Elongator: An ancestral complex driving transcription and migration through protein acetylation

Journal of Biomedicine and Biotechnology

Volumn 2011, Issue , 2011, Pages

  Buschbeck, Marcus ^a   Creppe, Catherine ^a  

^a Chromatin and Cell Fate Group   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TUBULIN; CELL PROTEIN; CYCLINE; ELONGATION FACTOR 1; ELONGATION FACTOR 3; ELONGATOR; HISTONE H3; I KAPPA B; PROTEIN KTI12; RNA POLYMERASE II; STAT3 PROTEIN; TRANSCRIPTION ELONGATION FACTOR; UNCLASSIFIED DRUG; HISTONE; HISTONE ACETYLTRANSFERASE; NERVE PROTEIN; TUBULIN;

ACETYLATION; AMYOTROPHIC LATERAL SCLEROSIS; CELL MIGRATION; CELL MOTILITY; CELL TRANSPORT; DEGENERATIVE DISEASE; DYSAUTONOMIA; ENZYME ACTIVITY; GENETIC CONSERVATION; GENETIC TRANSCRIPTION; HUMAN; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REVIEW; RNA TRANSLATION; STRUCTURE ANALYSIS; ANIMAL; CELL MOTION; GENETICS; METABOLISM; MOUSE; PHYSIOLOGY;

ACETYLATION; ANIMALS; CELL MOVEMENT; HISTONE ACETYLTRANSFERASES; HISTONES; HUMANS; MICE; NERVE TISSUE PROTEINS; NEURODEGENERATIVE DISEASES; TRANSCRIPTION, GENETIC; TUBULIN;

EID: 79952211581     PISSN: 11107243     EISSN: 11107251     Source Type: Journal    
DOI: 10.1155/2011/924898     Document Type: Review

References (80)

