Pharmacological profile of YM087, a novel potent nonpeptide vasopressin V(1A) and V2 receptor antagonist, in vitro and in vivo

Journal of Pharmacology and Experimental Therapeutics

Volumn 282, Issue 1, 1997, Pages 301-308

  Tahara, Atsuo ^a   Tomura, Yuichi ^a   Wada, Koh Ichi ^a   Kusayama, Toshiyuki ^a   Tsukada, Junko ^a   Takanashi, Masahiro ^a   Yatsu, Takeyuki ^a   Uchida, Wataru ^a   Tanaka, Akihiro ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 [1 [4 (3 ACETAMIDOPROPOXY)BENZOYL] 4 PIPERIDYL] 1,2,3,4 TETRAHYDRO 2 QUINOLINONE; 4' [(2 METHYL 1,4,5,6 TETRAHYDROIMIDAZO[4,5][1]BENZAZEPIN 6 YL)CARBONYL] 2 PHENYLBENZANILIDE; CALCIUM; CONIVAPTAN; CYCLIC AMP; MOZAVAPTAN; OXYTOCIN RECEPTOR; UNCLASSIFIED DRUG; VASOPRESSIN; VASOPRESSIN ANTAGONIST; VASOPRESSIN V1 RECEPTOR; VASOPRESSIN V2 RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING KINETICS; CALCIUM CELL LEVEL; DOSE RESPONSE; DRUG EFFECT; DRUG RECEPTOR BINDING; FEMALE; HORMONE INHIBITION; HORMONE RECEPTOR INTERACTION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; SECOND MESSENGER;

ANIMALS; ARGININE VASOPRESSIN; BENZAZEPINES; CALCIUM; CYCLIC AMP; FEMALE; MALE; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTORS, VASOPRESSIN;

