Dual vulnerability of tau to calpains and caspase-3 proteolysis under neurotoxic and neurodegenerative conditions

ASN Neuro

Volumn 3, Issue 1, 2011, Pages 25-36

  Liu, Ming Cheng ^a   Kobeissy, Firas ^a,b   Zheng, Wenrong ^a   Zhang, Zhiqun ^a   Hayes, Ronald L ^a,b   Wang, Kevin K W ^a,b  

^a BANYAN BIOMARKERS INC   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Cell death; Neurodegeneration; Protease; Tau protein; Tauopathy; Traumatic brain injury (TBI)

Indexed keywords

CALPAIN 2; CASPASE 3; DNA; EDETIC ACID; EXCITOTOXIN; ISOPROTEIN; N METHYL DEXTRO ASPARTIC ACID; TAU PROTEIN; CALPAIN; N METHYLASPARTIC ACID; NEUROTOXIN; PEPTIDE HYDROLASE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BINDING SITE; CONTROLLED STUDY; DEGENERATIVE DISEASE; DNA FRAGMENTATION; IMMUNOBLOTTING; IN VIVO STUDY; MALE; NERVE CELL CULTURE; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; PROTEIN AGGREGATION; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN SYNTHESIS INHIBITION; RAT; SIGNAL TRANSDUCTION; TRAUMATIC BRAIN INJURY; ANALYSIS OF VARIANCE; ANIMAL; BRAIN; BRAIN CORTEX; BRAIN INJURY; CELL CULTURE; CYTOLOGY; DISEASE MODEL; DRUG EFFECT; GENE EXPRESSION REGULATION; METABOLISM; MOLECULAR WEIGHT; NERVE CELL; NERVE DEGENERATION; NEWBORN; PATHOLOGY; PHYSIOLOGY; TOXICITY AND INTOXICATION;

ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; BRAIN; BRAIN INJURIES; CALPAIN; CASPASE 3; CELLS, CULTURED; CEREBRAL CORTEX; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; MALE; MOLECULAR WEIGHT; N-METHYLASPARTATE; NERVE DEGENERATION; NEURONS; NEUROTOXICITY SYNDROMES; NEUROTOXINS; PEPTIDE HYDROLASES; PROTEIN ISOFORMS; RATS; TAU PROTEINS;

EID: 79952364777     PISSN: None     EISSN: 17590914     Source Type: Journal    
DOI: 10.1042/AN20100012     Document Type: Article

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