Impact of thrombocytopenia on survival of baboons with genetically modified pig liver transplants

American Journal of Transplantation

Volumn 10, Issue 2, 2010, Pages 273-285

  Ekser, B ^a,b   Long, C ^a   Echeverri, G J ^a,c   Hara, H ^a   Ezzelarab, M ^a   Lin, C C ^a   De Vera, M E ^a   Wagner, R ^d   Klein, E ^d   Wolf, R F ^e   Ayares, D ^f   Cooper, D K C ^a   Gridelli, B ^a,g  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b UNIVERSITY OF PADOVA   (Italy)

^c FUNDACIÓN VALLE DEL LILI   (Colombia)

^d UNIVERSITY OF PITTSBURGH   (United States)

^e UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^f REVIVICOR INC   (United States)

^g MEDITERRANEAN INSTITUTE FOR TRANSPLANTATION AND ADVANCED SPECIALIZED THERAPIES ISMETT   (Italy)

Author keywords

3 galactosyltransferase gene knockout; Acute; Baboon; HCD46; Liver; Pig; Xenotransplantation; 1

Indexed keywords

ALPHA 1,3 GALACTOSYLTRANSFERASE; AMIKACIN; CEFAZOLIN; COBROTOXIN; CYCLOPHOSPHAMIDE; DOPAMINE; FAMOTIDINE; GANCICLOVIR; HEPARIN; IMIPENEM; KETOROLAC; MEMBRANE COFACTOR PROTEIN; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PROSTACYCLIN; TACROLIMUS; THROMBOPLASTIN; THYMOCYTE ANTIBODY; VITAMIN K GROUP;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BABOON; BLEEDING; BLOOD CELL COUNT; BLOOD CHEMISTRY; BLOOD CLOTTING; BLOOD CULTURE; CELL AGGREGATION; COMPLEMENT ACTIVATION; CONTINUOUS INFUSION; DETOXIFICATION; ENDOTHELIUM; GENETIC ENGINEERING; GRAFT FAILURE; GRAFT REJECTION; HISTOPATHOLOGY; IMMUNOSUPPRESSIVE TREATMENT; LIVER BIOPSY; LIVER FAILURE; LIVER FUNCTION; LIVER TRANSPLANTATION; MAINTENANCE THERAPY; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; REPERFUSION; SURVIVAL; SWINE; THROMBOCYTE; THROMBOCYTOPENIA; TRANSGENIC ANIMAL; TREATMENT DURATION; XENOTRANSPLANTATION;

EID: 75149191343     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2009.02945.x     Document Type: Article

References (44)