EID: 0030770540     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. BIRNBAUMER, M., SEIBOLD, A., GILBERT, S., ISHIDO, M., BARBERIS, C., ANTARAMIAN, A., BRABET, P. AND ROSENTHAL, W.: Molecular cloning of the receptor for human antidiuretic hormone. Nature 357: 333-335, 1992.
2. BRADFORD, M.M.: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72: 248-254, 1976.
3. BUTLEN, D., GUILLON, G., RAJERISON, R. M., JARD, S., SAWYER, W. H. AND MANNING, M.: Structural requirements for activation of vasopressin-sensitive adenylate cyclase, hormone binding, and antidiuretic actions. Mol. Pharmacol. 14: 1006-1017, 1978.
4. CAMPBELL, B. J., WOODWARD, G. AND BORBERG, V.: Calcium-mediated interactions between the antidiuretic hormone and renal plasma membranes. J. Biol. Chem. 247: 6167-6175, 1972.
5. 50) of an enzymatic reaction. Biochem. Pharmacol. 22: 3099-3108, 1973.
6. CREAGER, M. A., FAXON, D. P., CUTLER, S. S., KOHLMANN, O., RYAN, T. J. AND GAVRAS, H.: Contribution of vasopressin to vasoconstriction in patients with congestive heart failure. J. Am. Coll. Cardiol. 7: 758-765, 1986.
7. FUJISAWA, G., ISHIKAWA, S., TSUBOI, Y., OKADA, K. AND SAITO, T.: Therapeutic efficacy of non-peptide ADH antagonist OPC-31260 in SIADH rats. Kidney Int. 44: 19-23, 1993.
8. GOLDSMITH, S. R., FRANCIS, G. S., COWLEY, A. W. JR., GOLDENBERG, I. F. AND COHN, J. N.: Hemodynamic effects of infused arginine vasopressin in congestive heart failure. J. Am. Coll. Cardiol. 8: 779-783, 1986.
9. HOLLAND, J. D., SINGH, P., BRENNAND, J. C. AND GARMAN, A. J.: A nonseparation microplate receptor binding assay. Anal. Biochem. 222: 516-518, 1994.
10. HOWL, J., ISMAIL, T., STRAIN, A. J., KIRK, C. J., ANDERSON, D. AND WHEATLEY, M.: Characterization of the human liver vasopressin receptor. Biochem. J. 276: 189-195, 1991.
11. HULL, R. N., CHERRY, W. R. AND WEAVER, G. W.: The origin and characteristics of a pig kidney cell strain, LLC-PK. In Vitro. 12: 670-677, 1976.
12. 1 renal epithelial cells at physiological temperature. EMBO J. 8: 2481-2488, 1989.
13. JARD, S., GAILLARD, R. C., GUILLON, G., MARIE, J., SCHOENENBERG, P., MULLER, A. F., MANNING, M. AND SAWYER, W. H.: Vasopressin antagonists allow demonstration of a novel type of vasopressin receptor in the rat adenohypophysis. Mol. Pharmacol. 30: 171-177, 1986.
14. 1a type. Am. J. Physiol. 253: F41-F49, 1987.
15. KIM, J. K., MICHEL, J. B., SOUBRIER, F., DURR, J., CORVOL, P. AND SCHRIER, R. W.: Arginine vasopressin gene expression in chronic cardiac failure in rats. Kidney Int. 38: 818-822, 1990.
16. KIMES, B. W. AND BRANDT, B. L.: Characterization of two putative smooth muscle cell lines from rat thoracic aorta. Exp. Cell Res. 98: 349-366, 1976.
17. KRUSZYNSKI, M., LAMMEK, B., MANNING, M., SETO, J., HALDAR, J. AND SAWYER, W. H.: [1-(β-Mercapto-β,β-cyclopentamethylenepropionicacid),2-(O-methyl) tyrosine] arginine-vasopressin and [1-(β-mercapto-β,β-cyclopentamethylenepropionic acid)]arginine-vasopressin, two highly potent antagonists of the vasopressor response to arginine-vasopressin. J. Med. Chem. 23: 364-368, 1980.
18. LASZLO, F. A., LASZLO, F. JR. AND DE WIED, D.: Pharmacology and clinical perspectives of vasopressin antagonists. Pharmacol. Rev. 43: 73-108, 1991.
19. LEE, W. H. AND PACKER, M.: Prognostic importance of serum sodium concentration and its modification by converting-enzyme inhibition in patients with severe chronic heart failure. Circulation 73: 257-267, 1986.
20. LEVINE, T. B., FRANCIOSA, J. A., VROBEL, T. AND COHN, J. N.: Hyponatremia as a marker for high renin heart failure. Br. Heart J. 47: 161-166, 1982.
21. LUTZ-BUCHER, B. AND KOCH, B.: Characterization of specific receptors for vasopressin in the pituitary gland. Biochem. Biophys. Res. Commun. 115: 492-498, 1983.
22. MANNING, M. AND SAWYER, W. H.: Synthesis and receptor specificities of vasopressin antagonists. J. Cardiovasc. Pharmacol. 8: suppl. 7, S29-S35, 1986.
23. MICHELL, R. H., KIRK, C. J. AND BILLAH, M. M.: Hormonal stimulation of phosphatidyl-inositol breakdown with particular reference to the hepatic effects of vasopressin. Biochem. Soc. Trans. 7: 861-865, 1979.
24. MULINARI, R. A., GAVRAS, I., WANG, Y. X., FRANCO, R. AND GAVRAS, H.: Effects of a vasopressin antagonist with combined antipressor and antiantidiuretic activities in rats with left ventricular dysfunction. Circulation 81: 308-311, 1990.
25. NAITOH, M., SUZUKI, H., MURAKAMI, M., MATSUMOTO, A., ARAKAWA, K., ICHIHARA, A., NAKAMOTO, H., OKA, K., YAMAMURA, Y. AND SARUTA, T.: Effects of oral AVP receptor antagonists OPC-21268 and OPC-31260 on congestive heart failure in conscious dogs. Am. J. Physiol. 267: H2245-H2254, 1994.
26. NAKAMURA, T., TOMOMURA, A., NODA, C., SHIMOJI, M. AND ICHIHARA, A.: Acquisition of a beta-adrenergic response by adult rat hepatocytes during primary culture. J. Biol. Chem. 258: 9283-9289, 1983.
27. NICOD, P., WAEBER, B., BUSSIEN, J. P., GOY, J. J., TURINI, G., NUSSBERGER, J., HOFBAUER, K. G. AND BRUNNER, H. R.: Acute hemodynamic effect of a vascular antagonist of vasopressin in patients with congestive heart failure. Am. J. Cardiol. 55: 1043-1047, 1985.
28. Os, I., KJELDSEN, S. E., SKJOTO, J., WESTHEIM, A., LANDE, K., AAKESSON, I., FREDERICHSEN, P., LEREN, P., HJERMANN, I. AND EIDE, I. K.: Increased plasma vasopressin in low renin essential hypertension. Hypertension 8: 506-513, 1986.
29. PETTIBONE, D. J., WOYDEN, C. J. AND TOTARO, J. A.: Identification of functional oxytocin receptors in lactating rat mammary gland in vitro. Eur. J. Pharmacol. 188: 235-241, 1990.
30. 1a antagonist, on human vascular smooth muscle cells. Am. J. Physiol. 268: H404-H410, 1995.
31. 1a receptors. J. Clin. Invest. 92: 224-231, 1993.
32. 1b vasopressin receptor. J. Biol. Chem. 269: 27088-27092, 1994.
33. SZATALOWICZ, V. L., ARNOLD, P. E., CHAIMOVITZ, C., BICHET, D., BERL, T. AND SCHRIER, R. W.: Radioimmunoassay of plasma arginine vasopressin in hyponatremic patients with congestive heart failure. N. Engl. J. Med. 305: 263-266, 1981.
34. THIBONNIER, M. AND ROBERTS, J. M.: Characterization of human platelet vasopressin receptors. J. Clin. Invest. 76: 1857-1864, 1985.
35. 1a vasopressin receptor. J. Biol. Chem. 269: 3304-3310, 1994.
36. TOVEY, K. C., OLDHAM, K. G. AND WHELAN, J. A.: A simple direct assay for cyclic AMP in plasma and other biological samples using an improved competitive protein binding technique. Clin. Chim. Acta 56: 221-234, 1974.
37. YAMAMURA, Y., OGAWA, H., CHIHARA, T., KONDO, K., ONOGAWA, T., NAKAMURA, S., MORI, T., TOMINAGA, M. AND YABUUCHI, Y.: OPC-21268, an orally effective, nonpeptide vasopressin V1 receptor antagonist. Science 252: 572-574, 1991.
38. 2 receptor antagonist. Br. J. Pharmacol. 105: 787-791, 1992.
39. 2 receptor antagonist, in dogs. Eur. J. Pharmacol., in press, 1997.
40. ZAORAL, M., KOLC, J. AND SORM, F.: Amino acids and peptides. LXXII. Synthesis of 1-deamino-8-D-gamma-aminobutyrine-vasopressin, 1-deamino-8-D-lysinvasopressin, and 1-deamino-8-D-arginine-vasopressin. Coll. Czech. Chem. Commun. 32: 1250-1257, 1967.