Early childhood general anaesthesia exposure and neurocognitive development

British Journal of Anaesthesia

Volumn 105, Issue , 2010, Pages i61-i68

  Sun, L ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

anaesthesia, paediatric; children; neurocognitive outcome; neurotoxicity; risk

Indexed keywords

ANESTHETIC AGENT;

ANIMAL; BRAIN; CHEMICALLY INDUCED DISORDER; CHILD; COGNITIVE DEFECT; DEVELOPMENTAL DISORDER; DISEASE MODEL; DRUG EFFECT; EVIDENCE BASED MEDICINE; GENERAL ANESTHESIA; GROWTH, DEVELOPMENT AND AGING; HUMAN; INFANT; METHODOLOGY; PRESCHOOL CHILD; REVIEW;

ANESTHESIA, GENERAL; ANESTHETICS, GENERAL; ANIMALS; BRAIN; CHILD; CHILD, PRESCHOOL; COGNITION DISORDERS; DEVELOPMENTAL DISABILITIES; DISEASE MODELS, ANIMAL; EVIDENCE-BASED MEDICINE; HUMANS; INFANT;

EID: 79952199825     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aeq302     Document Type: Article

References (68)

1. DeFrances, CJ, Cullen, KA, Kozak, LJ, National Hospital Discharge Survey: 2005 annual summary with detailed diagnosis and procedure data. Vital Health Stat 13 (2007), 1–209.
2. Mellon, RD, Simone, AF, Rappaport, BA, Use of anesthetic agents in neonates and young children. Anesth Analg 104 (2007), 509–520 doi:10.1213/01.ane.0000255729.96438.b0.
3. Loepke, AW, Soriano, SG, An assessment of the effects of general anesthetics on developing brain structure and neurocognitive function. Anesth Analg 106 (2008), 1681–1707 doi:10.1213/ane.0b013e318167ad77.
4. Istaphanous, GK, Loepke, AW, General anesthetics and the developing brain. Curr Opin Anaesthesiol 22 (2009), 368–373 doi:10.1097/ACO.0b013e3283294c9e.
5. Loepke, AW, Developmental neurotoxicity of sedatives and anesthetics: a concern for neonatal and pediatric critical care medicine?. Pediatr Crit Care Med 11 (2010), 217–226.
6. Wilder, RT, Is there any relationship between long-term behavior disturbance and early exposure to anesthesia?. Curr Opin Anaesthesiol 23 (2010), 332–336 doi:10.1097/ACO.0b013e3283391f94.
7. Jevtovic-Todorovic, V, Hartman, RE, Izumi, Y, et al. Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits. J Neurosci 23 (2003), 876–882.
8. Jevtovic-Todorovic, V, Olney, JW, PRO: anesthesia-induced developmental neuroapoptosis: status of the evidence. Anesth Analg 106 (2008), 1659–1663 doi:10.1213/ane.0b013e3181731ff2.
9. Sanders, RD, Xu, J, Shu, Y, et al. Dexmedetomidine attenuates isoflurane-induced neurocognitive impairment in neonatal rats. Anesthesiology 110 (2009), 1077–1085 doi:10.1097/ALN.0b013e31819daedd.
10. Stratmann, G, Sall, JW, May, LD, et al. Isoflurane differentially affects neurogenesis and long-term neurocognitive function in 60-day-old and 7-day-old rats. Anesthesiology 110 (2009), 834–848 doi:10.1097/ALN.0b013e31819c463d.
11. Stratmann, G, Sall, JW, May, LD, Loepke, AW, Lee, MT, Beyond anesthetic properties: the effects of isoflurane on brain cell death, neurogenesis, and long-term neurocognitive function. Anesth Analg 110 (2010), 431–437.
12. Zhu, C, Gao, J, Karlsson, N, et al. Isoflurane anesthesia induced persistent, progressive memory impairment, caused a loss of neural stem cells, and reduced neurogenesis in young, but not adult, rodents. J Cereb Blood Flow Metab 30 (2010), 1017–1030 doi:10.1038/jcbfm.2009.274.
13. Rothstein, S, Simkins, T, Nunez, JL, Response to neonatal anesthesia: effect of sex on anatomical and behavioral outcome. Neuroscience 152 (2008), 959–969 doi:10.1016/j.neuroscience.2008.01.027.
14. Perouansky, M, Neurotoxicity of general anesthetics: cause for concern?. Anesthesiology 111 (2009), 1365–1367 doi:10.1097/ALN.0b013e3181bf1d61.
15. Brambrink, AM, Evers, AS, Avidan, MS, et al. Isoflurane-induced neuroapoptosis in the neonatal rhesus macaque brain. Anesthesiology 112 (2010), 834–841 doi:10.1097/ALN.0b013e3181d049cd.
