Synthesis and in vitro antimycobacterial activities of novel 6-substituted-3(2H)-pyridazinone-2-acetyl-2-(substituted/nonsubstituted acetophenone) hydrazone

Turkish Journal of Chemistry

Volumn 35, Issue 2, 2011, Pages 331-339

  Utku, Semra ^a   Gökçe, Mehtap ^b   Aslan, Gönül ^a   Bayram, Gül ^a   Ülger, Mahmut ^a   Emekdaş, Gürol ^a   Şahin, M Fethi ^b  

^a MERSIN UNIVERSITY   (Turkey)

^b GAZI UNIVERSITY   (Turkey)

Author keywords

3(2H) pyridazinone; Acetophenone hydrazone; Antimycobacterial activity; Antitubercular drugs

Indexed keywords

EID: 79952437599     PISSN: 13000527     EISSN: 13036130     Source Type: Journal    
DOI: 10.3906/kim-1009-63     Document Type: Article

References (38)

1. Tripathi, R. P.; Tewari, N.; Diwivedi, N.; Tivari, V. K. Med. Res. Rev. 2005, 25, 93-131.
2. Arcus, V. L.; Lott, J. S.; Johnston, J. M.; Baker, E. N. Drug Discov. Today 2006, 11, 28-35.
3. Umesiri, F. E.; Sanki, A. K.; Boucau, J.; Ronning, D. R.; Sucheck, S. J. Med. Res. Rev. 2010, 30, 290-326.
4. Haydel, S. E. Pharmaceuticals 2010, 3, 2268-2290.
5. Toossi, Z. J. Infect. Dis. 2003, 188, 1146-1155.
6. Kranzer, K.; Houben, R. M.; Glynn, J. R.; Bekker, L. G.; Wood, R.; Lawn, S. D. Lancet Infect. Dis. 2010, 10, 93-102.
7. Logu, A. D.; Onnis, V.; Saddi, B.; Congiu, C.; Schivo, M. L.; Cocco, M. T. J. Antimicrob. Chemoth. 2002, 49, 275-282.
8. Takahashi, K.; Hasegawa, Y.; Abe, T.; Yamamoto, T.; Nakashima, K.; Imaizumi, K.; Shimokata, K. Tuberculosis 2008, 88, 52-57.
9. Caminero, J. A.; Sotgiu, G.; Zumla, A.; Migliori, G. B. Lancet Infect. Dis. 2010, 10, 621-629.
10. Rollas, S.; Küçükgüzel, S. G. Molecules 2007, 12, 1910-1939.
11. Küçükgüzel, S. G.; Mazi, A.; Şahin, F.; Öztürk, S.; Stables, J. Eur. J. Med. Chem. 2003, 38, 1005-1013.
12. Özkay, Y.; Tunali, Y.; Karaca, H.; Işikdaǧ, İ. Eur. J. Med. Chem. 2010, 45, 3293-3298.
13. Ajani, O. O.; Obafemi, C. A.; Nwinyi, O. C.; Akinpelu, D. A. Bioorg. Med. Chem. 2010, 18, 214-221.
14. Salgin-Gökşen, U.; Gökhan-Kelekçi, N.; Göktaş, O.; Köysal, Y.; Kiliç, E.; Işik, S.; Aktay, G.; Ozalp, M. Bioorg. Med. Chem. 2007, 15, 5738-5751.
15. Sriram, D.; Yogeeswari, P.; Madhu, K. Bioorg. Med. Chem. Lett. 2005, 15, 4502-4505.
16. Maccari, R.; Ottaná, R.; Vigorita, M. G. Bioorg. Med. Chem. Lett. 2005, 15, 2509-2513.
17. Sriram, D.; Yogeeswari, P.; Devakaram, R. V. Bioorg. Med. Chem. 2006, 14, 3113-3118.
18. Koçyiǧit-Kaymakçioǧlu, B.; Oruç, E.; Unsalan, S.; Kandemirli, F.; Shvets, N.; Rollas, S.; Anatholy, D. Eur. J. Med. Chem. 2006, 41, 1253-1261.
