The growth hormoneIGF-I axis as a mediator for the association between FTO variants and body mass index: Results of the Study of Health in Pomerania

International Journal of Obesity

Volumn 35, Issue 3, 2011, Pages 364-372

  Rosskopf, D ^a   Schwahn, C ^a   Neumann, F ^a   Bornhorst, A ^a   Rimmbach, C ^a   Mischke, M ^a   Wolf, S ^a   Geissler, I ^a   Kocher, T ^a   Grabe, H J ^a   Nauck, M ^a   Hebebrand, J ^b   Kroemer, H K ^a   Friedrich, N ^a   Volzke H ^a   Wallaschofski, H ^a  

^a UNIVERSITY OF GREIFSWALD   (Germany)

^b UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

body weights and measures; epidemiology; genetics; insulin like growth factor I

Indexed keywords

FAT MASS AND OBESITY ASSOCIATED PROTEIN; PROTEIN; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C; UNCLASSIFIED DRUG; FTO PROTEIN, HUMAN; HUMAN GROWTH HORMONE;

ADULT; AGED; ALLELE; ARTICLE; BODY MASS; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DIABETES MELLITUS; FEMALE; GENDER; GENETIC ANALYSIS; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; GERMANY; GROUPS BY AGE; GROWTH HORMONE RELEASE; HEALTH STATUS; HUMAN; MAJOR CLINICAL STUDY; MALE; OBESITY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; BLOOD; GENETICS; METABOLISM; MIDDLE AGED;

ADULT; AGED; BODY MASS INDEX; CROSS-SECTIONAL STUDIES; FEMALE; GENETIC VARIATION; GENOTYPE; GERMANY; HUMAN GROWTH HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; INSULIN-LIKE GROWTH FACTOR I; MALE; MIDDLE AGED; OBESITY; PROTEINS; YOUNG ADULT;

EID: 79952700759     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2010.158     Document Type: Article

References (60)