1. United Network for Organ Sharing (UNOS). Available from : http://www.unos.org. Accessed March 29, 2009.
2. O'Grady JG, Portmann B, Wiliamms R. Fulminant hepatic failure. In : Schiff L, Schiff R, eds. Diseases of the liver. Philadelphia : JB Lippincott, 1993.
3. Bernuau J, Rueff B, Benhamou J. Fulminant and subfulminant hepatic failure: Definition and causes. Semin Liver Dis 1986 6 : 97 106.
4. Schiodt FV, Atillasoy E, Shakil AO et al. Etiology and outcome for 295 patients with acute liver in the United States. Liver Transpl Surg 1999 5 : 29 34
5. Shakil AO, Kramer D, Mazariegos GV, Fung JJ, Rakela J. Acute liver failure: Clinical features, outcome analysis, and applicability of prognostic criteria. Liver Transpl 2000 6 : 163 169.
6. Lee WM, Squires RH Jr., Nyberg SL, Doo E, Hoofnagle JH. Acute liver failure: Summary of a workshop. Hepatology 2008 47 : 1401 1415
7. Cooper DKC, Ye Y, Rolf LL, Zuhdi N. The pig as potential organ donor for man. In : Cooper DKC, Kemp E, Reemtsma K, White DJG, eds. Xenotransplantation. Heidelberg : Springer, 1991 : 481 500.
8. Cooper DKC, Dorling A, Pierson RN III. et al. α1,3- galactosyltransferase gene knockout pigs for xenotransplantation: Where do we go from here? Transplantation 2007 84 : 1 7.
9. Hara H, Gridelli B, Lin YJ, Marcos A, Cooper DKC. Liver xenografts for the treatment of acute liver failure: Clinical and experimental experience and remaining immunologic barriers. Liver Transplant 2008 14 : 425 434.
10. Ramirez P, Chavez R, Majado M et al. Life-supporting human complement regulator decay accelerating factor transgenic pig liver xenograft maintains the metabolic function and coagulation in the nonhuman primate for up to 8 days. Transplantation 2000 70 : 989 998.
11. Powelson J, Cosimi AB, Austen W Jr. et al. Porcine to primate orthotopic liver Tx. Transplant Proc 1994 26 : 1353 1354.
12. Calne RY, White HJ, Herbertson BM et al. Pig to baboon liver xenografts. Lancet 1968 1 : 1176 1778.
13. Hara H, Long C, Lin YJ et al. In vitro investigation of pig cells for resistance to human antibody-mediated rejection. Transpl Int 2008 12 : 1163 1174.
14. Phelps CJ, Koike C, Vaught TD et al. Production of 1,3- galactosyltransferase-deficient pigs. Science 2003 299 : 411 414.
15. Galili U, Shohet SB, Kobrin E, Stults CL, Macher BA. Man, apes, and old world monkeys differ from other mammals in the expression of alpha-galactosyl epitopes on nucleated cells. J Biol Chem 1988 263 : 17755 17762.
16. Good AH, Cooper DK, Malcolm AJ et al. Identification of carbohydrate structures that bind human antiporcine antibodies: Implications for discordant xenografting in man. Transplant Proc 1992 24 : 559 562.
17. Cozzi E, White DJ. The generation of transgenic pigs as potential organ donors for humans. Nat Med 1995 1 : 964 966.
18. Loveland BE, Milland J, Kyriakou P et al. Characterization of a CD46 transgenic pig and protection of transgenic kidneys against hyperacute rejection in non-immunosuppressed baboons. Xenotransplantation 2004 11 : 171 183.
19. McGregor CG, Davies WR, Oi K et al. Cardiac xenotransplantation: Recent preclinical progress with 3-month median survival. J Thorac Cardiovasc Surg 2005 130 : 844 851.
20. Kuwaki K, Tseng YL, Dor FJ et al. Heart transplantation in baboons using α1,3-galactosyltransferase gene-knockout pigs as donors: Initial experience. Nat Med 2005 11 : 29 31.
21. Cozzi E, Bhatti F, Schmoeckel M et al. Long-term survival of nonhuman primates receiving life-supporting transgenic porcine kidney xenografts. Transplantation 2000 70 : 15 21.
22. Yamada K, Yazawa K, Shimizu A et al. Marked prolongation of porcine renal xenograft survival in baboons through the use ofα1,3- galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue. Nat Med 2005 11 : 32 34.
23. Hara H, Ezzelarab M, Rood PP et al. Allosensitized humans are at no greater risk of humoral rejection of GT-KO pig organs than other humans. Xenotransplantation 2006 13 : 357 365.
24. Rood PPM, Tai HC, Hara H et al. Late onset of development of natural anti-nonGal antibodies in infant humans and baboons: Implications for xenotransplantation in infants. Transpl Int 2007 20 : 1050 1058.
25. Tai HC, Zhu X, Hara H et al. The pig-to-primate immune response: Relevance for xenotransplantation. Xenotransplantation 2007 14 : 227 235.
26. Rood PPM, Bottino R, Balamurugan AN et al. Reduction of early graft loss after intraportal porcine islet transplantation in monkeys. Transplantation 2007 83 : 202 210.
27. Chen G, Qian H, Starzl T et al. Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys. Nat Med 2005 11 : 1295 1298.
28. Ezzelarab M, Garcia B, Azimzadeh A, et al. The innate response and activation of coagulation inα1,3-galactosyltransferase gene-knockout xenograft recipients. Transplantation 2009 87 : 805 812.
29. Maggiano N, Citterio F, Evangelista A, Pozzetto U, Castagneto M, Capelli A. Immunomicroscopical localization of human preformed natural antibodies against pig tissues in xenogeneic transplantation. Histochem J 1994 26 : 553 562.
30. Ekser B, Gridelli B, Tector AJ, Cooper DKC. Pig liver xenotransplantation as a bridge to allotransplantation: Which patients might benefit? Transplantation 2009 : 1041 1049.
31. Mazariegos G, Chen Y, Squires R. Biological and artificial liver support system in children: A new perspective. Pediatr Crit Care Med 2005 6 : 616 617. (Pubitemid 41306775)
32. van de Kerkhove MP, Hoekstra R, Chamuleau RAFM, van Gulik TM. Clinical application of bioartificialliver support systems. Ann Surg 2004 240 : 216 223.
33. Sgroi A, Serre-Beinier V, Morel P, Bühler L. What clinical alternatives to whole liver transplantation? Current status of artificial devices and hepatocyte transplantation. Transplantation 2009 87 : 457 466.
34. Makowka L, Cramer DV, Hoffman A et al. The use of pig liver xenograft for temporary support of a patient with fulminant hepatic failure. Transplantation 1995 59 : 1654 1659.
35. rd., Zhang JP et al. Hyperacute lung rejection in the pig-to-human model. Part III. Platelet receptor inhibitors synergistically modulate complement activation and lung injury. Transplantation 2003 75 : 953 959.
36. Starzl TE, Fung J, Tzakis A et al. Baboon-to-human liver transplantation. Lancet 1993 341 : 65 71.
37. Tector AJ, Fridell JA, Elias N et al. Aberrations in hemostasis and coagulation in untreated discordant hepatic xenotransplantation: Studies in the dog-to-pig model. Liver Transplant 2002 8 : 153 159.
38. Miyata R, Shimazu M, Tanabe M et al. Clinical characteristics of thrombotic microangiopathy following ABO incompatible living donor liver transplantation. Liver Transplant 2007 13 : 1455 1462.
39. Rees MA, Butler AJ, Chavez-Cartaya G et al. Prolonged function of extracorporeal hDAF transgenic pig livers perfused with human blood. Transplantation 2002 73 : 1194 1202.
40. Lin CC, Chen D, McVey JH, Cooper DK, Dorling A. Expression of tissue factor and initiation of clotting by human platelets and monocytes after incubation with porcine endothelial cells. Transplantation 2008 86 : 702 709.
41. Lin CC, Cooper DK, Dorling A. Coagulation dysregulation as a barrier to xenotransplantation in the primate. Transplant Immunol 2009 21 : 75 80.
42. Demetris AJ, Jaffe R, Tzakis A et al. Antibody-mediated rejection of human orthotopic liver allografts. A study of liver transplantation across ABO blood group barriers. Am J Pathol 1988 132 : 489 502.
43. Iwamura S, Enzan H, Saibara T, Onishi S, Yamamoto Y. Hepatic sinusoidal endothelial cells can store and metabolize serum immuglobulin. Hepatology 1995 22 : 1456 1461.
44. Cooper DKC, Tseng, Y-L, Saidman, SL. Allo- and xeno-antibody cross-reactivity in transplantation. Transplantation 2004 77 : 1 5.