-
1
-
-
23744453364
-
Lifestyle intervention, glucose tolerance, and risk of developing type 2 diabetes mellitus
-
Mensink M (2005) Lifestyle intervention, glucose tolerance, and risk of developing type 2 diabetes mellitus. Metab Syndr Relat Disord 3: 26-34.
-
(2005)
Metab Syndr Relat Disord
, vol.3
, pp. 26-34
-
-
Mensink, M.1
-
2
-
-
67249117049
-
Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
-
Hindorff LA, Sethupathy P, Junkins HA, Ramos EM, Mehta JP, et al. (2009) Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc Natl Acad Sci U S A 106: 9362-9367.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 9362-9367
-
-
Hindorff, L.A.1
Sethupathy, P.2
Junkins, H.A.3
Ramos, E.M.4
Mehta, J.P.5
-
3
-
-
50049086521
-
The emerging genetic architecture of type 2 diabetes
-
Doria A, Patti ME, Kahn CR (2008) The emerging genetic architecture of type 2 diabetes. Cell Metab 8: 186-200.
-
(2008)
Cell Metab
, vol.8
, pp. 186-200
-
-
Doria, A.1
Patti, M.E.2
Kahn, C.R.3
-
4
-
-
66549087600
-
Genetic architecture of type 2 diabetes: Recent progress and clinical implications
-
Grant RW, Moore AF, Florez JC (2009) Genetic architecture of type 2 diabetes: recent progress and clinical implications. Diabetes Care 32: 1107-1114.
-
(2009)
Diabetes Care
, vol.32
, pp. 1107-1114
-
-
Grant, R.W.1
Moore, A.F.2
Florez, J.C.3
-
5
-
-
42449130081
-
Evidence of interaction between PPARG2 and HNF4A contributing to variation in insulin sensitivity in Mexican Americans
-
Black MH, Fingerlin TE, Allayee H, Zhang W, Xiang AH, et al. (2008) Evidence of interaction between PPARG2 and HNF4A contributing to variation in insulin sensitivity in Mexican Americans. Diabetes 57: 1048-1056.
-
(2008)
Diabetes
, vol.57
, pp. 1048-1056
-
-
Black, M.H.1
Fingerlin, T.E.2
Allayee, H.3
Zhang, W.4
Xiang, A.H.5
-
6
-
-
47749124258
-
Post genomewide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value
-
Cauchi S, Meyre D, Durand E, Proenca C, Marre M, et al. (2008) Post genomewide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value. PLoS One 3: e2031.
-
(2008)
PLoS One
, vol.3
-
-
Cauchi, S.1
Meyre, D.2
Durand, E.3
Proenca, C.4
Marre, M.5
-
7
-
-
21244439539
-
Analysis of separate and combined effects of common variation in KCNJ11 and PPARG on risk of type 2 diabetes
-
Hansen SK, Nielsen EM, Ek J, Andersen G, Glumer C, et al. (2005) Analysis of separate and combined effects of common variation in KCNJ11 and PPARG on risk of type 2 diabetes. J Clin Endocrinol Metab 90: 3629-3637.
-
(2005)
J Clin Endocrinol Metab
, vol.90
, pp. 3629-3637
-
-
Hansen, S.K.1
Nielsen, E.M.2
Ek, J.3
Andersen, G.4
Glumer, C.5
-
8
-
-
66249089500
-
Construction of a prediction model for type 2 diabetes mellitus in the Japanese population based on 11 genes with strong evidence of the association
-
Miyake K, Yang W, Hara K, Yasuda K, Horikawa Y, et al. (2009) Construction of a prediction model for type 2 diabetes mellitus in the Japanese population based on 11 genes with strong evidence of the association. J Hum Genet 54: 236-241.
