The hypothalamic control of feeding and thermogenesis - Implications on the development of obesity;O controle hipotalâmico da fome e da termogênese - Implicações no desenvolvimento da obesidade

Arquivos Brasileiros de Endocrinologia e Metabologia

Volumn 50, Issue 2, 2006, Pages 165-176

  Velloso, Lício A ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Inflammation; Insulin; Leptin; Obesity

Indexed keywords

LEPTIN;

EATING; GENETIC TRANSCRIPTION; GENETICS; HUMAN; HYPOTHALAMUS; INSULIN RESISTANCE; LIFESTYLE; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PHYSIOLOGY; REVIEW; THERMOGENESIS;

DIABETES MELLITUS, TYPE 2; EATING; HUMANS; HYPOTHALAMUS; INSULIN RESISTANCE; LEPTIN; LIFE STYLE; OBESITY; THERMOGENESIS; TRANSCRIPTION, GENETIC;

EID: 33744467955     PISSN: 00042730     EISSN: 16779487     Source Type: Journal    
DOI: 10.1590/S0004-27302006000200003     Document Type: Review

References (63)

1. Mayer J. Obesity. Postgrad Med 1972;51:66-9.
2. Baskin ML, Ard J, Franklin F, Allison DB. Prevalence of obesity in the United States. Obes Rev 2005;6:5-7.
3. Uauy R, Albala C, Kain J. Obesity trends in Latin America: Transiting from under- to overweight. J Nutr 2001;131:893S-9.
4. Kopelman PG. Obesity as a medical problem. Nature 2000;404:635-43.
5. Costa MB, Ferreira SR, Franco LJ, Gimeno SG, Iunes M. Dietary patterns in a high-risk population for glucose intolerance. Japanese-Brazilian Diabetes Study Group. J Epidemiol 2000;10:111-7.
6. Ferreira SR, Lerario DD, Gimeno SG, Sanudo A, Franco LJ. Obesity and central adiposity in Japanese immigrants: Role of the Western dietary pattern. J Epidemiol 2002;12:431-8.
7. Freire RD, Cardoso MA, Shinzato AR, Ferreira SR. Nutritional status of Japanese-Brazilian subjects: Comparison across gender and generation. Br J Nutr 2003;89:705-13.
8. Foster GD, Makris AP, Bailer BA. Behavioral treatment of obesity. Am J Clin Nutr 2005;82:230S-5.
9. Moyers SB. Medications as adjunct therapy for weight loss: Approved and off-label agents in use. J Am Diet Assoc 2005;105:948-59.
10. Zhang Y, Proença R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372:425-32.
11. Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, Devos R, et al. Identification and expression cloning of a leptin receptor, OB-R. Cell 1995;83:1263-71.
12. Tartaglia LA. The leptin receptor. J Biol Chem 1997;272:6093-6.
13. Chua Jr. SC, Chung WK, Wu-Peng XS, Zhang Y, Liu SM, Tartaglia L, et al. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science 1996;271:994-6.
14. Bjorbaek C, Uotani S, da Silva B, Flier JS. Divergent signaling capacities of the long and short isoforms of the leptin receptor. J Biol Chem 1997;272:32686-95.
15. Zabeau L, Lavens D, Peelman F, Eyckerman S, Vandekerckhove J, Tavernier J. The ins and outs of leptin receptor activation. FEBS Lett 2003;546:45-50.
16. Munzberg H, Myers Jr. MG. Molecular and anatomical determinants of central leptin resistance. Nat Neurosci 2005;8:566-70.
17. Kellerer M, Koch M, Metzinger E, Mushack J, Capp E, Haring HU. Leptin activates PI-3 kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways. Diabetologia 1997;40:1358-62.
18. Xu AW, Kaelin CB, Takeda K, Akira S, Schwartz MW, Barsh GS. PI3K integrates the action of insulin and leptin on hypothalamic neurons. J Clin Invest 2005;115:951-8.
19. Bjorbaek C, Buchholz RM, Davis SM, Bates SH, Pierroz DD, Gu H, et al. Divergent roles of SHP-2 in ERK activation by leptin receptors. J Biol Chem 2001;276:4747-55.
20. Bjorbaek C, Kahn BB. Leptin signaling in the central nervous system and the periphery. Recent Prog Horm Res 2004;59:305-31.
