
-
22
-
-
24044456340
-
Novel dimeric acetylcholinesterase inhibitor bis(7)-tacrine, but not donepezil, prevents glutamate-induced neuronal apoptosis by blocking N-methyl-D-aspartate receptors
-
DOI 10.1074/jbc.M411085200
-
Li W et al. Novel dimeric acetylcholinesterase inhibitor bis7-tacrine, but not donepezil, prevents glutamate-induced neuronal apoptosis by blocking N-methyl-D-aspartate receptors. J Biol Chem 2005; 280: 18179-18188. (Pubitemid 41389063)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.18
, pp. 18179-18188
-
-
Li, W.1
Pi, R.2
Chan, H.H.N.3
Fu, H.4
Lee, N.T.K.5
Tsang, H.W.6
Pu, Y.7
Chang, D.C.8
Li, C.9
Luo, J.10
Xiong, K.11
Li, Z.12
Xue, H.13
Carlier, P.R.14
Pang, Y.15
Tsim, K.W.K.16
Li, M.17
Han, Y.18
-
23
-
-
60049099128
-
Design, synthesis and biological evaluation of novel dual inhibitors of acetylcholinesterase and beta -secretase
-
Zhu Y et al. Design, synthesis and biological evaluation of novel dual inhibitors of acetylcholinesterase and beta -secretase. Bioorg Med Chem 2009; 17: 1600-1613.
-
(2009)
Bioorg Med Chem
, vol.17
, pp. 1600-1613
-
-
Zhu, Y.1
-
24
-
-
24144468631
-
Differential effect of PMS777, a new type of acetylcholinesterase inhibitor, and galanthamine on oxidative injury induced in human neuroblastoma SK-N-SH cells
-
DOI 10.1016/j.neulet.2005.07.026, PII S0304394005008281
-
Ezoulin MJ et al. Differential effect of PMS777, a new type of acetylcholinesterase inhibitor, and galanthamine on oxidative injury induced in human neuroblastoma SK-N-SH cells. Neurosci Lett 2005; 389: 61-65. (Pubitemid 41242886)
-
(2005)
Neuroscience Letters
, vol.389
, Issue.2
, pp. 61-65
-
-
Ezoulin, M.J.-M.1
Li, J.2
Wu, G.3
Dong, C.-Z.4
Ombetta, J.-E.5
Chen, H.-Z.6
Massicot, F.7
Heymans, F.8
-
25
-
-
70350445535
-
Phosphodiesterase 10A inhibitor activity in preclinical models of the positive, cognitive, and negative symptoms of schizophrenia
-
Grauer SM et al. Phosphodiesterase 10A inhibitor activity in preclinical models of the positive, cognitive, and negative symptoms of schizophrenia. J Pharmacol Exp Ther 2009; 331: 574-590.
-
(2009)
J Pharmacol Exp Ther
, vol.331
, pp. 574-590
-
-
Grauer, S.M.1
-
26
-
-
57749087002
-
Dual-target-directed drugs that block monoamine oxidase B and adenosine A(2A) receptors for Parkinson's disease
-
Petzer JP et al. Dual-target-directed drugs that block monoamine oxidase B and adenosine A(2A) receptors for Parkinson's disease. Neurotherapeutics 2009; 6: 141-151.
-
(2009)
Neurotherapeutics
, vol.6
, pp. 141-151
-
-
Petzer, J.P.1
-
27
-
-
51449101712
-
Dual inhibition of monoamine oxidase B and antagonism of the adenosine A(2A) receptor by (E,E)-8-(4- Phenylbutadien-1-yl)caffeine analogues
-
Pretorius J et al. Dual inhibition of monoamine oxidase B and antagonism of the adenosine A(2A) receptor by (E,E)-8-(4- phenylbutadien-1-yl)caffeine analogues. Bioorg Med Chem 2008; 16: 8676-8684.
-
(2008)
Bioorg Med Chem
, vol.16
, pp. 8676-8684
-
-
Pretorius, J.1
-
28
-
-
67449098178
-
Flavocoxid, a dual inhibitor of cyclooxygenase and 5-lipoxygenase, blunts pro-inflammatory phenotype activation in endotoxin-stimulated macrophages
-
Altavilla D et al. Flavocoxid, a dual inhibitor of cyclooxygenase and 5-lipoxygenase, blunts pro-inflammatory phenotype activation in endotoxin-stimulated macrophages. Br J Pharmacol 2009; 157: 1410-1418.
