메뉴 건너뛰기




Volumn 51, Issue 3, 2008, Pages 391-393

Candidate gene studies reveal that the WFS1 gene joins the expanding list of novel type 2 diabetes genes

Author keywords

Gene polymorphisms; Genetic risk; Type 2 diabetes

Indexed keywords

AMINO ACID; PROTEIN WFS 1; UNCLASSIFIED DRUG; WOLFRAMIN;

EID: 39049147926     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-007-0920-9     Document Type: Note
Times cited : (18)

References (19)
  • 2
    • 0028038337 scopus 로고
    • Linkage of the gene for Wolfram syndrome to markers on the short arm of chromosome 4
    • Polymeropoulos MH, Swift RG, Swift M (1994) Linkage of the gene for Wolfram syndrome to markers on the short arm of chromosome 4. Nat Genet 8:95-97
    • (1994) Nat Genet , vol.8 , pp. 95-97
    • Polymeropoulos, M.H.1    Swift, R.G.2    Swift, M.3
  • 3
    • 17344362695 scopus 로고    scopus 로고
    • A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome)
    • Inoue H, Tanizawa Y, Wasson J et al (1998) A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome). Nat Genet 20:143-148
    • (1998) Nat Genet , vol.20 , pp. 143-148
    • Inoue, H.1    Tanizawa, Y.2    Wasson, J.3
  • 4
    • 34548205978 scopus 로고    scopus 로고
    • Differential diagnosis of type 1 diabetes: Which genetic syndromes need to be considered?
    • Suppl 6
    • Barrett TG (2007) Differential diagnosis of type 1 diabetes: which genetic syndromes need to be considered? Pediatr Diabetes 8(Suppl 6):15-23
    • (2007) Pediatr Diabetes , vol.8 , pp. 15-23
    • Barrett, T.G.1
  • 5
    • 0036227462 scopus 로고    scopus 로고
    • Association studies of genetic variation in the WFS1 gene and type 2 diabetes in U.K. populations
    • Minton JA, Hattersley AT, Owen K et al (2002) Association studies of genetic variation in the WFS1 gene and type 2 diabetes in U.K. populations. Diabetes 51:1287-1290
    • (2002) Diabetes , vol.51 , pp. 1287-1290
    • Minton, J.A.1    Hattersley, A.T.2    Owen, K.3
  • 6
    • 34547536393 scopus 로고    scopus 로고
    • Common variants in WFS1 confer risk of type 2 diabetes
    • Sandhu MS, Weedon MN, Fawcett KA et al (2007) Common variants in WFS1 confer risk of type 2 diabetes. Nat Genet 39:951-953
    • (2007) Nat Genet , vol.39 , pp. 951-953
    • Sandhu, M.S.1    Weedon, M.N.2    Fawcett, K.A.3
  • 7
    • 39049146958 scopus 로고    scopus 로고
    • Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations
    • (in press) DOI 10.1007/s00125-007-0887-6
    • Franks PW, Rolandsson O, Debenham SL et al (2008) Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations. Diabetologia (in press) DOI 10.1007/s00125-007-0887-6
    • (2008) Diabetologia
    • Franks, P.W.1    Rolandsson, O.2    Debenham, S.L.3
  • 8
    • 34249888775 scopus 로고    scopus 로고
    • Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
    • Saxena R, Voight BF, Lyssenko V et al (2007) Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316:1331-1336
    • (2007) Science , vol.316 , pp. 1331-1336
    • Saxena, R.1    Voight, B.F.2    Lyssenko, V.3
  • 9
    • 34249885875 scopus 로고    scopus 로고
    • A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
    • Scott LJ, Mohlke KL, Bonnycastle LL et al (2007) A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316:1341-1345
    • (2007) Science , vol.316 , pp. 1341-1345
    • Scott, L.J.1    Mohlke, K.L.2    Bonnycastle, L.L.3
  • 10
    • 33847176604 scopus 로고    scopus 로고
    • A genome-wide association study identifies novel risk loci for type 2 diabetes
    • Sladek R, Rocheleau G, Rung J et al (2007) A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 445:881-885
    • (2007) Nature , vol.445 , pp. 881-885
    • Sladek, R.1    Rocheleau, G.2    Rung, J.3
  • 11
    • 39049100084 scopus 로고    scopus 로고
    • Testing of diabetes-associated WFS1 polymorphisms in the Diabetes Prevention Program
    • (in press) DOI 10.1007/s00125-007-0891-x