1. Otero G., Fellows J., Yang LI., De Bizemont T., Dirac A. M. G., Gustafsson C. M., Erdjument-Bromage H., Tempst P., Svejstrup J. Q., Elongator, a multisubunit component of a novel RNA polymerase II holoenzyme for transcriptional elon (Pubitemid 29292482)
2. Krogan N. J., Greenblatt J. F., Characterization of a six-subunit Holo-Elongator complex required for the regulated expression of a group of genes in Saccharomyces cerevisiae Molecular and Cellular Biology 2001 21 23 8203 8212 (Pubitemid 33051809)
3. Li Y., Takagi Y., Jiang Y., Tokunaga M., Erdjument-Bromage H., Tempst P., Kornberg R. D., A Multiprotein Complex That Interacts with RNA Polymerase II Elongator Journal of Biological Chemistry 2001 276 32 29628 29631
4. Sebastiaan Winkler G., Petrakis T. G., Ethelberg S., Tokunaga M., Erdjument-Bromage H., Tempst P., Svejstrup J. Q., RNA polymerase II elongator holoenzyme is composed of two discrete subcomplexes Journal of Biological Chemistry 2001 276 35 32743 32749
5. Wittschieben B.., Otero G., De Bizemont T., Fellows J., Erdjument-Bromage H., Ohba R., Li Y., Allis C. D., Tempst P., Svejstrup J. Q., A novel histone acetyltransferase is an integral subunit of elongating RNA polymerase II holoenzyme Molecular Cell 1999 4 1 123 128 (Pubitemid 29386138)
6. Nelissen H., Fleury D., Bruno L., Robles P., De Veylder L., Traas J., Micol J. L., Van Montagu M., Inz D., Van Lijsebettens M., The elongata mutants identify a functional Elongator complex in plants with a role in cell proliferation during organ growth Proceedings of the National Academy of Sciences of the United States of America 2005 102 21 7754 7759 (Pubitemid 40744244)
7. Chen Y. T., Hims M. M., Shetty R. S., Mull J., Liu L., Leyne M., Slaugenhaupt S. A., Loss of mouse ikbkap, a subunit of elongator, leads to transcriptional deficits and embryonic lethality that can be rescued by human IKBKAP Molecular and Cellular Biology 2009 29 3 736 744
8. Slaugenhaupt S. A., Blumenfeld A., Gill S. P., Leyne M., Mull J., Cuajungco M. P., Liebert C. B., Chadwick B., Idelson M., Reznik L., Robbins C. M., Makalowska I., Brownstein M. J., Krappmann D., Scheidereit C., Maayan C., Axelrod F. B., Gusella J. F., Tissue-specific expression of a splicing mutation in the IKBKAP gene causes familial dysautonomia American Journal of Human Genetics 2001 68 3 598 605 (Pubitemid 32202755)
9. Hawkes N. A., Otero G., Sebastiaan Winkler G., Marshall N., Dahmus M. E., Krappmann D., Scheidereit C., Thomas C. L., Schiavo G., Erdjument-Bromage H., Svejstrup J. Q., Purification and characterization of the human elongator complex Journal of Biological Chemistry 2002 277 4 3047 3052 (Pubitemid 34953342)
10. Kim J. H., Lane W. S., Reinberg D., Human elongator facilitates RNA polymerase II transcription through chromatin Proceedings of the National Academy of Sciences of the United States of America 2002 99 3 1241 1246 (Pubitemid 34136477)
11. Fichtner L., Frohloff F., Jablonowski D., Stark M. J. R., Schaffrath R., Protein interactions within Saccharomyces cerevisiae elongator, a complex essential for Kluyveromyces lactis zymocicity Molecular Microbiology 2002 45 3 817 826 (Pubitemid 34989187)
12. Pokholok D. K., Hannett N. M., Young R. A., Exchange of RNA polymerase II initiation and elongation factors during gene expression in vivo Molecular Cell 2002 9 4 799 809 (Pubitemid 34454890)
13. Svejstrup J. Q., Elongator complex: how many roles does it play? Current Opinion in Cell Biology 2007 19 3 331 336 (Pubitemid 46908882)
14. Creppe C., Malinouskaya L., Volvert M. L., Gillard M., Close P., Malaise O., Laguesse S., Cornez I., Rahmouni S., Ormenese S., Belachew S., Malgrange B., Chapelle J. P., Siebenlist U., Moonen G., Chariot A., Nguyen L., Elongator controls the migration and differentiation of cortical neurons through acetylation of -tubulin Cell 2009 136 3 551 564
15. Esberg A., Huang BO., Johansson M. J. O., Bystrm A. S., Elevated levels of two tRNA species bypass the requirement for elongator complex in transcription and exocytosis Molecular Cell 2006 24 1 139 148 (Pubitemid 44466676)
16. Huang BO., Johansson M. J. O., Bystrm A. S., An early step in wobble uridine tRNA modification requires the Elongator complex RNA 2005 11 4 424 436 (Pubitemid 40397176)
17. Rahl P. B., Chen C. Z., Collins R. N., Elp1p, the yeast homolog of the FD disease syndrome protein, negatively regulates exocytosis independently of transcriptional elongation Molecular Cell 2005 17 6 841 853 (Pubitemid 40386945)