-
(2009)
Br J Pharmacol
, vol.157
, pp. 1410-1418
-
-
Altavilla, D.1
-
29
-
-
0034863527
-
Dual inhibition of 5-lipoxygenase and cyclooxygenases 1 and 2 by ML3000 reduces joint destruction in adjuvant arthritis
-
Gay RE et al. Dual inhibition of 5-lipoxygenase and cyclooxygenases 1 and 2 by ML3000 reduces joint destruction in adjuvant arthritis. J Rheumatol 2001; 28: 2060-2065. (Pubitemid 32803785)
-
(2001)
Journal of Rheumatology
, vol.28
, Issue.9
, pp. 2060-2065
-
-
Gay, R.E.1
Neidhart, M.2
Pataky, F.3
Tries, S.4
Laufer, S.5
Gay, S.6
-
30
-
-
0029619616
-
Cardiovascular effects of the novel dual inhibitor of neutral endopeptidase and angiotensin-converting enzyme BMS-182657 in experimental hypertension and heart failure
-
Trippodo NC et al. Cardiovascular effects of the novel dual inhibitor of neutral endopeptidase and angiotensin-converting enzyme BMS-182657 in experimental hypertension and heart failure. J Pharmacol Exp Ther 1995; 275: 745-752. (Pubitemid 26027044)
-
(1995)
Journal of Pharmacology and Experimental Therapeutics
, vol.275
, Issue.2
, pp. 745-752
-
-
Trippodo, N.C.1
Robl, J.A.2
Asaad, M.M.3
Bird, J.E.4
Panchal, B.C.5
Schaeffer, T.R.6
Fox, M.7
Giancarli, M.R.8
Hong, S.C.9
-
31
-
-
0028087296
-
Characterization of a dual inhibitor of angiotensin I-converting enzyme and neutral endopeptidase
-
French JF et al. Characterization of a dual inhibitor of angiotensin I-converting enzyme and neutral endopeptidase. J Pharmacol Exp Ther 1994; 268: 180-186. (Pubitemid 24039086)
-
(1994)
Journal of Pharmacology and Experimental Therapeutics
, vol.268
, Issue.1
, pp. 180-186
-
-
French, J.F.1
Flynn, G.A.2
Giroux, E.L.3
Mehdi, S.4
Anderson, B.5
Beach, D.C.6
Koehl, J.R.7
Dage, R.C.8
-
33
-
-
70449396067
-
Effects of a dual L/N-type calcium channel blocker cilnidipine on blood pressure, pulse rate, and autonomic functions in patients with mild to moderate hypertension
-
Kai T, Kuzumoto Y. Effects of a dual L/N-type calcium channel blocker cilnidipine on blood pressure, pulse rate, and autonomic functions in patients with mild to moderate hypertension. Clin Exp Hypertens 2009; 31: 595-604.
-
(2009)
Clin Exp Hypertens
, vol.31
, pp. 595-604
-
-
Kai, T.1
Kuzumoto, Y.2
-
34
-
-
20044384201
-
Dual ECE/NEP inhibition on cardiac and neurohumoral function during the transition from hypertrophy to heart failure in rats
-
DOI 10.1161/01.HYP.0000168944.29525.da
-
Emoto N et al. Dual ECE/NEP inhibition on cardiac and neuro-humoral function during the transition from hypertrophy to heart failure in rats. Hypertension 2005; 45: 1145-1152. (Pubitemid 40770319)
-
(2005)
Hypertension
, vol.45
, Issue.6
, pp. 1145-1152
-
-
Emoto, N.1
Raharjo, S.B.2
Isaka, D.3
Masuda, S.4
Adiarto, S.5
Jeng, A.Y.6
Yokoyama, M.7
-
36
-
-
70350057331
-
V1/V2 Vasopressin receptor antagonism potentiates the renoprotection of renin-angiotensin system inhibition in rats with renal mass reduction
-
Perico N et al. V1/V2 Vasopressin receptor antagonism potentiates the renoprotection of renin-angiotensin system inhibition in rats with renal mass reduction. Kidney Int 2009; 76: 960-967.
-
(2009)
Kidney Int
, vol.76
, pp. 960-967
-
-
Perico, N.1
-
37
-
-
79952714508
-
A unique dual acting inhibitor for thrombosis: Combining anticoagulant & antiplatelet effects into a single molecule
-
Medicure Inc
-
Rehman A. A unique dual acting inhibitor for thrombosis: combining anticoagulant & antiplatelet effects into a single molecule. In: Non-Confidential Dossier. Medicure Inc, 2008.
-
(2008)
Non-Confidential Dossier
-
-
Rehman, A.1
-
39
-
-
34250649348
-
Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties
-
DOI 10.1073/pnas.0700746104
-
Wang J et al. Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties. Proc Natl Acad Sci USA 2007; 104: 7612-7616. (Pubitemid 47185954)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.18
, pp. 7612-7616
-
-
Wang, J.1
Kodali, S.2
Sang, H.L.3
Galgoci, A.4
Painter, R.5
Dorso, K.6
Racine, F.7
Motyl, M.8
Hernandez, L.9
Tinney, E.10
Colletti, S.L.11
Herath, K.12
Cummings, R.13
Salazar, O.14
Gonzalez, I.15
Basilio, A.16
Vicente, F.17
Genilloud, O.18
Pelaez, F.19
Jayasuriya, H.20
Young, K.21
Cully, D.F.22
Singh, S.B.23
more..
