Ecstasy toxicity: A comparison to methamphetamine and traumatic brain injury

Journal of Addictive Diseases

Volumn 25, Issue 4, 2006, Pages 115-123

  Warren, Matthew W ^a   Kobeissy, Firas H ^a   Liu, Ming Cheng ^a   Svetlov, Stanislav I ^a   Hayes, Ronald L ^a   Gold, Mark S ^a   Wang, Kevin K W ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Ecstasy; Hepatocytes; MDMA; Methamphetamine; Neurotoxicity

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; CALPAIN; CASPASE; FODRIN; METHAMPHETAMINE; PROTEINASE INHIBITOR; TAU PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG DEPENDENCE; LIVER CELL; LIVER TOXICITY; MALE; NEUROTOXICITY; NONHUMAN; PROTEIN DEGRADATION; RAT; TRAUMATIC BRAIN INJURY;

ANIMALS; BRAIN; BRAIN INJURIES; CENTRAL NERVOUS SYSTEM STIMULANTS; CEREBRAL CORTEX; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HALLUCINOGENS; HIPPOCAMPUS; IMMUNOBLOTTING; LIVER; MALE; METHAMPHETAMINE; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; RATS; RATS, SPRAGUE-DAWLEY; SEVERITY OF ILLNESS INDEX; SPECTRIN; SUBSTANCE-RELATED DISORDERS; TAU PROTEINS;

EID: 33750732270     PISSN: 10550887     EISSN: 15450848     Source Type: Journal    
DOI: 10.1300/J069v25n04_11     Document Type: Article

References (19)

1. DAWN Series D-24, DHHS Publication No. (SMA) 03-3780, Rockville, MD. Published 08/2003.
2. Larsen K, Fon E, Hastings T, Edwards R, Sulzer D. Methamphetamine-induced degeneration of dopaminergic neurons inovles autophagy and upregulation of dopamine synthesis. J Neuroscience 2002;22(20): 8951-8960.
3. Montiel-Duarte C, Varela-Rey M, Oses-Prieto JA, Lopez-Zabalza MJ, Beitia G, Cenarruzabeitia E, Iraburu MJ. 3,4-Methylenedioxymethamphetamine ("Ecstasy") induces apoptosis of cultured rat liver cells. Biochim Biophys Acta 2002;1588(1):26-32.
4. Warren MW, Kobeissy, FH, Liu MC, Hayes R, Gold MS, Wang KKW. Concurrent calpain and caspase-3 mediated proteolysis of αII-spectrin and tau in rat brain after methamphetamine exposure: A similar profile to traumatic brain injury. Life Sciences 2005;78:301-309.
5. Yuen P-W, Wang KKW. Calpain inhibitors: Novel neuroprotectants and potential anticataractic agents. Drugs Future 1998;23:741-749.
6. Nicholson W, Thornberry N. Caspases, killer proteases. Trends Biochem Sci 1997;22:299-306.
7. Wang KKW. Calpain and caspase: Can you tell the difference? Trends Neurosci 2000;23:20-26.
8. Nath R, Raser K, Stafford D, Hajimohammadreza I, Posner A, Allen H, Talanian R, Yuen P, Gilberstein R, Wang KKW. Non-erythroid αII-spectrin breakDaown by calpain and interleukin 1β-converting-enzyme-like protease(s) in apoptotic cells: Contributory roles of both protease families in neuronal apoptosis. Biochem J 1996; 319:683-690.
9. Wang KKW. Simultaneous degradation of alpha-II and beta-II sprectin by caspase 3 (CPP32) in apoptotic cells. J Biol Chem 1998;273:22490-22497.
10. Wallace T, Vorhees C, Zemlan F, Gudelsky G. Methamphetamine enhances the cleavage of the cytoskeletal protein tau in the rat brain. Neuroscience 2003; 116:1063-1068.
11. Ricaurte GA, Yuan J, Hatzidimitriou G, Cord BJ, McCann UD. Retraction of Severe dopaminergic neurotoxicity in primates after a common recreational dose regimen of MDMA ("ecstasy"). Science 2003;301(5639): 1479.
12. Deng X, Jayanthi S, Ladenheim B, Krasnova I, Cadet J. Mice with partial deficiency of c-Jun show attenuation of methamphetamine-induced neuronal apoptosis. Molecular Pharmacology 2002;62(5):993-1000.
13. Stephenson C, Hunt G, Topple A, McGregor I. The distribution of 3,4-methylenedioxymethamphetamine "Ecstasy"-induced c-fos expression in rat brain. Neuroscience 1999;92:1011-1023.
14. Hegadoren K, Baker G, Bourin M. 3,4-Methylenedioxy analogues of amphetamine: Defining the risks to humans. Neuroscience and Biobehavioral Reviews 1999;23:539-553.
15. Pineda J, Wang KKW, Hayes R. Biomarkers of proteolytic damage following traumatic brain injury. Brain Pathology 2004;14(2):202-209.
16. Stumm G, Schlegel J, Schafer T, Wurz C, Mennel H, Krieg J, Vedder H. Amphetamines induce apoptosis and regulation of bcl-x splice variants in neocortical neurons. Federation of American Societies for Experimental Biology Journal 1999;13(9):1065-1072.
17. Thiriet N, Jayanthi S, McCoy M, Ladenheim B, Lud-Cadet J. Methamphetamine increases expression of the apoptotic c-myc and L-myc genes in the mouse brain. Brain Research 2001;90(2):202-204.
18. Buki A, Farkas O, Doczi T, Povlishock J. Preinjury administration of calpain inhibitor MDL-28170 attenuates traumatically induced axonal injury. Journal of Neurotrauma 2003;20(3):261-268.
19. Knoblach S, Alroy D, Nikolaeva M, Cernak I, Stoica B, Faden A. Caspase inhibitor z-DEVD-fmk attenuates calpain and necrotic cell death in vitro and after traumatic brain injury. Journal of Cerebral Blood Flow and Metabolism 2004;24(10):1119-1132.