Axial chirality and affinity at the GABAA receptor of pyrimido[1,2-a][1,4]benzodiazepines and related compounds

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 21, 2008, Pages 9519-9523

  Lee, Shoukou ^b   Kamide, Tomonori ^b   Tabata, Hidetsugu ^a   Takahashi, Hideyo ^a   Shiro, Motoo ^c   Natsugari, Hideaki ^a  

^a TEIKYO UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c RIGAKU CORPORATION   (Japan)

Author keywords

Atropisomer; Estazolam; GABAA receptor; Pyrimido 1,2 a 1,4 benzodiazepine; Triazolam; X ray analysis

Indexed keywords

10 CHLORO 5,6 DIHYDRO 1 METHYL 8 PHENYL 3H PYRIMIDO[1,2 A][1,5]BENZODIAZOCIN 3 ONE; 10 CHLORO 5,6 DIHYDRO 3 METHYL 8 PHENYL 1H PYRIMIDO[1,2A][1,5]BENZODIAZOCIN 1 ONE; 4 AMINOBUTYRIC ACID A RECEPTOR; 9 CHLORO 1 METHYL 7 PHENYLPYRIMIDO[1,2 A][1,4]BENZODIAZEPIN 3(5H) ONE; 9 CHLORO 3 METHYL 7 PHENYLPYRIMIDO[1,2 A][1,4]BENZODIAZEPIN 1(5H) ONE; 9 CHLORO 7 (2 CHLOROPHENYL) 1 METHYLPYRIMIDO[1,2 A][1,4]BENZODIAZEPIN 3(5H) ONE; BENZODIAZEPINE DERIVATIVE; PYRIMIDINE DERIVATIVE; PYRIMIDO[1,2 A][1,4]BENZODIAZEPINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHIRALITY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IC 50; ISOMER; RECEPTOR AFFINITY; STEREOCHEMISTRY; STRUCTURE ANALYSIS;

BENZODIAZEPINES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRYSTALLOGRAPHY, X-RAY; GAMMA-AMINOBUTYRIC ACID; HUMANS; MOLECULAR STRUCTURE; PROTEIN BINDING; RECEPTORS, GABA-A; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 53749105016     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.09.037     Document Type: Article

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