Relationship between variants of the leptin gene and obesity and metabolic biomarkers in Brazilian individuals;Associação entre variantes do gene de leptina e obesidade e biomarcadores metabólicos em indivíduos Brasileiros

Arquivos Brasileiros de Endocrinologia e Metabologia

Volumn 54, Issue 3, 2010, Pages 282-288

  Hinuy, Hamilton M ^a   Hirata, Mario H ^a   Sampaio, Marcelo F ^b   Armaganijan, Dikran ^b   Arazi, Simone Sorkin ^a   Salazar, Luis A ^c   Hirata, Rosario D C ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b INSTITUTO DANTE PAZZANESE DE CARDIOLOGIA   (Brazil)

^c UNIVERSIDAD DE LA FRONTERA   (Chile)

Author keywords

Gene polymorphism; Leptin; Metabolic biomarkers; Obesity; Plasma leptin

Indexed keywords

BIOLOGICAL MARKER; LEPTIN;

BLOOD; BODY MASS; BRAZIL; EPIDEMIOLOGY; FEMALE; GENETIC VARIABILITY; GENETICS; HUMAN; MALE; MIDDLE AGED; OBESITY;

BIOLOGICAL MARKERS; BODY MASS INDEX; BRAZIL; EPIDEMIOLOGIC METHODS; FEMALE; GENETIC VARIATION; HUMANS; LEPTIN; MALE; MIDDLE AGED; OBESITY;

EID: 77953553843     PISSN: 00042730     EISSN: 16779487     Source Type: Journal    
DOI: 10.1590/S0004-27302010000300006     Document Type: Article

References (39)