-
(2009)
J Hum Genet
, vol.54
, pp. 236-241
-
-
Miyake, K.1
Yang, W.2
Hara, K.3
Yasuda, K.4
Horikawa, Y.5
-
9
-
-
35448944056
-
Gene-gene interactions between HNF4A and KCNJ11 in predicting Type 2 diabetes in women
-
Qi L, van Dam RM, Asselbergs FW, Hu FB (2007) Gene-gene interactions between HNF4A and KCNJ11 in predicting Type 2 diabetes in women. Diabet Med 24: 1187-1191.
-
(2007)
Diabet Med
, vol.24
, pp. 1187-1191
-
-
Qi, L.1
van Dam, R.M.2
Asselbergs, F.W.3
Hu, F.B.4
-
10
-
-
67349169201
-
Combined analysis of 19 common validated type 2 diabetes susceptibility gene variants shows moderate discriminative value and no evidence of gene-gene interaction
-
Sparso T, Grarup N, Andreasen C, Albrechtsen A, Holmkvist J, et al. (2009) Combined analysis of 19 common validated type 2 diabetes susceptibility gene variants shows moderate discriminative value and no evidence of gene-gene interaction. Diabetologia 52: 1308-1314.
-
(2009)
Diabetologia
, vol.52
, pp. 1308-1314
-
-
Sparso, T.1
Grarup, N.2
Andreasen, C.3
Albrechtsen, A.4
Holmkvist, J.5
-
11
-
-
33847361938
-
Evaluation of common variants in the six known maturity-onset diabetes of the young (MODY) genes for association with type 2 diabetes
-
Winckler W, Weedon MN, Graham RR, McCarroll SA, Purcell S, et al. (2007) Evaluation of common variants in the six known maturity-onset diabetes of the young (MODY) genes for association with type 2 diabetes. Diabetes 56: 685-693.
-
(2007)
Diabetes
, vol.56
, pp. 685-693
-
-
Winckler, W.1
Weedon, M.N.2
Graham, R.R.3
McCarroll, S.A.4
Purcell, S.5
-
12
-
-
1842866369
-
Multifactordimensionality reduction shows a two-locus interaction associated with Type 2 diabetes mellitus
-
Cho YM, Ritchie MD, Moore JH, Park JY, Lee KU, et al. (2004) Multifactordimensionality reduction shows a two-locus interaction associated with Type 2 diabetes mellitus. Diabetologia 47: 549-554.
-
(2004)
Diabetologia
, vol.47
, pp. 549-554
-
-
Cho, Y.M.1
Ritchie, M.D.2
Moore, J.H.3
Park, J.Y.4
Lee, K.U.5
-
13
-
-
33750876203
-
Combining information from common type 2 diabetes risk polymorphisms improves disease prediction
-
Weedon MN, McCarthy MI, Hitman G, Walker M, Groves CJ, et al. (2006) Combining information from common type 2 diabetes risk polymorphisms improves disease prediction. PLoS Med 3: e374.
-
(2006)
PLoS Med
, vol.3
-
-
Weedon, M.N.1
McCarthy, M.I.2
Hitman, G.3
Walker, M.4
Groves, C.J.5
-
14
-
-
0036155238
-
A perspective on epistasis: Limits of models displaying no main effect
-
Culverhouse R, Suarez BK, Lin J, Reich T (2002) A perspective on epistasis: limits of models displaying no main effect. Am J Hum Genet 70: 461-471.
-
(2002)
Am J Hum Genet
, vol.70
, pp. 461-471
-
-
Culverhouse, R.1
Suarez, B.K.2
Lin, J.3
Reich, T.4
-
15
-
-
33745677664
-
Threelocus and four-locus QTL interactions influence mouse insulin-like growth factor-I
-
Hanlon P, Lorenz WA, Shao Z, Harper JM, Galecki AT, et al. (2006) Threelocus and four-locus QTL interactions influence mouse insulin-like growth factor-I. Physiol Genomics 26: 46-54.
