Regulation of Activin/Nodal Signaling by Rap2-Directed Receptor Trafficking

Developmental Cell

Volumn 15, Issue 1, 2008, Pages 49-61

  Choi, Sun Cheol ^a   Kim, Gun Hwa ^a   Lee, Seung Joon ^a   Park, Eunjoo ^a   Yeo, Chang Yeol ^b   Han, Jin Kwan ^a  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

^b Ewha Womans University   (South Korea)

Author keywords

CELLBIO; DEVBIO; SIGNALING

Indexed keywords

ACTIVIN; PROTEIN NODAL; RAP2 PROTEIN; RAS PROTEIN; SMAD2 PROTEIN; SMAD7 PROTEIN;

ANIMAL CELL; ARTICLE; CELL SURFACE; CONTROLLED STUDY; EMBRYO; EMBRYO AXIS; EMBRYO PATTERN FORMATION; HUMAN; HUMAN CELL; INTERNALIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN METABOLISM; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; UPREGULATION; XENOPUS;

ACTIVIN RECEPTORS, TYPE I; ACTIVINS; ANIMALS; BIOLOGICAL TRANSPORT; BODY PATTERNING; CELL LINE; CELL NUCLEUS; EMBRYO, NONMAMMALIAN; ENDOCYTOSIS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, REPORTER; HELA CELLS; HUMANS; KIDNEY; LIGANDS; LUCIFERASES; MICROINJECTIONS; OLIGONUCLEOTIDES, ANTISENSE; PHOSPHORYLATION; RAP GTP-BINDING PROTEINS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD7 PROTEIN; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA; XENOPUS; XENOPUS PROTEINS;

EID: 46249083539     PISSN: 15345807     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.devcel.2008.05.004     Document Type: Article

References (33)

