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Volumn 6, Issue 3, 2009, Pages 321-323

Locked nucleic acid as a novel class of therapeutic agents

Author keywords

Antisense; Aptamers; LNA; miRNA; Oligonucleotides; RNA targeting; siRNA

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; APTAMER; COMPLEMENTARY RNA; LOCKED NUCLEIC ACID; MICRORNA; SMALL INTERFERING RNA;

EID: 67650486013     PISSN: 15476286     EISSN: 15558584     Source Type: Journal    
DOI: 10.4161/rna.6.3.8807     Document Type: Review
Times cited : (110)

References (36)
  • 1
    • 0036211366 scopus 로고    scopus 로고
    • Randomized dose-comparison studies of intravitreous fomivirsen for treatment of cytomegalovirus retinitis that has reactivated or is persistently active despite other therapies in patients with AIDS
    • DOI 10.1016/S0002-9394(02)01326-0, PII S0002939402013260
    • Vitravene study group. Randomized dose-comparison studies of intravitreous fomivirsen for treatment of cytomegalovirus retinitis that has reactivated or is persistently active despite other therapies in patients with AIDS. Am J Ophthalmol 2002; 133:475-483 (Pubitemid 34258057)
    • (2002) American Journal of Ophthalmology , vol.133 , Issue.4 , pp. 475-483
    • Hutcherson, S.L.1    Lanz, R.2
  • 2
    • 0343065617 scopus 로고    scopus 로고
    • LNA (locked nucleic acids): Synthesis and high-affinity nucleic acid recognition
    • Singh SK, Nielsen P, Koshkin AA, Wengel J. LNA (locked nucleic acids): synthesis and high-affinity nucleic acid recognition. Chem Commun 1998; 455-456 (Pubitemid 128675297)
    • (1998) Chemical Communications , Issue.4 , pp. 455-456
    • Singh, S.K.1    Nielsen, P.2    Koshkin, A.A.3    Wengel, J.4
  • 4
    • 0032560835 scopus 로고    scopus 로고
    • Stability and structural features of the duplexes containing nucleoside analogues with a fixed N-type conformation, 2'-O,4'-C- Methyleneribonucleosides
    • DOI 10.1016/S0040-4039(98)01084-3, PII S0040403998010843
    • Obika S, Nanbu D, Hari Y, Andoh J, Morio K, Doi T, Imanishi T. Stability and structural features of the duplexes containing nucleoside analogues with a fixed N-type conformation, 2′-O,4′-C-methyleneribonucleosides. Tetrahedron Lett 1998; 39:5401-5404 (Pubitemid 28295121)
    • (1998) Tetrahedron Letters , vol.39 , Issue.30 , pp. 5401-5404
    • Obika, S.1    Nanbu, D.2    Hari, Y.3    Andoh, J.-I.4    Morio, K.-I.5    Doi, T.6    Imanishi, T.7
  • 5
    • 0032473890 scopus 로고    scopus 로고
    • LNA (Locked Nucleic Acids): Synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil bicyclonucleoside monomers, oligomerisation, and unprecedented nucleic acid recognition
    • DOI 10.1016/S0040-4020(98)00094-5, PII S0040402098000945
    • Koshkin AA, Singh SK, Nielsen P, Rajwanshi VK, Kumar R, Meldgaard M, et al. LNA (Locked Nucleic Acids): Synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil bicyclonucleoside monomers, oligomerisation and unprecedented nucleic acid recognition. Tetrahedron 1998; 54:3607-3630 (Pubitemid 28108183)
    • (1998) Tetrahedron , vol.54 , Issue.14 , pp. 3607-3630
    • Koshkin, A.A.1    Singh, S.K.2    Nielsen, P.3    Rajwanshi, V.K.4    Kumar, R.5    Meldgaard, M.6    Olsen, C.E.7    Wengel, J.8
  • 6
    • 0032909507 scopus 로고    scopus 로고
    • Synthesis of 3′-C- And 4′-C-branched oligodeoxynucleotides and the development of Locked Nucleic Acid (LNA)
