7-Chloro-5-hydroxy-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5- tetrahydro-1H-1-benzazepine (OPC-41061): A potent, orally active nonpeptide arginine vasopressin V2 receptor antagonist

Bioorganic and Medicinal Chemistry

Volumn 7, Issue 8, 1999, Pages 1743-1754

  Kondo, Kazumi ^a   Ogawa, Hidenori ^a   Yamashita, Hiroshi ^a   Miyamoto, Hisashi ^a   Tanaka, Michinori ^a   Nakaya, Kenji ^a   Kitano, Kazuyoshi ^a   Yamamura, Yoshitaka ^a   Nakamura, Shigeki ^a   Onogawa, Toshiyuki ^a   Mori, Toyoki ^a   Tominaga, Michiaki ^a  

^a OTSUKA PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Aquaretic; Avp V2 antagonist; Nonpeptide; Orally active

Indexed keywords

BENZAZEPINE DERIVATIVE; TOLVAPTAN; UNCLASSIFIED DRUG; VASOPRESSIN RECEPTOR ANTAGONIST; VASOPRESSIN V2 RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIURESIS; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT;

ANIMALS; ARGININE VASOPRESSIN; BENZAZEPINES; DIURETICS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MOLECULAR STRUCTURE; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, VASOPRESSIN;

EID: 0032811742     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00101-7     Document Type: Article

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