1. Comuzzie AG, Allison DB. The search for human obesity genes. Science 1998; 280: 1374-1377. (Pubitemid 28264818)
2. Dina C, Meyre D, Gallina S, Durand E, Korner A, Jacobson P et al. Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet 2007; 39: 724-726. (Pubitemid 46848595)
3. Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007; 316: 889-894. (Pubitemid 46764279)
4. Hinney A, Nguyen TT, Scherag A, Friedel S, Bronner G, Muller TD et al. Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants. PLoS One 2007; 2: e1361.
5. Scott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, Li Y, Duren WL et al. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 2007; 316: 1341-1345. (Pubitemid 46871655)
6. Scuteri A, Sanna S, Chen WM, Uda M, Albai G, Strait J et al. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet 2007; 3: e115.
7. Cecil JE, Tavendale R, Watt P, Hetherington MM, Palmer CN. An obesity-associated FTO gene variant and increased energy intake in children. N Engl J Med 2008; 359: 2558-2566.
8. Speakman JR, Rance KA, Johnstone AM. Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure. Obesity (Silver Spring) 2008; 16: 1961-1965.
9. Wardle J, Carnell S, Haworth CM, Farooqi IS, O'Rahilly S, Plomin R. Obesity associated genetic variation in FTO is associated with diminished satiety. J Clin Endocrinol Metab 2008; 93: 3640-3643.
10. Hakanen M, Raitakari OT, Lehtimaki T, Peltonen N, Pahkala K, Sillanmaki L et al. FTO genotype is associated with body mass index after the age of seven years but not with energy intake or leisure-time physical activity. J Clin Endocrinol Metab 2009; 94: 1281-1287.
11. Jonsson A, Renstrom F, Lyssenko V, Brito EC, Isomaa B, Berglund G et al. Assessing the effect of interaction between an FTO variant (rs9939609) and physical activity on obesity in 15925 Swedish and 2511 Finnish adults. Diabetologia 2009; 52: 1334-1338.
12. Andreasen CH, Stender-Petersen KL, Mogensen MS, Torekov SS, Wegner L, Andersen G et al. Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation. Diabetes 2008; 57: 95-101.
13. Mitchell JA, Church TS, Rankinen T, Earnest CP, Sui X, Blair SN. FTO genotype and the weight loss benefits of moderate intensity exercise. Obesity (Silver Spring) 2010; 18: 641-643.
14. Fischer J, Koch L, Emmerling C, Vierkotten J, Peters T, Bruning JC et al. Inactivation of the Fto gene protects from obesity. Nature 2009; 458: 894-898.
15. Church C, Lee S, Bagg EA, McTaggart JS, Deacon R, Gerken T et al. A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene. PLoS Genet 2009; 5: e1000599.
16. Olszewski PK, Fredriksson R, Olszewska AM, Stephansson O, Alsio J, Radomska KJ et al. Hypothalamic FTO is associated with the regulation of energy intake not feeding reward. BMC Neurosci 2009; 10: 129.
17. Stratigopoulos G, Padilla SL, LeDuc CA, Watson E, Hattersley AT, McCarthy MI et al. Regulation of Fto/Ftm gene expression in mice and humans. Am J Physiol Regul Integr Comp Physiol 2008; 294: R1185-R1196. (Pubitemid 351490637)
18. Tung YC, Ayuso E, Shan X, Bosch F, O'Rahilly S, Coll AP et al. Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats. PLoS One 2010; 5: e8771.
19. Hofker M, Wijmenga C. A supersized list of obesity genes. Nat Genet 2009; 41: 139-140.
20. Gerken T, Girard CA, Tung YC, Webby CJ, Saudek V, Hewitson KS et al. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science 2007; 318: 1469-1472. (Pubitemid 350208961)
21. John U, Greiner B, Hensel E, Ludemann J, Piek M, Sauer S et al. Study of Health In Pomerania (SHIP): a health examination survey in an east German region: objectives and design. Soz Praventivmed 2001; 46: 186-194. (Pubitemid 32747278)
22. Hardy R, Wills AK, Wong A, Elks CE, Wareham NJ, Loos RJ et al. Life course variations in the associations between FTO and MC4R gene variants and body size. Hum Mol Genet 2010; 19: 545-552.
23. Jacobsson JA, Riserus U, Axelsson T, Lannfelt L, Schioth HB, Fredriksson R. The common FTO variant rs9939609 is not associated with BMI in a longitudinal study on a cohort of Swedish men born 1920-1924. BMC Med Genet 2009; 10: 131.
24. Qi L, Kang K, Zhang C, van Dam RM, Kraft P, Hunter D et al. Fat mass-and obesity-associated (FTO) gene variant is associated with obesity: longitudinal analyses in two cohort studies and functional test. Diabetes 2008; 57: 3145-3151.
25. Lamberts SW, van den Beld AW, van der Lely AJ. The endocrinology of aging. Science 1997; 278: 419-424. (Pubitemid 27454418)
26. Jones JI, Clemmons DR. Insulin-like growth factors and their binding proteins: biological actions. Endocr Rev 1995; 16: 3-34.
27. Laursen T. Clinical pharmacological aspects of growth hormone administration. Growth Horm IGF Res 2004; 14: 16-44. (Pubitemid 38094240)
28. Le Roith D, Bondy C, Yakar S, Liu JL, Butler A. The somatomedin hypothesis: 2001. Endocr Rev 2001; 22: 53-74.
29. Juul A. Serum levels of insulin-like growth factor I and its binding proteins in health and disease. Growth Horm IGF Res 2003; 13: 113-170. (Pubitemid 36986557)
30. Friedrich N, Alte D, Volzke H, Spilcke-Liss E, Ludemann J, Lerch MM et al. Reference ranges of serum IGF-1 and IGFBP-3 levels in a general adult population: results of the Study of Health in Pomerania (SHIP). Growth Horm IGF Res 2008; 18: 228-237. (Pubitemid 351479927)
31. Boissel S, Reish O, Proulx K, Kawagoe-Takaki H, Sedgwick B, Yeo GS et al. Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations. Am J Hum Genet 2009; 85: 106-111.
32. Han Z, Niu T, Chang J, Lei X, Zhao M, Wang Q et al. Crystal structure of the FTO protein reveals basis for its substrate specificity. Nature 2010; 464: 1205-1209.
33. Meyre D, Proulx K, Kawagoe-Takaki H, Vatin V, Gutierrez-Aguilar R, Lyon D et al. Prevalence of loss-of-function FTO mutations in lean and obese individuals. Diabetes 2010; 59: 311-318.