-
40
-
-
37849020692
-
Madurahydroxylactone derivatives as dual inhibitors of human immunodeficiency virus type 1 integrase and RNase H
-
Marchand C et al. Madurahydroxylactone derivatives as dual inhibitors of human immunodeficiency virus type 1 integrase and RNase H. Antimicrob Agents Chemother 2008; 52: 361-364.
-
(2008)
Antimicrob Agents Chemother
, vol.52
, pp. 361-364
-
-
Marchand, C.1
-
42
-
-
51649088622
-
PI-103, a dual inhibitor of Class IA phosphatidylinositide 3-kinase and mTOR, has antileukemic activity in AML
-
Park S et al. PI-103, a dual inhibitor of Class IA phosphatidylinositide 3-kinase and mTOR, has antileukemic activity in AML. Leukemia 2008; 22: 1698-1706.
-
(2008)
Leukemia
, vol.22
, pp. 1698-1706
-
-
Park, S.1
-
43
-
-
51049109033
-
Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity
-
Maira SM et al. Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity. Mol Cancer Ther 2008; 7: 1851-1863.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 1851-1863
-
-
Maira, S.M.1
-
44
-
-
77956255150
-
WJD008, a Dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the proliferation of transformed cells with oncogenic PI3K mutant
-
Li T et al. WJD008, a Dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the proliferation of transformed cells with oncogenic PI3K mutant. J Pharmacol Exp Ther 2010; 334: 830-838.
-
(2010)
J Pharmacol Exp Ther
, vol.334
, pp. 830-838
-
-
Li, T.1
-
45
-
-
43549112362
-
Potentiation of antileukemic therapies by the dual PI3K/PDK-1 inhibitor, BAG956: Effects on BCR-ABL- and mutant FLT3-expressing cells
-
Weisberg E et al. Potentiation of antileukemic therapies by the dual PI3K/PDK-1 inhibitor, BAG956: effects on BCR-ABL- and mutant FLT3-expressing cells. Blood 2008; 111: 3723-3734.
-
(2008)
Blood
, vol.111
, pp. 3723-3734
-
-
Weisberg, E.1
-
46
-
-
0030699166
-
Dual topoisomerase I/II poisons as anticancer drugs
-
Denny WA. Dual topoisomerase I/II poisons as anticancer drugs. Expert Opin Investig Drugs 1997; 6: 1845-1851. (Pubitemid 27517588)
-
(1997)
Expert Opinion on Investigational Drugs
, vol.6
, Issue.12
, pp. 1845-1851
-
-
Denny, W.A.1
-
47
-
-
35348981766
-
Promising antitumor activity of a novel quinoline derivative, TAS-103, against fresh clinical specimens of eight types of tumors measured by flow cytometric DNA analysis
-
DOI 10.1248/bpb.30.1923
-
Fujimoto S. Promising antitumor activity of a novel quinoline derivative, TAS-103, against fresh clinical specimens of eight types of tumors measured by flow cytometric DNA analysis. Biol Pharm Bull 2007; 30: 1923-1929. (Pubitemid 47607787)
-
(2007)
Biological and Pharmaceutical Bulletin
, vol.30
, Issue.10
, pp. 1923-1929
-
-
Fujimoto, S.1
-
48
-
-
29644440491
-
Leptosins isolated from marine fungus Leptoshaeria species inhibit DNA topoisomerases I and/or II and induce apoptosis by inactivation of Akt/protein kinase B
-
DOI 10.1111/j.1349-7006.2005.00117.x
-
Yanagihara M et al. Leptosins isolated from marine fungus Leptoshaeria species inhibit DNA topoisomerases I and/or II and induce apoptosis by inactivation of Akt/protein kinase B. Cancer Sci 2005; 96: 816-824. (Pubitemid 43019833)
-
(2005)
Cancer Science
, vol.96
, Issue.11
, pp. 816-824