1. Agius E., Oelgeschlager M., Wessely O., Kemp C., and De Robertis E.M. Endodermal Nodal-related signals and mesoderm induction in Xenopus. Development 127 (2000) 1173-1183
2. Anders R.A., Arline S.L., Dore J.J., and Leof E.B. Distinct endocytic responses of heteromeric and homomeric transforming growth factor β receptors. Mol. Biol. Cell 8 (1997) 2133-2143
3. Bhushan A., Chen Y., and Vale W. Smad7 inhibits mesoderm formation and promotes neural cell fate in Xenopus embryos. Dev. Biol. 200 (1998) 260-268
4. Chen C., and Shen M.M. Two modes by which Lefty proteins inhibit nodal signaling. Curr. Biol. 14 (2004) 618-624
5. Choi S.C., and Han J.K. Rap2 is required for Wnt/β-catenin signaling pathway in Xenopus early development. EMBO J. 24 (2005) 985-996
6. Cordenonsi M., Dupont S., Maretto S., Insinga A., Imbriano C., and Piccolo S. Links between tumor suppressors: p53 is required for TGF-β gene responses by cooperating with Smads. Cell 113 (2003) 301-314
7. Derynck R., and Zhang Y.E. Smad-dependent and Smad-independent pathways in TGF-β family signalling. Nature 425 (2003) 577-584
8. Di Guglielmo G.M., Le Roy C., Goodfellow A.F., and Wrana J.L. Distinct endocytic pathways regulate TGF-β receptor signalling and turnover. Nat. Cell Biol. 5 (2003) 410-421
9. Dyson S., and Gurdon J.B. The interpretation of position in a morphogen gradient as revealed by occupancy of activin receptors. Cell 93 (1998) 557-568
10. Hawley S.H., Wunnenberg-Stapleton K., Hashimoto C., Laurent M.N., Watabe T., Blumberg B.W., and Cho K.W. Disruption of BMP signals in embryonic Xenopus ectoderm leads to direct neural induction. Genes Dev. 9 (1995) 2923-2935
11. Hayashi H., Abdollah S., Qiu Y., Cai J., Xu Y.Y., Grinnell B.W., Richardson M.A., Topper J.N., Gimbrone Jr. M.A., Wrana J.L., et al. The MAD-related protein Smad7 associates with the TGFβ receptor and functions as an antagonist of TGFβ signaling. Cell 89 (1997) 1165-1173
12. Hayes S., Chawla A., and Corvera S. TGF β receptor internalization into EEA1-enriched early endosomes: role in signaling to Smad2. J. Cell Biol. 158 (2002) 1239-1249
13. Jones C.M., Dale L., Hogan B.L., Wright C.V., and Smith J.C. Bone morphogenetic protein-4 (BMP-4) acts during gastrula stages to cause ventralization of Xenopus embryos. Development 122 (1996) 1545-1554
14. Jullien J., and Gurdon J. Morphogen gradient interpretation by a regulated trafficking step during ligand-receptor transduction. Genes Dev. 19 (2005) 2682-2694
15. Kavsak P., Rasmussen R.K., Causing C.G., Bonni S., Zhu H., Thomsen G.H., and Wrana J.L. Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF β receptor for degradation. Mol. Cell 6 (2000) 1365-1375
16. Lee M.A., Heasman J., and Whitman M. Timing of endogenous activin-like signals and regional specification of the Xenopus embryo. Development 128 (2001) 2939-2952
17. Lin H.K., Bergmann S., and Pandolfi P.P. Cytoplasmic PML function in TGF-β signalling. Nature 431 (2004) 205-211
18. Lin X., Duan X., Liang Y.Y., Su Y., Wrighton K.H., Long J., Hu M., Davis C.M., Wang J., Brunicardi F.C., et al. PPM1A functions as a Smad phosphatase to terminate TGFβ signaling. Cell 125 (2006) 915-928
19. Maxfield F.R., and McGraw T.E. Endocytic recycling. Nat. Rev. Mol. Cell Biol. 5 (2004) 121-132
20. Mitchell H., Choudhury A., Pagano R.E., and Leof E.B. Ligand-dependent and -independent transforming growth factor-β receptor recycling regulated by clathrin-mediated endocytosis and Rab11. Mol. Biol. Cell 15 (2004) 4166-4178
21. Nakao A., Afrakhte M., Moren A., Nakayama T., Christian J.L., Heuchel R., Itoh S., Kawabata M., Heldin N.E., Heldin C.H., et al. Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling. Nature 389 (1997) 631-635
22. Nakayama T., Snyder M.A., Grewal S.S., Tsuneizumi K., Tabata T., and Christian J.L. Xenopus Smad8 acts downstream of BMP-4 to modulate its activity during vertebrate embryonic patterning. Development 125 (1998) 857-867
23. Piccolo S., Agius E., Leyns L., Bhattacharyya S., Grunz H., Bouwmeester T., and De Robertis E.M. The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals. Nature 397 (1999) 707-710
24. Rajagopal R., Ishii S., and Beebe D.C. Intracellular mediators of transforming growth factor beta superfamily signaling localize to endosomes in chicken embryo and mouse lenses in vivo. BMC Cell Biol. 8 (2007) 25
25. Sasai Y., Lu B., Steinbeisser H., and De Robertis E.M. Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus. Nature 376 (1995) 333-336
26. Schier A.F. Nodal signaling in vertebrate development. Annu. Rev. Cell Dev. Biol. 19 (2003) 589-621
27. Shen M.M. Nodal signaling: developmental roles and regulation. Development 134 (2007) 1023-1034
28. Takahashi S., Yokota C., Takano K., Tanegashima K., Onuma Y., Goto J., and Asashima M. Two novel nodal-related genes initiate early inductive events in Xenopus Nieuwkoop center. Development 127 (2000) 5319-5329
29. Tanegashima K., Haramoto Y., Yokota C., Takahashi S., and Asashima M. Xantivin suppresses the activity of EGF-CFC genes to regulate nodal signaling. Int. J. Dev. Biol. 48 (2004) 275-283
30. Whitman M. Nodal signaling in early vertebrate embryos: themes and variations. Dev. Cell 1 (2001) 605-617
31. Wilson P.A., Lagna G., Suzuki A., and Hemmati-Brivanlou A. Concentration-dependent patterning of the Xenopus ectoderm by BMP4 and its signal transducer Smad1. Development 124 (1997) 3177-3184
32. Yeo C., and Whitman M. Nodal signals to Smads through Cripto-dependent and Cripto-independent mechanisms. Mol. Cell 7 (2001) 949-957
33. Zhang L., Zhou H., Su Y., Sun Z., Zhang H., Zhang L., Zhang Y., Ning Y., Chen Y.G., and Meng A. Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of nodal receptors. Science 306 (2004) 114-117