Associations between insulin-like growth factor-I (IGF-I), IGF-binding protein-1, insulin and other metabolic measures after controlling for genetic influences: Results from middle-aged and elderly monozygotic twins

Journal of Endocrinology

Volumn 153, Issue 2, 1997, Pages 251-257

  Hong, Y ^a,b   Brismar, K ^b   Hall, K ^b   Pedersen, N L ^a,c   De Faire, U ^a,b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; SOMATOMEDIN BINDING PROTEIN 1; SOMATOMEDIN C;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; FEMALE; GENETICS; HUMAN; MAJOR CLINICAL STUDY; MALE; MONOZYGOTIC TWINS; PRIORITY JOURNAL;

EID: 0031004428     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.0.1530251     Document Type: Article

References (30)

1. Alitalo T, Kontula K, Koistinen R, Aalto-Setälä K, Julkunen M, Jänne OA, Seppäläm & de la Chapelle A 1989 The gene encoding human low-molecular weight insulin-like growth factor-binding protein (IGF-BP25): regional localization to 7p12-p13 and description of a DNA polymorphism. Human Genetics 83 335-338.
2. Bang P, Enksson U, Sara V, Wivall I-L & Hall K 1991 Comparison of acid ethanol extraction and acid gel filtration prior to IGF-I and IGF-II radioimmunoassays: Improvement of determinations in acid ethanol extracts by the use of truncated IGF-I as radioligand. Acta Endocrinologica 124 620-629.
3. Brismar K, Fernqvist-Forbers E, Wahern J & Hall K 1994 Effect of insulin on the hepatic production of insulin-like growth factor-binding protein-1 (IGFBP-1), IGFBP-3, and IGF-I in insulin-dependent diabetes. Journal of Clinical Endocrinology and Metabolism 79 872-878.
4. Cigolini M, Seidell JC, Targher G, Deslypere JP, Ellsinger BM, Charzewska J, Cruz A & Bjormtorp P 1995 Fasting serum insulin in relation to components of the metabolic syndrome in European healthy men: the European Fat Distribution Study. Metabolism: Clinical and Experimental 44 35-40.
5. Copeland KC, Colletti RB, Devlin JT & McAuliffe TL 1990 The relationship between insulin-like growth factor-I, adiposity, and aging. Metabolism: Clinical and Experimental 39 584-587.
6. DeFronzo RA & Ferrannini E 1991 Insulin resistance: A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 14 173-194.
7. Eriksson H, Welin L, Wilhelmsen L, Larsson B, Ohlson LO, Svardsudd K & Tibblin G 1992 Metabolic disturbances in hypertension: results from the population study on men born in 1913. Journal of Internal Medicine 232 389-395.
8. Froesch ER, Zenobi PD & Hussain M 1994 Metabolic and therapeutic effects of insulin-like growth factor I. Hormone Research 42 66-71.
9. Froesch ER, Bianda T & Hussain MA 1996 Insulin-like growth factor-I in the therapy of non-insulin-dependent diabetes mellitus and insulin resistance. Diabetes and Metabolism 22 261-267.
10. Gibson JM, Westwood M, Young RJ & White A 1996 Reduced insulin-like growth factor-binding protein-1 (IGFBP-1) levels correlate with increased cardiovascular risk in non-insulin dependent diabetes mellitus (NIDDM). Journal of Clinical Endocrinology and Metabolism 81 860-863.
11. Hall K, Brismar K, Grissom F, Lindgren B & Povoa G 1991 IGFBP-1: Production and control mechanisms. Acta Endocrinologica 124 48-54.
12. Harper ME, Ullnch A & Saunders GF 1981 Localization of the human insulin gene to the distal end of the short arm of chromosome 11. Proceedings of the National Academy of Sciences of the USA 78 4458-4480.
13. Hellenius ML, Brismar K, Berglund B & de Faire U 1995 Effects on glucose, insulin secretion, insulin-like growth factor-I, and its binding protein IGFBP-1 in a randomized controlled diet and exercise study in healthy middle-aged men. Journal of Internal Medicine 238 121-130.
