Synthesis and antituberculosis activity of novel mefloquine-isoxazole carboxylic esters as prodrugs

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 3, 2010, Pages 1263-1268

  Mao, Jialin ^a   Yuan, Hai ^a   Wang, Yuehong ^a   Wan, Baojie ^a   Pak, Dennis ^a   He, Rong ^a   Franzblau, Scott G ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Antituberculosis; Ester; Isoxazole; Quinoline; SAR

Indexed keywords

5 (2,8 BIS(TRIFLUOROMETHYL)QUINOLIN 4 YLOXYMETHYL)ISOXAZOLE 3 CARBOXYLIC ACID ETHYL ESTER; ESTER; MEFLOQUINE; PRODRUG; RIFAMPICIN; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG; CARBOXYLIC ACID; ISOXAZOLE DERIVATIVE;

ACIDITY; ARTICLE; BACILLUS ANTHRACIS; BACTERIAL COUNT; BACTERICIDAL ACTIVITY; CANDIDA ALBICANS; DRUG ACTIVITY; DRUG POTENCY; DRUG SYNTHESIS; ESCHERICHIA COLI; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MACROPHAGE; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM BOVIS; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; PH; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION; TUBERCULOSIS; COMPARATIVE STUDY; DRUG EFFECTS; GROWTH, DEVELOPMENT AND AGING; MICROBIAL SENSITIVITY TEST; SYNTHESIS;

BACTERIA (MICROORGANISMS); MYCOBACTERIUM TUBERCULOSIS;

ANTITUBERCULAR AGENTS; CARBOXYLIC ACIDS; ESTERS; HUMANS; ISOXAZOLES; MEFLOQUINE; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM TUBERCULOSIS; PRODRUGS;

EID: 74049097181     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.11.105     Document Type: Article

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