-
-
Yanagihara, M.1
Sasaki-Takahashi, N.2
Sugahara, T.3
Yamamoto, S.4
Shinomi, M.5
Yamashita, I.6
Hayashida, M.7
Yamanoha, B.8
Numata, A.9
Yamori, T.10
Andoh, T.11
-
49
-
-
0042627801
-
Ex vivo effects of the dual topoisomerase inhibitor tafluposide (F 11782) on cells isolated from fresh tumor samples taken from patients with cancer
-
DOI 10.1097/00001813-200307000-00013
-
Sargent JM et al. Ex vivo effects of the dual topoisomerase inhibitor tafluposide (F 11782) on cells isolated from fresh tumor samples taken from patients with cancer. Anticancer Drugs 2003; 14: 467-473. (Pubitemid 36951799)
-
(2003)
Anti-Cancer Drugs
, vol.14
, Issue.6
, pp. 467-473
-
-
Sargent, J.M.1
Elgie, A.W.2
Williamson, C.J.3
Hill, B.T.4
-
50
-
-
0036180994
-
In vitro and in vivo characterization of XR11576, a novel, orally active, dual inhibitor of topoisomerase I and II
-
DOI 10.1097/00001813-200201000-00002
-
Mistry P et al. In vitro and in vivo characterization of XR11576, a novel, orally active, dual inhibitor of topoisomerase I and II. Anticancer Drugs 2002; 13: 15-28. (Pubitemid 34169523)
-
(2002)
Anti-Cancer Drugs
, vol.13
, Issue.1
, pp. 15-28
-
-
Mistry, P.1
Stewart, A.J.2
Dangerfield, W.3
Baker, M.4
Liddle, C.5
Bootle, D.6
Kofler, B.7
Laurie, D.8
Denny, W.A.9
Baguley, B.10
Charlton, P.A.11
-
51
-
-
33748169241
-
Novel targeted approaches to treating biliary tract cancer: The dual epidermal growth factor receptor and ErbB-2 tyrosine kinase inhibitor NVP-AEE788 is more efficient than the epidermal growth factor receptor inhibitors gefitinib and erlotinib
-
DOI 10.1097/01.cad.0000217433.48870.37, PII 0000181320060800000006
-
Wiedmann M et al. Novel targeted approaches to treating biliary tract cancer: the dual epidermal growth factor receptor and ErbB-2 tyrosine kinase inhibitor NVP-AEE788 is more efficient than the epidermal growth factor receptor inhibitors gefitinib and erlotinib. Anticancer Drugs 2006; 17: 783-795. (Pubitemid 44310175)
-
(2006)
Anti-Cancer Drugs
, vol.17
, Issue.7
, pp. 783-795
-
-
Wiedmann, M.1
Feisthammel, J.2
Bluthner, T.3
Tannapfel, A.4
Kamenz, T.5
Kluge, A.6
Mossner, J.7
Caca, K.8
-
52
-
-
34247609952
-
AS602868, a dual inhibitor of IKK2 and FLT3 to target AML cells
-
DOI 10.1038/sj.leu.2404614, PII 2404614
-
Griessinger E et al. AS602868, a dual inhibitor of IKK2 and FLT3 to target AML cells. Leukemia 2007; 21: 877-885. (Pubitemid 46672062)
-
(2007)
Leukemia
, vol.21
, Issue.5
, pp. 877-885
-
-
Griessinger, E.1
Imbert, V.2
Lagadec, P.3
Gonthier, N.4
Dubreuil, P.5
Romanelli, A.6
Dreano, M.7
Peyron, J.-F.8
-
53
-
-
4544354752
-
Recent approaches to novel anti-Alzheimer therapy
-
DOI 10.2174/1381612043383421
-
Carreiras MC, Marco JL. Recent approaches to novel anti-Alzheimer therapy. Curr Pharm Des 2004; 10: 3167-3175. (Pubitemid 39242911)
-
(2004)
Current Pharmaceutical Design
, vol.10
, Issue.25
, pp. 3167-3175
-
-
Carreiras, M.C.1
Marco, J.L.2
-
54
-
-
33845669856
-
A multifunctional, neuroprotective drug, ladostigil (TV3326), regulates holo-APP translation and processing
-
Yogev-Falach M et al. A multifunctional, neuroprotective drug, ladostigil (TV3326), regulates holo-APP translation and processing. FASEB J 2006; 20: 2177-2179.
