Inhibition of β-amyloid1-42 internalization attenuates neuronal death by stabilizing the endosomal-lysosomal system in rat cortical cultured neurons

Neuroscience

Volumn 178, Issue , 2011, Pages 181-188

  Song, M S ^a   Baker, G B ^a   Todd, K G ^a   Kar, S ^a,b  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Alzheimer's disease; Cathepsin D; Clathrin mediated endocytosis; Neurodegeneration; Neuroprotection; NMDA receptor antagonists

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; ARSENOSOBENZENE; CATHEPSIN D; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RAB PROTEIN; RAB7 PROTEIN; SUCROSE; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-42); ORGANOARSENIC DERIVATIVE; PEPTIDE FRAGMENT;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN CELL; CELL CULTURE; CELL VIABILITY; CONTROLLED STUDY; ENDOCYTOSIS; ENDOSOME; FEMALE; INTERNALIZATION; LYSOSOME; NERVE CELL NECROSIS; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN STABILITY; RAT; ANIMAL; BRAIN CORTEX; CELL SURVIVAL; CULTURE TECHNIQUE; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; NERVE CELL; PATHOLOGY; SPRAGUE DAWLEY RAT;

AMYLOID BETA-PEPTIDES; ANIMALS; ARSENICALS; CATHEPSIN D; CELL CULTURE TECHNIQUES; CELL SURVIVAL; CEREBRAL CORTEX; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOCYTOSIS; ENDOSOMES; LYSOSOMES; NERVE DEGENERATION; NEURONS; PEPTIDE FRAGMENTS; RAB GTP-BINDING PROTEINS; RAB5 GTP-BINDING PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; SUCROSE;

EID: 79952007060     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2010.12.055     Document Type: Article

References (37)