    • Wengel J. Synthesis of 3′-C- and 4′-C-branched oligodeoxynucleotides and the development of Locked Nucleic Acid (LNA). Acc Chem Res 1999; 32:301-310
    • (1999) Acc Chem Res , vol.32 , pp. 301-310
    • Wengel, J.1
  • 7
    • 0037310844 scopus 로고    scopus 로고
    • LNA: A versatile tool for therapeutics and genomics
    • DOI 10.1016/S0167-7799(02)00038-0
    • Petersen M, Wengel J. LNA: a versatile tool for therapeutics and genomics. Trends Biotechnol 2003; 21:74-81. (Pubitemid 36165007)
    • (2003) Trends in Biotechnology , vol.21 , Issue.2 , pp. 74-81
    • Petersen, M.1    Wengel, J.2
  • 8
    • 6344277190 scopus 로고    scopus 로고
    • LNA (Locked Nucleic Acid): High-affinity targeting of complementary RNA and DNA
    • Vester B, Wengel J. LNA (Locked Nucleic Acid): High-affinity targeting of complementary RNA and DNA. Biochemistry 2004; 43:13233-13241 (Pubitemid 39391124)
    • (2004) Biochemistry , vol.43 , Issue.42 , pp. 13233-13241
    • Vester, B.1    Wengel, J.2
  • 9
    • 3342961686 scopus 로고    scopus 로고
    • Locked Nucleic Acid: A potent nucleic acid analog in therapeutics and biotechnology
    • Jespen JS, Sørensen MD, Wengel J. Locked Nucleic Acid: A potent nucleic acid analog in therapeutics and biotechnology. Oligonucleotides 2004; 14:130-146
    • (2004) Oligonucleotides , vol.14 , pp. 130-146
    • Jespen, J.S.1    Sørensen, M.D.2    Wengel, J.3
  • 10
    • 0030862285 scopus 로고    scopus 로고
    • Synthesis of 2′-O,4′-Cmethyleneuridine and -cytidine. Novel bicyclic nucleosides having a fixed C3'-endo sugar puckering
    • Obika S, Nanbu D, Hari Y, Morio K, In Y, Ishida T, Imanishi T. Synthesis of 2′-O,4′-Cmethyleneuridine and -cytidine. Novel bicyclic nucleosides having a fixed C3'-endo sugar puckering. Tetrahedron Lett 1997; 38:8735-8738
    • (1997) Tetrahedron Lett , vol.38 , pp. 8735-8738
    • Obika, S.1    Nanbu, D.2    Hari, Y.3    Morio, K.4    In, Y.5    Ishida, T.6    Imanishi, T.7
  • 11
    • 0037140761 scopus 로고    scopus 로고
    • Locked Nucleic Acid (LNA) recognition of RNA: NMR solution structures of LNA:RNA hybrids
    • Petersen M, Bondensgaard K, Wengel J, Jacobsen JP. Locked Nucleic Acid (LNA) recognition of RNA: NMR solution structures of LNA:RNA hybrids. J Am Chem Soc 2002; 124:5974-5982
    • (2002) J Am Chem Soc , vol.124 , pp. 5974-5982
    • Petersen, M.1    Bondensgaard, K.2    Wengel, J.3    Jacobsen, J.P.4
  • 12
    • 2442695613 scopus 로고    scopus 로고
    • NMR studies of fully modified locked nucleic acid (LNA) hybrids: Solution structure of an LNA:RNA hybrid and characterization of an LNA:DNA hybrid
    • DOI 10.1021/bc034145h
    • Nielsen KE, Rasmussen J, Kumar R, Wengel J, Jacobsen JP, Petersen M. NMR Studies of Fully Modified Locked Nucleic Acid (LNA) Hybrids: Solution structure of an LNA:RNA hybrid and characterization of an LNA:DNA hybrid. Bioconjugate Chem 2004; 15:449-457 (Pubitemid 38657849)
    • (2004) Bioconjugate Chemistry , vol.15 , Issue.3 , pp. 449-457
    • Nielsen, K.E.1    Rasmussen, J.2    Kumar, R.3    Wengel, J.4    Jacobsen, J.P.5    Petersen, M.6
  • 13
    • 27244447208 scopus 로고    scopus 로고
    • Locked Nucleic Acid (LNA): High-affinity targeting of RNA for diagnostics and therapeutics
    • Kauppinen S, Vester B, Wengel J. Locked Nucleic Acid (LNA): High-affinity targeting of RNA for diagnostics and therapeutics. Drug Discovery Today: Technologies 2005; 2:287-290
    • (2005) Drug Discovery Today: Technologies , vol.2 , pp. 287-290