-
(2006)
FASEB J
, vol.20
, pp. 2177-2179
-
-
Yogev-Falach, M.1
-
55
-
-
11144316146
-
Bifunctional drug derivatives of MAO-B inhibitor rasagiline and iron chelator VK-28 as a more effective approach to treatment of brain ageing and ageing neurodegenerative diseases
-
DOI 10.1016/j.mad.2004.08.023, PII S0047637404002064, The Voyage to Old Age: Searching for Human Longevity Genes
-
Youdim MB et al. Bifunctional drug derivatives of MAO-B inhibitor rasagiline and iron chelator VK-28 as a more effective approach to treatment of brain ageing and ageing neurodegenerative diseases. Mech Ageing Dev 2005; 126: 317-326. (Pubitemid 40038353)
-
(2005)
Mechanisms of Ageing and Development
, vol.126
, Issue.2
, pp. 317-326
-
-
Youdim, M.B.H.1
Fridkin, M.2
Zheng, H.3
-
56
-
-
33750355579
-
M30, a novel multifunctional neuroprotective drug with potent iron chelating and brain selective monoamine oxidase-ab inhibitory activity for Parkinson's disease
-
Gal S et al. M30, a novel multifunctional neuroprotective drug with potent iron chelating and brain selective monoamine oxidase-ab inhibitory activity for Parkinson's disease. J Neural Transm Suppl 2006; 70: 447-456. (Pubitemid 44622237)
-
(2006)
Journal of Neural Transmission, Supplement
, Issue.70
, pp. 447-456
-
-
Gal, S.1
Fridkin, M.2
Amit, T.3
Zheng, H.4
Youdim, M.B.H.5
-
57
-
-
33845918390
-
Dual binding site acetylcholinesterase inhibitors: Potential new disease-modifying agents for AD
-
del Monte-Millán M et al. Dual binding site acetylcholinesterase inhibitors: potential new disease-modifying agents for AD. J Mol Neurosci 2006; 30: 85-88.
-
(2006)
J Mol Neurosci
, vol.30
, pp. 85-88
-
-
Del Monte-Millán, M.1
-
58
-
-
33750883640
-
Targeting beta-amyloid pathogenesis through acetylcholinesterase inhibitors
-
DOI 10.2174/138161206778792985
-
Castro A, Martinez A. Targeting beta-amyloid pathogenesis through acetylcholinesterase inhibitors. Curr Pharm Des 2006; 12: 4377-4387. (Pubitemid 44718295)
-
(2006)
Current Pharmaceutical Design
, vol.12
, Issue.33
, pp. 4377-4387
-
-
Castro, A.1
Martinez, A.2
-
59
-
-
0037298750
-
Beta-Amyloid aggregation induced by human acetylcholinesterase: Inhibition studies
-
DOI 10.1016/S0006-2952(02)01514-9, PII S0006295202015149
-
Bartolini M et al. Beta-amyloid aggregation induced by human acetylcholinesterase: inhibition studies. Biochem Pharmacol 2003; 65: 407-416. (Pubitemid 36084557)
-
(2003)
Biochemical Pharmacology
, vol.65
, Issue.3
, pp. 407-416
-
-
Bartolini, M.1
Bertucci, C.2
Cavrini, V.3
Andrisano, V.4
-
61
-
-
33846150057
-
A molecular link between the active component of marijuana and Alzheimer's disease pathology
-
DOI 10.1021/mp060066m
-
Eubanks LM et al. A molecular link between the active component of marijuana and Alzheimer's disease pathology. Mol Pharm 2006; 3: 773-777. (Pubitemid 46087493)
-
(2006)
Molecular Pharmaceutics
, vol.3
, Issue.6
, pp. 773-777
-
-
Eubanks, L.M.1
Rogers, C.J.2
Beuscher IV, A.E.3
Koob, G.F.4
Olson, A.J.5
Dickerson, T.J.6
Janda, K.D.7
-
62
-
-
0035341472
-
Interleukin-10 prevents glutamate-mediated cerebellar granule cell death by blocking caspase-3-like activity
-
Bachis A et al. Interleukin-10 prevents glutamate-mediated cerebellar granule cell death by blocking caspase-3-like activity. J Neurosci 2001; 21: 3104-3112. (Pubitemid 32323492)
-
(2001)
Journal of Neuroscience
, vol.21
, Issue.9
, pp. 3104-3112
-
-
Bachis, A.1
Colangelo, A.M.2
Vicini, S.3
Doe, P.P.4
De Bernardi, M.A.5
Brooker, G.6
Mocchetti, I.7
-
63
-
-
0036975963
-
The separate roles of calcium and mechanical forces in mediating cell death in mechanically injured neurons
-
Lusardi TA et al. The separate roles of calcium and mechanical forces in mediating cell death in mechanically injured neurons. Biorheology 2003; 40: 401-409. (Pubitemid 36164568)
-
(2002)
Biorheology
, vol.40
, Issue.1-3
, pp. 401-409
-
-
Lusardi, T.A.1
Smith, D.H.2
Wolf, J.A.3
Meaney, D.F.4
-
64
-
-
37549066630
-
Multi-target-directed coumarin derivatives: HAChE and BACE1 inhibitors as potential anti-Alzheimer compounds
-
Piazzi L et al. Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds. Bioorg Med Chem Lett 2008; 18: 423-426.