18. Nguyen L., Humbert S., Saudou F., Chariot A., Elongatoran emerging role in neurological disorders Trends in Molecular Medicine 2010 16 1 1 6
19. Chen Z., Zhang H., Jablonowski D., Zhou X., Ren X., Hong X., Schaffrath R., Zhu J. K., Gong Z., Mutations in ABO1/ELO2, a subunit of holo-elongator, increase abscisic acid sensitivity and drought tolerance in Arabidopsis thaliana Molecular and Cellular Biology 2006 26 18 6902 6912 (Pubitemid 44387639)
20. Li F., Lu J., Han Q., Zhang G., Huang B., The Elp3 subunit of human Elongator complex is functionally similar to its counterpart in yeast Molecular Genetics and Genomics 2005 273 3 264 272 (Pubitemid 40768513)
21. Frohloff F., Jablonowski D., Fichtner L., Schaffrath R., Subunit communications crucial for the functional integrity of the yeast RNA polymerase II elongator ( -toxin target (TOT)) complex Journal of Biological Chemistry 2003 278 2 956 961 (Pubitemid 36790771)
22. Lipardi C., Paterson B. M., Identification of an RNA-dependent RNA polymerase in Drosophila involved in RNAi and transposon suppression Proceedings of the National Academy of Sciences of the United States of America 2009 106 37 15645 15650
23. Fellows J., Erdjument-Bromage H., Tempst P., Svejstrup J. Q., The Elp2 subunit of elongator and elongating RNA polymerase II holoenzyme is a WD40 repeat protein Journal of Biological Chemistry 2000 275 17 12896 12899 (Pubitemid 30241445)
24. Petrakis T. G., Wittschieben B.., Svejstrup J. Q., Molecular architecture, structure-function relationship, and importance of the Elp3 subunit for the RNA binding of holo-Elongator Journal of Biological Chemistry 2004 279 31 32087 32092 (Pubitemid 39014654)
25. Wittschieben B.., Fellows J., Wendy DU., Stillman D. J., Svejstrup J. Q., Overlapping roles for the histone acetyltransferase activities of SAGA and Elongator in vivo EMBO Journal 2000 19 12 3060 3068 (Pubitemid 30386776)
26. Paraskevopoulou C., Fairhurst S. A., Lowe D. J., Brick P., Onesti S., The Elongator subunit Elp3 contains a FeS cluster and binds S-adenosylmethionine Molecular Microbiology 2006 59 3 795 806
27. Greenwood C., Selth L. A., Barbara Dirac-Svejstrup A., Svejstrup J. Q., An iron-sulfur cluster domain in Elp3 important for the structural integrity of elongator Journal of Biological Chemistry 2009 284 1 141 149
28. Chinenov Y., A second catalytic domain in the Elp3 histone acetyltransferases: a candidate for histone demethylase activity? Trends in Biochemical Sciences 2002 27 3 115 117 (Pubitemid 34219316)
29. Han Q., Hou X., Su D., Pan L., Duan J., Cui L., Huang B., Lu J., HELP3 subunit of the Elongator complex regulates the transcription of HSP70 gene in human cells Acta Biochimica et Biophysica Sinica 2007 39 6 453 461 (Pubitemid 46990237)
30. Okada Y., Yamagata K., Hong K., Wakayama T., Zhang YI., A role for the elongator complex in zygotic paternal genome demethylation Nature 2010 463 7280 554 558
31. Ponting C. P., Novel domains and orthologues of eukaryotic transcription elongation factors Nucleic Acids Research 2002 30 17 3643 3652 (Pubitemid 35021228)
32. Li Q., Fazly A. M., Zhou H., Huang S., Zhang Z., Stillman B., The elongator complex interacts with PCNA and modulates transcriptional silencing and sensitivity to DNA damage agents PLoS Genetics 2009 5 10
33. Frohloff F., Fichtner L., Jablonowski D., Breunig K. D., Schaffrath R., Saccharomyces cerevisiae Elongator mutations confer resistance to the Kluyveromyces lactis zymocin EMBO Journal 2001 20 8 1993 2003 (Pubitemid 32397401)
34. Winkler G. S., Kristjuhan A., Erdjument-Bromage H., Tempst P., Svejstrup J. Q., Elongator is a histone H3 and H4 acetyltransferase important for normal histone acetylation levels in vivo Proceedings of the National Academy of Sciences of the United States of America 2002 99 6 3517 3522 (Pubitemid 34252140)
35. Cohen L., Henzel W. J., Baeuerle P. A., IKAP is a scaffold protein of the I B kinase complex Nature 1998 395 6699 292 296 (Pubitemid 28447556)
36. Collum R. G., Brutsaert S., Lee G., Schindler C., A Stat3-interacting protein (StIP1) regulates cytokine signal transduction Proceedings of the National Academy of Sciences of the United States of America 2000 97 18 10120 10125
37. Jablonowski D., Fichtner L., Stark M. J. R., Schaffrath R., The yeast elongator histone acetylase requires Sit4-dependent dephosphorylation for toxin-target capacity Molecular Biology of the Cell 2004 15 3 1459 1469 (Pubitemid 38316251)
38. Mehlgarten C., Jablonowski D., Breunig K. D., Stark M. J. R., Schaffrath R., Elongator function depends on antagonistic regulation by casein kinase Hrr25 and protein phosphatase Sit4 Molecular Microbiology 2009 73 5 869 881
