Amelioration of retinal degeneration and proteolysis in acute ocular hypertensive rats by calpain inhibitor ((1S)-1-((((1S)-1-benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbo nyl)-3-methylbutyl)carbamic acid 5-methoxy-3-oxapentyl ester

Neuroscience

Volumn 141, Issue 4, 2006, Pages 2139-2145

  Oka, T ^a   Walkup, R D ^b   Tamada, Y ^a   Nakajima, E ^a   Tochigi, A ^a   Shearer, T R ^b   Azuma, M ^a,b  

^a SENJU PHARMACEUTICAL CO LTD   (Japan)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

spectrin; calpain; calpain inhibitor SNJ 1945; calpastatin; glaucoma; retinal ganglion cell

Indexed keywords

1 [[[(1 BENZYL 3 CYCLOPROPYLAMINO 2,3 DIOXOPROPYL)AMINO]CARBONYL] 3 METHYLBUTYL]CARBAMIC ACID 5 METHOXY 3 OXAPENTYL ESTER; CALPAIN; ENZYME INHIBITOR; SNJ 1945; SPECTRIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME SUBSTRATE; GLAUCOMA; HUMAN; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INTRAOCULAR HYPERTENSION; INTRAOCULAR PRESSURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; QUANTITATIVE ANALYSIS; RAT; RETINA DEGENERATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ZYMOGRAPHY;

ANIMALS; CALCIUM-BINDING PROTEINS; CALPAIN; CARBAMATES; DISEASE MODELS, ANIMAL; DRUG ADMINISTRATION ROUTES; GLYCOPROTEINS; HAPLORHINI; HUMANS; INTRAOCULAR PRESSURE; OCULAR HYPERTENSION; RATS; RATS, SPRAGUE-DAWLEY; RETINAL DEGENERATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STAINING AND LABELING; TIME FACTORS;

EID: 33747357512     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2006.05.060     Document Type: Article

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