-
(2008)
Bioorg Med Chem Lett
, vol.18
, pp. 423-426
-
-
Piazzi, L.1
-
65
-
-
31544477481
-
Novel tacrine-melatonin hybrids as dual-acting drugs for alzheimer disease, with improved acetylcholinesterase inhibitory and antioxidant properties
-
DOI 10.1021/jm050746d
-
Rodríguez-Franco MI et al. Novel tacrine-melatonin hybrids as dual-acting drugs for Alzheimer disease, with improved acetylcholinesterase inhibitory and antioxidant properties. J Med Chem 2006; 49: 459-462. (Pubitemid 43157478)
-
(2006)
Journal of Medicinal Chemistry
, vol.49
, Issue.2
, pp. 459-462
-
-
Rodriguez-Franco, M.I.1
Fernandez-Bachiller, M.I.2
Perez, C.3
Hernandez-Ledesma, B.4
Bartolome, B.5
-
66
-
-
0036689436
-
Current use of atypical antipsychotics
-
DOI 10.1016/S0924-9338(03)00077-4
-
Müller-Spahn F. Current use of atypical antipsychotics. Eur Psychiatry 2002; 17: 377-384. (Pubitemid 34987837)
-
(2002)
European Psychiatry
, vol.17
, Issue.SUPPL. 4
, pp. 377-384
-
-
Muller-Spahn, F.1
-
67
-
-
55049106809
-
Upcoming agents for the treatment of schizophrenia: Mechanism of action, efficacy and tolerability
-
Bishara D, Taylor D. Upcoming agents for the treatment of schizophrenia: mechanism of action, efficacy and tolerability. Drugs 2008; 68: 2269-2292.
-
(2008)
Drugs
, vol.68
, pp. 2269-2292
-
-
Bishara, D.1
Taylor, D.2
-
68
-
-
32144459234
-
Single-action versus dual-action antidepressants
-
Jain R. Single-action versus dual-action antidepressants. Prim Care Companion J Clin Psychiatry 2004; 6: 7-11.
-
(2004)
Prim Care Companion J Clin Psychiatry
, vol.6
, pp. 7-11
-
-
Jain, R.1
-
69
-
-
57749090403
-
Dual- and triple-acting agents for treating core and co-morbid symptoms of major depression: Novel concepts, new drugs
-
Millan MJ. Dual- and triple-acting agents for treating core and co-morbid symptoms of major depression: novel concepts, new drugs. Neurotherapeutics 2009; 6: 53-77.
-
(2009)
Neurotherapeutics
, vol.6
, pp. 53-77
-
-
Millan, M.J.1
-
70
-
-
19944432573
-
Discovery and structure-activity relationships of novel selective norepinephrine and dual serotonin/norepinephrine reuptake inhibitors
-
DOI 10.1016/j.bmcl.2004.11.025, PII S0960894X04013757
-
Boot J et al. Discovery and structure-activity relationships of novel selective norepinephrine and dual serotonin/ norepinephrine reuptake inhibitors. Bioorg Med Chem Lett 2005; 15: 699-703. (Pubitemid 40143150)
-
(2005)
Bioorganic and Medicinal Chemistry Letters
, vol.15
, Issue.3
, pp. 699-703
-
-
Boot, J.1
Cases, M.2
Clark, B.P.3
Findlay, J.4
Gallagher, P.T.5
Hayhurst, L.6
Man, T.7
Montalbetti, C.8
Rathmell, R.E.9
Rudyk, H.10
Walter, M.W.11
Whatton, M.12
Wood, V.13
-
71
-
-
0031029632
-
Mirtazapine: An antidepressant with noradrenergic and specific serotonergic effects
-
Stimmel GL et al. Mirtazapine: an antidepressant with noradrenergic and specific serotonergic effects. Pharmacotherapy 1997; 17: 10-21. (Pubitemid 27057115)
-
(1997)
Pharmacotherapy
, vol.17
, Issue.1
, pp. 10-21
-
-
Stimmel, G.L.1
Dopheide, J.A.2
Stahl, S.M.3
-
72
-
-
33847767095
-
The role of dopamine in the pathophysiology of depression
-
DOI 10.1001/archpsyc.64.3.327
-
Dunlop BW, Nemeroff CB. The role of dopamine in the pathophysiology of depression. Arch Gen Psychiatry 2007; 64: 327-337. (Pubitemid 46376789)
-
(2007)
Archives of General Psychiatry
, vol.64
, Issue.3
, pp. 327-337
-
-
Dunlop, B.W.1
Nemeroff, C.B.2
-
73
-
-
68549135115
-
Preclinical characterization of WAY-211612: A dual 5-HT uptake inhibitor and 5-HT (1A) receptor antagonist and potential novel antidepressant
-
Beyer CE et al. Preclinical characterization of WAY-211612: a dual 5-HT uptake inhibitor and 5-HT (1A) receptor antagonist and potential novel antidepressant. Br J Pharmacol 2009; 157: 307-319.