19. Imramovský, A.; Polanc, S.; Vinsová, J.; Kocevar, M.; Jampílek, J.; Reckova, Z.; Kaustová, J. Bioorg. Med. Chem. 2007, 15, 2551-2559.
20. Turan-Zitouni, G.; Özdemir, A.; Kapancikli, Z. A.; Benkli, K.; Chevallet, P.; Akalin G. Eur. J. Med. Chem. 2008, 43, 981-985.
21. Pavan, F. R.; Maia, P. I.; Liete, S. R. A.; Deflon, V. M.; Batista, A. A.; Sato, D. N.; Franzbau, S. G.; Liete, C. Q. F. Eur. J. Med. Chem. 2010, 45, 1898-1905.
22. Abdel-Aal, M. T.; El-Sayed, W. A.; El-Ashry, E. H. Arch. Pharm. Chem. Life Sci. 2006, 339, 656-663.
23. El-Sabbagh, O. I.; Rady, H. M. Eur. J. Med. Chem. 2009, 44, 3680-3686.
24. Walcourt, A.; Loyevsky, M.; Lovejoy, D. B.; Gordeuk, V. R.; Richardson, D. R. Int. J. Biochem. Cell B 2004, 36, 401-407.
25. Gemma, S.; Kukreja, G.; Fattorusso, C.; Persico, M.; Romano, M. P.; Altarelli, M.; Savini, L.; Campiani, G.; Fattorusso, E.; Basilico, N.; Taramelli, D.; Yardley, V.; Butini, S. Bioorg. Med. Chem. Lett. 2006, 16, 5384-5388.
26. National Committee for Clinical Laboratory Standards. Susceptibility Testing of Mycobacteria, Nocardia, and Other Aerobic Actinomycetes:;pproved Standard NCCLS Document M24-A. Wayne, Pennsylvania, 2003.
27. Clinical and Laboratory Standards Institute (CLSI) (formerly NCCLS). Antimycobacterial Susceptibility Testing for M. tuberculosis: Tentative Standard NCCLS Document M24-T. Villanova, Pennsylvania, 2002.
28. Boissier, J. R.; Ratouis, R.; Dumont, C. J. Med. Chem. 1963, 6, 541-544.
29. Elvio, B.; Paravicini, F.; Emilio, T. Farmaco Ed. Sci. 1969, 24, 919-929.
30. Gökçe, M.; Doǧruer, D. S.; Şahin, M. F. Il Farmaco 2001, 56, 233-237.
31. Şahin, M. F.; Badiçoǧlu, B.; Gökçe, M.; Küpeli, E.; Yeşilada, E. Arch. Pharm. Pharm. Med. Chem. 2004, 337, 445-452.
32. Dündar, Y.; Gökçe, M.; Küpeli, E.; Şahin, M. F. Arzneim-Forsch Drug Res. 2007, 57, 777-781.
33. Yelken, G. 6-Sübstitüe-3 (2H)-Piridazinon 2-il Asetohidrazit Türevi Bileşiklerin Sentezi Antibakteriyel ve Antifungal Aktivetelerinin İncelenmesi. Gazi University, Institute of Health Science, Ankara, Turkey, 2008.
34. Gökçe, M.; Utku, S.; Küpeli, E.;ur. J. Med. Chem. 2009, 44, 3760-3764.
35. Sriram, D.; Yogeeswari, P.; Madhu, K. Bioorg. Med. Chem. Lett. 2006, 16, 876-878.
36. Sriram, D.; Yogeeswari P.; Reddy, S. P. Bioorg. Med. Chem. Lett. 2006, 16, 2113-2116.
37. Ali, M. A.; Shaharyar, M. Bioorg. Med. Chem. 2007, 15, 1896-1902.
38. Fassihi, A.; Azadpour, Z.; Delbari, N.; Saghaie, L.; Memarian, H. R.; Sabet, R.; Alborzi, A.; Miri, R.; Pourabbas, B.; Mardaneh, J.; Mousavi, P.; Moeinifard, B.; Sadeghi-aliabadi, H. Eur. J. Med. Chem. 2009, 44, 3253-3258.