Antagonists of the human adenosine A2A receptor. Part 1: Discovery and synthesis of thieno[3,2-d]pyrimidine-4-methanone derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 9, 2008, Pages 2916-2919

  Gillespie, Roger J ^a   Adams, David R ^a   Bebbington, David ^a   Benwell, Karen ^a   Cliffe, Ian A ^a   Dawson, Claire E ^a   Dourish, Colin T ^a   Fletcher, Allan ^a   Gaur, Suneel ^a   Giles, Paul R ^a   Jordan, Allan M ^a   Knight, Antony R ^a   Knutsen, Lars J S ^a   Lawrence, Anthony ^a   Lerpiniere, Joanne ^a   Misra, Anil ^a   Porter, Richard H P ^a   Pratt, Robert M ^a   Shepherd, Robin ^a   Upton, Rebecca ^a   Ward, Simon E ^a   Weiss, Scott M ^a   Williamson, Douglas S ^a   more..

^a Vernalis PLC   (United Kingdom)

Author keywords

Adenosine A2A receptor; Mefloquine; Parkinson's disease

Indexed keywords

ADENOSINE A2 RECEPTOR ANTAGONIST; HALOPERIDOL; MEFLOQUINE; THIENO[3,2 D]PYRIMIDINE 4 METHANONE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DRUG ANTAGONISM; DRUG BINDING SITE; DRUG DESIGN; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENANTIOMER; IN VIVO STUDY; MOUSE; NONHUMAN; PARKINSON DISEASE; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ANTIMALARIALS; ANTIPARKINSON AGENTS; HUMANS; MODELS, CHEMICAL; PARKINSONIAN DISORDERS; PYRIMIDINES; RECEPTOR, ADENOSINE A2A; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 42949171996     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.03.075     Document Type: Article

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