Elp1p, the yeast homolog of the FD disease syndrome protein, negatively regulates exocytosis independently of transcriptional elongation

Molecular Cell

Volumn 17, Issue 6, 2005, Pages 841-853

  Rahl, Peter B ^a   Chen, Catherine Z ^a   Collins, Ruth N ^a  

^a Cornell University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN; PROTEIN ELP1P; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSOL; EXOCYTOSIS; GENE IDENTIFICATION; GENETIC TRANSCRIPTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN INTERACTION; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; YEAST;

EUKARYOTA;

EID: 15244355534     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2005.02.018     Document Type: Article

References (42)

1. T. Bouwmeester, A. Bauch, H. Ruffner, P.O. Angrand, G. Bergamini, K. Croughton, C. Cruciat, D. Eberhard, J. Gagneur, and S. Ghidelli A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway Nat. Cell Biol. 6 2004 97 105
2. L. Cohen, W.J. Henzel, and P.A. Baeuerle IKAP is a scaffold protein of the IkappaB kinase complex Nature 395 1998 292 296
3. R.N. Collins Rab and ARF GTPase regulation of exocytosis Mol. Membr. Biol. 20 2003 105 115
4. R.G. Collum, S. Brutsaert, G. Lee, and C. Schindler A Stat3-interacting protein (StIP1) regulates cytokine signal transduction Proc. Natl. Acad. Sci. USA 97 2000 10120 10125
5. N.B. Elkind, C. Walch-Solimena, and P.J. Novick The role of the COOH terminus of Sec2p in the transport of post-Golgi vesicles J. Cell Biol. 149 2000 95 110
6. J. Fellows, H. Erdjument-Bromage, P. Tempst, and J.Q. Svejstrup The Elp2 subunit of elongator and elongating RNA polymerase II holoenzyme is a WD40 repeat protein J. Biol. Chem. 275 2000 12896 12899
7. L. Fichtner, F. Frohloff, D. Jablonowski, M.J. Stark, and R. Schaffrath Protein interactions within Saccharomyces cerevisiae Elongator, a complex essential for Kluyveromyces lactis zymocicity Mol. Microbiol. 45 2002 817 826
8. F.P. Finger, T.E. Hughes, and P. Novick Sec3p is a spatial landmark for polarized secretion in budding yeast Cell 92 1998 559 571
9. F.P. Finger, and P. Novick Sec3p is involved in secretion and morphogenesis in Saccharomyces cerevisiae Mol. Biol. Cell 8 1997 647 662
10. M. Hampsey A review of phenotypes in Saccharomyces cerevisiae Yeast 13 1997 1099 1133
11. G.A. Hartzog, T. Wada, H. Handa, and F. Winston Evidence that Spt4, Spt5, and Spt6 control transcription elongation by RNA polymerase II in Saccharomyces cerevisiae Genes Dev. 12 1998 357 369
12. N.A. Hawkes, G. Otero, G.S. Winkler, N. Marshall, M.E. Dahmus, D. Krappmann, C. Scheidereit, C.L. Thomas, G. Schiavo, and H. Erdjument-Bromage Purification and characterization of the human elongator complex J. Biol. Chem. 277 2002 3047 3052
13. C. Holmberg, S. Katz, M. Lerdrup, T. Herdegen, M. Jaattela, A. Aronheim, and T. Kallunki A novel specific role for I kappa B kinase complex-associated protein in cytosolic stress signaling J. Biol. Chem. 277 2002 31918 31928
14. J.K. Hood, and P.A. Silver Cse1p is required for export of Srp1p/importin-alpha from the nucleus in Saccharomyces cerevisiae J. Biol. Chem. 273 1998 35142 35146
15. E. Izaurralde, C. McGuigan, and I.W. Mattaj Nuclear localization of a cap-binding protein complex Cold Spring Harb. Symp. Quant. Biol. 60 1995 669 675
16. G. Jedd, J. Mulholland, and N. Segev Two new Ypt GTPases are required for exit from the yeast trans-Golgi compartment J. Cell Biol. 137 1997 563 580
17. G. Jedd, C. Richardson, R. Litt, and N. Segev The Ypt1 GTPase is essential for the first two steps of the yeast secretory pathway J. Cell Biol. 131 1995 583 590
18. A. Kaffman, N.M. Rank, E.M. O'Neill, L.S. Huang, and E.K. O'Shea The receptor Msn5 exports the phosphorylated transcription factor Pho4 out of the nucleus Nature 396 1998 482 486
19. T. Kouzarides Acetylation: a regulatory modification to rival phosphorylation? EMBO J. 19 2000 1176 1179
20. K.G. Kozminski, L. Beven, E. Angerman, A.H. Tong, C. Boone, and H.O. Park Interaction between a Ras and a Rho GTPase couples selection of a growth site to the development of cell polarity in yeast Mol. Biol. Cell 14 2003 4958 4970