    • Florez JC, Jablonski KA, McAteer J et al (2008) Testing of diabetes-associated WFS1 polymorphisms in the Diabetes Prevention Program. Diabetologia (in press) DOI 10.1007/s00125-007-0891-x
    • (2008) Diabetologia
    • Florez, J.C.1    Jablonski, K.A.2    McAteer, J.3
  • 12
    • 0041919371 scopus 로고    scopus 로고
    • Wolfram syndrome: Structural and functional analyses of mutant and wild-type wolframin, the WFS1 gene product
    • Hofmann S, Philbrook C, Gerbitz KD, Bauer MF (2003) Wolfram syndrome: structural and functional analyses of mutant and wild-type wolframin, the WFS1 gene product. Hum Mol Genet 12:2003-2012
    • (2003) Hum Mol Genet , vol.12 , pp. 2003-2012
    • Hofmann, S.1    Philbrook, C.2    Gerbitz, K.D.3    Bauer, M.F.4
  • 13
    • 0347362797 scopus 로고    scopus 로고
    • Wolframin expression induces novel ion channel activity in endoplasmic reticulum membranes and increases intracellular calcium
    • Osman AA, Saito M, Makepeace C et al (2003) Wolframin expression induces novel ion channel activity in endoplasmic reticulum membranes and increases intracellular calcium. J Biol Chem 278:52755-52762
    • (2003) J Biol Chem , vol.278 , pp. 52755-52762
    • Osman, A.A.1    Saito, M.2    Makepeace, C.3
  • 14
    • 27744523525 scopus 로고    scopus 로고
    • Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis
    • Riggs AC, Bernal-Mizrachi E, Ohsugi M et al (2005) Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis. Diabetologia 48:2313-2321
    • (2005) Diabetologia , vol.48 , pp. 2313-2321
    • Riggs, A.C.1    Bernal-Mizrachi, E.2    Ohsugi, M.3
  • 15
    • 22744444016 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress induces Wfs1 gene expression in pancreatic beta-cells via transcriptional activation
    • Ueda K, Kawano J, Takeda K et al (2005) Endoplasmic reticulum stress induces Wfs1 gene expression in pancreatic beta-cells via transcriptional activation. Eur J Endocrinol 153:167-176
    • (2005) Eur J Endocrinol , vol.153 , pp. 167-176
    • Ueda, K.1    Kawano, J.2    Takeda, K.3
  • 16
    • 33747849846 scopus 로고    scopus 로고
    • Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1
    • Lipson KL, Fonseca SG, Ishigaki S et al (2006) Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1. Cell Metab 4:245-254
    • (2006) Cell Metab , vol.4 , pp. 245-254
    • Lipson, K.L.1    Fonseca, S.G.2    Ishigaki, S.3
  • 17
    • 0034968330 scopus 로고    scopus 로고
    • Diabetes mellitus and exocrine pancreatic dysfunction in Perk-/- mice reveals a role for translational control in secretory cell survival
    • Harding HP, Zeng H, Zhang Y et al (2001) Diabetes mellitus and exocrine pancreatic dysfunction in Perk-/- mice reveals a role for translational control in secretory cell survival. Mol Cell 7:1153-1163
    • (2001) Mol Cell , vol.7 , pp. 1153-1163
    • Harding, H.P.1    Zeng, H.2    Zhang, Y.3
  • 18
    • 3042696843 scopus 로고    scopus 로고
    • Wolcott-Rallison syndrome: Clinical, genetic, and functional study of EIF2AK3 mutations and suggestion of genetic heterogeneity
    • Senee V, Vattem KM, Delepine M et al (2004) Wolcott-Rallison syndrome: clinical, genetic, and functional study of EIF2AK3 mutations and suggestion of genetic heterogeneity. Diabetes 53:1876-1883
    • (2004) Diabetes , vol.53 , pp. 1876-1883
    • Senee, V.1    Vattem, K.M.2    Delepine, M.3
  • 19
    • 2942731683 scopus 로고    scopus 로고
    • Disruption of the WFS1 gene in mice causes progressive beta-cell loss and impaired stimulus-secretion coupling in insulin secretion
    • Ishihara H, Takeda S, Tamura A et al (2004) Disruption of the WFS1 gene in mice causes progressive beta-cell loss and impaired stimulus-secretion coupling in insulin secretion. Hum Mol Genet 13:1159-1170
    • (2004) Hum Mol Genet , vol.13 , pp. 1159-1170
    • Ishihara, H.1    Takeda, S.2    Tamura, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.