Discovery and structure-activity relationships of novel selective norepinephrine and dual serotonin/norepinephrine reuptake inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 3, 2005, Pages 699-703

  Boot, John ^a   Cases, Manuel ^a   Clark, Barry P ^a   Findlay, Jeremy ^a   Gallagher, Peter T ^a   Hayhurst, Lorna ^a   Man, Teresa ^a   Montalbetti, Christian ^b   Rathmell, Richard E ^a   Rudyk, Hélène ^a   Walter, Magnus W ^a   Whatton, Maria ^a   Wood, Virginia ^a  

^a ELI LILLY AND COMPANY   (United States)

^b EVOTEC UK LTD   (United Kingdom)

Author keywords

Dual reuptake inhibitor; Monoamine reuptake inhibitors; Norepinephrine; SAR; Selective norepinephrine reuptake inhibitor; Serotonin

Indexed keywords

MORPHOLINE DERIVATIVE; NORADRENALIN UPTAKE INHIBITOR; REBOXETINE; SEROTONIN UPTAKE INHIBITOR;

ALDOL REACTION; ARTICLE; DRUG POTENCY; DRUG SYNTHESIS; DRUG TARGETING; ENANTIOMER; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ADRENERGIC UPTAKE INHIBITORS; BIOGENIC AMINES; HUMANS; MORPHOLINES; NOREPINEPHRINE; SEROTONIN UPTAKE INHIBITORS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 19944432573     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.11.025     Document Type: Article

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