16. Bree, B, Gourdin, M, De Kock, M, Anesthesia and cerebral apoptosis. Acta Anaesthesiol Belg 59 (2008), 127–137.
17. Briner, A, De Roo, M, Dayer, A, Muller, D, Habre, W, Vutskits, L, Volatile anesthetics rapidly increase dendritic spine density in the rat medial prefrontal cortex during synaptogenesis. Anesthesiology 112 (2010), 546–556 doi:10.1097/ALN.0b013e3181cd7942.
18. Cattano, D, Williamson, P, Fukui, K, et al. Potential of xenon to induce or to protect against neuroapoptosis in the developing mouse brain. Can J Anaesth 55 (2008), 429–436 doi:10.1007/BF03016309.
19. Creeley, CE, Olney, JW, The young: neuroapoptosis induced by anesthetics and what to do about it. Anesth Analg 110 (2009), 442–448 doi:10.1213/ANE.0b013e3181c6b9ca.
20. Fredriksson, A, Ponten, E, Gordh, T, Eriksson, P, Neonatal exposure to a combination of N-methyl-D-aspartate and gamma-aminobutyric acid type A receptor anesthetic agents potentiates apoptotic neurodegeneration and persistent behavioral deficits. Anesthesiology 107 (2007), 427–436 doi:10.1097/01.anes.0000278892.62305.9c.
21. Gascon, E, Klauser, P, Kiss, JZ, Vutskits, L, Potentially toxic effects of anaesthetics on the developing central nervous system. Eur J Anaesthesiol 24 (2007), 213–224 doi:10.1017/S0265021506002365.
22. Ikonomidou, C, Bosch, F, Miksa, M, et al. Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain. Science 283 (1999), 70–74 doi:10.1126/science.283.5398.70.
23. Johnson, SA, Young, C, Olney, JW, Isoflurane-induced neuroapoptosis in the developing brain of nonhypoglycemic mice. J Neurosurg Anesthesiol 20 (2008), 21–28 doi:10.1097/ANA.0b013e3181271850.
24. Loepke, AW, Istaphanous, GK, McAuliffe, JJ 3rd, et al. The effects of neonatal isoflurane exposure in mice on brain cell viability, adult behavior, learning, and memory. Anesth Analg 108 (2009), 90–104 doi:10.1213/ane.0b013e31818cdb29.
25. Lu, LX, Yon, JH, Carter, LB, Jevtovic-Todorovic, V, General anesthesia activates BDNF-dependent neuroapoptosis in the developing rat brain. Apoptosis 11 (2006), 1603–1615 doi:10.1007/s10495-006-8762-3.
26. Ma, D, Williamson, P, Januszewski, A, et al. Xenon mitigates isoflurane-induced neuronal apoptosis in the developing rodent brain. Anesthesiology 106 (2007), 746–753 doi:10.1097/01.anes.0000264762.48920.80.
27. Nikizad, H, Yon, JH, Carter, LB, Jevtovic-Todorovic, V, Early exposure to general anesthesia causes significant neuronal deletion in the developing rat brain. Ann N Y Acad Sci 1122 (2007), 69–82 doi:10.1196/annals.1403.005.
28. Olney, JW, Farber, NB, Wozniak, DF, Jevtovic-Todorovic, V, Ikonomidou, C, Environmental agents that have the potential to trigger massive apoptotic neurodegeneration in the developing brain. Environ Health Perspect 108(:Suppl. 3 (2000), 383–388 doi:10.2307/3454524.
29. Rizzi, S, Carter, LB, Ori, C, Jevtovic-Todorovic, V, Clinical anesthesia causes permanent damage to the fetal guinea pig brain. Brain Pathol 18 (2008), 198–210 doi:10.1111/j.1750-3639.2007.00116.x.
30. Rizzi, S, Ori, C, Jevtovic-Todorovic, V, Timing versus duration: determinants of anesthesia-induced developmental apoptosis in the young mammalian brain. Ann N Y Acad Sci 1199 (2010), 43–51 doi:10.1111/j.1749-6632.2009.05173.x.
31. Rudin, M, Ben-Abraham, R, Gazit, V, Tendler, Y, Tashlykov, V, Katz, Y, Single-dose ketamine administration induces apoptosis in neonatal mouse brain. J Basic Clin Physiol Pharmacol 16 (2005), 231–243.
32. Satomoto, M, Satoh, Y, Terui, K, et al. Neonatal exposure to sevoflurane induces abnormal social behaviors and deficits in fear conditioning in mice. Anesthesiology 110 (2009), 628–637 doi:10.1097/ALN.0b013e3181974fa2.
