Synthesis and analgesic and anti-inflammatory activities 6-substituted-3(2H)-pyridazinone-2-acetyl-2-(p-substituted/nonsubstituted benzal)hydrazone derivatives

European Journal of Medicinal Chemistry

Volumn 44, Issue 9, 2009, Pages 3760-3764

  Gökçe, Mehtap ^a   Utku, Semra ^b   Küpeli, Esra ^a  

^a GAZI UNIVERSITY   (Turkey)

^b MERSIN UNIVERSITY   (Turkey)

Author keywords

Analgesic; Anti inflammatory activity; Benzal hydrazone; Pyridazinone

Indexed keywords

6 [4 (3 CHLOROPHENYL)PIPERAZINE] 3(2H) PYRIDAZINONE 2 ACETYL 2 BENZAL HYDRAZONE; 6 [4 (4 CHLOROPHENYL)PIPERAZINE] 3(2H) PYRIDAZINONE 2 ACETYL 2 BENZAL HYDRAZONE; 6 [4 (PYRIDYL)PIPERAZINE] 3(2H) PYRIDAZINONE 2 ACETYL 2 BENZAL HYDRAZONE; ACETYLSALICYLIC ACID; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; HYDRAZONE DERIVATIVE; INDOMETACIN; PYRIDAZINONE DERIVATIVE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; MALE; MOUSE; NONHUMAN; PAW EDEMA; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; ULCEROGENESIS;

ABDOMINAL PAIN; ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; EDEMA; HYDRAZONES; INFLAMMATION; MALE; MICE; PAIN MEASUREMENT; PYRIDAZINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 67650351974     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.04.048     Document Type: Article

References (28)

1. Vergelli C., Giovannoni M.P., Pieretti S., Di Giannuario A., and Dal Piaz V. Bioorg. Med. Chem. 15 16 (2007) 5563-5575
2. Motawi T.K., Abd Elgawad H.M., and Shahin N.N. J. Biochem. Mol Toxicol. 21 5 (2007) 280-288
3. Nakano Y., Kuroda E., Kito T., Uematsu S., Akira S., Yokota A., Nishizawa S., and Yamashita U. J. Neurosurg. 108 2 (2008) 311-319
4. Singh P., and Mittal A. Mini. Rev. Med. Chem. 8 1 (2008) 73-90 Review
5. Gökçe M., Doǧruer D., and Şahin M.F. IL Farmaco 56 (2001) 233-237
6. Gökçe M., Şahin M.F., Küpeli E., and Yeşilada E. Arzneim. Forsch. Drug Res. 54 (2004) 396-401
7. Şahin M.F., Badi{dotless}çoǧlu B., Gökçe M., Küpeli E., and Yeşilada E. Arch. Pharm. Pharm. Med. 337 (2004) 445-452
8. Gökçe M., Baki{dotless}r G., Şahin M.F., Küpeli E., and Yeşilada E. Arzneim. Forsch. Drug Res. 55 (2005) 318-325
9. Dündar Y., Gökçe M., Küpeli E., and Şahin M.F. Arzneim. Forsch. Drug Res. 57 (2007) 777-781
10. Sato M., Ishizuka Y., and Yamagucci A. Arzneim. Forsch. Drug Res. 31 (1981) 1738-1745
11. Viaud M.C., Jamoneau P., Flouzat C., Bizod-Espiard J.G., Pfeiffer B., Renard P., Caignard D.H., Adam G., and Guillaument G. J. Med. Chem. 38 8 (1995) 1278-1286.
12. Rohet F., Rubat C., Coudert P., Albuisson E., and Couquelet J. Chem. Pharm. Bull. (Tokyo) 44 5 (1996) 980-986
13. Dal Piaz V., Vergelli C., Giovannoni M.P., Scheider M.A., Petrone G., and Zaratin P. Eur. J. Med. Chem. 58 (2003) 1063-1071
14. Rubat C., Coudert P., Tronche P., Bastide J., Bastide P., and Privat A.M. Chem. Pharm. Bull. 37 10 (1989) 2832-2835
15. Rubat C., Coudert P., Albussion E., Bastide J., Couquelet J., and Tronche P. J. Pharm. Sci. 81 (1992) 1084-1087
16. Dal Piaz V., Giovannoni M.P., Ciciani G., Barlocco D., Giardina G., Petrone G., and Clarke G.D. Eur. J. Med. Chem. 31 (1996) 65-70
17. N. Cesari, C. Biancalani, C. Vergelli, V. Dal Piaz, A. Graziano, P. Biagini, C. Ghelardini, N. Galeotti, M.P. Giovannoni, J. Med. Chem. 49 (26) (2006) 7826-7835.
18. Giovannoni M.P., Vergelli C., Chelardini C., Nicoletta G., Bartolini A., and Dal Piaz V. J. Med. Chem. 46 (2003) 1055-1059
19. A Santagati N., Duro F., Caruso A., Trombadore S., and Amico-Roxas M. IL Farmaco Ed. Sci. 40 (1985) 921-929
20. Banoǧlu E., Akoǧlu C., Ünlü S., Küpeli E., Yeşilada E., and Şahin M.F. Arch. Pharm. Pharm. Med. Chem. 337 (2004) 7-14
21. Dogruer D.S., Sahin M.F., Unlu S., and Ito S. Arch. Pharm. Pharm. Med. Chem. 333 (2000) 79-86
22. Boissier J.R., Ratouis R., and Dumont C. J. Med. Chem. 6 (1963) 541-544
23. Elvio B., Paravicini F., and Emilio T. Farmaco Ed. Sci. 24 (1969) 919-929
24. G. Yelken, Msc. Thesis, Gazi University, Institute of Health Science, Ankara, Turkey, 2008.
25. Okun R., Liddon S.C., and Lasagnal L. J. Pharmacol. Exp. Ther. 139 (1963) 107-114
26. Kasahara Y., Hikino H., Tsurufuji{dotless} S., and Watanabe M. Planta Med. 51 (1985) 325
27. Palla G., Predieri G., and Domiano G. Tetrahedron 42 (1986) 3649-3654
28. Wryzykiewicz E., and Prakula D. J. Heterocycl. Chem. 35 (1988) 381-386