1. Bahr B.A., Hofman K.B., Yang A.J., Hess U.S., Glabe C.G., Lynch G. Amyloid β protein is internalized selectively by hippocampal field CA1 and causes neurons to accumulate amyloidogenic carboxyterminal fragments of the amyloid precursor protein. J Comp Neurol 1998, 397:139-147.
2. Bi X., Gall C.M., Zhou J., Lynch G. Uptake and pathogenic effects of amyloid beta peptide 1-42 are enhanced by integrin antagonists and blocked by NMDA receptor antagonists. Neuroscience 2002, 112:827-840.
3. Bu G., Cam J., Zerbinatti C. LRP in amyloid β production and metabolism. Ann NY Acad Sci 2006, 1086:35-53.
4. 1-42 in differentiated PC12 cells. Brain Res 1997, 746:275-284.
5. Casas C., Sergeant N., Itier J.M., Blanchard V., Wirths O., van der Kolk N., Vingtdeux V., van de Steeg E., Ret G., Canton T., Drobecq H., Clark A., Bonici B., Delacourte A., Benavides J., Schmitz C., Tremp G., Bayer T.A., Benoit P., Pradier L. Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model. Am J Pathol 2004, 165:1289-1300.
6. Cataldo A.M., Hamilton D.J., Barnett J.L., Paskevich P.A., Nixon R.A. Properties of the endosomal-lysosomal system in the human central nervous system: disturbances mark most neurons in populations at risk to degenerate in Alzheimer's disease. J Neurosci 1996, 16:186-199.
7. Cataldo A.M., Peterhoff C.M., Troncoso J.C., Gomez-Isla T., Hyman B.T., Nixon R.A. Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations. Am J Pathol 2000, 157:277-286.
8. Chwieralski C., Welte T., Buhling F. Cathepsin-regulated apoptosis. Apoptosis 2006, 11:143-149.
9. Deane R., Du Yan S., Submamaryan R.K., LaRue B., Jovanovic S., Hogg E., Welch D., Manness L., Lin C., Yu J., Zhu H., Ghiso J., Frangione B., Stern A., Schmidt A.M., Armstrong D.L., Arnold B., Liliensiek B., Nawroth P., Hofman F., Kindy M., Stern D., Zlokovic B. RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain. Nat Med 2003, 9:907-913.
10. Ditaranto K., Tekirian T.L., Yang A.J. Lysosomal membrane damage in soluble Aβ-mediated cell death in Alzheimer's disease. Neurobiol Dis 2001, 8:19-31.
11. Floden A.M., Li S., Combs C.K. β-amyloid-stimulated microglia induce neuron death via synergistic stimulation of tumor necrosis factor α and NMDA receptors. J Neurosci 2005, 25:2566-2575.
12. Gibson A.E., Noel R.J., Herlihy J.T., Ward W.F. Phenylarsine oxide inhibition of endocytosis: effects on asialofetuin internalization. Am J Physiol 1989, 257:C182-C184.
13. Gouras G.K., Almeida C.G., Takahashi R.H. Intraneuronal Aβ accumulation and origin of plaques in Alzheimer's disease. Neurobiol Aging 2005, 26:1235-1244.
14. Grbovic O.M., Mathews P.M., Jiang Y., Schmidt S.D., Dinakar R., Summers-Terio N.B., Ceresa B.P., Nixon R.A., Cataldo A.M. Rab5-stimulated up-regulation of the endocytic pathway increases intracellular beta-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Aβ production. J Biol Chem 2003, 278:31261-31268.
15. Hardy J. Amyloid, the presenilins and Alzheimer's disease. Trends Neurosci 1997, 20:154-159.
16. Hibbert A.P., Kramer B.M., Miller F.D., Kaplan D.R. The localization, trafficking and retrograde transport of BDNF bound to p75NTR in sympathetic neurons. Mol Cell Neurosci 2006, 32:387-402.
17. Iqbal K., Alonso Adel C., Chen S., Chohan M.O., El-Akkad E., Gong C.X., Khatoon S., Li B., Liu F., Rahman A., Tanimukai H., Grundke-Iqbal I. Tau pathology in Alzheimer's disease and other tauopathies. Biochim Biophys Acta 2005, 1739:198-210.
18. Kar S., Slowikowski S.P., Westaway D., Mount H.T.J. Beta-amyloid peptide and central cholinergic neurons: functional interrelationships and possible implications in Alzheimer's disease pathology. J Psychiatry Neurosci 2004, 29:427-441.
19. Lopez O.L., DeKosky S.T. Neuropathology of Alzheimer's disease and mild cognitive impairment. Rev Neurol 2003, 37:155-163.
20. Miguel-Hidalgo J.J., Alvarez X.A., Cacabelos R., Quack G. Neuroprotection by memantine against neurodegenration induced by β-amyloid(1-40). Brain Res 2002, 958:210-221.
21. Nagele R.G., D'Andrea M.R., Anderson W.J., Wang H.Y. Intracellular accumulation of beta-amyloid(1-42) in neurons is facilitated by the alpha 7 nicotinic acetylcholine receptor in Alzheimer's disease. Neuroscience 2002, 110:199-211.
22. Nixon R.A. Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases. Neurobiol Aging 2005, 26:373-382.
23. Oakley H., Cole S.L., Logan S., Maus E., Shao P., Craft J., Guillozet-Bongaarts A., Ohno M., Disterhoft J., Van Eldik L., Berry R., Vassar R. Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation. J Neurosci 2006, 26:10129-10140.
24. Oddo S., Caccamo A., Smith I.F., Green K.N., LaFerla F.M. A dynamic relationship between intracellular and extracellular pools of Abeta. Am J Pathol 2006, 168:184-194.
25. Picone P., Carrotta R., Montana G., Nobile M.R., San Biagio P.L., Di Carlo M. Aβ oligomers and fibrillar aggregates induce different apoptotic pathways in LAN5 neuroblastoma cell cultures. Biophys J 2009, 96:4200-4211.
26. Saavedra L., Mohamed A., Ma V., Kar S., de Chaves E.P. Internalization of β-amyloid peptide by primary neurons in the absence of apolipoprotein E. J Biol Chem 2007, 282:35722-35732.
27. Selkoe D.J., Schenk D. Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics. Annu Rev Pharmacol Toxicol 2003, 43:545-584.
28. Smith W.W., Gorospe M., Kusiak J.W. Signaling mechanisms underlying Abeta toxicity: potential therapeutic targets for Alzheimer's disease. CNS Neurol Disord Drug Targets 2006, 5:355-361.
29. Song M.S., Saavedra L., de Chaves E.I. Apoptosis is secondary to non-apoptotic axonal degeneration in neurons exposed to Aβ in distal axons. Neurobiol Aging 2006, 27:1224-1238.
30. Song M.S., Rauw G., Baker G.B., Kar S. Memantine protects rat cortical cultured neurons against β-amyloid-induced toxicity by attenuating tau phosphorylation. Eur J Neurosci 2008, 28:1989-2002.
31. Tremblay R., Chakravarthy B., Hewitt K., Tauskela J., Morley P., Atkinson T., Durkin J.P. Transient NMDA receptor inactivation provides long-term protection to cultured cortical neurons from a variety of death signals. J Neurosci 2000, 20:7183-7192.
32. Turk B., Stoka V., Rozman-Pungercar J., Cirman T., Droga-Mazovec G., Oresic K., Turk V. Apoptotic pathways: involvement of lysosomal proteases. Biol Chem 2002, 383:1035-1044.
33. Wirths O., Multhaup G., Bayer T.A. A modified beta-amyloid hypothesis: intraneuronal accumulation of the beta-amyloid peptide-the first step of a fatal cascade. J Neurochem 2004, 91:513-520.
34. Wu X., Zhao X., Baylor L., Kaushal S., Eisenberg E., Greene L.E. Clathrin exchange during clathrin-mediated endocytosis. J Cell Biol 2001, 155:291-300.
35. 1-42 pathogenesis. J Neurosci Res 1998, 52:691-698.
36. Yazawa H., Yu Z.X.Takeda, Le Y., Gong W., Ferrans V.J., Oppenheim J.J., Li C.C., Wang J.M. Beta amyloid peptide (Abeta42) is internalized via the G-protein-coupled receptor FPRL1 and forms fibrillar aggregates in macrophages. FASEB J 2001, 15:2454-2462.
37. Yu C., Nwabuisi-Heath E., Laxton K., Ladu M.J. Endocytic pathways mediating oligomeric Aβ neurotoxicity. Mol. Neurodegener 2010, 5:19.