39. Muse G. W., Gilchrist D. A., Nechaev S., Shah R., Parker J. S., Grissom S. F., Zeitlinger J., Adelman K., RNA polymerase is poised for activation across the genome Nature Genetics 2007 39 12 1507 1511 (Pubitemid 350191341)
40. Zeitlinger J., Stark A., Kellis M., Hong J. W., Nechaev S., Adelman K., Levine M., Young R. A., RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryo Nature Genetics 2007 39 12 1512 1516 (Pubitemid 350191345)
41. Sims R. J., Belotserkovskaya R., Reinberg D., Elongation by RNA polymerase II: the short and long of it Genes and Development 2004 18 20 2437 2468 (Pubitemid 39362887)
42. Close P., Hawkes N., Cornez I., Creppe C., Lambert C. A., Rogister B., Siebenlist U., Merville M. P., Slaugenhaupt S. A., Bours V., Svejstrup J. Q., Chariot A., Transcription impairment and cell migration defects in elongator-depleted cells: implication for familial dysautonomia Molecular Cell 2006 22 4 521 531 (Pubitemid 44255542)
43. Nelissen H., De Groeve S., Fleury D., Neyt P., Bruno L., Bitonti M. B., Vandenbussche F., Van Der Straeten D., Yamaguchi T., Tsukaya H., Witters E., De Jaeger G., Houben A., Van Lijsebettens M., Plant Elongator regulates auxin-related genes during RNA polymerase II transcription elongation Proceedings of the National Academy of Sciences of the United States of America 2010 107 4 1678 1683
44. Cornez I., Creppe C., Gillard M., Hennuy B., Chapelle J. P., Dejardin E., Merville M. P., Close P., Chariot A., Deregulated expression of pro-survival and pro-apoptotic p53-dependent genes upon Elongator deficiency in colon cancer cells Biochemical Pharmacology 2008 75 11 2122 2134
45. Kouskouti A., Talianidis I., Histone modifications defining active genes persist after transcriptional and mitotic in activation EMBO Journal 2005 24 2 347 357 (Pubitemid 40216139)
46. Gilbert C., Kristjuhan A., Winkler G. S., Svejstrup J. Q., Elongator interactions with nascent mRNA revealed by RNA immunoprecipitation Molecular Cell 2004 14 4 457 464 (Pubitemid 38648799)
47. Mtivier R., Penot G., Hbner M. R., Reid G., Brand H., Ko M., Gannon F., Estrogen receptor- directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter Cell 2003 115 6 751 763 (Pubitemid 38030303)
48. Formosa T., Ruone S., Adams M. D., Olsen A. E., Eriksson P., Yu Y., Rhoades A. R., Kaufman P. D., Stillman D. J., Defects in SPT16 or POB3 (yFACT) in Saccharomyces cerevisiae cause dependence on the Hir/Hpc pathway: polymerase passage may degrade chromatin structure Genetics 2002 162 4 1557 1571 (Pubitemid 36114646)
49. Etienne-Manneville S., Actin and microtubules in cell motility: which one is in control? Traffic 2004 5 7 470 477 (Pubitemid 38923174)
50. Liao G., Nagasaki T., Gundersen G. G., Low concentrations of nocodazole interfere with fibroblast locomotion without significantly affecting microtubule level: implications for the role of dynamic microtubules in cell locomotion Journal of Cell Science 1995 108 11 3473 3483
51. Downing K. H., Nogales E., Tubulin structure: insights into microtubule properties and functions Current Opinion in Structural Biology 1998 8 6 785 791 (Pubitemid 29004677)
52. Horio T., Hotani H., Visualization of the dynamic instability of individual microtubules by dark-field microscopy Nature 1986 321 6070 605 607 (Pubitemid 16042210)
53. Mitchinson T., Kirschner M., Dynamic instability of microtubule growth Nature 1984 312 5991 237 242 (Pubitemid 15201998)
54. Small J. V., Kaverina I., Microtubules meet substrate adhesions to arrange cell polarity Current Opinion in Cell Biology 2003 15 1 40 47 (Pubitemid 36044713)
55. Vicente-Manzanares M., Webb D. J., Horwitz A. R., Cell migration at a glance Journal of Cell Science 2005 118 21 4917 4919 (Pubitemid 41672422)
56. Verhey K. J., Gaertig J., The tubulin code Cell Cycle 2007 6 17 2152 2160 (Pubitemid 47450417)
57. Downing K. H., Nogales E., Tubulin and microtubule structure Current Opinion in Cell Biology 1998 10 1 16 22 (Pubitemid 28066117)
58. L'Hernault S. W., Rosenbaum J. L., Chlamydomonas -tubulin is posttranslationally modified by acetylation on the -amino group of a lysine Biochemistry 1985 24 2 473 478 (Pubitemid 15105622)
59. LeDizet M., Piperno G., Identification of an acetylation site of Chlamydomonas alpha-tubulin Proceedings of the National Academy of Sciences of the United States of America 1987 84 16 5720 5724
60. Hubbert C., Guardiola A., Shao R., Kawaguchi Y., Ito A., Nixon A., Yoshida M., Wang X. F., Yao T. P., HDAC6 is a microtubule-associated deacetylase Nature 2002 417 6887 455 458 (Pubitemid 34563539)
