Inhibitory effect of ursolic acid derivatives on hydrogen peroxide- and glutathione-mediated degradation of hemin: A possible additional mechanism of action for antimalarial activity

Experimental Parasitology

Volumn 125, Issue 3, 2010, Pages 202-207

  Mullié, Catherine ^a   Jonet, Alexia ^a   Dassonville Klimpt, Alexandra ^a   Gosmann, Grace ^b   Sonnet, Pascal ^a  

^a Faculte de Pharmacie   (France)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Hematin; Glutathione; Hydrogen peroxide; Plasmodium falciparum; Ursolic acid

Indexed keywords

ACETYLURSOLIC ACID; ANTIMALARIAL AGENT; ANTIPARASITIC AGENT; ANTIPROTOZOAL AGENT; ANTISPOROZOAL AGENT; ASCORBIC ACID; CHLOROQUINE; FERRIC ION; GLUTATHIONE; HEMIN; HYDROGEN PEROXIDE; MEFLOQUINE; N [3 [4 (4 AMINOPROPYL)PIPERAZINYL]PROPYL] 3 O ACETYLURSOLAMIDE; N [3 [4 [3 [(4 HYDROXYBENZYL)AMINO]PROPYL]PIPERAZINYL]PROPYL] 3 O ACETYLURSOLAMIDE; N [3 [4 [3 [BIS(4 HYDROXYBENZYL)AMINO]PROPYL]PIPERAZINYL]PROPYL] 3 O ACETYLURSOLAMIDE; PHENYL GROUP; PIPERAZINE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; URSOLIC ACID; URSOLIC ACID DERIVATIVE;

ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DEGRADATION; DRUG COMPETITION; DRUG STRUCTURE; IN VITRO STUDY; NONHUMAN; PEROXIDATION; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ANTIMALARIALS; GLUTATHIONE; HEMEPROTEINS; HEMIN; HYDROGEN PEROXIDE; ILEX PARAGUARIENSIS; PLANT LEAVES; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP; TRITERPENES;

PLASMODIUM FALCIPARUM;

EID: 77952582719     PISSN: 00144894     EISSN: 10902449     Source Type: Journal    
DOI: 10.1016/j.exppara.2010.01.016     Document Type: Article

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