-
(2006)
Physiol Genomics
, vol.26
, pp. 46-54
-
-
Hanlon, P.1
Lorenz, W.A.2
Shao, Z.3
Harper, J.M.4
Galecki, A.T.5
-
16
-
-
67650447975
-
Epistasis and the evolutionary dynamics of measured genotypic values during simulated serial bottlenecks
-
Jarvis JP, Cheverud JM (2009) Epistasis and the evolutionary dynamics of measured genotypic values during simulated serial bottlenecks. J Evol Biol 22: 1658-1668.
-
(2009)
J Evol Biol
, vol.22
, pp. 1658-1668
-
-
Jarvis, J.P.1
Cheverud, J.M.2
-
17
-
-
57649190746
-
Populationspecific risk of type 2 diabetes conferred by HNF4A P2 promoter variants: A lesson for replication studies
-
Barroso I, Luan J, Wheeler E, Whittaker P, Wasson J, et al. (2008) Populationspecific risk of type 2 diabetes conferred by HNF4A P2 promoter variants: a lesson for replication studies. Diabetes 57: 3161-3165.
-
(2008)
Diabetes
, vol.57
, pp. 3161-3165
-
-
Barroso, I.1
Luan, J.2
Wheeler, E.3
Whittaker, P.4
Wasson, J.5
-
18
-
-
39649085581
-
Genetic study of Saudi diabetes (GSSD): Significant association of the KCNJ11 E23K polymorphism with type 2 diabetes
-
Alsmadi O, Al-Rubeaan K, Wakil SM, Imtiaz F, Mohamed G, et al. (2008) Genetic study of Saudi diabetes (GSSD): significant association of the KCNJ11 E23K polymorphism with type 2 diabetes. Diabetes Metab Res Rev 24: 137-140.
-
(2008)
Diabetes Metab Res Rev
, vol.24
, pp. 137-140
-
-
Alsmadi, O.1
Al-Rubeaan, K.2
Wakil, S.M.3
Imtiaz, F.4
Mohamed, G.5
-
19
-
-
0037317981
-
Largescale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes
-
Gloyn AL, Weedon MN, Owen KR, Turner MJ, Knight BA, et al. (2003) Largescale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes. Diabetes 52: 568-572.
-
(2003)
Diabetes
, vol.52
, pp. 568-572
-
-
Gloyn, A.L.1
Weedon, M.N.2
Owen, K.R.3
Turner, M.J.4
Knight, B.A.5
-
20
-
-
0037280761
-
E23K single nucleotide polymorphism in the islet ATP-sensitive potassium channel gene (Kir6.2) contributes as much to the risk of Type II diabetes in Caucasians as the PPARgamma Pro12Ala variant
-
Love-Gregory L, Wasson J, Lin J, Skolnick G, Suarez B, et al. (2003) E23K single nucleotide polymorphism in the islet ATP-sensitive potassium channel gene (Kir6.2) contributes as much to the risk of Type II diabetes in Caucasians as the PPARgamma Pro12Ala variant. Diabetologia 46: 136-137.
-
(2003)
Diabetologia
, vol.46
, pp. 136-137
-
-
Love-Gregory, L.1
Wasson, J.2
Lin, J.3
Skolnick, G.4
Suarez, B.5
-
21
-
-
0036314298
-
K(IR)6.2 polymorphism predisposes to type 2 diabetes by inducing overactivity of pancreatic beta-cell ATP-sensitive K(+) channels
-
Schwanstecher C, Meyer U, Schwanstecher M (2002) K(IR)6.2 polymorphism predisposes to type 2 diabetes by inducing overactivity of pancreatic beta-cell ATP-sensitive K(+) channels. Diabetes 51: 875-879.
-
(2002)
Diabetes
, vol.51
, pp. 875-879
-
-
Schwanstecher, C.1
Meyer, U.2
Schwanstecher, M.3
-
22
-
-
39049100084
-
Testing of diabetes-associated WFS1 polymorphisms in the Diabetes Prevention Program
-
Florez JC, Jablonski KA, McAteer J, Sandhu MS, Wareham NJ, et al. (2008) Testing of diabetes-associated WFS1 polymorphisms in the Diabetes Prevention Program. Diabetologia 51: 451-457.
