Synthesis of pyrazinamide Mannich bases and its antitubercular properties

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 8, 2006, Pages 2113-2116

  Sriram, Dharmarajan ^a   Yogeeswari, Perumal ^a   Reddy, Sushma Pobba ^a  

^a BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE   (India)

Author keywords

Antitubercular; Mannich bases; Pyrazinamide; Synthesis

Indexed keywords

1 CYCLOPROPYL 6 FLUORO 1,4 DIHYDRO 8 METHOXY 7 [3 METHYL 4[(PYRAZINE 2 CARBOXAMIDO)METHYL]PIPERAZIN 1 YL] 4 OXOQUINOLINE 3 CARBOXYLIC ACID; FORMALDEHYDE; MANNICH BASE; PIPERAZINE DERIVATIVE; PYRAZINAMIDE; PYRAZINE DERIVATIVE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIMICROBIAL ACTIVITY; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; FEMALE; IN VITRO STUDY; IN VIVO STUDY; LUNG; MICROWAVE IRRADIATION; MINIMUM INHIBITORY CONCENTRATION; MOUSE; MYCOBACTERIOSIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; SPLEEN;

ANIMALS; ANTITUBERCULAR AGENTS; LUNG; MANNICH BASES; MICE; MICROBIAL SENSITIVITY TESTS; MODELS, CHEMICAL; MYCOBACTERIUM TUBERCULOSIS; PYRAZINAMIDE; SPLEEN;

ANIMALIA; BACTERIA (MICROORGANISMS); MYCOBACTERIUM TUBERCULOSIS;

EID: 33644810533     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.01.064     Document Type: Article

References (14)

1. Ryan, F. The Forgotten Plague. How the Battle against Tuberculosis Was Won and Lost, p 3. Boston: Little, Brown. 1993, 460 pp.
2. World Health Organization. 2003. The World Health Organization Global Tuberculosis Program. http://www.who.int/gtb/ Center for Disease Control. Morb. Mortal. Wkly. Rep. 1991, 42, 433.
3. Tuberculosis: a global emergency. World Health Forum 1993, 14, 438.
4. H.I. Boshoff, V. Mizrahi, and C.E. Barry J. Bacteriol. 8 2002 2167
5. M.H. Cynamon, S.P. Klemens, T.S. Chou, R.H. Gimi, and J.T. Welch J. Med. Chem. 35 1992 1212
6. L. Trnka, J. Kuska, and A. Harvel Chemotherapy 9 1964 158
7. John W.T.; Heifets, L.B.; Leonid, B.; Cynamon, M.H. United States Patent, 2002, 6,399,607.
8. 5: C, 58.82; H, 5.33; N, 16.46. Found: C, 58.81; H, 5.29; N, 16.49.
9. National Committee for Clinical Laboratory Standards. Antimycobacterial susceptibility testing. Proposed standard M24-P. National Committee for Clinical Laboratory Standards, Villanova, PA, 1990.
10. L.B. Heifets, M.A. Flory, and P.J. Lindholm-Levy Antimicrob. Agents Chemother. 33 1989 1252
11. Y. Zhang, and D. Mitchison Int. J. Tuberc. Lung Dis. 7 2003 21
12. K. Takacs-Novak, B. Noszal, I. Hermecz, G. Kereszturi, B. Podanyi, and G. Szasz J. Pharm. Sci. 79 1990 1023
13. L.L. Gundersen, J. Nissen-Meyer, and B. Spilsberg J. Med. Chem. 45 2002 1383
14. D. Sriram, P. Yogeeswari, S.J. Basha, D.R. Radha, and V. Nagaraja Bioorg. Med. Chem. 13 2005 5774