-
(2009)
Br J Pharmacol
, vol.157
, pp. 307-319
-
-
Beyer, C.E.1
-
74
-
-
69949151009
-
Inhibition of serotonin and norepinephrine reuptake and inhibition of phosphodiesterase by multi-target inhibitors as potential agents for depression
-
Cashman JR, Ghirmai S. Inhibition of serotonin and norepinephrine reuptake and inhibition of phosphodiesterase by multi-target inhibitors as potential agents for depression. Bioorg Med Chem 2009; 17: 6890-6897.
-
(2009)
Bioorg Med Chem
, vol.17
, pp. 6890-6897
-
-
Cashman, J.R.1
Ghirmai, S.2
-
75
-
-
0036099571
-
Selective COX-2 inhibitors and dual acting anti-inflammatory drugs: Critical remarks
-
Bertolini A et al. Selective COX-2 inhibitors and dual acting anti-inflammatory drugs: critical remarks. Curr Med Chem 2002; 9: 1033-1043. (Pubitemid 34537535)
-
(2002)
Current Medicinal Chemistry
, vol.9
, Issue.10
, pp. 1033-1043
-
-
Bertolini, A.1
Ottani, A.2
Sandrini, M.3
-
77
-
-
0345118245
-
Vasodilating b-adrenoceptor blockers as cardiovascular therapeutics
-
DOI 10.1016/j.pharmthera.2003.09.001
-
Toda N. Vasodilating b-adrenoceptor blockers as cardiovascular therapeutics. Pharmacol Ther 2003; 100: 215-234. (Pubitemid 37494907)
-
(2003)
Pharmacology and Therapeutics
, vol.100
, Issue.3
, pp. 215-234
-
-
Toda, N.1
-
78
-
-
1642479992
-
Effects of Efonidipine, an L- And T-Type Dual Calcium Channel Blocker, on Heart Rate and Blood Pressure in Patients with Mild to Severe Hypertension: An Uncontrolled, Open-Label Pilot Study
-
DOI 10.1016/j.curtheres.2003.11.004
-
Shimizu M et al. Effects of efonidipine, an L- and T-type dual calcium channel blocker, on heart rate and blood pressure in patients with mild to severe hypertension: an uncontrolled, open-label pilot study. Curr Ther Res 2003; 64: 707-714. (Pubitemid 38130686)
-
(2003)
Current Therapeutic Research - Clinical and Experimental
, vol.64
, Issue.9
, pp. 707-714
-
-
Shimizu, M.1
Ogawa, K.2
Sasaki, H.3
Uehara, Y.4
Otsuka, Y.5
Okumura, H.6
Kusaka, M.7
Hasuda, T.8
Yamada, T.9
Mochizuki, S.10
-
80
-
-
0034034295
-
Fasidotril: The first dual inhibitor of neprilysin and ACE
-
Bralet J et al. Fasidotril: the first dual inhibitor of neprilysin and ACE. Cardiovasc Drug Rev 2006; 18: 1-24.
-
(2006)
Cardiovasc Drug Rev
, vol.18
, pp. 1-24
-
-
Bralet, J.1
-
81
-
-
0034110537
-
Antihypertensive effects of fasidotril, a dual inhibitor of neprilysin and angiotensin-converting enzyme, in rats and humans
-
Laurent S et al. Antihypertensive effects of fasidotril, a dual inhibitor of neprilysin and angiotensin-converting enzyme, in rats and humans. Hypertension 2000; 35: 1148-1153. (Pubitemid 30327272)
-
(2000)
Hypertension
, vol.35
, Issue.5
, pp. 1148-1153
-
-
Laurent, S.1
Boutouyrie, P.2
Azizi, M.3
Marie, C.4
Gros, C.5
Schwartz, J.-C.6
Lecomte, J.-M.7
Bralet, J.8
-
82
-
-
0141628437
-
Pharmacological modulation of the natriuretic peptide system
-
Venugopal J. Pharmacological modulation of the natriuretic peptide system. Expert Opin Ther Pat 2003; 13: 1389.
-
(2003)
Expert Opin Ther Pat
, vol.13
, pp. 1389
-
-
Venugopal, J.1
-
84
-
-
77950628157
-
Blood-pressure reduction with LCZ696, a novel dual-acting inhibitor of the angiotensin II receptor and neprilysin: A randomised, double-blind, placebo-controlled, active comparator study
-
Ruilope LM et al. Blood-pressure reduction with LCZ696, a novel dual-acting inhibitor of the angiotensin II receptor and neprilysin: a randomised, double-blind, placebo-controlled, active comparator study. Lancet 2010; 375: 1255-1266.