1. Klok MD, Jakobsdottir S, Drent ML. The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review. Obes Rev. 2007;8:21-34.
2. Korner J, Woods SC, Woodworth KA. Regulation of energy homeostasis and health consequences in obesity. Am J Med. 2009;122(S1):S12-8.
3. Considine RV. Human leptin: an adipocyte hormone with weight-regulatory and endocrine functions. Semin Vasc Med. 2005;5:15-24.
4. Paracchini V, Pedotti P, Taioli E. Genetics of leptin and obesity: a HuGE review. Am J Epidemiol. 2005;162:101-4.
5. Rankinen T, Zuberi A, Chagnon YC, Weisnagel SJ, Argyropoulos G, Walts B, et al. The human obesity gene map: the 2005 update. Obesity (Silver Spring). 2006;14:529-644.
6. Martinez-Hernandez A, Enriquez L, Moreno-Moreno MJ, Marti A. Genetics of obesity. Public Health Nutr. 2007:10:1138-44.
7. Yiannakouris N, Melistas L, Yannakoulia M, Mungal K, Mantzoros CS. The-2548G/A polymorphism in the human leptin gene promoter region is associated with plasma free leptin levels; interaction with adiposity and gender in healthy subjects. Hormones (Athens). 2003;2:229-36.
8. Hinuy HM, Hirata MH, Forti N, Diament J, Sampaio MF, Armaganijan D, et al. Leptin G-2548A promoter polymorphism is associated with increased plasma leptin and BMI in Brazilian women. Arq Bras Endocrinol Metabol. 2008;52:611-6.
9. Ali SB, Kallel A, Ftouhi B, Sediri Y, Feki M, Slimane H, et al. Association of G-2548A LEP polymorphism with plasma leptin levels in Tunisian obese patients. Clin Biochem. 2009;42:584-8.
10. Gardezi AZ, Ziaei YZ, Marahi SM. Microsatellite polymorphism of the human leptin gene and risk of obesity. J Crit Care. 2008;23:440-4.
11. Hinuy HM, Hirata MH, Sampaio MF, Armaganijan D, Salazar LA, Hirata RD. LEP 3'HVR is associated with obesity and leptin levels in Brazilian individuals. Mol Genet Metab. 2006;89:374-80.
12. Parra FC, Amado RC, Lambertucci JR, Rocha J, Antunes CM, Pena SD. Color and genomic ancestry in Brazilians. Proc Natl Acad Sci USA. 2003;100:177-82.
13. Salazar LA, Hirata MH, Cavalli SA, Machado MO, Hirata RD. Optimized procedure for DNA isolation from fresh and cryopreserved clotted human blood useful in clinical molecular testing. Clin Chem. 1998;44:1748-50.
14. Yoo J, Seo B, Kim Y. SNPAnalyzer: a web-based integrated workbench for single-nucleotide polymorphism analysis. Nucleic Acids Res. 2005;33:W483-8.
15. Mammes O, Betoulle D, Aubert R, Herbeth B, Siest G, Fumeron F. Association of the G-2548A polymorphism in the 5' region of the LEP gene with overweight. Ann Hum Genet. 2000;64:391-4.
16. Wang TN, Huang MC, Chang WT, Ko AM, Tsai EM, Liu CS, et al. G-2548A polymorphism of the leptin gene is correlated with extreme obesity in Taiwanese aborigines. Obesity (Silver Spring). 2006;14:183-7.
17. Jiang Y, Wilk JB, Borecki I, Williamson S, DeStefano AL, Xu G, et al. Common variants in the 5' region of the leptin gene are associated with body mass index in men from the National Heart, Lung, and Blood Institute Family Heart Study. Am J Hum Genet. 2004;75:220-30.
18. Bouchard L, Tremblay A, Bouchard C, Perusse L. Contribution of several candidate gene polymorphisms in the determination of adiposity changes: results from the Québec Family Study. Int J Obes (Lond). 2007;31:891-9.
19. Ellingrod VL, Bishop JR, Moline J, Lin YC, Miller del D. Leptin and leptin receptor gene polymorphisms and increases in body mass index (BMI) from olanzapine treatment in persons with schizophrenia. Psychopharmacol Bull. 2007;40:57-62.
20. Kang SG, Lee HJ, Park YM, Choi JE, Han C, Kim YK, et al. Possible association between the -2548A/G polymorphism of the leptin gene and olanzapine-induced weight gain. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32:160-3.
21. Portoles O, Sorli JV, Frances F, Coltell O, Gonzalez JI, Saiz C, et al. Effect of genetic variation in the leptin gene promoter and the leptin receptor gene on obesity risk in a population-based casecontrol study in Spain. Eur J Epidemiol. 2006;21:605-12.
22. Le Stunff C, Le Bihan C, Schork NJ, Bougneres P. A common promoter variant of the leptin gene is associated with changes in the relationship between serum leptin and fat mass in obese girls. Diabetes. 2000;49:2196-200.
23. Ren W, Zhang SH, Wu J, Ni YX. Polymorphism of the leptin gene promoter in pedigrees of type 2 diabetes mellitus in Chongqing, China. Chin Med J (Engl). 2004;117:558-61.
24. Poitou C, Lacorte JM, Coupaye M, Bertrais S, Bedel JF, Lafon N, et al. Relationship between single nucleotide polymorphisms in leptin, IL6 and adiponectin genes and their circulating product in morbidly obese subjects before and after gastric banding surgery. Obes Surg. 2005;15:11-23.
25. Hoffstedt J, Eriksson P, Mottagui-Tabar S, Arner P. A polymorphism in the leptin promoter region (-2548 g/a) influences gene expression and adipose tissue secretion of leptin. Horm Metab Res. 2002;43:355-9.
26. Gong DW, Bi S, Pratley RE, Weintraub BD. Genomic structure and promoter analysis of the human obese gene. J Biol Chem. 1996;271:3971-4.
27. Mason MM, He Y, Chen H, Quon MJ, Reitman M. Regulation of leptin promoter function by Sp1, C/EBP, and a novel factor. Endocrinology. 1998;139:1013-22.
28. Bi S, Gavrilova O, Gong DW, Mason MM, Reitman M. Identification of a placental enhancer for the human leptin gene. J Biol Chem. 1997;272:30583-8.
29. Moreno-Aliaga MJ, Swarbrick MM, Lorente-Cebrian S, Stanhope KL, Havel PJ, Martinez JA. Sp1-mediated transcription is involved in the induction of leptin by insulin-stimulated glucose metabolism. J Mol Endocrinol. 2007;38:537-46.
30. Chagnon YC, Wilmore JH, Borecki IB, Gagnon J, Pérusse L, Chagnon M, et al. Associations between the leptin receptor gene and adiposity in middle-aged Caucasian males from the HERITAGE family study. J Clin Endocrinol Metab. 2000;85:29-34.
31. Mattevi VS, Zembrzuski VM, Hutz MH. Association analysis of genes involved in the leptin-signaling pathway with obesity in Brazil. Int J Obes Relat Metab Disord. 2002;26:1179-85.
32. Mizuta E, Kokubo Y, Yamanaka I, Miyamoto Y, Okayama A, Yoshimasa Y, et al. Leptin gene and leptin receptor gene polymorphisms are associated with sweet preference and obesity. Hypertens Res. 2008;31:1069-77.
33. Ali BS, Kallel A, Sediri Y, Ftouhi B, Feki M, Slimene H, et al. LEPR p.Q223R Polymorphism influences plasma leptin levels and body mass index in Tunisian obese patients. Arch Med Res. 2009;40:186-90.
34. Duarte SF, Francischetti EA, Genelhu VA, Cabello PH, Pimentel MM. LEPR p.Q223R, beta3-AR p.W64R and LEP c.-2548G>A gene variants in obese Brazilian subjects. Genet Mol Res. 2007;6:1035-43.
35. Hart Sailors ML, Folsom AR, Ballantyne CM, Hoelscher DM, Jackson AS, Linda Kao WH, et al. Genetic variation and decreased risk for obesity in the Atherosclerosis Risk in Communities Study. Diabetes Obes Metab. 2007;9:548-7.
36. Shintani M, Ikegami H, Fujisawa T, Kawaguchi Y, Ohishi M, Katsuya T, et al. Leptin gene polymorphism is associated with hypertension independent of obesity. J Clin Endocrinol Metab. 2002;87:2909-12.
37. Rutkowski MP, Klanke CA, Su YR, Reif M, Menon AG. Genetic markers at the leptin (OB) locus are not significantly linked to hypertension in African Americans. Hypertension. 1998;31:1230-4.
38. Maestrini S, Mencarelli M, Verti B, Walker GE, Savia G, Marzullo P, et al. Lack of association between the tetranucleotide repeat polymorphism in the 3'-flanking region of the leptin gene and hypertension in severely obese patients. J Endocrinol Invest. 2006;29:776-80.
39. Porreca E, Di Febbo C, Pintor S, Baccante G, Gatta V, Moretta V, et al. Microsatellite polymorphism of the human leptin gene (LEP) and risk of cardiovascular disease. Int J Obes (Lond). 2006;30:209-13.