21. N.J. Krogan, and J.F. Greenblatt Characterization of a six-subunit holo-elongator complex required for the regulated expression of a group of genes in Saccharomyces cerevisiae Mol. Cell. Biol. 21 2001 8203 8212
22. N.J. Krogan, M. Kim, S.H. Ahn, G. Zhong, M.S. Kobor, G. Cagney, A. Emili, A. Shilatifard, S. Buratowski, and J.F. Greenblatt RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approach Mol. Cell. Biol. 22 2002 6979 6992
23. A. Kumar, S. Vidan, and M. Snyder Insertional mutagenesis: transposon-insertion libraries as mutagens in yeast Methods Enzymol. 350 2002 219 229
24. Y. Li, Y. Takagi, Y. Jiang, M. Tokunaga, H. Erdjument-Bromage, P. Tempst, and R.D. Kornberg A multiprotein complex that interacts with RNA polymerase II elongator J. Biol. Chem. 276 2001 29628 29631
25. Z. Luo, and D. Gallwitz Biochemical and genetic evidence for the involvement of yeast Ypt6-GTPase in protein retrieval to different Golgi compartments J. Biol. Chem. 278 2003 791 799
26. F. Mercurio, B.W. Murray, A. Shevchenko, B.L. Bennett, D.B. Young, J.W. Li, G. Pascual, A. Motiwala, H. Zhu, M. Mann, and A.M. Manning IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex Mol. Cell. Biol. 19 1999 1526 1538
27. J. Nair, H. Muller, M. Peterson, and P. Novick Sec2 protein contains a coiled-coil domain essential for vesicular transport and a dispensable carboxy terminal domain J. Cell Biol. 110 1990 1897 1909
28. D. Ortiz, M. Medkova, C. Walch-Solimena, and P. Novick Ypt32 recruits the Sec4p guanine nucleotide exchange factor, Sec2p, to secretory vesicles; evidence for a Rab cascade in yeast J. Cell Biol. 157 2002 1005 1015
29. G. Otero, J. Fellows, Y. Li, T. de Bizemont, A.M. Dirac, C.M. Gustafsson, H. Erdjument-Bromage, P. Tempst, and J.Q. Svejstrup Elongator, a multisubunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation Mol. Cell 3 1999 109 118
30. S.R. Pfeffer Rab GTPases: specifying and deciphering organelle identity and function Trends Cell Biol. 11 2001 487 491
31. D.K. Pokholok, N.M. Hannett, and R.A. Young Exchange of RNA polymerase II initiation and elongation factors during gene expression in vivo Mol. Cell 9 2002 799 809
32. D.W. Pruyne, D.H. Schott, and A. Bretscher Tropomyosin-containing actin cables direct the Myo2p-dependent polarized delivery of secretory vesicles in budding yeast J. Cell Biol. 143 1998 1931 1945
33. A. Salminen, and P.J. Novick A ras-like protein is required for a post-Golgi event in yeast secretion Cell 49 1987 527 538
34. S.A. Slaugenhaupt, and J.F. Gusella Familial dysautonomia Curr. Opin. Genet. Dev. 12 2002 307 311
35. K. Stade, C.S. Ford, C. Guthrie, and K. Weis Exportin 1 (Crm1p) is an essential nuclear export factor Cell 90 1997 1041 1050
36. A.H. Tong, M. Evangelista, A.B. Parsons, H. Xu, G.D. Bader, N. Page, M. Robinson, S. Raghibizadeh, C.W. Hogue, and H. Bussey Systematic genetic analysis with ordered arrays of yeast deletion mutants Science 294 2001 2364 2368
37. C. Walch-Solimena, R.N. Collins, and P.J. Novick Sec2p mediates nucleotide exchange on Sec4p and is involved in polarized delivery of post-Golgi vesicles J. Cell Biol. 137 1997 1495 1509
38. G.S. Winkler, T.G. Petrakis, S. Ethelberg, M. Tokunaga, H. Erdjument-Bromage, P. Tempst, and J.Q. Svejstrup RNA polymerase II elongator holoenzyme is composed of two discrete subcomplexes J. Biol. Chem. 276 2001 32743 32749
39. B.O. Wittschieben, J. Fellows, W. Du, D.J. Stillman, and J.Q. Svejstrup Overlapping roles for the histone acetyltransferase activities of SAGA and elongator in vivo EMBO J. 19 2000 3060 3068
40. B.O. Wittschieben, G. Otero, T. de Bizemont, J. Fellows, H. Erdjument-Bromage, R. Ohba, Y. Li, C.D. Allis, P. Tempst, and J.Q. Svejstrup A novel histone acetyltransferase is an integral subunit of elongating RNA polymerase II holoenzyme Mol. Cell 4 1999 123 128
41. Z. Xiao, J.T. McGrew, A.J. Schroeder, and M. Fitzgerald-Hayes CSE1 and CSE2, two new genes required for accurate mitotic chromosome segregation in Saccharomyces cerevisiae Mol. Cell. Biol. 13 1993 4691 4702
42. H. Yajima, M. Tokunaga, A. Nakayama-Murayama, and F. Hishinuma Characterization of IKI1 and IKI3 genes conferring pGKL killer sensitivity on Saccharomyces cerevisiae Biosci. Biotechnol. Biochem. 61 1997 704 709