-
(2010)
Lancet
, vol.375
, pp. 1255-1266
-
-
Ruilope, L.M.1
-
86
-
-
0035856509
-
2 vasopressin receptor antagonist, in patients with advanced heart failure
-
Udelson JE et al. Acute hemodynamic effects of conivaptan, a dual V(1A) and V(2) vasopressin receptor antagonist, in patients with advanced heart failure. Circulation 2001; 104: 2417-2423. (Pubitemid 33108374)
-
(2001)
Circulation
, vol.104
, Issue.20
, pp. 2417-2423
-
-
Udelson, J.E.1
Smith, W.B.2
Hendrix, G.H.3
Painchaud, C.A.4
Ghazzi, M.5
Thomas, I.6
Ghali, J.K.7
Selaru, P.8
Chanoine, F.9
Pressler, M.L.10
Konstam, M.A.11
-
87
-
-
77954464376
-
Meta-analysis of randomized controlled trials on treatment of pulmonary arterial hypertension
-
He B et al. Meta-analysis of randomized controlled trials on treatment of pulmonary arterial hypertension. Circ J 2010; 74: 1458-1464.
-
(2010)
Circ J
, vol.74
, pp. 1458-1464
-
-
He, B.1
-
88
-
-
79952726925
-
International Nonproprietary Names for Pharmaceutical Substances
-
Available from
-
International Nonproprietary Names for Pharmaceutical Substances. WHO Drug Information 7 (4). 1993. Available from: http://whqlibdoc.who.int/inn/ proposed-lists/prop-INN- list70.pdf.
-
(1993)
WHO Drug Information
, vol.7
, Issue.4
-
-
-
89
-
-
5444240463
-
Therapeutics of platelet glycoprotein IIb/IIIa receptor antagonism
-
Gowda RM et al. Therapeutics of platelet glycoprotein IIb/IIIa receptor antagonism. Am J Ther 2004; 11: 302-307.
-
(2004)
Am J Ther
, vol.11
, pp. 302-307
-
-
Gowda, R.M.1
-
90
-
-
0035653204
-
Use of niacin in the prevention and management of hyperlipidemia
-
Robinson AWet al. Use of niacin in the prevention and management of hyperlipidemia. Prog Cardiovasc Nurs 2001; 16: 14-20.
-
(2001)
Prog Cardiovasc Nurs
, vol.16
, pp. 14-20
-
-
Robinson, A.W.1
-
91
-
-
77952965850
-
Structure-activity relationships (SAR) research of thiourea derivatives as dual inhibitors targeting both HIV-1 capsid and human cyclophilin A
-
Chen K et al. Structure-activity relationships (SAR) research of thiourea derivatives as dual inhibitors targeting both HIV-1 capsid and human cyclophilin A. Chem Biol Drug Des 2010; 76: 25-33.
-
(2010)
Chem Biol Drug des
, vol.76
, pp. 25-33
-
-
Chen, K.1
-
92
-
-
2542622944
-
Activity of topoisomerase inhibitors daunorubicin, idarubicin, and aclarubicin in the Drosophila somatic mutation and recombination test
-
DOI 10.1002/em.20023
-
Lehmann M et al. Activity of topoisomerase inhibitors daunorubicin, idarubicin, and aclarubicin in the Drosophila somatic mutation and recombination test. Environ Mol Mutagen 2004; 43: 250-257. (Pubitemid 38702631)
-
(2004)
Environmental and Molecular Mutagenesis
, vol.43
, Issue.4
, pp. 250-257
-
-
Lehmann, M.1
Vilar, K.D.S.P.2
Franco, A.3
Reguly, M.L.4
De Andrade, H.H.R.5
-
93
-
-
1842833444
-
Gliotoxin is a dual inhibitor of farnesyltransferase and geranylgeranyltransferase I with antitumor activity against breast cancer in vivo
-
Vigushi DM et al. Gliotoxin is a dual inhibitor of farnesyltransferase and geranylgeranyltransferase I with antitumor activity against breast cancer in vivo. Med Oncol 2004; 21: 20-21.
-
(2004)
Med Oncol
, vol.21
, pp. 20-21
-
-
Vigushi, D.M.1
-
94
-
-
74649084195
-
The dietary flavonoids myricetin and fisetin act as dual inhibitors of DNA topoisomerases I and II in cells
-
López-Lázaro M et al. The dietary flavonoids myricetin and fisetin act as dual inhibitors of DNA topoisomerases I and II in cells. Mutat Res 2010; 696: 41-47.
-
(2010)
Mutat Res
, vol.696
, pp. 41-47
-
-
López-Lázaro, M.1
-
95
-
-
65649088361
-
State-dependent block of HERG potassium channels by R-roscovitine: Implications for cancer therapy
-
Ganapathi SB et al. State-dependent block of HERG potassium channels by R-roscovitine: implications for cancer therapy. Am J Physiol Cell Physiol 2009; 296: 701-710.
-
(2009)
Am J Physiol Cell Physiol
, vol.296
, pp. 701-710
-
-
Ganapathi, S.B.1
|