First enantioselective synthesis of 4-aminoalcohol quinoline derivatives through a regioselective SN2 epoxide opening mechanism

Tetrahedron Asymmetry

Volumn 22, Issue 2, 2011, Pages 138-148

  Jonet, Alexia ^a   Dassonville Klimpt, Alexandra ^a   Da Nascimento, Sophie ^a   Leger, Jean Michel ^b   Guillon, Jean ^b   Sonnet, Pascal ^a  

^a UNIVERSITÉ DE PICARDIE JULES VERNE   (France)

^b Laboratoire de Pharmacochimie   (France)

Author keywords

[No Author keywords available]

Indexed keywords

1 ( 2,8 BIS(TRIFLUOROMETHYL)QUINOLIN 4 YL) 2 ((TERT BITYLDIMETHYLSILYL)OXY)ETHYL 3,3,3 TRIFLUORO 2 METHOXY 2 PHENYLPROPANOIC ACID; 1 ( 2,8 BIS(TRIFLUOROMETHYL)QUINOLIN 4 YL) 2 ((TERT BUTYLDIMETHYLSILYL)OXY)ETHANOL; 1 ( 2,8 BIS(TRIFLUOROMETHYL)QUINOLIN 4 YL) 2 ((TERT BUTYLDIMETHYLSILYL)OXY)ETHYL 3,3,3 TRIFLUORO 2 METHOXY 2 PHENYLPROPANOIC ACID; 1 ( 2,8 BIS(TRIFLUOROMETHYL)QUINOLIN 4 YL) 2 (HEXYLAMINO)ETHANOL; 1 ( 2,8 BIS(TRIFLUOROMETHYL)QUINOLIN 4 YL) 2 (PENTYLAMINO)ETHANOL; 1 [ 2,8 BIS(TRIFLUOROMETHYL)QUINOLIN 4 YL]ETHANE 1,2 DIOL; 2 (BENZYLAMINO) 1 ( 2,8 BIS(TRIFLUOROMETHYL)QUINOLIN 4 YL)ETHANOL; 2,8 BIS(TRIFLUOROMETHYL) 4 VINYLQUINOLINE; 2,8 BIS(TRIFLUOROMETHYL)QUINOLIN 4 YL 4 METHYLBENZENESULFONIC ACID; 2,8 BIS(TRIFLUOROMETHYL)QUINOLIN 4 YL TRIFLUOROMETHANE SULFONIC ACID; 4 (OXIRAN 2 YL) 2,8 BIS(TRIFLUOROMETHYL)QUINOLINE; 4 AMINOALCOHOL QUINOLINE DERIVATIVE; 4 AMINOQUINOLINE DERIVATIVE; 4 BROMO 2.8 BIS(TRIFLUOROMETHYL)QUINOLINE; 4 OXIRANE; AMINE; EPOXIDE; ETHYL 4 ( 4 ( 2 ( 2,8 BIS(TRIFLUOROMETHYL)QUINOLIN 4 YL) 2 (HYDROXYETHYL)PIPERAZIN 1 YL))BUTANOIC ACID; ETHYLENE OXIDE DERIVATIVE; MEFLOQUINE; QUINOLINE DERIVATIVE; TERT BUTYL ( 3 ( 4 ( 3 (( 2 ( 2,8 BIS(TRIFLUOROMETHYL)QUINOLIN 4YL) 2 (HYDROXYETHYL)AMINO)PROPYL)PIPERAZIN 1 YL)CARBAMIC ACID; TERT BUTYL ( 3 ( 4 ( 3 (( 2,8 BIS(TRIFLUOROMETHYL)QUINOLIN 4 YL) 2 (HYDROXYETHYL)AMINO)PROPYL)PIPERAZIN 1 YL)PROPYL)CARBAMIC ACID; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; ENANTIOMER; ENANTIOSELECTIVITY; IN VITRO STUDY; IN VIVO STUDY; PRIORITY JOURNAL; RING OPENING; STEREOCHEMISTRY; SYNTHESIS;

EID: 79952486544     PISSN: 09574166     EISSN: 1362511X     Source Type: Journal    
DOI: 10.1016/j.tetasy.2011.01.003     Document Type: Article

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