33. Scallet, AC, Schmued, LC, Slikker, W Jr, et al. Developmental neurotoxicity of ketamine: morphometric confirmation, exposure parameters, and multiple fluorescent labeling of apoptotic neurons. Toxicol Sci 81 (2004), 364–370 doi:10.1093/toxsci/kfh224.
34. Blusse Van Oud-Alblas, HJ, Bosenberg, AT, Tibboel, D, Awareness in children: another two cases. Paediatr Anaesth 18 (2008), 654–657 doi:10.1111/j.1460-9592.2008.02576.x.
35. Straiko, MM, Young, C, Cattano, D, et al. Lithium protects against anesthesia-induced developmental neuroapoptosis. Anesthesiology 110 (2009), 862–868 doi:10.1097/ALN.0b013e31819b5eab.
36. Wang, C, Sadovova, N, Fu, X, et al. The role of the N-methyl-D-aspartate receptor in ketamine-induced apoptosis in rat forebrain culture. Neuroscience 132 (2005), 967–977 doi:10.1016/j.neuroscience.2005.01.053.
37. Yon, JH, Carter, LB, Reiter, RJ, Jevtovic-Todorovic, V, Melatonin reduces the severity of anesthesia-induced apoptotic neurodegeneration in the developing rat brain. Neurobiol Dis 21 (2006), 522–530 doi:10.1016/j.nbd.2005.08.011.
38. Yon, JH, Daniel-Johnson, J, Carter, LB, Jevtovic-Todorovic, V, Anesthesia induces neuronal cell death in the developing rat brain via the intrinsic and extrinsic apoptotic pathways. Neuroscience 135 (2005), 815–827 doi:10.1016/j.neuroscience.2005.03.064.
39. Young, C, Jevtovic-Todorovic, V, Qin, YQ, et al. Potential of ketamine and midazolam, individually or in combination, to induce apoptotic neurodegeneration in the infant mouse brain. Br J Pharmacol 146 (2005), 189–197 doi:10.1038/sj.bjp.0706301.
40. Zou, X, Patterson, TA, Sadovova, N, et al. Potential neurotoxicity of ketamine in the developing rat brain. Toxicol Sci 108 (2009), 149–158 doi:10.1093/toxsci/kfn270.
41. Stratmann, G, May, LD, Sall, JW, et al. Effect of hypercarbia and isoflurane on brain cell death and neurocognitive dysfunction in 7-day-old rats. Anesthesiology 110 (2009), 849–861 doi:10.1097/ALN.0b013e31819c7140.
42. Lunardi, N, Ori, C, Erisir, A, Jevtovic-Todorovic, V, General anesthesia causes long-lasting disturbances in the ultrastructural properties of developing synapses in young rats. Neurotox Res 17 (2010), 179–188 doi:10.1007/s12640-009-9088-z.
43. Culley, DJ, Xie, Z, Crosby, G, General anesthetic-induced neurotoxicity: an emerging problem for the young and old?. Curr Opin Anaesthesiol 20 (2007), 408–413 doi:10.1097/ACO.0b013e3282efd18b.
44. Sall, JW, Stratmann, G, Leong, J, et al. Isoflurane inhibits growth but does not cause cell death in hippocampal neural precursor cells grown in culture. Anesthesiology 110 (2009), 826–833 doi:10.1097/ALN.0b013e31819b62e2.
45. Bercker, S, Bert, B, Bittigau, P, et al. Neurodegeneration in newborn rats following propofol and sevoflurane anesthesia. Neurotox Res 16 (2009), 140–147 doi:10.1007/s12640-009-9063-8.
46. Jevtovic-Todorovic, V, Carter, LB, The anesthetics nitrous oxide and ketamine are more neurotoxic to old than to young rat brain. Neurobiol Aging 26 (2005), 947–956 doi:10.1016/j.neurobiolaging.2004.07.009.
47. Wang, C, Sadovova, N, Hotchkiss, C, et al. Blockade of N-methyl-D-aspartate receptors by ketamine produces loss of postnatal day 3 monkey frontal cortical neurons in culture. Toxicol Sci 91 (2006), 192–201 doi:10.1093/toxsci/kfj144.
48. Vutskits, L, Gascon, E, Tassonyi, E, Kiss, JZ, Effect of ketamine on dendritic arbor development and survival of immature GABAergic neurons in vitro. Toxicol Sci 91 (2006), 540–549 doi:10.1093/toxsci/kfj180.
49. Vutskits, L, Gascon, E, Kiss, JZ, Effects of ketamine on the developing central nervous system. Ideggyogy Sz 60 (2007), 109–112.
50. Slikker, W Jr, Zou, X, Hotchkiss, CE, et al. Ketamine-induced neuronal cell death in the perinatal rhesus monkey. Toxicol Sci 98 (2007), 145–158 doi:10.1093/toxsci/kfm084.
