Atropisomerism in the vaptan class of vasopressin receptor ligands: The active conformation recognized by the receptor

Angewandte Chemie - International Edition

Volumn 50, Issue 13, 2011, Pages 3075-3079

  Tabata, Hidetsugu ^a   Nakagomi, Jun ^a   Morizono, Daisuke ^b   Oshitari, Tetsuta ^a   Takahashi, Hideyo ^a   Natsugari, Hideaki ^a  

^a TEIKYO UNIVERSITY   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

1,5 Benzodiazepine; Atropisomerism; Chirality; Receptors; Vasopressin

Indexed keywords

1,5-BENZODIAZEPINE; ATROPISOMERISM; ATROPISOMERS; CHEMICAL EQUATIONS; NITROGEN HETEROCYCLES; ORTHO-SUBSTITUTION; RECEPTOR LIGANDS; RECEPTORS; VASOPRESSIN;

CHIRALITY; CONFORMATIONS; ENANTIOMERS; STEREOCHEMISTRY;

LIGANDS;

BENZAZEPINE DERIVATIVE; LIGAND; VASOPRESSIN RECEPTOR;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DRUG ANTAGONISM; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

BENZAZEPINES; CRYSTALLOGRAPHY, X-RAY; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; RECEPTORS, VASOPRESSIN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79952666391     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201007772     Document Type: Article

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