-
(2008)
Diabetologia
, vol.51
, pp. 451-457
-
-
Florez, J.C.1
Jablonski, K.A.2
McAteer, J.3
Sandhu, M.S.4
Wareham, N.J.5
-
23
-
-
39049146958
-
Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations
-
Franks PW, Rolandsson O, Debenham SL, Fawcett KA, Payne F, et al. (2008) Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations. Diabetologia 51: 458-463.
-
(2008)
Diabetologia
, vol.51
, pp. 458-463
-
-
Franks, P.W.1
Rolandsson, O.2
Debenham, S.L.3
Fawcett, K.A.4
Payne, F.5
-
24
-
-
0036227462
-
Association studies of genetic variation in the WFS1 gene and type 2 diabetes in U.K. populations
-
Minton JA, Hattersley AT, Owen K, McCarthy MI, Walker M, et al. (2002) Association studies of genetic variation in the WFS1 gene and type 2 diabetes in U.K. populations. Diabetes 51: 1287-1290.
-
(2002)
Diabetes
, vol.51
, pp. 1287-1290
-
-
Minton, J.A.1
Hattersley, A.T.2
Owen, K.3
McCarthy, M.I.4
Walker, M.5
-
25
-
-
34547536393
-
Common variants in WFS1 confer risk of type 2 diabetes
-
Sandhu MS, Weedon MN, Fawcett KA, Wasson J, Debenham SL, et al. (2007) Common variants in WFS1 confer risk of type 2 diabetes. Nat Genet 39: 951-953.
-
(2007)
Nat Genet
, vol.39
, pp. 951-953
-
-
Sandhu, M.S.1
Weedon, M.N.2
Fawcett, K.A.3
Wasson, J.4
Debenham, S.L.5
-
26
-
-
39049147926
-
Candidate gene studies reveal that the WFS1 gene joins the expanding list of novel type 2 diabetes genes
-
Wasson J, Permutt MA (2008) Candidate gene studies reveal that the WFS1 gene joins the expanding list of novel type 2 diabetes genes. Diabetologia 51: 391-393.
-
(2008)
Diabetologia
, vol.51
, pp. 391-393
-
-
Wasson, J.1
Permutt, M.A.2
-
27
-
-
33745599582
-
A flexible computational framework for detecting, characterizing, and interpreting statistical patterns of epistasis in genetic studies of human disease susceptibility
-
Moore JH, Gilbert JC, Tsai CT, Chiang FT, Holden T, et al. (2006) A flexible computational framework for detecting, characterizing, and interpreting statistical patterns of epistasis in genetic studies of human disease susceptibility. J Theor Biol 241: 252-261.
-
(2006)
J Theor Biol
, vol.241
, pp. 252-261
-
-
Moore, J.H.1
Gilbert, J.C.2
Tsai, C.T.3
Chiang, F.T.4
Holden, T.5
-
28
-
-
0035119822
-
A genome scan for type 2 diabetes susceptibility loci in a genetically isolated population
-
Permutt MA, Wasson JC, Suarez BK, Lin J, Thomas J, et al. (2001) A genome scan for type 2 diabetes susceptibility loci in a genetically isolated population. Diabetes 50: 681-685.
-
(2001)
Diabetes
, vol.50
, pp. 681-685
-
-
Permutt, M.A.1
Wasson, J.C.2
Suarez, B.K.3
Lin, J.4
Thomas, J.5
-
29
-
-
0002472579
-
Genetic Diseases in the Ashkenazi Population: Evolutionary Considerations
-
In: Bonné-Tamir B, Adam A, eds., New York: Oxford University Press
-
Jordes L (1992) Genetic Diseases in the Ashkenazi Population: Evolutionary Considerations. In: Bonné-Tamir B, Adam A, eds. Genetic Diversity Among Jews: Diseases and Markers at the DNA Level. New York: Oxford University Press. pp 305-318.
