Effects of leptin replacement on macro- and micronutrient preferences

International Journal of Obesity

Volumn 31, Issue 12, 2007, Pages 1859-1863

  Licinio, J ^a,b   Ribeiro, L ^a   Busnello, J V ^a   Delibasi, T ^c   Thakur, S ^c   Elashoff, R M ^c   Sharma, A ^c   Jardack, P M ^d   DePaoli, A M ^e   Wong, Ma Li ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e AMGEN INC   (United States)

Author keywords

Amino acids; Leptin; Leptin deficient; Macronutrients; Micronutrients; Vitamins

Indexed keywords

AMINO ACID; CARBOHYDRATE DERIVATIVE; LEPTIN; MINERAL; TRACE ELEMENT; VITAMIN;

ARTICLE; CALORIC INTAKE; CASE REPORT; COMPUTER PROGRAM; CONTROLLED STUDY; DIET THERAPY; FEMALE; FOOD INTAKE; GENE MUTATION; HEREDITY; HORMONE DEFICIENCY; HORMONE SUBSTITUTION; HUMAN; MACRONUTRIENT; MALE; NONHUMAN; PRIORITY JOURNAL; TREATMENT DURATION;

ANALYSIS OF VARIANCE; DIET RECORDS; DIETARY CARBOHYDRATES; DIETARY FATS; DIETARY PROTEINS; ENERGY INTAKE; FEMALE; FOOD PREFERENCES; HUMANS; LEPTIN; MALE; MICRONUTRIENTS; NUTRITIVE VALUE; SATIATION; TIME FACTORS;

EID: 36448938300     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/sj.ijo.0803703     Document Type: Article

References (7)

1. Licinio J, Caglayan S, Ozata M, Yildiz BO, de Miranda PB, O'Kirwan F et al. Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults. Proc Natl Acad Sci USA 2004; 101: 4531-4536.
2. Farooqi IS, O'Rahilly S. Monogenic obesity in humans. Annu Rev Med 2005; 56: 443-458.
3. Ozata M, Ozdemir IC, Licinio J. Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects. J Clin Endocrinol Metab 1999; 84: 3686-3695.
4. Williamson DA, Ravussin E, Wong ML, Wagner A, Dipaoli A, Caglayan S et al. Microanalysis of eating behavior of three leptin deficient adults treated with leptin therapy. Appetite 2005; 45: 75-80.
5. Wetzler S, Dumaz V, Goubern M, Tome D, Larue-Achagiotis C. Intraperitoneal leptin modifies macronutrient choice in self-selecting rats. Physiol Behav 2004; 83: 65-72.
6. Ceddia RB, Koistinen HA, Zierath JR, Sweeney G. Analysis of paradoxical observations on the association between leptin and insulin resistance. FASEB J 2002; 16: 1163-1176.
7. Poitout V, Rouault C, Guerre-Millo M, Reach G. Does leptin regulate insulin secretion? Diabetes Metab 1998; 24: 321-326.