51. Wang, C, Slikker, W Jr, Strategies and experimental models for evaluating anesthetics: effects on the developing nervous system. Anesth Analg 106 (2008), 1643–1658 doi:10.1213/ane.ob013e3181732c01.
52. Hayashi, H, Dikkes, P, Soriano, SG, Repeated administration of ketamine may lead to neuronal degeneration in the developing rat brain. Paediatr Anaesth 12 (2002), 770–774 doi:10.1046/j.1460-9592.2002.00883.x.
53. Head, BP, Patel, HH, Niesman, IR, Drummond, JC, Roth, DM, Patel, PM, Inhibition of p75 neurotrophin receptor attenuates isoflurane-mediated neuronal apoptosis in the neonatal central nervous system. Anesthesiology 110 (2009), 813–825 doi:10.1097/ALN.0b013e31819b602b.
54. Neal, AP, Stansfield, KH, Worley, PF, Thompson, RE, Guilarte, TR, Lead exposure during synaptogenesis alters vesicular proteins and impairs vesicular release: potential role of NMDA receptor-dependent BDNF signaling. Toxicol Sci 116 (2010), 249–263 doi:10.1093/toxsci/kfq111.
55. Bartels, M, Althoff, RR, Boomsma, DI, Anesthesia and cognitive performance in children: no evidence for a causal relationship. Twin Res Hum Genet 12 (2009), 246–253 doi:10.1375/twin.12.3.246.
56. DiMaggio, C, Sun, LS, Kakavouli, A, Byrne, MW, Li, G, A retrospective cohort study of the association of anesthesia and hernia repair surgery with behavioral and developmental disorders in young children. J Neurosurg Anesthesiol 21 (2009), 286–291 doi:10.1097/ANA.0b013e3181a71f11.
57. Kalkman, CJ, Peelen, L, Moons, KG, et al. Behavior and development in children and age at the time of first anesthetic exposure. Anesthesiology 110 (2009), 805–812 doi:10.1097/ALN.0b013e31819c7124.
58. Sprung, J, Flick, RP, Wilder, RT, et al. Anesthesia for cesarean delivery and learning disabilities in a population-based birth cohort. Anesthesiology 111 (2009), 302–310 doi:10.1097/ALN.0b013e3181adf481.
59. Wilder, RT, Flick, RP, Sprung, J, et al. Early exposure to anesthesia and learning disabilities in a population-based birth cohort. Anesthesiology 110 (2009), 796–804 doi:10.1097/01.anes.0000344728.34332.5d.
60. Bartels, M, Rietveld, MJ, Van Baal, GC, Boomsma, DI, Heritability of educational achievement in 12-year-olds and the overlap with cognitive ability. Twin Res 5 (2002), 544–553 doi:10.1375/136905202762342017.
61. Jacobson, JL, Jacobson, SW, Methodological issues in research on developmental exposure to neurotoxic agents. Neurotoxicol Teratol 27 (2005), 395–406 doi:10.1016/j.ntt.2005.01.009.
62. Susser, E, Bresnahan, M, Epidemiologic approaches to neurodevelopmental disorders. Mol Psychiatry 7:Suppl. 2 (2002), S2–S3 doi:10.1038/sj.mp.4001161.
63. Winneke, G, Appraisal of neurobehavioral methods in environmental health research: the developing brain as a target for neurotoxic chemicals. Int J Hyg Environ Health 210 (2007), 601–609 doi:10.1016/j.ijheh.2007.07.015.
64. Hack, M, Taylor, HG, Drotar, D, et al. Poor predictive validity of the Bayley Scales of Infant Development for cognitive function of extremely low birth weight children at school age. Pediatrics 116 (2005), 333–341 doi:10.1542/peds.2005-0173.
65. Adeniran, JO, Abdur-Rahman, L, One-stage correction of intermediate imperforate anus in males. Pediatr Surg Int 21 (2005), 88–90 doi:10.1007/s00383-004-1211-x.
66. Korkman, M, Kemp, SL, Kirk, U, Effects of age on neurocognitive measures of children ages 5 to 12: a cross-sectional study on 800 children from the United States. Dev Neuropsychol 20 (2001), 331–354 doi:10.1207/S15326942DN2001_2.
67. Sowell, ER, Peterson, BS, Thompson, PM, Welcome, SE, Henkenius, AL, Toga, AW, Mapping cortical change across the human life span. Nat Neurosci 6 (2003), 309–315 doi:10.1038/nn1008.
68. Casey, BJ, Giedd, JN, Thomas, KM, Structural and functional brain development and its relation to cognitive development. Biol Psychol 54 (2000), 241–257 doi:10.1016/S0301-0511(00)00058-2.