The challenge of atropisomerism in drug discovery

Angewandte Chemie - International Edition

Volumn 48, Issue 35, 2009, Pages 6398-6401

  Clayden, Jonathan ^a   Moran, Wesley J ^a   Edwards, Paul J ^b   Laplante, Steven R ^b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b BOEHRINGER INGELHEIM CANADA LTD   (Canada)

Author keywords

Atropisomerism; Chirality; Conformers; Drug discovery; Kinetics

Indexed keywords

ATROPISOMERISM; ATROPISOMERS; CONFORMERS; DRUG CANDIDATES; DRUG DISCOVERY; GENERAL APPROACH; REGULATORY AGENCIES;

CHIRALITY; ENANTIOMERS;

STEREOCHEMISTRY;

DRUG;

CHEMISTRY; CONFORMATION; DRUG DEVELOPMENT; ISOMERISM; REVIEW;

DRUG DISCOVERY; ISOMERISM; MOLECULAR CONFORMATION; PHARMACEUTICAL PREPARATIONS;

EID: 70349894963     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200901719     Document Type: Article

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