61. Zhang Y., Li N., Caron C., Matthias G., Hess D., Khochbin S., Matthias P., HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo The EMBO Journal 2003 22 5 1168 1179 (Pubitemid 36313600)
62. North B. J., Marshall B. L., Borra M. T., Denu J. M., Verdin E., The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase Molecular Cell 2003 11 2 437 444 (Pubitemid 36293837)
63. Solinger J. A., Paolinelli R., Kl H., Scorza F. B., Marchesi S., Sauder U., Mitsushima D., Capuani F., Strzenbaum S. R., Cassata G., The Caenorhabditis elegans elongator complex regulates neuronal -tubulin acetylation PLoS Genetics 2010 6 1
64. Akella J. S., Wloga D., Kim J., Starostina N. G., Lyons-Abbott S., Morrissette N. S., Dougan S. T., Kipreos E. T., Gaertig J., MEC-17 is an -tubulin acetyltransferase Nature 2010 467 7312 218 222
65. Dompierre J. P., Godin J. D., Charrin B. C., Cordelires F. P., King S. J., Humbert S., Saudou F., Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation Journal of Neuroscience 2007 27 13 3571 3583 (Pubitemid 46515140)
66. Reed N. A., Cai D., Blasius T. L., Jih G. T., Meyhofer E., Gaertig J., Verhey K. J., Microtubule acetylation promotes kinesin-1 binding and transport Current Biology 2006 16 21 2166 2172 (Pubitemid 44692098)
67. Haggarty S. J., Koeller K. M., Wong J. C., Grozinger C. M., Schreiber S. L., Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation Proceedings of the National Academy of Sciences of the United States of America 2003 100 8 4389 4394 (Pubitemid 36457739)
68. Endow S. A., Microtubule motors in spindle and chromosome motility European Journal of Biochemistry 1999 262 1 12 18 (Pubitemid 29242603)
69. Sablin E. P., Case R. B., Dai S. C., Hart C. L., Ruby A., Vale R. D., Fletterick R. J., Direction determination in the minus-end-directed kinesin motor ncd Nature 1998 395 6704 813 816 (Pubitemid 28485450)
70. Mallik R., Gross S. P., Molecular motors: strategies to get along Current Biology 2004 14 22 R971 R982
71. Schliwa M., Woehlke G., Molecular motors Nature 2003 422 6933 759 765 (Pubitemid 36514119)
72. Anderson S. L., Coli R., Daly I. W., Kichula E. A., Rork M. J., Volpi S. A., Ekstein J., Rubin B. Y., Familial dysautonomia is caused by mutations of the IKAP gene American Journal of Human Genetics 2001 68 3 753 758 (Pubitemid 32202767)
73. Simpson C. L., Lemmens R., Miskiewicz K., Broom W. J., Hansen V. K., van Vught P. W. J., Landers J. E., Sapp P., van Den Bosch L., Knight J., Neale B. M., Turner M. R., Veldink J. H., Ophoff R. A., Tripathi V. B., Beleza A., Shah M. N., Proitsi P., Van Hoecke A., Carmeliet P., Horvitz H. R., Leigh P. N., Shaw C. E., van den Berg L. H., Sham P. C., Powell J. F., Verstreken P., Brown R. H., Robberecht W., Al-Chalabi A., Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration Human Molecular Genetics 2009 18 3 472 481
74. Axelrod F. B., Familial dysautonomia Muscle and Nerve 2004 29 3 352 363 (Pubitemid 38269753)
75. Cuajungco M. P., Leyne M., Mull J., Gill S. P., Lu W., Zagzag D., Axelrod F. B., Maayan C., Gusella J. F., Slaugenhaupt S. A., Tissue-specific reduction in splicing efficiency of IKBKAP due to the major mutation associated with familial dysautonomia American Journal of Human Genetics 2003 72 3 749 758 (Pubitemid 36255975)
76. De vos K. J., Chapman A. L., Tennant M. E., Manser C., Tudor E. L., Lau K. F., Brownlees J., Ackerley S., Shaw P. J., Mcloughlin D. M., Shaw C. E., Leigh P. N., Miller C. C. J., Grierson A. J., Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content Human Molecular Genetics 2007 16 22 2720 2728 (Pubitemid 350018514)
77. Saha A. R., Hill J., Utton M. A., Asuni A. A., Ackerley S., Grierson A. J., Miller C. C., Davies A. M., Buchman V. L., Anderton B. H., Hanger D. P., Parkinson's disease -synuclein mutations exhibit defective axonal transport in cultured neurons Journal of Cell Science 2004 117 7 1017 1024 (Pubitemid 38456084)
78. Stokin G. B., Lillo C., Falzone T. L., Brusch R. G., Rockenstein E., Mount S. L., Raman R., Davies P., Masliah E., Williams D. S., Goldstein L. S. B., Axonopathy and transport deficits early in the pathogenesis of Alzheimer's diseases Science 2005 307 5713 1282 1288 (Pubitemid 40299973)
79. Hammond J. W., Cai D., Verhey K. J., Tubulin modifications and their cellular functions Current Opinion in Cell Biology 2008 20 1 71 76
80. Strahl B. D., Allis C. D., The language of covalent histone modifications Nature 2000 403 6765 41 45 (Pubitemid 30038513