    • Kauppinen, S.1    Vester, B.2    Wengel, J.3
  • 14
    • 0034938693 scopus 로고    scopus 로고
    • Locked nucleic acids (LNA): A promising molecular family for genefunction analysis and antisense drug development
    • ørum H and Wengel J. Locked nucleic acids (LNA): A promising molecular family for genefunction analysis and antisense drug development. Curr Opin Mol Ther 2001; 3:239-243
    • (2001) Curr Opin Mol Ther , vol.3 , pp. 239-243
    • Ørum, H.1    Wengel, J.2
  • 15
    • 34248657564 scopus 로고    scopus 로고
    • Efficient inhibition of HIV-1 expression by LNA modified antisense oligonucleotides and DNAzymes targeted to functionally selected binding sites
    • DOI 10.1186/1742-4690-4-29
    • Jakobsen MR, Haasnoot J, Wengel J, Berkhout B, Kjems J. Efficient inhibition of HIV-1 expression by LNA modified antisense oligonucleotides and DNAzymes targeted to functionally selected binding sites. Retrovirology 2007; 26; 4:29. (Pubitemid 46767386)
    • (2007) Retrovirology , vol.4 , pp. 29
    • Jakobsen, M.R.1    Haasnoot, J.2    Wengel, J.3    Berkhout, B.4    Kjems, J.5
  • 17
    • 70349783572 scopus 로고    scopus 로고
    • Antagomirzymes: Oligonucleotide enzymes that specifically silence MicroRNA function
    • Jadhav VM, Scaria V, Maiti S. Antagomirzymes: Oligonucleotide enzymes that specifically silence MicroRNA function. Angew Chem Int Ed 2009; 48:2557-2560
    • (2009) Angew Chem Int Ed , vol.48 , pp. 2557-2560
    • Jadhav, V.M.1    Scaria, V.2    Maiti, S.3
  • 18
    • 3242677639 scopus 로고    scopus 로고
    • SiRNAs: Applications in functional genomics and potential as therapeutics
    • Dorsett Y, Tuschl T. siRNAs: Applications in functional genomics and potential as therapeutics. Nature Rev 2004; 3:318-329 (Pubitemid 38499759)
    • (2004) Nature Reviews Drug Discovery , vol.3 , Issue.4 , pp. 318-329
    • Dorsett, Y.1    Tuschl, T.2
  • 19
    • 34147180058 scopus 로고    scopus 로고
    • Evaluation of locked nucleic acid-modified small interfering RNA in vitro and in vivo
    • DOI 10.1158/1535-7163.MCT-06-0195
    • Mook OR, Baas F, de Wissel MB, Fluiter K. Evaluation of locked nucleic acid-modified small interfering RNA in vitro and in vivo. Mol Cancer Ther 2007; 6:833-843 (Pubitemid 46554553)
    • (2007) Molecular Cancer Therapeutics , vol.6 , Issue.3 , pp. 833-843
    • Mook, O.R.1    Baas, F.2    De Wissel, M.B.3    Fluiter, K.4
  • 21
    • 0035966319 scopus 로고    scopus 로고
    • MicroRNAs: Tiny regulators with great potential
    • DOI 10.1016/S0092-8674(01)00616-X
    • Ambros V. MicroRNAs: Tiny regulators with great potential. Cell 2001; 107:823-826 (Pubitemid 34084973)
    • (2001) Cell , vol.107 , Issue.7 , pp. 823-826
    • Ambros, V.1
  • 22
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, Biogenesis, Mechanism, and Function
    • DOI 10.1016/S0092-8674(04)00045-5
    • Bartel DP. MicroRNAs: Genomics, biogenesis, mechanism and function. Cell 2004; 116:281-297 (Pubitemid 38167318)
    • (2004) Cell , vol.116 , Issue.2 , pp. 281-297
    • Bartel, D.P.1
  • 24
    • 0032860385 scopus 로고    scopus 로고
    • Aptamers: An emerging class of molecules that rival antibodies in diagnostics
    • Jayasena SD. Aptamers: An emerging class of molecules that rival antibodies in diagnostics. Clinical Chem 1999; 45:1628-1650 (Pubitemid 29419030)
    • (1999) Clinical Chemistry , vol.45 , Issue.9 , pp. 1628-1650
    • Jayasena, S.D.1
  • 25