34. Sanchez-Pulido L, Andrade-Navarro MA. The FTO (fat mass and obesity associated) gene codes for a novel member of the non-heme dioxygenase superfamily. BMC Biochem 2007; 8: 23.
35. Jia G, Yang CG, Yang S, Jian X, Yi C, Zhou Z et al. Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO. FEBS Lett 2008; 582: 3313-3319.
36. Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L et al. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell 2006; 124: 315-329. (Pubitemid 43121980)
37. Niedernhofer LJ, Garinis GA, Raams A, Lalai AS, Robinson AR, Appeldoorn E et al. A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis. Nature 2006; 444: 1038-1043. (Pubitemid 46018517)
38. van der Pluijm I, Garinis GA, Brandt RM, Gorgels TG, Wijnhoven SW, Diderich KE et al. Impaired genome maintenance suppresses the growth hormone-insulin-like growth factor 1 axis in mice with Cockayne syndrome. PLoS Biol 2007; 5: e2.
39. Vartanian V, Lowell B, Minko IG, Wood TG, Ceci JD, George S et al. The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase. Proc Natl Acad Sci USA 2006; 103: 1864-1869. (Pubitemid 43228784)
40. den Hoed M, Westerterp-Plantenga MS, Bouwman FG, Mariman EC, Westerterp KR. Postprandial responses in hunger and satiety are associated with the rs9939609 single nucleotide polymorphism in FTO. Am J Clin Nutr 2009; 90: 1426-1432.
41. Fredriksson R, Hagglund M, Olszewski PK, Stephansson O, Jacobsson JA, Olszewska AM et al. The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain. Endocrinology 2008; 149: 2062-2071. (Pubitemid 351574484)
42. Siejka A, Schally AV, Barabutis N. Activation of Janus kinase/signal transducer and activator of transcription 3 pathway by growth hormone-releasing hormone. Cell Mol Life Sci 2010; 67: 959-964.
43. Fodor M, Csaba Z, Kordon C, Epelbaum J. Growth hormone-releasing hormone, somatostatin, galanin and beta-endorphin afferents to the hypothalamic periventricular nucleus. J Chem Neuroanat 1994; 8: 61-73.
44. Mondal MS, Date Y, Yamaguchi H, Toshinai K, Tsuruta T, Kangawa K et al. Identification of ghrelin and its receptor in neurons of the rat arcuate nucleus. Regul Pept 2005; 126: 55-59. (Pubitemid 40037743)
45. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999; 402: 656-660. (Pubitemid 129516334)
46. Hartman ML, Veldhuis JD, Johnson ML, Lee MM, Alberti KG, Samojlik E et al. Augmented growth hormone (GH) secretory burst frequency and amplitude mediate enhanced GH secretion during a two-day fast in normal men. J Clin Endocrinol Metab 1992; 74: 757-765.
47. Ho KY, Veldhuis JD, Johnson ML, Furlanetto R, Evans WS, Alberti KG et al. Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man. J Clin Invest 1988; 81: 968-975.
48. Clemmons DR. Quantitative measurement of IGF-I and its use in diagnosing and monitoring treatment of disorders of growth hormone secretion. Endocr Dev 2005; 9: 55-65.
49. De Boer H, Blok GJ, Popp-Snijders C, Stuurman L, Baxter RC, van der Veen E. Monitoring of growth hormone replacement therapy in adults, based on measurement of serum markers. J Clin Endocrinol Metab 1996; 81: 1371-1377. (Pubitemid 26118565)
50. Borofsky ND, Vogelman JH, Krajcik RA, Orentreich N. Utility of insulin-like growth factor-1 as a biomarker in epidemiologic studies. Clin Chem 2002; 48: 2248-2251. (Pubitemid 35397570)
51. Hong Y, Brismar K, Hall K, Pedersen NL, de Faire U. Associations between insulin-like growth factor-I (IGF-I), IGF-binding protein-1, insulin and other metabolic measures after controlling for genetic influences: results from middle-aged and elderly monozygotic twins. J Endocrinol 1997; 153: 251-257. (Pubitemid 27219457)
52. Gomez JM, Maravall FJ, Gomez N, Navarro MA, Casamitjana R, Soler J. The IGF-I system component concentrations that decrease with ageing are lower in obesity in relationship to body mass index and body fat. Growth Horm IGF Res 2004; 14: 91-96. (Pubitemid 38332074)
53. Yamamoto H, Kato Y. Relationship between plasma insulin-like growth factor I (IGF-I) levels and body mass index (BMI) in adults. Endocr J 1993; 40: 41-45. (Pubitemid 23265494)
54. Schneider HJ, Saller B, Klotsche J, Marz W, Erwa W, Wittchen HU et al. Opposite associations of age-dependent insulin-like growth factor-I standard deviation scores with nutritional state in normal weight and obese subjects. Eur J Endocrinol 2006; 154: 699-706. (Pubitemid 43810856)
55. Laughlin GA, Barrett-Connor E, Criqui MH, Kritz-Silverstein D. The prospective association of serum insulin-like growth factor I (IGF-I) and IGF-binding protein-1 levels with all cause and cardiovascular disease mortality in older adults: the Rancho Bernardo Study. J Clin Endocrinol Metab 2004; 89: 114-120. (Pubitemid 38183869)
56. Roubenoff R, Parise H, Payette HA, Abad LW, D'Agostino R, Jacques PF et al. Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham Heart Study. Am J Med 2003; 115: 429-435. (Pubitemid 37237554)
57. Friedrich N, Haring R, Nauck M, Ludemann J, Rosskopf D, Spilcke-Liss E et al. Mortality and serum insulin-like growth factor (IGF)-I and IGF binding protein 3 concentrations. J Clin Endocrinol Metab 2009; 94: 1732-1739.
58. Doney AS, Dannfald J, Kimber CH, Donnelly LA, Pearson E, Morris AD et al. The FTO gene is associated with an atherogenic lipid profile and myocardial infarction in patients with type 2 diabetes: a Genetics of Diabetes Audit and Research Study in Tayside Scotland (Go-DARTS) study. Circ Cardiovasc Genet 2009; 2: 255-259.
59. Zimmermann E, Kring SI, Berentzen TL, Holst C, Pers TH, Hansen T et al. Fatness-associated FTO gene variant increases mortality independent of fatness-in cohorts of Danish men. PLoS One 2009; 4: e4428.
60. Ho AJ, Stein JL, Hua X, Lee S, Hibar DP, Leow AD et al. A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly. Proc Natl Acad Sci USA 2010; 107: 8404-8409.