14. Hilding A, Brismar K, Degerblad M, Thoren M & Hall K 1995 Altered relation between circulating levels of insulin-like growth factor-binding protein-1 and insulin in growth hormone-deficient patients and insulin-dependent diabetic patients compared with that in healthy subjects. Journal of Clinical Endocrinology and Metabolism 80 2646-2652.
15. Holly JMP & Martin JL 1994 Insulin-like growth factor binding proteins: a review of methodological aspects of their purification, analysis and regulation. Growth Regulation 4 (suppl 1) 20-30.
16. Hong Y, Pedersen N, Brismar K, Hall K & de Faire U 1996 Quantitative genetic analyses of insulin-like growth factor-I (IGF-I), IGF-binding protein-1 (IGFBP-1), and insulin in middle-aged and elderly twins. Journal of Clinical Endocrinology and Metabolism 81 1791-1797.
17. Hoppener JWM, de Pagter-Holthuizen P, van Kessel AHMG, Jansen M, Kittur SD, Antonarakis SE, Lipis CJ & Sussenbach JS 1985 The human gene encoding insulin-like growth factor-I is located on chromosome 12. Human Genetics 69 157-160.
18. Howard BV 1993 Insulin, insulin resistance, and dyslipidemia. Annals of the New York Academy of Sciences 683 1-8.
19. Juul A, Bang P, Hertel NT, Main K, Dalgård P, Giwercman A, Jørgensen K, Müller J, Hall K & Skakkebæk NE 1994 Serum insulin-like growth factor-I (IGF-I) in 1030 healthy children, adolescents and adults; relations to age, sex, stage of puberty, testicular size and body mass index. Journal of Clinical Endocrinology and Metabolism 78 744-752.
20. Lee PDK, Conover CA & Powell DR 1993 Regulation and function of insulin-like growth factor-binding protein-1. Proceedings of the Society for Experimental Biology and Medicine 204 4-29.
21. Lewitt MS & Baxter RC 1989 Regulation of growth hormone-independent insulin-like growth factor binding protein (BP-28) in cultured human fetal liver explants. Journal of Clinical Endocrinology and Metabolism 69 246-252.
22. Modan M, Halkin H, Almog S, Lusky A, Eshkol A, Shefi M, Shitrit A & Fuchs Z 1985 Hyperinsulinaemia: a link between hypertension, obesity and glucose intolerance. Journal of Clinical Investigation 75 809-817.
23. Pagano G, Bargero G, Vuolo A & Bruno G 1994 Prevalence and clinical feature of known type 2 diabetes in the elderly: a population-based study. Diabetic Medicine 11 475-479.
24. Pedersen NL, Friberg L, Floderus-Myrhed B, McClearn GE & Plomin R 1984 Swedish early separated twins: identification and characterization. Acta Geneticae Medicae et Gemellologiae 33 243-250.
25. Pedersen NL, McClearn GE, Plomin R, Nesselroade JR, Berg S & de Faire U 1991 The Swedish Adoption Twin study of Aging: an update. Acta Geneticae Medicae et Gemellologiae 40 7-20
26. Povoa G, Enberg G, Jörnvall H & Hall K 1984 Isolation and characterization of a somatomedin-binding protein from mid-term human amniotic fluid. European Journal of Biochemistry 144 199-204.
27. Reaven GM 1988 Role of insulin resistance in human disease. Diabetes 37 1595-1607.
28. Seigler L & Wu WT 1981 Separation of serum high-density lipoprotein for cholesterol determination: ultracentrifugation vs precipitation with sodium phosphotungstate and magnesium chloride. Clinical Chemistry 27 838-841.
29. Thissen JP, Ketelslegers JM & Underwood LE 1994 Nutritional regulation of the insulin-like growth factors. Endocrine Reviews 15 80-101.
30. Workshop 1990 Treatment of insulin dependent diabetes mellitus. National Board of Health and Welfare, Drug Information Committee, Sweden 2 185.