21. Carvalheira JB, Siloto RM, Ignacchitti I, Brenelli SL, Carvalho CR, Leite A, et al. Insulin modulates leptin-induced STAT3 activation in rat hypothalamus. FEBS Lett 2001;500:119-24.
22. Carvalheira JB, Ribeiro EB, Folli F, Velloso LA, Saad MJ. Interaction between leptin and insulin signaling pathways differentially affects JAK-STAT and PI 3-kinase-mediated signaling in rat liver. Biol Chem 2003;384:151-9.
23. Carvalheira JB, Torsoni MA, Ueno M, Amaral ME, Araújo EP, Velloso LA, et al. Cross-talk between the insulin and leptin signalling systems in rat hypothalamus. Obes Res 2005;13:48-57.
24. Kasuga M, Karlsson FA, Kahn CR. Insulin stimulates the phosphorylation of the 95,000-dalton subunit of its own receptor. Science 1982;215:185-7.
25. Saltiel AR, Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 2001;414:799-806.
26. Margolis RU, Altszuler N. Insulin in the cerebrospinal fluid. Nature 1967;215:1375-6.
27. Havrankova J, Roth J, Brownstein MJ. Concentrations of insulin and insulin receptors in the brain are independent of peripheral insulin levels. Studies of obese and streptozotocin-treated rodents. J Clin Invest 1979;64:636-42.
28. Woods SC, Lotter EC, McKay LD, Porte Jr. D. Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons. Nature 1979;282:503-5.
29. White MF. The insulin signaling system and the IRS proteins. Diabetologia 1997;40(suppl. 2):S2-17.
30. Torsoni MA, Carvalheira JB, Pereira da Silva M, de Carvalho-Filho MA, Saad MJ, Velloso LA. Molecular and functional resistance to insulin in hypothalamus of rats exposed to cold. Am J Physiol Endocrinol Metab 2003;285:E216-23.
31. Carvalheira JB, Ribeiro EB, Araújo EP, Guimarães RB, Telles MM, Torsoni M, et al. Selective impairment of insulin signalling in the hypothalamus of obese Zucker rats. Diabetologia 2003;46:1629-40.
32. Plum L, Schubert M, Bruning JC. The role of insulin receptor signaling in the brain. Trends Endocrinol Metab 2005;16:59-65.
33. Saad MJ, Carvalho CR, Thirone AC, Velloso LA. Insulin induces tyrosine phosphorylation of JAK2 in insulin-sensitive tissues of the intact rat. J Biol Chem 1996;271:22100-4.
34. Sivitz WI, Walsh SA, Morgan DA, Thomas MJ, Haynes WG. Effects of leptin on insulin sensitivity in normal rats. Endocrinology 1997;138:3395-401.
35. Flier JS. Obesity wars: Molecular progress confronts an expanding epidemic. Cell 2004;116:337-50.
36. Folli F, Bonfanti L, Renard E, Kahn CR, Merighi A. Insulin receptor substrate-1 (IRS-1) distribution in the rat central nervous system. J Neurosci 1994;14:6412-22.
37. de LAFML, Saad MJ, Velloso LA. Insulin induces tyrosine phosphorylation of the insulin receptor and SHC, and SHC/GRB2 association in cerebellum but not in forebrain cortex of rats. Brain Res 1999;826:74-82.
38. Schwartz MW, Woods SC, Porte Jr. D, Seeley RJ, Baskin DG. Central nervous system control of food intake. Nature 2000;404:661-71.
39. Pereira da Silva M, Torsoni MA, Nourani HV, Augusto VD, Souza CT, Gasparetti AL, et al. Hypothalamic melanin-concentrating hormone is induced by cold exposure and participates in the control of energy expenditure in rats. Endocrinology 2003;144:4831-40.
40. Nandi A, Kitamura Y, Kahn CR, Accili D. Mouse models of insulin resistance. Physiol Rev 2004;84:623-47.
41. Snyder EE, Walts B, Perusse L, Chagnon YC, Weisnagel SJ, Rankinen T, et al. The human obesity gene map: The 2003 update. Obes Res 2004;12:369-439.
42. Eckel RH, Grundy SM, Zimmet PZ. The metabolic syndrome. Lancet 2005;365:1415-28.
43. Radziuk J. Insulin sensitivity and its measurement: Structural commonalities among the methods. J Clin Endocrinol Metab 2000;85:4426-33.