-
(1992)
Genetic Diversity Among Jews: Diseases and Markers at the DNA Level
, pp. 305-318
-
-
Jordes, L.1
-
30
-
-
33646251112
-
Lipoprotein genotype and conserved pathway for exceptional longevity in humans
-
Atzmon G, Rincon M, Schechter CB, Shuldiner AR, Lipton RB, et al. (2006) Lipoprotein genotype and conserved pathway for exceptional longevity in humans. PLoS Biol 4: e113.
-
(2006)
PLoS Biol
, vol.4
-
-
Atzmon, G.1
Rincon, M.2
Schechter, C.B.3
Shuldiner, A.R.4
Lipton, R.B.5
-
31
-
-
0142088521
-
Unique lipoprotein phenotype and genotype associated with exceptional longevity
-
Barzilai N, Atzmon G, Schechter C, Schaefer EJ, Cupples AL, et al. (2003) Unique lipoprotein phenotype and genotype associated with exceptional longevity. Jama 290: 2030-2040.
-
(2003)
Jama
, vol.290
, pp. 2030-2040
-
-
Barzilai, N.1
Atzmon, G.2
Schechter, C.3
Schaefer, E.J.4
Cupples, A.L.5
-
32
-
-
0036244869
-
Assessing allele frequencies of single nucleotide polymorphisms in DNA pools by pyrosequencing technology
-
passim
-
Wasson J, Skolnick G, Love-Gregory L, Permutt MA (2002) Assessing allele frequencies of single nucleotide polymorphisms in DNA pools by pyrosequencing technology. Biotechniques 32: 1144-1146, 1148, 1150 passim.
-
(2002)
Biotechniques
, vol.32
-
-
Wasson, J.1
Skolnick, G.2
Love-Gregory, L.3
Permutt, M.A.4
-
33
-
-
47049090142
-
Adiponectin levels and genotype: A potential regulator of life span in humans
-
Atzmon G, Pollin TI, Crandall J, Tanner K, Schechter CB, et al. (2008) Adiponectin levels and genotype: a potential regulator of life span in humans. J Gerontol A Biol Sci Med Sci 63: 447-453.
-
(2008)
J Gerontol A Biol Sci Med Sci
, vol.63
, pp. 447-453
-
-
Atzmon, G.1
Pollin, T.I.2
Crandall, J.3
Tanner, K.4
Schechter, C.B.5
-
34
-
-
0035873429
-
Commentary: Facing the challenge of geneenvironment interaction: The two-by-four table and beyond
-
Botto LD, Khoury MJ (2001) Commentary: facing the challenge of geneenvironment interaction: the two-by-four table and beyond. Am J Epidemiol 153: 1016-1020.
-
(2001)
Am J Epidemiol
, vol.153
, pp. 1016-1020
-
-
Botto, L.D.1
Khoury, M.J.2
-
35
-
-
15944383403
-
Gene-environment interactions in human diseases
-
Hunter DJ (2005) Gene-environment interactions in human diseases. Nat Rev Genet 6: 287-298.
-
(2005)
Nat Rev Genet
, vol.6
, pp. 287-298
-
-
Hunter, D.J.1
-
36
-
-
0034973569
-
Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer
-
Ritchie MD, Hahn LW, Roodi N, Bailey LR, Dupont WD, et al. (2001) Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer. Am J Hum Genet 69: 138-147.
-
(2001)
Am J Hum Genet
, vol.69
, pp. 138-147
-
-
Ritchie, M.D.1
Hahn, L.W.2
Roodi, N.3
Bailey, L.R.4
Dupont, W.D.5
-
37
-
-
0037433052
-
Multifactor dimensionality reduction software for detecting gene-gene and gene-environment interactions
-
Hahn LW, Ritchie MD, Moore JH (2003) Multifactor dimensionality reduction software for detecting gene-gene and gene-environment interactions. Bioinformatics 19: 376-382.