    • 0033797244 scopus 로고    scopus 로고
    • Nucleic acid aptamers-from selection in vitro to applications in vivo
    • Famulok M, Mayer G, Blind M. Nucleic acid aptamers-from selection in vitro to applications in vivo. Acc Chem Res 2000; 33:591-599
    • (2000) Acc Chem Res , vol.33 , pp. 591-599
    • Famulok, M.1    Mayer, G.2    Blind, M.3
  • 27
    • 2942631142 scopus 로고    scopus 로고
    • LNA/DNA chimeric oligomers mimic RNA aptamers targeted to the TAR RNA element of HIV-1
    • Darfeuille F, Hansen JB, ørum H, Di Primo C, Tolumé JJ. LNA/DNA chimeric oligomers mimic RNA aptamers targeted to the TAR RNA element of HIV-1. Nucleic Acids Res 2004; 32:3101-3107
    • (2004) Nucleic Acids Res , vol.32 , pp. 3101-3107
    • Darfeuille, F.1    Hansen, J.B.2    Ørum, H.3    Di Primo, C.4    Tolumé, J.J.5
  • 28
    • 33749359169 scopus 로고    scopus 로고
    • Aptamers targeted to an RNA hairpin show improved specificity compared to that of complementary oligonucleotides
    • Darfeuille F, Hansen JB, ørum H, Di Primo C, Tolumé JJ. Aptamers targeted to an RNA hairpin show improved specificity compared to that of complementary oligonucleotides. Biochemistry 2006; 45:12076-12082
    • (2006) Biochemistry , vol.45 , pp. 12076-12082
    • Darfeuille, F.1    Hansen, J.B.2    Ørum, H.3    Di Primo, C.4    Tolumé, J.J.5
  • 30
    • 34047151422 scopus 로고    scopus 로고
    • LNA derivatives of a kissing aptamer targeted to the trans-activating responsive RNA element of HIV-1
    • Lebars I, Richard T, Di Primo C, Tolumé JJ. LNA derivatives of a kissing aptamer targeted to the trans-activating responsive RNA element of HIV-1. Blood Cells Mol Dis 2007; 38:204-209
    • (2007) Blood Cells Mol Dis , vol.38 , pp. 204-209
    • Lebars, I.1    Richard, T.2    Di Primo, C.3    Tolumé, J.J.4
  • 32
    • 0025074907 scopus 로고
    • In vitro selection of RNA molecules that bind specific ligands
    • Ellington AD, Szostak JW. In vitro selection of RNA molecules that bind specific ligands. Nature 1990; 346:818-822
    • (1990) Nature , vol.346 , pp. 818-822
    • Ellington, A.D.1    Szostak, J.W.2
  • 33
    • 0025194307 scopus 로고
    • Systemic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase
    • Turek C, Gold L. Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science 1990; 249:505-510 (Pubitemid 20248891)
    • (1990) Science , vol.249 , Issue.4968 , pp. 505-510
    • Tuerk, C.1    Gold, L.2
  • 34
    • 85011940577 scopus 로고    scopus 로고
    • http://www.santaris.com
  • 35
    • 46049121018 scopus 로고    scopus 로고
    • Polymerase chain reaction and transcription using locked nucleic acid nucleotide triphosphates
    • DOI 10.1021/ja801389n
    • Veedu RN, Vester B, Wengel J. Polymerase chain reaction and transcription using locked nucleic acid nucleotide triphosphates. J Am Chem Soc 2008; 130:8124-8125 (Pubitemid 351898512)
    • (2008) Journal of the American Chemical Society , vol.130 , Issue.26 , pp. 8124-8125
    • Veedu, R.N.1    Vester, B.2    Wengel, J.3
  • 36
    • 67649329663 scopus 로고    scopus 로고
    • Efficient enzymatic synthesis of LNA-modified DNA duplexes using KOD DNA polymerase
    • Veedu RN, Vester B, Wengel J. Efficient enzymatic synthesis of LNA-modified DNA duplexes using KOD DNA polymerase. Org Biomol Chem 2009; 7:1404-1409
    • (2009) Org Biomol Chem , vol.7 , pp. 1404-1409
    • Veedu, R.N.1    Vester, B.2    Wengel, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.