44. Prada PO, Zecchin HG, Gasparetti AL, Torsoni MA, Ueno M, Hirata AE, et al. Western diet modulates insulin signaling, c-Jun N-terminal kinase activity, and insulin receptor substrate-1ser307 phosphorylation in a tissue-specific fashion. Endocrinology 2005;146:1576-87.
45. Araújo EP, de Souza CT, Gasparetti AL, Ueno M, Boschero AC, Saad MJ, et al. Short-term in vivo inhibition of insulin receptor substrate-1 expression leads to insulin resistance, hyperinsulinemia, and increased adiposity. Endocrinology 2005;146:1428-37.
46. Hileman SM, Pierroz DD, Masuzaki H, Bjorbaek C, El-Haschimi K, Banks WA, et al. Characterization of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity. Endocrinology 2002;143:775-83.
47. Caro JF, Kolaczynski JW, Nyce MR, Ohannesian JP, Opentanova I, Goldman WH, et al. Decreased cerebrospinal-fluid/serum leptin ratio in obesity: A possible mechanism for leptin resistance. Lancet 1996;348:159-61.
48. Banks WA, Jaspan JB, Huang W, Kastin AJ. Transport of insulin across the blood-brain barrier: Saturability at euglycemic doses of insulin. Peptides 1997;18:1423-9.
49. Kaiyala KJ, Prigeon RL, Kahn SE, Woods SC, Schwartz MW. Obesity induced by a high-fat diet is associated with reduced brain insulin transport in dogs. Diabetes 2000;49:1525-33.
50. Yiannakouris N, Yannakoulia M, Melistas L, Chan JL, Klimis-Zacas D, Mantzoros CS. The Q223R polymorphism of the leptin receptor gene is significantly associated with obesity and predicts a small percentage of body weight and body composition variability. J Clin Endocrinol Metab 2001;86:4434-9.
51. Clement K, Vaisse C, Lahlou N, Cabrol S, Pelloux V, Cassuto D, et al. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 1998;392:398-401.
52. Paracchini V, Pedotti P, Taioli E. Genetics of leptin and obesity: A HuGE review. Am J Epidemiol 2005;162:101-14.
53. Kosztolanyi G. Leprechaunism/Donohue syndrome/insulin receptor gene mutations: A syndrome delineation story from clinicopathological description to molecular understanding. Eur J Pediatr 1997;156:253-5.
54. Taylor SI, Kadowaki T, Kadowaki H, Accili D, Cama A, McKeon C. Mutations in insulin-receptor gene in insulin-resistant patients. Diabetes Care 1990;13:257-79.
55. Bruning JC, Gautam D, Burks DJ, Gillette J, Schubert M, Orban PC, et al. Role of brain insulin receptor in control of body weight and reproduction. Science 2000;289:2122-5.
56. El-Haschimi K, Pierroz DD, Hileman SM, Bjorbaek C, Flier JS. Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity. J Clin Invest 2000;105:1827-32.
57. Alexander WS, Hilton DJ. The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response. Annu Rev Immunol 2004;22:503-29.
58. Bjorbaek C, El-Haschimi K, Frantz JD, Flier JS. The role of SOCS-3 in leptin signaling and leptin resistance. J Biol Chem 1999;274:30059-65.
59. Howard JK, Cave BJ, Oksanen LJ, Tzameli I, Bjorbaek C, Flier JS. Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3. Nat Med 2004;10:734-8.
60. De Souza CT, Araújo EP, Bordin S, Ashimine R, Zollner RL, Boschero AC, et al. Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus. Endocrinology 2005;146:4192-9.
61. Kohn LD, Wallace B, Schwartz F, McCall K. Is type 2 diabetes an autoimmune-inflammatory disorder of the innate immune system? Endocrinology 2005;146:4189-91.
62. Neel BG, Gu H, Pao L. The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling. Trends Biochem Sci 2003;28:284-93.
63. Zhang EE, Chapeau E, Hagihara K, Feng GS. Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism. Proc Natl Acad Sci USA 2004;101:16064-9.