-
(2003)
Bioinformatics
, vol.19
, pp. 376-382
-
-
Hahn, L.W.1
Ritchie, M.D.2
Moore, J.H.3
-
38
-
-
34247338434
-
A balanced accuracy function for epistasis modeling in imbalanced datasets using multifactor dimensionality reduction
-
Velez DR, White BC, Motsinger AA, Bush WS, Ritchie MD, et al. (2007) A balanced accuracy function for epistasis modeling in imbalanced datasets using multifactor dimensionality reduction. Genet Epidemiol 31: 306-315.
-
(2007)
Genet Epidemiol
, vol.31
, pp. 306-315
-
-
Velez, D.R.1
White, B.C.2
Motsinger, A.A.3
Bush, W.S.4
Ritchie, M.D.5
-
40
-
-
34250821108
-
A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence
-
Lou XY, Chen GB, Yan L, Ma JZ, Zhu J, et al. (2007) A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence. Am J Hum Genet 80: 1125-1137.
-
(2007)
Am J Hum Genet
, vol.80
, pp. 1125-1137
-
-
Lou, X.Y.1
Chen, G.B.2
Yan, L.3
Ma, J.Z.4
Zhu, J.5
-
41
-
-
34548790660
-
The importance of TCF7L2
-
Weedon MN (2007) The importance of TCF7L2. Diabet Med 24: 1062-1066.
-
(2007)
Diabet Med
, vol.24
, pp. 1062-1066
-
-
Weedon, M.N.1
-
43
-
-
0037677524
-
Youngonset type 2 diabetes families are the major contributors to genetic loci in the Diabetes UK Warren 2 genome scan and identify putative novel loci on chromosomes 8q21, 21q22, and 22q11
-
Frayling TM, Wiltshire S, Hitman GA, Walker M, Levy JC, et al. (2003) Youngonset type 2 diabetes families are the major contributors to genetic loci in the Diabetes UK Warren 2 genome scan and identify putative novel loci on chromosomes 8q21, 21q22, and 22q11. Diabetes 52: 1857-1863.
-
(2003)
Diabetes
, vol.52
, pp. 1857-1863
-
-
Frayling, T.M.1
Wiltshire, S.2
Hitman, G.A.3
Walker, M.4
Levy, J.C.5
-
44
-
-
33646884801
-
Reconstruction of a functional human gene network, with an application for prioritizing positional candidate genes
-
Franke L, van Bakel H, Fokkens L, de Jong ED, Egmont-Petersen M, et al. (2006) Reconstruction of a functional human gene network, with an application for prioritizing positional candidate genes. Am J Hum Genet 78: 1011-1025.
-
(2006)
Am J Hum Genet
, vol.78
, pp. 1011-1025
-
-
Franke, L.1
van Bakel, H.2
Fokkens, L.3
de Jong, E.D.4
Egmont-Petersen, M.5
-
45
-
-
27744523525
-
Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis
-
Riggs AC, Bernal-Mizrachi E, Ohsugi M, Wasson J, Fatrai S, et al. (2005) Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis. Diabetologia 48: 2313-2321.
-
(2005)
Diabetologia
, vol.48
, pp. 2313-2321
-
-
Riggs, A.C.1
Bernal-Mizrachi, E.2
Ohsugi, M.3
Wasson, J.4
Fatrai, S.5
-
46
-
-
34247500820
-
Macrosomia and hyperinsulinaemic hypoglycaemia in patients with heterozygous mutations in the HNF4A gene
-
Pearson ER, Boj SF, Steele AM, Barrett T, Stals K, et al. (2007) Macrosomia and hyperinsulinaemic hypoglycaemia in patients with heterozygous mutations in the HNF4A gene. PLoS Med 4: e118.
-
(2007)
PLoS Med
, vol.4
-
-
Pearson, E.R.1
Boj, S.F.2
Steele, A.M.3
Barrett, T.4
Stals, K.5
|