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(a) H. Natsugari, Y. Ikeura, Y. Kiyota, Y. Ishichi, T. Ishimaru, O. Saga, H. Shirafuji, T. Tanaka, I. Kamo, T. Doi and M. Otsuka, J. Med. Chem., 1995, 38, 3106;
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Natsugari, H.1
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0031243671
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(b) Y. Ikeura, T. Tanaka, Y. Kiyota, S. Morimoto, M. Ogino, T. Ishimaru, I. Kamo, T. Doi and H. Natsugari, Chem. Pharm. Bull., 1997, 45, 1642;
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Natsugari, H.9
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21844460100
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in the press
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(c) Y. Ikeura, Y. Ishichi, T. Tanaka, A. Fujishima, M. Murabayashi, M. Kawada, T. Ishimaru, I. Kamo, T. Doi and H. Natsugari, J. Med. Chem., in the press.
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Ikeura, Y.1
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Recent review articles for tachykinin antagonists: S. MacLean, Med. Res. Rev., 1996, 16, 297;
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MacLean, S.1
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6
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84981828672
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The italic letter a before the corresponding R and S denotes an axial chirality as suggested by Cahn et.al.; R. S. Cahn, C. Ingold and V. Prelog, Angew. Chem., Int. Ed. Engl., 1966, 5, 385.
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Cahn, R.S.1
Ingold, C.2
Prelog, V.3
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7
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0029935516
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As for synthesis and separation of atropisomers of some aromatic carboxamides, see S. Thayumanavan, P. Beak and D. P. Curran, Tetrahedron Lett., 1996, 37, 2899;
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J. Clayden, N. Westlund and F. X. Wilson, Tetrahedron Lett., 1996, 37, 577;
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A. Ohno, M. Kashiwagi, Y. Ishihara, S. Ushida and S. Oka, Tetrahedron, 1986, 42, 961.
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H. Natsugari, T. Ishimaru, T. Doi, Y. Ikeura and C. Kimura, Eur. Pat. Appl., EP733632, 1996
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Natsugari, H.1
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0348201335
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(Chem. Abst., 1997, 126, 8145).
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0025282772
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As for atropisomerism in seven-membered heterocycles, see N. W. Gilman, P. Rosen, J. V. Earley, C. Cook and L. J. Todaro, J. Am. Chem. Soc., 1990, 112, 3969.
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21844433829
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note
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-1, reflections measured = 2386, R = 0.068. CCDC 182/988.
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17
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0027065565
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M. A. Cascieri, E. Ber, T. N. Fong, S. Sadowski, A. Basal, C. Swain, E. Seward, B. Frances, D. Burns and C. D. Strader, Mol. Pharmacol., 1992, 42, 458.
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Cascieri, M.A.1
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Basal, A.5
Swain, C.6
Seward, E.7
Frances, B.8
Burns, D.9
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0025840388
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A. Eglezos, S. Giuliani, G. Viti and C. A. Maggi, Eur. J. Pharmacol., 1991, 209, 277.
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Eglezos, A.1
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